Download or read book Perioperative Chemotherapy written by U. Metzger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: One reason for failure to cure solid tumors by surgery appears to be the impossibility of controlling metastases that are present but latent at the time of operation. This failure is a common clinical experience with aggressive neoplasms. but it is not always appreciated in tumors with longer survival times. e. g .• breast and colon cancer. In addition. recent evidence indicates that after resection of a primary tumor micrometas tases from it might be enhanced by suppression of immune and reticu loendothelial functions of the host. Other factors, such as increase of coagulability and stress in the perioperative period, can also promote tumor growth. The development of new metastases might be facilitated by cells forced into the circulation during operative manipulations. Such events could be important for the outcome of treatment and it is suggested that preventive measures should be directed to this systemic component of solid tumors. Radical surgery can reduce the number of tumor cells to a subclinical 3 6 stage (10 to 10 cells) in which chemotherapy might be more effective than in advanced stages. Chemotherapy, on the other hand, might aggravate the surgical morbidity by influencing the wound healing pro cess, by decreasing the immune response, and/or by toxicity to the bone marrow and to the gastrointestinal tract, for example.

Download or read book The Iron Trial Magisterium 1 written by Holly Black and published by Scholastic Inc.. This book was released on 2014-09-09 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: From NEW YORK TIMES bestselling authors Holly Black and Cassandra Clare comes a riveting new series that defies what you think you know about the world of magic. Most kids would do anything to pass the Iron Trial. Not Callum Hunt. He wants to fail. All his life, Call has been warned by his father to stay away from magic. If he succeeds at the Iron Trial and is admitted into the Magisterium, he is sure it can only mean bad things for him. So he tries his best to do his worst - and fails at failing. Now the Magisterium awaits him. It's a place that's both sensational and sinister, with dark ties to his past and a twisty path to his future. The Iron Trial is just the beginning, for the biggest test is still to come . . . From the remarkable imaginations of bestselling authors Holly Black and Cassandra Clare comes a heart-stopping, mind-blowing, pulse-pounding plunge into the magical unknown.

Download or read book Trial of Magic written by K. M. Shea and published by . This book was released on 2021-07-30 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Wicked Arts written by Per Sörlin and published by BRILL. This book was released on 1999 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on an extensive body of Swedish sources, this study presents new information on the regional pattern of European witch-trials, providing insight into how social and cultural perceptions of local wichcraft were generated by interactions in the legal process.

Download or read book Cancer on Trial written by Peter Keating and published by University of Chicago Press. This book was released on 2014-04-18 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: There were no medical oncologists until a few decades ago. In the early 1960s, not only were there no such specialists, many practitioners regarded the treatment of terminally-ill cancer patients with heroic courses of chemotherapy as highly questionable. Physicians loath to assign patients randomly to competing treatments also expressed their outright opposition to the randomized clinical trials that were then relatively rare. And yet today these trials form the basis of medical oncology. How did such a spectacular change occur? How did medical oncology move from a non-entity and in some regards a reviled practice to the central position it now occupies in modern medicine? Cancer on Trial answers these questions by exploring how practitioners established a new style of practice, at the center of which lies the cancer clinical trial.

Download or read book Successful Randomized Trials written by Michael J. Domanski and published by Lippincott Williams & Wilkins. This book was released on 2009 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is a ready reference on the theory and operation of modern large, multicenter randomized clinical trials, which have come to be the basis of evidence-based medicine. Written in a concise, engaging style geared to physicians, the book explains the rationale and theoretical foundations for clinical trials, the components of modern clinical trials including their functions and interactions, and practical considerations in the design and implementation of these studies including an introduction to the economics and business aspects.

Download or read book A Trial of Sorcerers written by Elise Kova and published by . This book was released on 2021-03-04 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: ICE IS IN HER BLOOD.Eira Landan was the most forgettable Waterrunner in the Tower of Sorcerers until the day she decided to compete for a spot in the Tournament of Five Kingdoms. She knew going against the best sorcerers in the Empire wouldn't be easy.Eira expected a fight.She didn't expect that not everyone would make it out alive.

Download or read book Murder Magic Madness written by Davies Owen and published by Routledge. This book was released on 2014-05-22 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1856 William Dove, a young tenant farmer, was tried and executed for the poisoning of his wife Harriet. The trial might have been a straightforward case of homicide, but because Dove became involved with Henry Harrison, a Leeds wizard, and demonstrated through his actions and words a strong belief in magic and the powers of the devil, considerable effort was made to establish whether these beliefs were symptomatic of insanity. It seems that Dove murdered his wife to hasten a prediction made by Harrison that he would remarry a more attractive and wealthy woman. Dove employed Harrison to perform various acts of magic, and also made his own written pact with the devil to improve his personal circumstances. The book will study Dove’s beliefs and Harrison’s activities within the rural and urban communities in which they lived, and examine how modern cultures attempted to explain this largely hidden mental world, which was so sensationally exposed. The Victorian period is often portrayed as an age of great social and educational progress. This book shows how beliefs dismissed by some Victorians as ‘medieval superstitions’ continued to influence the thoughts and actions of many people, viz most famously Conan `table tapper' Doyle.

Download or read book The Book of Magic written by George R. R. Martin and published by Bantam. This book was released on 2018-10-16 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new anthology celebrating the witches and sorcerers of epic fantasy—featuring stories by George R. R. Martin, Scott Lynch, Megan Lindholm, and many others! Hot on the heels of Gardner Dozois’s acclaimed anthology The Book of Swords comes this companion volume devoted to magic. How could it be otherwise? For every Frodo, there is a Gandalf . . . and a Saruman. For every Dorothy, a Glinda . . . and a Wicked Witch of the West. What would Harry Potter be without Albus Dumbledore . . . and Severus Snape? Figures of wisdom and power, possessing arcane, often forbidden knowledge, wizards and sorcerers are shaped—or misshaped—by the potent magic they seek to wield. Yet though their abilities may be godlike, these men and women remain human—some might say all too human. Such is their curse. And their glory. In these pages, seventeen of today’s top fantasy writers—including award-winners Elizabeth Bear, John Crowley, Kate Elliott, K. J. Parker, Tim Powers, and Liz Williams—cast wondrous spells that thrillingly evoke the mysterious, awesome, and at times downright terrifying worlds where magic reigns supreme: worlds as far away as forever, and as near as next door. FEATURING SIXTEEN ALL-NEW STORIES: “The Return of the Pig” by K. J. Parker “Community Service” by Megan Lindholm “Flint and Mirror” by John Crowley “The Friends of Masquelayne the Incomparable” by Matthew Hughes “The Biography of a Bouncing Boy Terror: Chapter Two: Jumping Jack in Love” by Ysabeau S. Wilce “Song of Fire” by Rachel Pollack “Loft the Sorcerer” by Eleanor Arnason “The Governor” by Tim Powers “Sungrazer” by Liz Williams “The Staff in the Stone” by Garth Nix “No Work of Mine” by Elizabeth Bear “Widow Maker” by Lavie Tidhar “The Wolf and the Manticore” by Greg Van Eekhout “The Devil’s Whatever” by Andy Duncan “Bloom” by Kate Elliott “The Fall and Rise of the House of the Wizard Malkuril” by Scott Lynch Plus George R. R. Martin’s classic story “A Night at the Tarn House” and an introduction by Gardner Dozois Praise for The Book of Magic “In The Book of Magic, you get everything you expect and more! Assembling seventeen great authors in one place is a difficult job but this book, with a lot of help from editor Gardner Dozois, does just that. . . . This compilation is a treat for any who love a good fantasy tale.”—Geeks of Doom

Download or read book GI Surgery Annual written by Peush Sahni and published by Springer. This book was released on 2019-03-29 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 25th volume of this highly successful series covers a range of interesting topics, including biological therapy in inflammatory bowel disease, recent surgical approaches in rectal cancer, tumor markers in HPB and GI malignancies, bridging therapy for hepatocellular carcinoma, adjuncts to liver resection, IgG-related HPB diseases, ERCP-induced perforations and superior mesenteric artery syndrome. As in the previous volumes, the chapter on advances in GI surgery reviews the important new developments in the field. The GI Surgery Annual 25th Volume provides up-to-date information on current hot topics.

Download or read book Trial of Intentions written by Peter Orullian and published by Macmillan. This book was released on 2015-05-26 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: The gods who created this world have abandoned it. In their mercy, however, they chained the rogue god—and the monstrous creatures he created to plague mortalkind—in the vast and inhospitable wasteland of the Bourne. The magical Veil that contains them has protected humankind for millennia and the monsters are little more than tales told to frighten children. But the Veil has become weak and creatures of Nightmare have come through. To fight them, the races of men must form a great alliance to try and stop the creatures. But there is dissent. One king won't answer the call, his pride blinding him even to the poison in his own court. Another would see Convocation fail for his own political advantage. And still others believe Convocation is not enough. Some turn to the talents of the Sheason, who can shape the very essence of the world to their will. But their order is divided, on the brink of collapse. Tahn Junell remembers friends who despaired in a place left barren by war. One of the few who have actually faced the unspeakable horde in battle, Tahn sees something else at work and wonders about the nature of the creatures on the other side of the Veil. He chooses to go to a place of his youth, a place of science, daring to think he can find a way to prevent slaughter, prevent war. And his choices may reshape a world . . . . The second title in the Vault of Heaven series, Peter Orullian's Trial of Intentions is a mesmerizing fantasy epic that turns the conventions of the genre on its head

Download or read book The Sunbearer Trials written by Aiden Thomas and published by Feiwel & Friends. This book was released on 2022-09-06 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: Welcome to The Sunbearer Trials, where teen semidioses compete in a series of challenges with the highest of stakes, in this electric new Mexican-inspired fantasy from Aiden Thomas, the New York Times bestselling author of Cemetery Boys. “Only the most powerful and honorable semidioses get chosen. I’m just a Jade. I’m not a real hero.” As each new decade begins, the Sun’s power must be replenished so that Sol can keep traveling along the sky and keep the chaotic Obsidian gods at bay. Sol selects ten of the most worthy semidioses to compete in the Sunbearer Trials. The winner carries light and life to all the temples of Reino del Sol, but the loser has the greatest honor of all—they will be sacrificed to Sol, their body melted down to refuel the Sun Stones, protecting the world for another ten years. Teo, a seventeen-year-old Jade semidiós and the trans son of the goddess of birds, isn't worried about the Trials . . . at least, not for himself. His best friend, Niya is a Gold semidiós and a shoo-in for the Trials, and while he trusts her abilities, the odds of becoming the sacrifice is one-in-ten. But then, for the first time in over a century, the impossible happens. Sol chooses not one, but two Jade competitors. Teo, and Xio, the thirteen-year-old child of the god of bad luck. Now they must compete in five trials against Gold opponents who are more powerful and better trained. Worst of all, Teo’s annoyingly handsome ex-best friend and famous semidiós Hero, Aurelio is favored to win. Teo is determined to get himself and his friends through the trials unscathed—for fame, glory, and their own survival.

Download or read book Wicked Arts written by Per Sörlin and published by BRILL. This book was released on 2023-10-16 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on an extensive body of Swedish sources, this study presents new information on the regional pattern of European witch-trials, providing insight into how social and cultural perceptions of local wichcraft were generated by interactions in the legal process.

Download or read book Dragon Trials written by Ava Richardson and published by Createspace Independent Publishing Platform. This book was released on 2015-11-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-born Agathea Flamma intends to bring honor to her family by following in her brothers' footsteps and taking her rightful place as a Dragon Rider. With her only other option being marriage, Thea will not accept failure. She's not thrilled at her awkward, scruffy partner, Seb, but their dragon has chosen, and now the unlikely duo must learn to work as a team. Seventeen-year-old Sebastian has long been ashamed of his drunken father and poor upbringing, but then he's chosen to train as a Dragon Rider at the prestigious academy. Thrust into a world where he doesn't fit in, Seb finds a connection with his dragon that is even more powerful than he imagined. Soon, he's doing all he can to succeed and not embarrass his new partner, Thea. When Seb hears rumors that an old danger is reemerging, he and Thea begin to investigate. Armed only with their determination and the dragon they both ride, Thea and Seb may be the only defense against the Darkening that threatens to sweep the land. Together, they will have to learn to work together to save their kingdom...or die trying.

Download or read book Preoperative Neoadjuvant Chemotherapy written by Joseph Ragaz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite recent advances in adjuvant therapies of cancer, the regi mens of postoperative adjuvant chemotherapy treatment which are presently available fail to cure the majority of cancer patients. Pre operative (neoadjuvant) chemotherapy represents a new approach in drug scheduling, based on sound theoretical, pharmacokinetic, and experimental principles. The preoperative timing of chemotherapy before definitive sur gery is not a minor change in the therapy of cancer. To be successful, large numbers of practitioners and their patients must participate. Substantial alterations of many aspects of the present management of cancer will have to follow. Therefore, before such therapy can be fully and routinely implemented, results of the novel treatment and its rationale have to be carefully evaluated. In preoperative treatment, other features will likely gain impor tance. For the first time, clinicians have a chance to follow the in vivo response of the tumor exposed to preoperative chemotherapy. The subsequent histological assessment of the tumor sample may likely become an important prognostic guide, permitting more re fined individual approaches to the planning of postoperative adju vant treatment. The value of such a treatment strategy can already be appreciated in the clinical setting, as seen from the therapy of osteosarcoma. Furthermore, preoperative chemotherapy might render previously inoperable tumors operable and hence resectable with a curative intention. The preoperative reduction of tumor bulk may also effectively decrease the need for more radical operations, permitting a more uniform adoption of conservative surgery.

Download or read book Gastrointestinal Malignancies written by David Bentrem and published by Springer. This book was released on 2016-07-27 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively summarizes the current state of knowledge on malignancies of the gastrointestinal tract. Dedicated organ-based chapters evaluate current treatments and management and provide information on incidence, etiology and biological characteristics. The state of the art in the radiologic and endoscopic staging of gastrointestinal malignancies is described, and guidance is offered on the role of interventional radiology and interventional gastroenterology in the treatment of these challenging tumors. In addition, the book explores novel and evolving treatments, including personalized systemic therapy and minimally invasive surgical and radiology techniques, and addresses patient-reported outcomes and survivorship challenges. It closes by discussing animal models of gastrointestinal malignancies and examining the significance of the Ras superfamily of GTPases. It will be of benefit to all surgeons, oncologists and other specialists who treat these malignancies, as well as to trainees looking to increase their understanding of the field.

Download or read book Gastric Cancer written by Vivian E. Strong and published by Springer. This book was released on 2015-06-10 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides the most comprehensive and complete resource available on all aspects of gastric cancer and it’s management. The book covers topics such as oncologic approaches to staging, treating, and following patients, filling a critical need for resource materials on these areas. As multidisciplinary care is an integral part of gastric cancer treatment, this text is unique in including a renowned group of expert authors from a variety of disciplines, including pathology, gastroenterology, medical oncology, surgery and clinical genetics. In addition, authors from an international pool of gastric cancer experts have covered the breadth of practice and understanding globally. Edited and organized by an expert from one of the most highly respected cancer institutions in the country, Gastric Cancer: Principles and Practice is an expert review of this field, serving as a valuable reference for physicians in training and in practice, as well as for researchers who are interested in the scope of issues and advances in this important malignancy.