Download or read book Off The Planet Surviving Five Perilous Months Aboard The Space Station MIR written by Jerry M. Linenger and published by McGraw Hill Professional. This book was released on 2000-01-13 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: “An engrossing report.”—Booklist “Vividly captures the challenges and privations [Dr. Linenger] endured both before and during his flight.”—Library Journal Nothing on earth compares to Off the Planet—Dr. Jerry Linenger’s dramatic account of space exploration turned survival mission during his 132 days aboard the decaying and unstable Russian space station Mir. Not since Apollo 13 has an American astronaut faced so many catastrophic malfunctions and life-threatening emergencies in one mission. In his remarkable narrative, Linenger chronicles power outages that left the crew in complete darkness, tumbling out of control; chemical leaks and near collisions that threatened to rupture Mir’s hull; and most terrifying of all—a raging fire that almost destroyed the space station and the lives of its entire crew.
Download or read book Medical Epigenetics written by and published by Academic Press. This book was released on 2021-08-27 with total page 972 pages. Available in PDF, EPUB and Kindle. Book excerpt: **Selected for Doody's Core Titles® 2024 in Clinical Genetics** Medical Epigenetics, Second Edition provides a comprehensive analysis of epigenetics in health management, across a broad spectrum of disease categories and specialties, and with a focus on human systems, epigenetic diseases that affect these systems, and evolving modes of epigenetic-based treatment. Here, more than 40 leading researchers examine how each human system is affected by epigenetic maladies, offering an all-in-one resource on medical epigenetics not only for those directly involved with health care, but investigators in life sciences, biotech companies, graduate students, and others who are interested in applied aspects of epigenetics. Incorporating both diagnostic and prognostic epigenetic approaches, this volume also fully supports the application of epigenetics in precision medicine. This second edition of Medical Epigenetics, a volume in the Translational Epigenetics series, has been fully revised to address recent advances in disease epigenetics and role of epigenetics in precision medicine, with all-new chapters on skin cancer epigenetics, network analysis in medical epigenetics, machine learning in epigenetic diseases, and clinical trials of epigenetics drugs. - Features chapters from leading researchers and clinicians dedicated to the burgeoning role of epigenetics in medical practice - Covers emerging topics, including twin epigenetics, as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine - Organized from system disorders to multi-system disorders that involve epigenetic aberrations - Examines the role of epigenetics in precision medicine
Download or read book The Story of Space Station Mir written by David M. Harland and published by Springer Science & Business Media. This book was released on 2007-12-26 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: * Details how a succession of Salyut space stations led to the development of Mir. * Depicts Mir’s assembly piece by piece, in space, between 1982 and 1996. * Describes how Mir became an international research laboratory. * Advises how Mir technology went on to form the ‘core modules’ of the ISS. * The definitive account of Mir throughout its life through to de-orbiting in March 2001.
Download or read book Regulatory RNAs written by Bibekanand Mallick and published by Springer Science & Business Media. This book was released on 2012-02-02 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent progress in high-throughput technologies and genome wide transcriptome studies have lead to a significant scientific milestone of discovering non-coding RNAs (ncRNAs) which spans through a major portion of the genome. These RNAs most often act as riboregulators, and actively participate in the regulation of important cellular functions at the transcriptional and/or post-transcriptional levels rather than simply being an intermediated messenger between DNA and proteins. As the appreciation for the importance of ncRNAs continues to emerge, it is also increasingly clear that these play critical roles in gene regulatory processes during development and differentiation. Further, regulatory RNAs are useful biomarkers for diagnosis of diseases. Hence these RNA regulators are essential to the development of therapeutics. This book on “Regulatory RNAs” offers a comprehensive view on our current understanding of these regulatory RNAs viz. siRNA, miRNA, piRNA, snoRNA, long non-coding RNA, small RNA etc. It addresses both the biogenesis and mechanism of action of regulatory RNAs with a primary focus on their annotation, experimental methodologies (microarray, next-gen sequencing etc.) for their discovery, computational tools for their prediction, and above all, applications of these revolutionary regulatory molecules in understanding biological systems and diseases, including therapeutics. This comprehensive volume is intended for readers with research or teaching interests in ncRNA biology and will provide a major information resource on current research in the fast-moving fields of RNA and gene expression regulation. Cutting-edge and concise, “Regulatory RNAs: Basics, Methods and Applications” promises to support vital research in the field of regulatory RNAs, ever-continuing to grow rapidly and gain increasing importance in basic and translational biology.
Download or read book Gallbladder Cancer written by Vijay Kumar Shukla and published by Springer Nature. This book was released on 2023-01-30 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book discusses the recent progress in understanding the therapeutic targets for gallbladder cancer to provide opportunities for research and for developing innovative strategies that may enhance the benefit of conventional chemotherapy. The book focuses on identifying candidate molecules and the overall status of the targeted therapies available for gallbladder cancer, as there is an urgent need to discover new molecular targets that can guide the emergence of new treatment strategies to improve patient outcomes and act as biomarkers for the early detection of diseases. Recently, new treatment therapeutics targets for gallbladder cancer patients have been identified and the field is evolving rapidly. The book is relevant for the clinical researcher, surgeon, scientist and academician.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1975 with total page 1210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Combinational Immunotherapy of Cancer Novel Targets Mechanisms and Strategies written by Xuyao Zhang and published by Frontiers Media SA. This book was released on 2024-01-15 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer immunotherapy, including immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T-cell (CAR-T) therapy, has revolutionized the paradigm in cancer treatment. However, the clinical outcome of immunotherapy varies considerably among patients and only a minority of patients achieve long-term clinical benefits. This is largely attributed to the fact that existing cancer immunotherapies, which concentrate on several classical targets (CTAL-4, PD-1/PD-L1, etc.) and limited types of immune cell populations (T cells), are insufficient to cope with the complexity of highly heterogeneous tumor microenvironment (TME). This calls for more efforts to not only expand our toolbox for manipulating anticancer immunity but also diversify our combinational strategies. To this end, it is urgent to deeper our understanding of cancer immunotherapy by using both experimental and computational methodologies from multi-scale perspectives: 1) novel targets from either tumor cells or non-tumor cells within TME (e.g., tumor intrinsic resistance drivers, new immune checkpoints, neoantigens), 2) in-depth characterization of more immune cell populations (e.g., macrophages, Tregs, B cells) and their interactions and dynamics within TME, 3) landscape of actionable targets in patient populations for combination design. These efforts will open the avenue of rational design of combinational immunotherapies, allowing researchers and clinicians to design novel targeting therapeutics or to optimally orchestrate combinatory strategies aiming to surmount resistance mechanisms and improve clinical outcomes.
Download or read book written by S. W. Fallon and published by . This book was released on 1879 with total page 1266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Dictionary of the Welsh Language Explained in English written by William Owen and published by . This book was released on 1803 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fuzzy Fractional Differential Operators and Equations written by Tofigh Allahviranloo and published by Springer Nature. This book was released on 2020-06-15 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains new and useful materials concerning fuzzy fractional differential and integral operators and their relationship. As the title of the book suggests, the fuzzy subject matter is one of the most important tools discussed. Therefore, it begins by providing a brief but important and new description of fuzzy sets and the computational calculus they require. Fuzzy fractals and fractional operators have a broad range of applications in the engineering, medical and economic sciences. Although these operators have been addressed briefly in previous papers, this book represents the first comprehensive collection of all relevant explanations. Most of the real problems in the biological and engineering sciences involve dynamic models, which are defined by fuzzy fractional operators in the form of fuzzy fractional initial value problems. Another important goal of this book is to solve these systems and analyze their solutions both theoretically and numerically. Given the content covered, the book will benefit all researchers and students in the mathematical and computer sciences, but also the engineering sciences.
Download or read book The Earth s Dissipative Structures written by Oleg V. Petrov and published by Springer. This book was released on 2018-12-30 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes physical, formal mathematical and exterior (morpho-structural) manifestations of wave dynamics of the Earth, defining both its deep structural image, and the external shape of planet. In addition to the standard imagination about waves in the geological environment as short-term seismological and seismic effects, wave dynamics of the Earth are considered as long-time process, comparable to the geochronological scale. The book consists of a systematic description of the conformities discovered in the set of heterogeneous and different-order objects, which have space-related regularity and recurrence at the different levels of resolution of analysis of natural systems. For expert-geologist it includes the basis of the geodynamic wave-related concept which enables to add to the traditional concept of plate tectonics, as well as the methods of quantitative interpretation of measured geo-fields.
Download or read book The role of epigenetics in infectious diseases written by Veron Ramsuran and published by Frontiers Media SA. This book was released on 2023-03-08 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book MicroRNA in Regenerative Medicine written by Chandan K. Sen and published by Elsevier. This book was released on 2014-11-26 with total page 1305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work encapsulates the uses of miRNA across stem cells, developmental biology, tissue injury and tissue regeneration. In particular contributors provide focused coverage of methodologies, intervention and tissue engineering. Regulating virtually all biological processes, the genome's 1048 encoded microRNAs appear to hold considerable promise for the potential repair and regeneration of tissues and organs in future therapies. In this work, 50 experts address key topics of this fast-emerging field. Concisely summarizing and evaluating key findings emerging from fundamental research into translational application, they point to the current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA across repair and regeneration, and special coverage of methodologies and interventions as they point towards organ and tissue engineering - Multi-colour text layout with 150 colour figures to illustrate important findings - Take home messages encapsulate key lessons throughout text - Short chapters offer focused discussion and clear 'voice'
Download or read book MicroRNAs Novel Biomarkers and Therapeutic Targets for Human Cancers written by Takahiro Ochiya and published by MDPI. This book was released on 2018-10-16 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers" that was published in JCM
Download or read book Plasticity in the Nervous System written by Boris I. Kotliar and published by CRC Press. This book was released on 1992-07-08 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews aspects of nervous plasticity, emphasizing how the higher nervous activity of humans and animals are an expression of plastic properties of the brain. Covers the plasticity of nerve cells and its mechanisms, plasticity of the brain as the basis of individual forms of adaptive behavior, and its role in disturbances of brain function. Updated and translated from the award-winning 1986 edition, which is now a standard text in many neuroscience departments. Annotation copyrighted by Book News, Inc., Portland, OR
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Women in radiation oncology 2021 written by Christina Tsien and published by Frontiers Media SA. This book was released on 2023-04-12 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:
