Download or read book Lysophospholipid Receptors and Effects in Breast Cancer written by and published by . This book was released on 2002 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are widely-distributed stimuli of cellular growth and functions, which are generated enzymatically from precursors in membranes of activated normal cells and at much higher levels from many types of cancers. A subfamily of 0 protein-coupled receptors encoded by endothelial differentiation genes (Edg Rs) bind and transduce cellular signals from LPA (Edg-2, -4, -7) and S1P (Edg-l, -3,-S, -6, and -8). Human breast cancer cells (BCCs) express principally Edg-3, less Edg-4, very low levels of Edg-2 and Edg-5, and no Edg-1, -6,-? or -8. BCCs have much higher levels of Edg-3 S1P Rs than normal human breast epithelial cells. These Edg Rs mediate proliferation of BCCs directly by signaling growth-related immediate-early genes, through a distinctive set of transcription factors, and indirectly by increasing BCCs secretion of several autocrine protein growth factors. Delivery of LPA to BCCs by specific plasma protein carriers, such as gelsolin, and novel mechanisms for regulation of expression of Edg-3 Rs also may distinguish mechanisms of action of SIP and LPA in BCCs from those in normal breast epithelial cells. Detection of elevated levels of Edg-3 Rs and splice variants of Edg-3 Rs may become a diagnostic index of breast cancer and Edg R- directed antagonists may suppress growth and dissemination of breast cancers.
Download or read book Role of Lysophospholipids in the Initiation Progression and Therapy of Breast Cancer written by and published by . This book was released on 2004 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the initiation of this proposal, we have demonstrated that while LPP1 and LPP3 mRNA levels are decreased approximately 2 fold in breast cancer cells, autotaxin levels are increased approximately 28 fold in breast cancer cells isolated directly from patients. This should result in increased LPA and S1P production by breast cancer cells in patients. Using a novel enzyme activity assay, we have demonstrated that autotaxin activity is not significantly different in blood from control and breast cancer patients. Thus, the increased mRNA levels in tumor cells are not translated into increased autotaxin activity in the blood stream. We have demonstrated that down regulation of autotaxin by RNAi results in a decreased signaling, a novel S phase arrest and apoptosis in breast cancer cells. We have utilized a novel Si1P antibody to neutralize S1P in vitro and are currently treating mice with breast cancer xenografts to determine effects on cell growth. We have established transgenic mice expression the three LPA receptors as well as autotaxin in breast epithelium. We have obtained a LPP transgenic mouse to determine the effects of degradation of LPA and S1P on breast function and tumorigenesis by crossing to the above mice and to tumor prone mice.
Download or read book Lysophospholipid Receptors written by Jerold Chun and published by John Wiley & Sons. This book was released on 2013-02-06 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current state of the science supporting new research in lysophospholipids The study of lysophospholipids exploded with the discovery of cell surface receptors on both lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Since then, thousands of original research reports ranging from fundamental cell signaling to the physiology and pathophysiology of individual organ systems have centered on lysophospholipids. This book draws together and analyzes the current literature to provide readers with a state-of-the-science review as well as current techniques that support research in all aspects of the field of lysophospholipid signaling. Lysophospholipid Receptors is divided into three sections: Receptors and other possible effectors Enzymes Physiology and pathophysiology Within each section, the authors explain the similarities and differences between LPA and S1P signaling. Examples are provided that demonstrate the underlying mechanisms of lysophospholipid signaling across a broad range of organ systems, such as S1P signaling in cardiovascular physiology and disease and the neural effects of LPA signaling. Extensive references at the end of each chapter provide a gateway to the literature and facilitate further research into individual topics. Each chapter has been authored by one or more leading international authorities in lysophospholipid research. Based on a thorough analysis of the current research, the authors set forth what is established science and offer their expert opinion and perspective on new and emerging areas of research, setting the stage for further investigations that will solve current problems in the field.
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 2010 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metabolic Profiling Its Role in Biomarker Discovery and Gene Function Analysis written by George G. Harrigan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.
Download or read book International Review of Cell and Molecular Biology written by Kwang W. Jeon and published by Academic Press. This book was released on 2012-06 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field Provides up-to-date information and directions for future research Valuable reference material for advanced undergraduates, graduate students and professional scientists
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1796 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metabolism and Functions of Bioactive Ether Lipids in the Brain written by Akhlaq A. Farooqui and published by Springer Science & Business Media. This book was released on 2008-04-13 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Information on bioactive ether lipids and their involvement in neurological disorders is currently scattered throughout the literature. This book provides readers with a comprehensive description of metabolism of bioactive ether lipids in the brain, activities of enzymes involved in their metabolism, and their involvement in neurological disorders. It is the first book to describe the involvement of these lipids with abnormal signal transduction processes in neurological disorders.
Download or read book Functional Lipidomics written by Li Feng and published by CRC Press. This book was released on 2005-09-14 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipids play an essential role in cell signaling and subcellular structure. Systematic analysis of the total lipid structure of a cell or organism, the lipodome, can reveal novel avenues of therapeutic intervention and diagnosis. This analysis is best modeled after the lessons learned from proteomics. With contributions from pioneering researchers f
Download or read book Cancer Research written by and published by . This book was released on 2008-08 with total page 886 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book AACR 2019 Proceedings Abstracts 2749 5314 written by American Association for Cancer Research and published by Coe Truman International, LLC. This book was released on 2019-03-08 with total page 3012 pages. Available in PDF, EPUB and Kindle. Book excerpt: American Association for Cancer Research 2019 Proceedings: Abstracts 2749-5314 - Part B
Download or read book Phospholipases in Physiology and Pathology written by Sajal Chakraborti and published by Elsevier. This book was released on 2023-08-01 with total page 2974 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phospholipases in Physiology and Pathology presents a comprehensive overview on the physiology and pathology of phospholipases. This seven-volume set considers the biochemical and molecular mechanisms of normal and abnormal cell function upon dysregulation of phospholipases in different diseases. Volumes cover signal transduction mechanisms, implications in cancer, infectious diseases, neural diseases, cardiovascular diseases and other diseases, implications in inflammation, apoptosis, gene expression and non-coding RNAs, the role of natural and synthetic compounds, and stem cell therapies, nanotechnology-based therapies, and more. Together, these volumes give researchers critical insight on the mechanistic and therapeutic aspects of phospholipases. Discusses the biochemical and molecular mechanisms of normal and abnormal cell function in different disease processes Covers a wide range of basic and translational research appropriate for scientists engaged in studying the regulation of phospholipases from interdisciplinary perspectives Features state-of-the-art chapter contributions from international leaders in the field
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1876 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Sphingolipids in Cancer written by and published by Academic Press. This book was released on 2018-07-27 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sphingolipids in Cancer, Volume 140, the latest release in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Topics discussed in this updated volume include Mechanisms of ceramide-dependent cancer cell death, Sphingolipids as regulators of autophagy and endocytic trafficking, The role and function of sphingomyelin biosynthesis in the development of cancer, Neutral sphingomyelinases in cancer: Friend or foe?, Sphingolipid rendezvous at the crossroad of NAFLD and senescence, Ceramide signaling and p53 pathways, Sphingolipid regulation of RNA Biology in cancer phenotypes, The role of ceramide-1-phosphate in tumor cell survival and dissemination, and more. Provides information on cancer research, with this release focusing on sphingolipids Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike
Download or read book Anticancer Research written by and published by . This book was released on 1999 with total page 936 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book EndoCANNABINOIDS written by Mary E. Abood and published by Springer Science & Business Media. This book was released on 2013 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cloning of two G protein-coupled cannabinoid receptors, termed CB1 and CB2, in the early 1990s has stimulated and facilitated research conducted on the physiological function of cannabinoid actions in the brain and throughout the body. In the twenty years since the identification of these two receptors, endogenous ligands (endocannabinoids) for these receptors have been identified, their biosynthetic and metabolic pathways have been discerned, and their functional and regulatory action for signalling through CB1 and CB2 receptors have been described. More recently, it has become has become evident that cannabinoids exert actions at non-CB1, non-CB2 receptors. Much less is understood about these actions. Many of these novel?targets? are in the process of being characterized functionally and physiologically, and the therapeutic value of targeting these non-CB1, non-CB2 receptors is being evaluated. The purpose of this volume is to present the current knowledge on the atypical actions of cannabinoids on these new targets. This book is intended as a scientific resource for cannabinoid researchers carrying out animal and human experiments, and for those who are interested in learning about future directions in cannabinoid research. Additionally, this book may be of value to investigators currently working outside the field of cannabinoid research who have an interest in learning about these compounds and their atypical cannabinoid signalling. This book provides insight into the potential medical application of cannabinoids and their therapeutic development for the treatment of human disease.
Download or read book Translational Research in Breast Cancer written by Dong-Young Noh and published by Springer Nature. This book was released on 2021-05-13 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.
