Download or read book Lipid Based Drug Delivery Systems for Parenteral Delivery of Proteins written by Lene Jørgensen and published by . This book was released on 2004 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Peptide and Protein Delivery written by Chris Van Der Walle and published by Academic Press. This book was released on 2011-05-12 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market
Download or read book Role of Lipid Excipients in Modifying Oral and Parenteral Drug Delivery written by Kishor M. Wasan and published by John Wiley & Sons. This book was released on 2007-01-09 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive resource covers the fundamentals, formulation, and biopharmaceutical issues of lipid-based drug delivery. It presents the principles of lipid absorption and covers formulation issues, such as dissolution testing and stability testing, and physiological and biopharmaceutical issues, including the role of specific enzymes, the evaluation of transport systems in the body, and the mechanisms governing the transport of water-insoluble drugs.
Download or read book Lipid Based Drug Delivery Systems written by Bhupendra Prajapati and published by CRC Press. This book was released on 2023-12-01 with total page 837 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book appraises the role of lipid-based drug delivery systems (LBDDSs) with respect to the bioavailability and controlled delivery of complex drug molecules for improving their clinical viability. It covers the latest developments and advancements in the field of drug delivery, and explores and compiles information on the current situation of lipid-based formulations used as versatile excipients and all their possible routes to improve therapeutic benefits. The book discusses novel formulations such as depot formulations, micro- and nanoemulsions, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), liposomes, nanoliposomes, micelles, nanosuspensions, lipid implants and inserts, and lipid nanotubes. It presents preparation methods of LBDDSs and their physicochemical properties, and portrays their various application angles and their impacts on drug-conveyance frameworks when employed in vitro and in vivo. The book is beneficial for researchers working on lipid-based drug formulations as well as biological and translational drug delivery. It is also a useful resource for course work of students of various academic degree programs such as pharmacy, health sciences, biotechnology, and microbiology; postgraduate and PhD students; and postdoctoral fellows researching on nanomedicine-based drug delivery systems.
Download or read book Oral Delivery of Therapeutic Peptides and Proteins written by Puneet Tyagi and published by Elsevier. This book was released on 2022-08-15 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral Delivery of Therapeutic Peptides and Proteins provides a complete overview of the journey scientists pursue to attain protein and peptide oral delivery. The book highlights the physiological challenges that must be accounted for in addition to overcoming protease inhibition and acid stability issues that are commonly mentioned in this area of research. Primary topics include formulation technologies being adopted for oral delivery of proteins and peptides, modification of actives to make them more suited for oral delivery, animal models and their shortcomings in assessing oral bioavailability, and in vitro models to simulate drug absorption and transport. Academics and industry researchers working in formulation development and researchers and advanced students in biotechnology and pharmacy will find this a useful resource. Demonstrates how proteins and peptides transport throughout the gastrointestinal tract and how to evaluate their biological fate when encapsulated into certain delivery systems Examines developing technologies to improve future oral bioavailability Includes the in vitro and preclinical techniques needed for development
Download or read book Protein Delivery written by Lynda M. Sanders and published by Springer Science & Business Media. This book was released on 2005-11-21 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thirteen chapters by industrial and academic authorities in this rapidly evolving field present detailed case histories and reviews of current sophisticated protein-drug delivery technologies. Highlights include a comprehensive overview of insulin delivery and a discussion of the use of biodegradable microspheres.
Download or read book Nanopharmaceutical Advanced Delivery Systems written by Vivek Dave and published by John Wiley & Sons. This book was released on 2020-12-29 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a single volume covering detailed descriptions about various delivery systems, their principles and how these are put in use for the treatment of multiple diseases. It is divided into four sections where the first section deals with the introduction and importance of novel drug delivery system. The second section deals with the most advanced drug delivery systems like microbubbles, dendrimers, lipid-based nanoparticles, nanofibers, microemulsions etc., describing the major principles and techniques of the preparations of the drug delivery systems. The third section elaborates on the treatments of diverse diseases like cancer, topical diseases, tuberculosis etc. The fourth and final section provides a brief informative description about the regulatory aspects of novel drug delivery system that is followed in various countries.
Download or read book Recent Advances in Novel Drug Carrier Systems written by Ali Demir Sezer and published by BoD – Books on Demand. This book was released on 2012-10-31 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.
Download or read book Advances in Drug Delivery Systems 6 written by James M. Anderson and published by Elsevier. This book was released on 2013-10-22 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Drug Delivery Systems, 6 focuses on the progress in drug delivery systems as manifested in the fields of international pharmaceutics, polymer science, biotechnology, molecular biology, and cell biology. The selection first tackles biologically engineered microstructures and approaches to targeting bioactive compounds. Discussions focus on therapeutic efficiency of fatty acylated antiviral antibodies; effect of artificial fatty acylation on protein binding and uptake; and controlled release of proteins from lipid microcylinders. The text then elaborates on mucosal delivery of macromolecules and targeted delivery of diagnostic agents by surface-modified liposomes. The book examines the factors on in vitro micelle stability of adriamycin-block copolymer conjugates; vaginal and reproductive system treatments using a bioadhesive polymer; and control of the disposition profiles of proteins in the kidney via chemical modification. The publication also takes a look at drug delivery using biodegradable microspheres; approaches to improved antibody- and peptide-mediated targeting for imaging and therapy of cancer; and biodegradable microspheres for the delivery of oral vaccines. The selection is a valuable source material for scientists and readers interested in the advances in the systems of drug delivery.
Download or read book Silk based Drug Delivery Systems written by Elia Bari and published by Royal Society of Chemistry. This book was released on 2020-10-07 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin.
Download or read book Degradation of Lipid Based Drug Delivery Systems and Characterization of Semi synthetic Spider Silk Proteins for the Application in Pharmaceutical Technology written by Martin Schwab and published by . This book was released on 2009 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Long Acting Injections and Implants written by Jeremy C. Wright and published by Springer Science & Business Media. This book was released on 2012-01-29 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Long acting injections and implants improve therapy, enhance patient compliance, improve dosing convenience, and are the most appropriate formulation choice for drugs that undergo extensive first pass metabolism or that exhibit poor oral bioavailability. An intriguing variety of technologies have been developed to provide long acting injections and implants. Many considerations need to go into the design of these systems in order to translate a concept from the lab bench to actual therapy for a patient. This book surveys and summarizes the field. Topics covered in Long Acting Injections and Implants include the historical development of the field, drugs, diseases and clinical applications for long acting injections and implants, anatomy and physiology for these systems, specific injectable technologies (including lipophilic solutions, aqueous suspensions, microspheres, liposomes, in situ forming depots and self-assembling lipid formulations), specific implantable technologies (including osmotic implants, drug eluting stents and microfabricated systems), peptide, protein and vaccine delivery, sterilization, drug release testing and regulatory aspects of long acting injections and implants. This volume provides essential information for experienced development professionals but was also written to be useful for scientists just beginning work in the field and for others who need an understanding of long acting injections and implants. This book will also be ideal as a graduate textbook.
Download or read book Delivery Systems for Peptide Drugs written by S.S. Davis and published by Springer. This book was released on 1986 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen enormous advances in the field of protein and peptide engineering and a greater understanding in the way in which biological response modifiers function in the body. It is now possible through the use of recombinant DNA techniques, or by solid phase protein synthesis, to produce significant quantities of a wide variety of regulatory agents that are therapeutically applicable. The list of these response modifiers expands almost daily to include interferons, macrophage activation factors, neuropeptides and agents that may have potential in cardiovascular disease, inflammation, contraception etc. Prospects to use some of these materials in medicine have reached the stage where products have either been approved by regulatory authorities or are the subject of applications as investigatory drugs or as new therapeutic agents. In some uses the pertinent agent will be administered on an acute basis in the form of a simple injection, as, for example, the use of a tissue plasminogen activator for the treatment of coronary infarct. In other cases regulatory proteins and peptides are indicated for chronic therapy and here they will need to be administered by an appropriate delivery system. Unfortunately, the research on delivery systems for peptides and proteins has not kept pace with the rapid progress in biotechnology and, consequently, there are presently few systems that are entirely appropriate for the administration of macromolecular drugs according to complex dosage regimens, (eg intermittent and pulsed therapy). Furthermore essential pharmacokinetic and pharmacodynamic data may be missing.
Download or read book Bioinspired Symmetrical Lipids for Controlled Drug Delivery written by Sara Yazdi and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designing new drug delivery systems requires tight control of drug release kinetics. Historically, polymers have been strong contenders in the field. However, achieving a narrow polydispersity and reducing batch-to-batch variability in synthesis can be difficult. Therefore researchers have expanded to other materials such as lipids, which mat have more favorable drug release properties. Lipids are a chemically unique category of molecules that plays a role in functionality and architecture of all living cells. Thus when used as materials for design of drug delivery systems, they will be considered biodegradable and biocompatible. In addition they offer more robust control over design of molecular architecture and thus directly impact the release kinetics of model drugs. The aim of this study was to better understand the mass transport mechanism involved in controlled release of a model drug from lipid based parenteral delivery systems. A family of dihydroxyacetone (DHA) derived symmetrical lipids with varying hydrocarbon chain length was synthesized to systematically analyze how lipid chain length influences drug release kinetics. Our results showed that microparticles prepared using solvent emulsification are porous and polydisperse in size. The effects of several formulation and processing parameters (lipid and surfactant concentration) on the resulting release kinetics were measured. As expected smaller particles (25[MICRO SIGN]m) showed faster release kinetics possibly due to shorter diffusion pathway length compared to the larger particles ([25-40] [MICRO SIGN]m and 40 [MICRO SIGN]m). Our results showed that porosity controls the release kinetics of the anti-inflammatory drug piroxicam more strongly than hydrophobicity. Further investigation of parenteral delivery systems made from DHA derived symmetrical diglcycerides showed that protein release is dependent on the hydrophobicity of the matrix. With lysozyme as a model protein drug, long chain diglycerides (C16 and C14) showed slower release compared to short chain, less hydrophobic diglycerides (C10 and C12). As with solid microparticles, the effect of varying formulation and processing parameters (e.g. lysozomal loading, compression force) was studied. SDS gel electrophoresis and enzymatic study in M. lysodeikticus suspensions were used to study the structural integrity and activity of dispersed model drug. The results showed that there is slight aggregation and loss of activity possibly as a result of heat generation during compression. Furthermore diglyceride implants showed acute inflammatory response in early time points of the biocompatibility study conducted using rat animal models. The inflammatory response subsided for later time points. Histological inspection of the tissues showed presence of granulomas but no sign of tissue necrosis.
Download or read book Drug Delivery Systems written by Kewal K. Jain and published by Springer Science & Business Media. This book was released on 2008-03-07 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this concise and systematic book, a team of experts select the most important, cutting-edge technologies used in drug delivery systems. They take into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful Methods in Molecular BiologyTM series format, offering readily reproducible results vital for pharmaceutical physicians and scientists.
Download or read book Advanced Drug Delivery Systems in the Management of Cancer written by Kamal Dua and published by Elsevier. This book was released on 2021-06-24 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems
Download or read book Nanoparticulate Drug Delivery Systems written by Deepak Thassu and published by CRC Press. This book was released on 2007-03-30 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. Nanoparticulate Drug Delivery Systems addresses the scientific methodologies, formulation, processing, applications, recent trends, and e
