Download or read book Lectins and Cancer written by Hans-Joachim Gabius and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular recognition undoubtedly governs any aspect of cellular interaction. To understand tumor cell growth regulation and spread, analysisof protein carbohydrate interactions can contribute to lead to the establishment of rational methods for diagnosis and therapy. Chemically and biochemically optimized preparation of adequate tools, their application for localization of receptor (tissue lectin) and ligand (cellular glycoconjugate) pairs in tumor cells and tumor sections and the usefulness of a lectin from a plant extract as potent immunomodulator indicate the prospect for a place of such techniques in pathology and oncology.
Download or read book Lectins and Pathology written by Michel Caron and published by CRC Press. This book was released on 2003-09-02 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present understanding of the various implications of lectins in pathology are summarised in this timely text. With contributions from leading investigators in the field of lectin research, Lectins and Pathology provides up-to-date information on key developments within this field, including the use of lectins and lectin-binding molecules as tools, the involvement of endogenous (animal or human) lectins in inflammation, cancer invasion and metastasis, as well as the importance of lectins in bacteriology and parasitology. This volume contains useful knowledge for clinical investigators, cell biologists, biochemists and biotechnologists, as well as for the graduate students interested in getting a comprehensive coverage of this field.
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Download or read book Lectins and Glycoconjugates in Oncology written by Hans-Joachim Gabius and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular glycoconjugates and their specific receptors, e.g. lectins, form a recognitive and informative transfer system that justifies special scientific and clinical attention. In various contributions reviewing the initiation and recent progress in this rapidly developing field advances in clinical oncology are discussed with regard to basic sciences as well as their application in clinical sciences. The approaches comprise reports from diverse fields such as biochemistry, cell biology, pathology and clinical oncology, addressing questions of how tumors grow and spread, and leading to the improvement of clinical management and tumor diagnosis.
Download or read book Lectins and Cancer written by Hans-Joachim Gabius and published by Springer Verlag. This book was released on 1991 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Lectins written by Arpad Pusztai and published by CRC Press. This book was released on 2005-08-02 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lectins form a ubiquitous and important class of natural carbohydrate- binding information proteins. Although the main scientific interest was originally focussed on toxic lectins such as ricin, recent emphasis has shifted to exploring their involvement in cell-to-cell communication and recognition in microorganisms, plants and animals.; As knowledge of the basic properties and biological activities of lectins has increased, exciting opportunities have arisen for the exploitation of some of the advantageous aspects of fundamental lectinology.; "Lectins: Biomedical Perspectives" records the major achievements of an initiative, funded by the European Community, to coordinate lectin research throughout Europe.
Download or read book Lectins written by Preetham Elumalai and published by Springer Nature. This book was released on 2022-03-09 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the relationship between receptors, carbohydrate moieties, and pathogenic surfaces and lectins’ pathophysiology of immune responses and examines the mechanisms of action of the molecules for the treatment potentials. Increasing evidence has suggested that lectin-carbohydrate interactions perform important roles in various regulations of immune responses, but much remains to be learned about these crucial properties and their interplay with other molecules. In addition, a better understanding of the structural and functional properties of lectin and the activated immune response will be of critical importance for the development of new diagnostic tools and therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the various lectin types from animal and plant as well as microbial or marine lectins, and this wide range of molecular knowledge directs us to various diseases, including infectious diseases and cancer. In presenting state-of-the-art knowledge on the interactions between lectin and its interactions,the book will help to pave the way for the development of novel targets for the prevention and treatment of many disorders.
Download or read book Development of Lectins for Cancer specific Fucosylation written by Harmin Herrera and published by . This book was released on 2019 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Changes in serum glycosylation have long been associated with hepatocellular carcinoma (HCC), and these modifications are often detected with sugar-binding proteins called lectins. HCC is associated with increased serum fucosylation, and this sugar is often detected with the Aleuria aurantia lectin (AAL). However, this lectin binds fucose in several forms, one of which is associated with cancer ([alpha]1-6 linked fucosylation) and some of which are not. Thus, its use in clinical and tissue analysis is limited. We have created a recombinant AAL, which contains a single amino acid mutation: N224Q (rAALN224Q), within the binding site 5, and this lectin has increased sensitivity to the cancer-specific fucosylated glycan. Our analysis of rAALN224Q has shown that the mutation within one specific fucose binding pocket had a major impact upon the mutated site as well as on sites that were not mutated and led to a lectin with altered binding specificities. This lectin is currently part of a diagnostic test under evaluation for the early detection of HCC. We have further explored the changes in N-linked glycosylation associated directly with HCC tissue through a method of N-linked glycan matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS). MALDI IMS of N-linked glycan revealed inter- and intra-tumor heterogeneity shown by expression and spatial localization of glycans in the tumor. Tumors were associated with alterations in mannosylation, fucosylation, branching, and complex glycan formation. Importantly, all tumors were associated with some change in glycosylation, but there was significant glycan heterogeneity.
Download or read book Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics written by Pandurangan, Ashok Kumar and published by IGI Global. This book was released on 2022-03-18 with total page 643 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many chemotherapeutic agents are available in today’s market that are highly effective against a variety of cancer types; however, the major drawbacks of these chemotherapeutic agents are the many side effects. As an alternative to these chemotherapeutic agents, there are a number of natural agents that are effective against cancer that have been tested in preclinical and clinical models over the years. These natural products must be documented and discussed in order to provide a thorough overview of all the options available for cancer treatment. The Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics emphasizes the list of natural agents against all types of cancers and discusses the current state of research in the fields of natural products and their derivatives against cancer in preclinical and clinical models. This book also provides insight into the applications of meditation and mindfulness-based interventions in clinical and non-clinical conditions. Covering topics such as cancer therapy, antioxidants, and flavonoids, it is ideal for students, research scholars, academicians, professors, scientists, oncologists, doctors, and medical practitioners.
Download or read book Plant Lectins written by A. Pusztai and published by Cambridge University Press. This book was released on 1991 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume surveys the chemistry, biochemistry, biosynthesis, metabolism and pharmacological properties of lectins. Lectins, which are most commonly found in plants, are widespread natural products with striking biological activities. Their specific ability to recognise and bind to simple or complex saccharides facilitates their role as effective information protein molecules. As agents of cell-to-cell recognition, lectins promote symbiosis between plants and specific nitrogen-fixing soil bacteria. As natural defensive molecules, they can protect plants against predators such as bacteria, fungi and insects. As part of our diet, lectins are powerful exogenous growth factors in the small intestine and influence our health, the digestive function and the bacterial ecology of the alimentary tract. Lectins are also important research tools in preparative biochemistry and cell science.
Download or read book Lectin Blocking written by J. Beuth and published by Lubrecht & Cramer, Limited. This book was released on 1994 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Analysis of Lectin Binding and Lectin Effects on Human Colon Cancer and Non cancer Cell Lines written by Karineh Petrossian and published by . This book was released on 2007 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functional Foods in Cancer Prevention and Therapy written by Yearul Kabir and published by Academic Press. This book was released on 2020-04-07 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Foods in Cancer Prevention and Therapy presents the wide range of functional foods associated with the prevention and treatment of cancer. In recent decades, researchers have made progress in our understanding of the association between functional food and cancer, especially as it relates to cancer treatment and prevention. Specifically, substantial evidence from epidemiological, clinical and laboratory studies show that various food components may alter cancer risk, the prognosis after cancer onset, and the quality of life after cancer treatment. The book documents the therapeutic roles of well-known functional foods and explains their role in cancer therapy. The book presents complex cancer patterns and evidence of the effective ways to control cancers with the use of functional foods. This book will serve as informative reference for researchers focused on the role of food in cancer prevention and physicians and clinicians involved in cancer treatment. Discusses the role of functional foods in cancer therapy Presents research-based evidence of the role of herbs and bioactive foods in cancer treatment and prevention Provides the most current, concise, scientific information regarding the efficacy of functional foods in preventing cancer and improving the quality of life Explores antioxidants, phytochemicals, nutraceuticals, herbal medicine and supplements in relation to cancer prevention and treatment Contains a clinical approach to the use of functional foods to prevent and treat cancer Emphasizes the role and mechanism of functional foods, including the characterization of active compounds on cancer prevention and treatment
Download or read book The Plant Paradox written by Dr. Steven R. Gundry, MD and published by HarperCollins. This book was released on 2017-04-25 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: From renowned cardiac surgeon Steven R. Gundry, MD, the New York Times bestselling The Plant Paradox is a revolutionary look at the hidden compounds in "healthy" foods like fruit, vegetables, and whole grains that are causing us to gain weight and develop chronic disease. Most of us have heard of gluten—a protein found in wheat that causes widespread inflammation in the body. Americans spend billions of dollars on gluten-free diets in an effort to protect their health. But what if we’ve been missing the root of the problem? In The Plant Paradox, renowned cardiologist Dr. Steven Gundry reveals that gluten is just one variety of a common, and highly toxic, plant-based protein called lectin. Lectins are found not only in grains like wheat but also in the “gluten-free” foods most of us commonly regard as healthy, including many fruits, vegetables, nuts, beans, and conventional dairy products. These proteins, which are found in the seeds, grains, skins, rinds, and leaves of plants, are designed by nature to protect them from predators (including humans). Once ingested, they incite a kind of chemical warfare in our bodies, causing inflammatory reactions that can lead to weight gain and serious health conditions. At his waitlist-only clinics in California, Dr. Gundry has successfully treated tens of thousands of patients suffering from autoimmune disorders, diabetes, leaky gut syndrome, heart disease, and neurodegenerative diseases with a protocol that detoxes the cells, repairs the gut, and nourishes the body. Now, in The Plant Paradox, he shares this clinically proven program with readers around the world. The simple (and daunting) fact is, lectins are everywhere. Thankfully, Dr. Gundry offers simple hacks we easily can employ to avoid them, including: Peel your veggies. Most of the lectins are contained in the skin and seeds of plants; simply peeling and de-seeding vegetables (like tomatoes and peppers) reduces their lectin content. Shop for fruit in season. Fruit contain fewer lectins when ripe, so eating apples, berries, and other lectin-containing fruits at the peak of ripeness helps minimize your lectin consumption. Swap your brown rice for white. Whole grains and seeds with hard outer coatings are designed by nature to cause digestive distress—and are full of lectins. With a full list of lectin-containing foods and simple substitutes for each, a step-by-step detox and eating plan, and delicious lectin-free recipes, The Plant Paradox illuminates the hidden dangers lurking in your salad bowl—and shows you how to eat whole foods in a whole new way.
Download or read book Handbook of Plant Lectins written by Els. J. M. Van Damme and published by John Wiley & Sons. This book was released on 1998-03-06 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant lectins are extensively used as tools and as bioactiveproteins in different areas of biomedical and biological research.The Handbook of Plant Lectins provides a comprehensive yet conciseoverview of the biochemical properties, carbohydrate-bindingspecificity, biological activities and applications of most of thecurrently known plant lectins. This handbook consists of two majorsections: an introductory guide and a quick reference dictionary.Part I acquaints the newcomer to the lectin field with theessential information on lectins and their importance tobiomedicine: * what are lectins? * their carbohydrate-binding specificity * effects on nutrition and immunology * use in histochemistry * application as therapeutic agents Part II lists approximately 200 lectin entries in alphabeticalorder. Each entry deals with the lectin(s) of a particular plantand provides, (where known), details of: * isolation and characterisation; * sugar binding specificity; * biological activities; * applications; * commercial availability; and, * a bibliography. Useful summary tables list lectins according to their specificity,thereby allowing the user to choose the best lectin for theirapplication. A list of suppliers is also provided. Handbook ofPlant Lectins will be of interest to biologists and biomedicalresearchers studying cell biology, cancer research, nutrition,immunology, pathology and physiology.
Download or read book Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds written by Evandro Fei Fang and published by Springer. This book was released on 2015-04-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The modern unhealthy diet and lifestyle in conjunction with pathogens, environmental carcinogens and multiple other risk factors increase humans’ susceptibility to different diseases exemplified by elevated levels of cancers, cardiovascular and communicable diseases. Screening of potential drugs from medicinal plants and animals provides a promising strategy for the alleviation of the impact of these diseases. Components with potential medicinal applications include RIPs, RNases, lectins, protease inhibitors and numerous small compounds. These compounds have shown both preventive and therapeutic effects for humans. This book is a compilation of articles written by internationally renowned experts exploring the different uses of medicinal compounds in human therapeutics. Here we provide a comprehensive outlook on both qualitative and quantitative studies focusing on medicinal plants and animals, and establishing a link between laboratory research discovery and clinical applications.
Download or read book Lectins and Their Ligands in Shaping Immune Responses written by Bernd Lepenies and published by Frontiers Media SA. This book was released on 2019-12-23 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt:
