Download or read book Laser Photodissociation and Spectroscopy of Mass separated Biomolecular Ions written by Nicolas C. Polfer and published by Springer Science & Business Media. This book was released on 2013-09-03 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: This lecture notes book presents how enhanced structural information of biomolecular ions can be obtained from interaction with photons of specific frequency - laser light. The methods described in the book "Laser photodissociation and spectroscopy of mass-separated biomolecular ions" make use of the fact that the discrete energy and fast time scale of photoexcitation can provide more control in ion activation. This activation is the crucial process producing structure-informative product ions that cannot be generated with more conventional heating methods, such as collisional activation. The book describes how the powerful separation capabilities and sensitivity of mass spectrometry (MS) can be combined with the structural insights from spectroscopy by measuring vibrational and electronic spectra of trapped analytes. The implementation of laser-based photodissociation techniques in MS requires basic knowledge of tunable light sources and ion trapping devices. This book introduces the reader to key concepts and approaches in molecular spectroscopy, and the light sources and ion traps employed in such experiments. The power of the methods is demonstrated by spectroscopic interrogation of a range of important biomolecular systems, including peptides, proteins, and saccharides, with laser light in the ultraviolet-visible, and infrared range. The book "Laser photodissociation and spectroscopy of mass-separated biomolecular ions" is an indispensable resource for students and researchers engaged or interested in this emerging field. It provides the solid background of key concepts and technologies for the measurements, discusses state-of-the-art experiments, and provides an outlook on future developments and applications.
Download or read book Ion Mobility Mass Spectrometry written by Frank Sobott and published by Royal Society of Chemistry. This book was released on 2021-11-26 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a comprehensive guide to the technique, each chapter is written by an internationally recognised expert and will help the end users understand the practicalities of using different instruments for different ion mobility purposes.
Download or read book Hyperspectral Image Unmixing Incorporating Adjacency Information written by Bauer, Sebastian and published by KIT Scientific Publishing. This book was released on 2018-07-18 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the spectral information contained in hyperspectral images is rich, the spatial resolution of such images is in many cases very low. Many pixel spectra are mixtures of pure materials' spectra and therefore need to be decomposed into their constituents. This work investigates new decomposition methods taking into account spectral, spatial and global 3D adjacency information. This allows for faster and more accurate decomposition results.
Download or read book Advanced Fragmentation Methods in Biomolecular Mass Spectrometry written by Frederik Lermyte and published by Royal Society of Chemistry. This book was released on 2020-12-11 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breaking down large biomolecules into fragments in a controlled manner is key to modern biomolecular mass spectrometry. This book is a high-level introduction, as well as a reference work for experienced users, to ECD, ETD, EDD, NETD, UVPD, SID, and other advanced fragmentation methods. It provides a comprehensive overview of their history, mechanisms, instrumentation, and key applications. With contributions from leading experts, this book will act as an authoritative guide to these methods. Aimed at postgraduate and professional researchers, mainly in academia, but also in industry, it can be used as supplementary reading for advanced students on mass spectrometry or analytical (bio)chemistry courses.
Download or read book Lasers and Mass Spectrometry written by David M. Lubman and published by Oxford University Press. This book was released on 1990-04-12 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contributors to this volume focus on the fundamentals of the technique of analyzing material based on the atomic weight of the species, using the power and definition of lasers to enable measurement of smaller quantities and more finely localized particles. Each chapter deals with a particular application area and should be sufficient to form an entry point for the utilization of mass spectrometry by graduate students and researchers. The book provides the first full discussion of the new techniques of laser applications in the field.
Download or read book Developments in Laser Desorption and Photodissociation Fourier Transform Mass Spectrometry written by Lydia Marie Nuwaysir and published by . This book was released on 1990 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Photophysics of Ionic Biochromophores written by Steen Brøndsted Nielsen and published by Springer Science & Business Media. This book was released on 2013-10-16 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a concise overview of the photophysics and spectroscopy of bio chromophore ions. The book "Photophysics of Ionic Biochromophores" summarizes important recent advances in the spectroscopy of isolated biomolecular ions in vacuo, which has within the last decade become a highly active research field. Advanced instrumental apparatus and the steady increase in more and more powerful computers have made this development possible, both for experimentalists and theoreticians. Applied techniques described here include absorption and fluorescence spectroscopy, which are excellent indicators of environmental effects and can thus shed light on the intrinsic electronic structures of ions without perturbations from e.g. water molecules, counter ions, nearby charges, and polar amino acid residues. When compared with spectra of the chromophores in their natural environment, such spectra allow to identify possible perturbations. At the same time gas-phase spectra provide important benchmarks for quantum chemistry calculations of electronically excited states. This volume focuses on biological systems from protein biochromophores, e.g. the protonated Schiff-base retinal responsible for vision, and individual aromatic amino acids to peptides and whole proteins, studied using visible, ultraviolet and vacuum ultraviolet light. Work on DNA nucleotides and strands that are amenable to mass spectrometric studies because of the negatively charged sugarphosphate backbone are also presented. DNA strands represent an example of the interplay between multiple chromophores, which is even harder to model correctly than just single chromophores due to spatially extended excited states and weak coupling terms. The experimental techniques used to measure spectra and commonly used theoretical methods are described with a discussion on limitations and advantages. The volume includes an updated status of the field and interesting future directions such as cold ion spectroscopy.
Download or read book Gas Phase IR Spectroscopy and Structure of Biological Molecules written by Anouk M. Rijs and published by Springer. This book was released on 2015-06-03 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students.
Download or read book Principles of Mass Spectrometry Applied to Biomolecules written by Chava Lifshitz and published by John Wiley & Sons. This book was released on 2006-10-27 with total page 707 pages. Available in PDF, EPUB and Kindle. Book excerpt: An extensive compilation of articles by leading professionals, this reference explains the fundamental principles of mass spectrometry as they relate to the life sciences. Topics covered include spectroscopy, energetics and mechanisms of peptide fragmentation, electron capture dissociation, ion-ion and ion-molecule reactions, reaction dynamics, collisional activation, soft-landing, protein structure and interactions, thermochemistry, and more. The book empowers readers to develop new ways of using these techniques.
Download or read book Spectroscopy and Modeling of Biomolecular Building Blocks written by Jean-Pierre Schermann and published by Elsevier. This book was released on 2007-10-16 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spectroscopy and Modeling of Biomolecular Building Blocks presents an overview of recent advances in the intertwining of the following research fields: photon and electron spectroscopy, quantum chemistry, modelling and mass-spectrometry. The coupling of these disciplines offers a new point of view to the understanding of isolated elementary building blocks of biomolecules and their assemblies. It allows the unambiguous separation between intrinsic properties of biomolecular systems and those induced by the presence of their environment. The first chapters provide background in modelling (I), frequency-resolved spectroscopy using microwave, infrared and UV photons, time-resolved spectroscopy in the femtosecond domain and energy-resolved electron spectroscopy (II) and production of gas-phase neutral and ionic biomolecular species, mass-spectrometry, ion mobility and BIRD techniques (III). Chapter IV is devoted to case studies of gas-phase experimental investigations coupled to quantum or classical calculations. The topics are structural studies of nucleobases and oligonucleotides, peptides and proteins, sugars; neuromolecules; non-covalent complexes; chiral systems, interactions of low-energy electrons with biomolecules in the radiation chemistry context and very large gas-phase biomolecular systems. The fifth chapter concerns the link between gas-phase and liquid-phase. Different treatments of solvation are illustrated through examples pointing out the influence of progressive addition of water molecules upon properties of nucleobases, peptides, sugars and neuromolecules. Offer a new perspective to the understanding of isolated elementary building blocks of bio molecules Includes case studies of experimental investigations coupled to quantum or classical calculations
Download or read book Applied Laser Spectroscopy for Nuclear Physics written by Thomas Day Goodacre and published by Springer Nature. This book was released on 2021-09-25 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis explores two distinct applications of laser spectroscopy: the study of nuclear ground state properties, and element selective radioactive ion beam production. It also presents the methods and results of an investigation into isotope shifts in the mercury isotopic chain. These Resonance Ionization Laser Ion Source (RILIS) developments are detailed, together with an RILIS ionization scheme that allowed laser ionized ion beams of chromium, germanium, radium and tellurium to be generated at the Isotope Mass Separator On-Line (ISOLDE) facility. A combination of laser spectroscopy with decay spectroscopy and mass spectrometry unambiguously demonstrated a cessation of the extreme shape staggering first observed in the 1970s and revealed the characteristic kink at the crossing of the N=126 shell closure. A series of RILIS developments were required to facilitate this experiment, including mercury “ionization scheme” development and the coupling of the RILIS with an arc discharge ion source. Laser spectroscopy has since become a powerful tool for nuclear physics and the Resonance Ionization Laser Ion Source (RILIS), of the ISOLDE facility at CERN, is a prime example. Highlighting important advances in this field, the thesis offers a unique and revealing resource.
Download or read book Laser Spectroscopy and Photochemistry on Metal Surfaces written by Hai-Lung Dai and published by World Scientific. This book was released on 1995 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1991 with total page 1336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of High resolution Spectroscopy written by Martin Quack and published by John Wiley & Sons. This book was released on 2011-09-26 with total page 2236 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of High-Resolution Spectroscopy has been considerably extended and even redefined in some areas. Combining the knowledge of spectroscopy, laser technology, chemical computation, and experiments, Handbook of High-Resolution Spectroscopy provides a comprehensive survey of the whole field as it presents itself today, with emphasis on the recent developments. This essential handbook for advanced research students, graduate students, and researchers takes a systematic approach through the range of wavelengths and includes the latest advances in experiment and theory that will help and guide future applications. The first comprehensive survey in high-resolution molecular spectroscopy for over 15 years Brings together the knowledge of spectroscopy, laser technology, chemical computation and experiments Brings the reader up-to-date with the many advances that have been made in recent times Takes the reader through the range of wavelengths, covering all possible techniques such as Microwave Spectroscopy, Infrared Spectroscopy, Raman Spectroscopy, VIS, UV and VUV Combines theoretical, computational and experimental aspects Has numerous applications in a wide range of scientific domains Edited by two leaders in this field Provides an overview of rotational, vibration, electronic and photoelectron spectroscopy Volume 1 - Introduction: Fundamentals of Molecular Spectroscopy Volume 2 - High-Resolution Molecular Spectroscopy: Methods and Results Volume 3 - Special Methods & Applications
Download or read book Nucleic Acids in the Gas Phase written by Valérie Gabelica and published by Springer. This book was released on 2014-07-28 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives physical chemists a broader view of potential biological applications of their techniques for the study of nucleic acids in the gas phase. It provides organic chemists, biophysicists, and pharmacologists with an introduction to new techniques they can use to find the answers to yet unsolved questions. Laboratory sciences have bloomed with a variety of techniques to decipher the properties of the molecules of life. This volume introduces techniques used to investigate the properties of nucleic acids in the absence of solvent. It highlights the specificities pertaining to the studies of nucleic acids, although some of the techniques can similarly be applied to the study of other biomolecules, like proteins. The first part of the book introduces the techniques, from the transfer of nucleic acids to the gas-phase, to their detailed physico-chemical investigation. Each chapter is devoted to a specific molecular property, and illustrates how various approaches (experimental and theoretical) can be combined for the interpretation. The second part of the book is devoted to applying the gas-phase approaches to solve specific questions related to the biophysics, biochemistry or pharmacology of nucleic acids.
Download or read book Infrared Spectroscopy of Hydrated and Biomolecular Ions written by Matthew Francis Bush and published by . This book was released on 2008 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Physics with Trapped Charged Particles written by Martina Knoop and published by World Scientific. This book was released on 2014-01-06 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collection of articles on Physics with Trapped Charged Particles by speakers at the Les Houches Winter School. The articles cover all types of physics with charged particles, and are aimed at introducing the basic issues at hand, as well as the latest developments in the field. It is appropriate for PhD students and early career researchers, or interested parties new to the area. Contents:Physics with Trapped Charged Particles (M Knoop, N Madsen and R C Thompson)Detection Techniques for Trapped Ions (M Knoop)Cooling Techniques for Trapped Ions (D M Segal and Ch Wunderlich)Accumulation, Storage and Manipulation of Large Numbers of Positrons in Traps I — The Basics (C M Surko)Accumulation, Storage and Manipulation of Large Numbers of Positrons in Traps II — Selected Topics (C M Surko, J R Danielson and T R Weber)Waves in Non-neutral Plasma (F Anderegg)Internal Transport in Non-neutral Plasma (F Anderegg)Antihydrogen Formation and Trapping (N Madsen)Quantum Information Processing with Trapped Ions (C F Roos)Optical Atomic Clocks in Ion Traps (H S Margolis)Novel Penning Traps (J Verdú)Trapped Electrons as Electrical (Quantum) Circuits (J Verdú) Readership: University and college students undertaking mechanical, aerospace, electromechanical, engineering or applied mechanics programs. Key Features:Gives a basic overview of this new, vibrant area of researchGives a good introduction to the key issues in physics of this fieldContains contributions from researchers at the forefront of the fieldKeywords:Charged Particles;Particle Traps;Non-Neutral Plasma;Quantum Information;Penning Trap;Paul Trap;Rotating Wall;Laser Cooling;RF Trap;Atomic Clock
