Download or read book Laser Desorption Fourier Transform Ion Cyclotron Resonance LD FT ICR Mass Spectrometry for High Mass Ions written by Troy Dale Wood and published by . This book was released on 1993 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book FT ICR MS written by Bruce Asamoto and published by Wiley-VCH. This book was released on 1991 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ion Detection and Structural Mass Spectrometry by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Matrix Assisted Laser Desorption Ionization written by Touradj Solouki and published by . This book was released on 1994 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Developments in Laser Desorption and Photodissociation Fourier Transform Mass Spectrometry written by Lydia Marie Nuwaysir and published by . This book was released on 1990 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Development of Cs Ion Desorption Ionization Methods for the Analysis of Large Biomolecules by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by Mauro Eliseo Castro and published by . This book was released on 1987 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Matrix assisted Laser Desorption Fourier Transform Mass Spectrometry for Biological Compounds written by and published by . This book was released on 1990 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent development of matrix-assisted UV laser desorption (LD) mass spectrometry has made possible the ionization and detection of extremely large molecules (with molecular weights exceeding 100,000 Daltons). This technique has generated enormous interest in the biological community for the direct examination of large peptides and oligonucleotides. Although this matrix-assisted ionization method has been developed and used almost exclusively with time-of-flight (TOF) mass spectrometers, research is currently in progress to demonstrate this technique with trapped ion mass spectrometers, such as Fourier transform ion cyclotron resonance mass spectrometry (FTMS). The potential capabilities of FTMS for wide mass range, high resolution measurement, and ion trapping experiments suggest that this instrumental technique should be useful for the detailed structural characterization of large ions generated by the matrix-assisted technique. We have recently demonstrated that matrix-assisted ultraviolet laser desorption can be successfully used with FTMS for the ionization of small peptides. The objective of this report is to summarize the application and current limitations of matrix-assisted laser desorption FTMS for the characterization of peptides and oligonucleotides at the isomeric level. 4 refs., 3 figs., 2 tabs.
Download or read book Laser Desorption Fourier Transform Mass Spectrometry of Saccharides and Glycosiodes written by Mildred Loleta Coates and published by . This book was released on 1987 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Lasers and Mass Spectrometry written by David M. Lubman and published by Oxford University Press. This book was released on 1990-04-12 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contributors to this volume focus on the fundamentals of the technique of analyzing material based on the atomic weight of the species, using the power and definition of lasers to enable measurement of smaller quantities and more finely localized particles. Each chapter deals with a particular application area and should be sufficient to form an entry point for the utilization of mass spectrometry by graduate students and researchers. The book provides the first full discussion of the new techniques of laser applications in the field.
Download or read book Laser Desorption Fourier Transform Ion Cyclotron Resonance Mass Spectrometry of Organic Compounds written by Ronald Edward Shomo and published by . This book was released on 1985 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Laser Desorption Fourier Transform Mass Spectrometric Studies of Oligopeptides written by Liub-Chii Yang and published by . This book was released on 1988 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Practical Aspects of Trapped Ion Mass Spectrometry Volume IV written by Raymond E. March and published by CRC Press. This book was released on 2010-05-25 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting the substantial increase in popularity of quadrupole ion traps and Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometers, Practical Aspects of Trapped Ion Mass Spectrometry, Volume IV: Theory and Instrumentation explores the historical origins of the latest advances in this expanding field. It covers new methods for trapp
Download or read book Theoretical Advances and Laser Desorption Applications in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by Michael Alan May and published by . This book was released on 1994 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Multiphoton Ionization of Laser Desorbed Neutral Molecules in a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer written by Jeffrey A. Zimmerman and published by . This book was released on 1990 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: Resonant multiphoton ionization of laser desorbed non-volatile samples has been achieved in a Fourier transform ion cyclotron resonance mass spectrometer (FTICR). The detection of iron at the 100 parts-per-million doping level in an indium phosphide compound semiconductor sample and the production of molecular ions for a hexapeptide have been observed in a modified FTICR analyzer cell. A unique three laser experiment has been devised in which infrared muliphoton dissociation of laser desorbed dipeptide ions, formed by resonant multiphoton ionization of laser desorbed neutrals, is performed. Multiphoton ionization (MPI), Laser desorption, Semiconductor materials, Trace analysis, Peptide sequencing, Fourier transform ion cyclotron resonance mass spectrometry. (JG).
Download or read book Matrix assisted Laser Desorption ionization and Ion Activation by Fourier transform Mass Spectroscopy written by John Anthony Castoro and published by . This book was released on 1993 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Novel Computational and Instrumentation Methodologies for Biological Fourier transform Ion Cyclotron Resonance Mass Spectrometric FT ICR MS Imaging written by Konstantin Aizikov and published by . This book was released on 2010 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Mass spectrometry imaging (MSI) is an emerging experimental methodology whose primary objective is the investigation of spatial variation of molecular composition within and across selected biological tissues to enable biomarker discovery, molecular diagnosis, and studies of drug metabolism, among other applications. The two major challenges, therefore, are the unambiguous identification and precise localization of biologically relevant compounds. These challenges can be recast as a problem of improving the accuracy and resolution of mass analyzers as well as the accuracy of the sample positioning robotics. The first part of this work reports on the progress and outlines the strategies of application of a recently developed high resolution spectral analysis technique, called the Filter Diagonalization Method (FDM), for the investigation of space-charge related phenomena inside the detection cell of a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer (FT-ICR MS), understanding of which lies at the heart of the quest for further improvements in mass accuracy and resolution. The FDM spectrographic analysis revealed previously unobserved rapid isotope- beat space-charge induced ICR frequency modulations, shown to reach up to +/- 400 ppm even on high quality spectra. The application of this methodology to the investigation of a frequently observed but previously unexplained phenomenon in FT-ICR MS, the Spontaneous Loss of Coherence Catastrophe, conclusively demonstrated that it is tied directly to the space charge effect and magnetron expansion. The second part of this work reports on the development of the ionization source and vacuum compatible high precision sample positioning robotics for biological MSI applications, purpose built for FT-ICR MS. The complete design and implementation is reported herein, along with the demonstration of its performance and biological application. The XY-positioning stage capable of operating under 10 -8 mbar vacuum with submicron positioning accuracy along the entire ranges of motion of 100x100 mm was designed, built, and installed into the ionization sources of three MALDI FT-ICR MS instruments. Two dimensional chemo-spatial maps of rat brain tissue selections were constructed with 150 micron spatial resolution, identifying multiple ionic species with their distinct and discreet spatial localizations. These demonstrated performance characteristics greatly surpass current state-of-the-art robotics available for MALDI MSI and shift the effort of further improvements in spatial resolution to the ionization methodologies, and other ion source design issues, such as laser optics.
Download or read book Experimental Mass Spectrometry written by David H. Russell and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass spectrometry underwent dramatic changes during the decade of the 1980s. Fast atom bombardment (F AB) ionization, developed by Barber and coworkers, made it possible for all mass spectrometry laboratories to analyze polar, highly functionalized organic molecules, and in some cases ionic, inorganic, and organometallic compounds. The emphasis of much of this work was on molecular weight determination. Parallel with the development of ionization methods (molecular weight mass spectrometry) for polar biological molecules, the increased mass range of sector and quadrupole mass spectrometers and the development of new instruments for tandem mass spectrometry fostered a new era in structural mass spectrometry. It was during this same period that new instrument technologies, such as Fourier transform ion cyclotron resonance, radio frequency quadrupole ion trap, and new types of time-of-flight mass spectrometers, began to emerge as useful analytical instruments. In addi tion, laser methods useful for both sample ionization and activation became commonplace in almost every analytical mass spectrometry laboratory. In the last 5 years, there has been explosive growth in the area of biological mass spectrometry. Such ionization methods as electrospray and matrix-assisted laser desorption ionization (MALDI) have opened new frontiers for both molecular weight and structural mass spectrometry, with mass spectrometry being used for analysis at the picomole and even femto mole levels. In ideal cases, subfemtomole sample levels can be successfully analyzed. Sample-handling methods are now the limiting factor in analyz ing trace amounts of biological samples.
Download or read book FT ICR MS written by Bruce Asamoto and published by Wiley-VCH. This book was released on 1991 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
