Download or read book Meaning Making in Early Childhood Research written by Jeanne Marie Iorio and published by Routledge. This book was released on 2017-12-12 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Meaning Making in Early Childhood Research asks readers to rethink research in early childhood education through qualitative research practices reflective of arts-based pedagogies. This collection explores how educators and researchers can move toward practices of meaning making in early childhood education. The text’s narrative style provides an intimate portrait of engaging in research that challenges assumptions and thinking in a variety of international contexts, and each chapter offers a way to engage in meaning making based on the experiences of young children, their families, and educators.

Download or read book Mercies in Disguise written by Gina Kolata and published by St. Martin's Press. This book was released on 2017-03-21 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: The phone rings; the doctor has the results. "Are you ready Amanda?" The two people Amanda Baxley loves the most had begged her not to be tested. But she had to find out.If your family carried a mutated gene that foretold brutal illness and you could find out if you inherited it, would you do it? Would you confront it, accepting whatever answer came? Or ignore it while you could? In Mercies in Disguise, acclaimed New York Times reporter and bestselling author Gina Kolata tells the story of the Baxleys, an upstanding family in small town South Carolina. Many of them were doctors, but still, they are struck down by an inscrutable illness. Finally, they discover the cause of the disease after a remarkable sequence of providential events. Meanwhile, science, progressing for 50 years along a parallel track, handed the Baxleys a question - not a cure, but a blood test that would reveal who had the gene for the disease. Science offered another dilemma - fertility specialists had created a way to spare the children. A work of narrative nonfiction in the tradition of the The Immortal Life of Henrietta Lacks, Mercies in Disguise tells the story of a family that took matters into its own hands when medicine could not help. It's a story of a family dealing with unspeakable tragedy without being driven apart. It is the story of a young woman-Amanda Baxley - who faced the future, determined to find a way to disrupt her destiny.

Download or read book Karen Hsiao written by Karen Hsiao and published by . This book was released on 2010-07-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Karen Hsiao uses a simple object, the rubber duck, and a single location, the bathtub, to examine and expose various stages of the human life cycle. From birth to death, through good times and bad, in sickness and in health, the human condition is a series of thematic episodes that Karen Hsiao presents as simple yet shocking portraits of unusual bathing beauties who represent our inner selves. Children, monsters, lovers, fighters, victims, and caregivers are all represented by charismatic models (some famous fetish models) in the tub with their rubber ducks. Dirty, insightful fun.

Download or read book Decoding Darkness written by Rudolph E Tanzi and published by Basic Books. This book was released on 2008-01-07 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Working from the intriguing hypothesis that Alzheimer's dementia is the result of a renegade protein-beta amyloid-Tanzi and others set out to find the gene responsible for its production. Decoding Darkness takes us deep into the minds and far-flung labs of many a prominent researcher, offering an intimate view of the high stakes of molecular genetics, the revolution that propels it, the obstacles that threaten to derail it, and the families whose lives are so dependent upon it. Tanzi and Parson ultimately reveal that Alzheimer's, like heart disease, may be effectively treated-even prevented.

Download or read book Infectious Processes written by E. Seguin and published by Springer. This book was released on 2004-04-29 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years a number of scholars have analyzed the management of BSE, also known as 'mad cow disease'. The BSE crisis is regarded by many as an example of the failure of officials and politicians to handle risk situations. Yet, BSE is also characterized by a unique trait, that is, the infectious agent that causes it. Thus far, no one has paid attention to the fact that BSE and other transmissible spongiform encephalopathy's (TSEs) are allegedly caused by a novel agent - a prion - distinct from all other known infectious agents such as bacteria and viruses. The prion hypothesis was introduced by the American scientist Stanley Prusiner in 1982. It immediately created a controversy among scientists and is still rejected by some. Yet, despite this lack of consensus in the scientific community, Prusiner was awarded the Nobel Prize for medicine in 1997. This book analyzes the introduction, reception, development and consequences of the prion hypothesis. It shows that BSE is a unique case not only in virtue of its political mismanagement but also because its infectious agent has created a form of revolution in biology.

Download or read book The Forgetting written by David Shenk and published by Anchor. This book was released on 2003-05-20 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: NATIONAL BESTSELLER A powerfully engaging, scrupulously researched, and deeply empathetic narrative of the history of Alzheimer’s disease, how it affects us, and the search for a cure. Afflicting nearly half of all people over the age of 85, Alzheimer’s disease kills nearly 100,000 Americans a year as it insidiously robs them of their memory and wreaks havoc on the lives of their loved ones. It was once minimized and misunderstood as forgetfulness in the elderly, but Alzheimer’s is now at the forefront of many medical and scientific agendas, for as the world’s population ages, the disease will touch the lives of virtually everyone. David Shenk movingly captures the disease’s impact on its victims and their families, and he looks back through history, explaining how Alzheimer’s most likely afflicted such figures as Jonathan Swift, Ralph Waldo Emerson, and Willem de Kooning. The result is a searing and graceful account of Alzheimer’s disease, offering a sobering, compassionate, and ultimately encouraging portrait.

Download or read book Charney Nestler s Neurobiology of Mental Illness written by Dennis S. Charney and published by Oxford University Press. This book was released on 2018 with total page 1025 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preceded by Neurobiology of mental illness / edited by Dennis S. Charney ... [et al.]. 4th ed. 2013.

Download or read book Madness and Memory written by Stanley B. Prusiner and published by Yale University Press. This book was released on 2014-04-28 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this “utterly fascinating” science memoir, the Nobel Prize–winning author chronicles his revolutionary discovery of a major cause of brain diseases (The New York Times). In 1997, Stanley B. Prusiner received the Nobel Prize in Physiology or Medicine for his research on devastating brain diseases. That he was the award’s sole recipient was entirely appropriate. His struggle to identify the agent responsible for scrapie and mad cow disease in animals, and Creutzfeldt-Jakob disease in humans, had been waged largely alone, and in some cases, in the face of strenuous opposition. In Madness and Memory, Prusiner recounts the journey to his remarkable discovery of prions—infectious proteins that replicate and cause disease, but surprisingly contain no genetic material. Along the way, he sheds light on the world of contemporary science and the meticulousness and perseverance it requires. Through his telling, the agony and triumph of years of research comes to life, along with fascinating portraits of fellow scientists racing to make breakthrough discoveries. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and provides a path toward conquering such pervasive scourges as Alzheimer’s, Parkinson’s, Lou Gehrig’s, and others diseases. “Madness and Memory is the story of one of the most important discoveries in recent medical history, and it is also a vivid and compelling portrait of a life in science.” —Oliver Sacks, MD, neurologist and author of Hallucinations

Download or read book Handbook of Animal Models in Alzheimer s Disease written by G. Casadesus and published by IOS Press. This book was released on 2011-07-05 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animals have been used to model diseases or test new treatments since around 300 BC, and undoubtedly our ability to model disease in animals – including transgenic animals – has provided major breakthroughs in all fields of biomedical research. Due to their complexity and plurality of pathology and symptomatology, the study of neurodegenerative diseases relies heavily on animal models. These models have been developed in many species in the attempt to undercover the complex nature of the disease mechanisms involved. The ultimate goal is to test promising therapies and to manage, prevent or cure neurodegenerative disease. But because most animal models in this area do not reproduce the full phenotypical disease spectrum and the etiology and clinical presentation of neurodegenerative diseases differ from one patient to the next, the testing of these diseases in animal models often translates poorly to indices of efficacy when applied to the clinical population. Written by experts in the field with these advances and challenges in mind, this handbook provides an updated overview of the animal models being developed and used to study complex disease dynamics. The first part of the book presents an overview of animal models of various species and includes a review of new invertebrate animal models to study neurodegeneration. The second section presents the use of animal models to pinpoint disease mechanisms, and the last part of the handbook examines the various therapeutic interventions being used in models of neurodegenerative disease.

Download or read book Clinical and Molecular Aspects of Neurotropic Virus Infection written by Donald H. Gilden and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the summer of 1984, both of us were working with Professor Yechiel Becker in the Laboratory for Molecular Virology at the Hebrew University-Hadassah Medical center in Jerusalem. During a discussion about the increasing number of specialized journals and monographs, Dr. Becker pointed out that none covered both the clinical and molecular aspects of neurotropic virus infections, and he urged us to develop such a book with the help of colleagues who were conducting highly-regarded research in their individual areas related to neurotropic viruses. The responses to our request were gratifying, and each contribution provided both a comprehensive clinical description of the neurologic disease produced by a specific virus and an up-to-date review of the current research in the pathogenesis of the disease, with particular attention given to molecular mechanisms. Most, but not all chapters were written by clinical neurologists who applied basic science strategies and methodologies to the question of how neurotropic viruses produce disease. other chapters were written by virologists known for their longstanding commitment and expertise in the analysis of the pathogenesis of neurotropic virus infections. Thus, this unique monograph should be valuable to all clinicians caring for patients with CNS viral diseases and to "neurovirologists" needing an update of the clinical and molecular pathogenesis of neurotropic virus infections. While this monograph was being prepared, a rapidly expanding literature indicated that the human lenteviruses, human immunodeficiency viruses (HIV) and HTLV-1 were highly neurotropic.

Download or read book Genetics Neurology Behavior and Diet in Dementia written by Colin R Martin and published by Academic Press. This book was released on 2020-08-11 with total page 954 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 consolidates different fields of dementia research into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, and molecular biology. This foundational, comprehensive book assembles the latest understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. Offers comprehensive coverage of a broad range of topics related to dementia Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about dementia

Download or read book Molecular Mechanisms of Dementia written by Wilma Wasco and published by Springer Science & Business Media. This book was released on 1996-11-01 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal of Molecular Mechanisms of Dementia is to address the various mechanisms and multi faceted approaches currently being employed to more clearly delineate the etiological and pathogenic events responsible for the onset of dementia. Perhaps the greatest boon to obtaining a clearer understanding of the causes of AD has come from genetic and molecular biological studies carried out over the past decade. At the genetic level, it has become increasingly clear that AD is a heteroge neous disorder that can be broadly classified into two categories. "Late onset" (>60 yr) cases, which account for the vast majority of AD, genetically involve "susceptibility" genes representing risk factors for the disease (e. g. , inheritance of the 84 allele of the Apolipoprotein E gene). In many cases, the susceptibility gene can act as a "modifier" that modulates the pathogenic cascade occurring subsequent to a separate etiological event "initiating" or "causing" the disorder.

Download or read book The Social Construction of Disease written by Kiheung Kim and published by Routledge. This book was released on 2006-11-22 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: A historical exploration of scientific disputes on the causation of so-called ‘prion diseases’, this fascinating book covers diseases including Scrapie, Creutzfeldt-Jakob Disease (CJD) and Bovine Spongiform Encephalopathy (BSE). Firstly tracing the twentieth-century history of disease research and biomedicine, the text then focuses on the relations between scientific practice and wider social transformations, before finally building upon the sociologically informed methodological framework. Incisive and thought-provoking, The Social Construction of Disease provides a valuable contribution to that well-established tradition of social history of science, which refers primarily to the theoretical works of the sociology of scientific knowledge.

Download or read book The NIH Record written by and published by . This book was released on 1998 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book What s Wrong With My Mouse written by Jacqueline N. Crawley and published by John Wiley & Sons. This book was released on 2007-03-23 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters: "Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. "Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, "The Next Generation," examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.

Download or read book Animal Models of Cognitive Impairment written by Edward D. Levin and published by CRC Press. This book was released on 2006-06-22 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen

Download or read book The Aging Brain written by Lawrence J. Whalley and published by Columbia University Press. This book was released on 2001 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why do some people remain alert and vigorous at an age when others are declining mentally and physically? Does their apparent advantage have a biological basis? These are just some of the questions answered in this fascinating book by Lawrence Whalley, a researcher who specializes in the study of Alzheimer's disease. Illustrations.