Download or read book Journal of Madame Callegari 2nd Edn BW written by Douglas Wilkie and published by Blurb. This book was released on 2022-08-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of the Journal of Madame Callegari contains new details of Marie Callegari's life that have come to light since publication of the first edition in 2015. In addition, numerous aspects of Marie Callegari's life and activities have been revised and expanded to provide a more nuanced account of those activities, and the historical and geographical contexts in which they occurred.
Download or read book Drug like Properties Concepts Structure Design and Methods written by Li Di and published by Elsevier. This book was released on 2010-07-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. Serves as an essential working handbook aimed at scientists and students in medicinal chemistry Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies Discusses improvements in pharmacokinetics from a practical chemist's standpoint
Download or read book Lore of Running written by Timothy Noakes and published by Human Kinetics. This book was released on 2003 with total page 948 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Noakes explores the physiology of running, all aspects of training, and recognizing, avoiding, and treating injuries. 133 illustrations.
Download or read book Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine written by National Academies Of Sciences Engineeri and published by National Academies Press. This book was released on 2022-07-20 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Strategy for Combating Antibiotic Resistant Bacteria, published in 2014, sets out a plan for government work to mitigate the emergence and spread of resistant bacteria. Direction on the implementation of this strategy is provided in five-year national action plans, the first covering 2015 to 2020, and the second covering 2020 to 2025. Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine evaluates progress made against the national strategy. This report discusses ways to improve detection of resistant infections and estimate the risk to human health from environmental sources of resistance. In addition, the report considers the effect of agricultural practices on human and animal health and animal welfare and ways these practices could be improved, and advises on key drugs and diseases for which animal-specific test breakpoints are needed.
Download or read book Sexual Dysfunctions in Mentally Ill Patients written by Emmanuele A. Jannini and published by Springer. This book was released on 2018-08-28 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the fundamental importance of the proper assessment and treatment of sexual disorders in patients with mental disorders with regard to their treatment outcomes and adherence to therapies. In fact, patients with mental disorders often suffer from sexual dysfunctions and in many cases, pharmacological treatment causes sexual-dysfunction side-effects. However, anxiety disorders, personality disorders, eating disorders and psychotic disorders are often also characterized by sexual symptoms that have a profound impact on sexual function. The psychopathology of sexual behavior investigates deficits in the mind-body relationship that are expressed through sexual symptoms such as erectile dysfunction, premature ejaculation, vaginismus, orgasmic disorders, or lack of sexual desire. These symptoms can be considered both prodromal and as a consequence of psychological or psychiatric suffering. Written by a multidisciplinary team of experts, this book offers a valuable guide for psychiatrists, andrologists, gynecologists and psychologists.
Download or read book Emmy Noether 1882 1935 written by DICK and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: N 1964 at the World's Fair in New York I City one room was dedicated solely to mathematics. The display included a very at tractive and informative mural, about 13 feet long, sponsored by one of the largest com puter manufacturing companies and present ing a brief survey of the history of mathemat ics. Entitled, "Men of Modern Mathematics," it gives an outline of the development of that science from approximately 1000 B. C. to the year of the exhibition. The first centuries of this time span are illustrated by pictures from the history of art and, in particular, architec ture; the period since 1500 is illuminated by portraits of mathematicians, including brief descriptions of their lives and professional achievements. Close to eighty portraits are crowded into a space of about fourteen square feet; among them, only one is of a woman. Her face-mature, intelligent, neither pretty nor handsome-may suggest her love of sci- 1 Emmy Noether ence and creative gift, but certainly reveals a likeable personality and a genuine kindness of heart. It is the portrait of Emmy Noether ( 1882 - 1935), surrounded by the likenesses of such famous men as Joseph Liouville (1809-1882), Georg Cantor (1845-1918), and David Hilbert (1862 -1943). It is accom panied by the following text: Emmy Noether, daughter of the mathemati cian Max, was often called "Der Noether," as if she were a man.
Download or read book Bio Geo Interactions in Metal Contaminated Soils written by Erika Kothe and published by Springer Science & Business Media. This book was released on 2012-01-05 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal contamination is an increasing ecological and eco-toxicological risk. Understanding the processes involved in metal mobilization, sorption and mineralization in soils are key features for soil bioremediation. Following an introduction to the physical, chemical and biological components of contaminated soils, various chapters address the interactions of soil, microorganisms, plants and the water phase necessary to transfer metals into biological systems. These include topics such as potential hazards at mining sites; rare earth elements in biotic and abiotic acidic systems; manganese redox reactions; biomineralisation, uranium in seepage water; metal-resistant streptomycetes; mycorrhiza in re-forestation; metal (hyper)accummulation in plants; microbial metal uptake; and their potential for bioremediation. This book will be of interest to soil biologists, geologists and chemists, researchers and graduate students, as well as consulting companies and small enterprises involved in bioremediation.
Download or read book Pharmaceutical Biotechnology written by Carlos A. Guzmán and published by Springer. This book was released on 2012-03-14 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical Biotechnology is a unique compilation of reviews addressing frontiers in biologicals as a rich source for innovative medicines. This book fulfills the needs of a broad community of scientists interested in biologicals from diverse perspectives—basic research, biotechnology, protein engineering, protein delivery, medicines, pharmaceuticals and vaccinology. The diverse topics range from advanced biotechnologies aimed to introduce novel, potent engineered vaccines of unprecedented efficacy and safety for a wide scope of human diseases to natural products, small peptides and polypeptides engineered for discrete prophylaxis and therapeutic purposes. Modern biologicals promise to dramatically expand the scope of preventive medicine beyond the infectious disease arena into broad applications in immune and cancer treatment, as exemplified by anti-EGFR receptors antibodies for the treatment of breast cancer. The exponential growth in biologicals such as engineered proteins and vaccines has been boosted by unprecedented scientific breakthroughs made in the past decades culminating in an in-depth fundamental understanding of the scientific underpinnings of immune mechanisms together with knowledge of protein and peptide scaffolds that can be deliberately manipulated. This has in turn led to new strategies and processes. Deciphering the human, mammalian and numerous pathogens’ genomes provides opportunities that never before have been available—identification of discrete antigens (genomes and antigenomes) that lend themselves to considerably improved antigens and monoclonal antibodies, which with more sophisticated engineered adjuvants and agonists of pattern recognition receptors present in immune cells, deliver unprecedented safety and efficacy. Technological development such a nanobiotechnologies (dendrimers, nanobodies and fullerenes), biological particles (viral-like particles and bacterial ghosts) and innovative vectors (replication-competent attenuated, replication-incompetent recombinant and defective helper-dependent vectors) fulfill a broad range of cutting-edge research, drug discovery and delivery applications. Most recent examples of breakthrough biologicals include the human papilloma virus vaccine (HPV, prevention of women genital cancer) and the multivalent Pneumoccocal vaccines, which has virtually eradicated in some populations a most prevalent bacterial ear infection (i.e., otitis media). It is expected that in the years to come similar success will be obtained in the development of vaccines for diseases which still represent major threats for human health, such as AIDS, as well as for the generation of improved vaccines against diseases like pandemic flu for which vaccines are currently available. Furthermore, advances in comparative immunology and innate immunity revealed opportunities for innovative strategies for ever smaller biologicals and vaccines derived from species such as llama and sharks, which carry tremendous potential for innovative biologicals already in development stages in many pharmaceutical companies. Such recent discoveries and knowledge exploitations hold the promise for breakthrough biologicals, with the coming decade. Finally, this book caters to individuals not directly engaged in the pharmaceutical drug discovery process via a chapter outlining discovery, preclinical development, clinical development and translational medicine issues that are critical the drug development process. The authors and editors hope that this compilation of reviews will help readers rapidly and completely update knowledge and understanding of the frontiers in pharmaceutical biotechnologies.
Download or read book Everyday Luxuries written by Amanda Phillips and published by Kettler Verlag. This book was released on 2016 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: -A comprehensive introduction to the art and culture of the Ottoman Empire -Volume 2 in the Connecting Art Histories in the Museum series, published in co-operation with the Berlin State Museums From patterned silks and porcelains to printed cottons and earthenwares, art and commodities flowed through Ottoman Constantinople, eddying around artisans, shop-keepers, residents and visitors. Guilds of spoon-makers and workers in mother-of-pearl, textile merchants from India and Italy, sellers of coffee and ceramics together thronged neighborhoods up and down the Bosphorus and along the Golden Horn. This book offers a comprehensive introduction to the art and material culture of the Ottoman Empire, taking as its premise the key role of every day activities. It also argues for new modes of studying all kinds of mass-produced goods destined for popular consumption. Also available in the series: Mshatta in Berlin: Keystone in Islamic Art, Connecting Histories in the Museum Vol. 1 ISBN 9783862063970 Praying for Myriad Virtues: On Ding Guanpeng's 'The Buddha Peaching' in the Berlin Collection, Connecting Art Histories in the Museum Vol. 3 ISBN 9783862064786
Download or read book Enterprise Information Systems written by Slimane Hammoudi and published by Springer. This book was released on 2017-06-29 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes revised selected papers from the 18th International Conference on Enterprise Information Systems, ICEIS 2016, held in Rome, Italy, in April 2016. The 23 papers presented in this volume were carefully reviewed and selected from a total of 257 submissions to ICEIS 2016. The volume also contains one invited talk in full paper length. The papers selected to be included in this book contribute to the understanding of relevant trends of current research on enterprise information systems, including issues with regard to enterprise engineering, heterogeneous systems, security, software engineering, systems integration, business process management, human factors and affective computing, ubiquitous computing, social computing, knowledge management, and artificial intelligence.
Download or read book Automation in Garment Manufacturing written by Rajkishore Nayak and published by Woodhead Publishing. This book was released on 2017-11-10 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Automation in Garment Manufacturing provides systematic and comprehensive insights into this multifaceted process. Chapters cover the role of automation in design and product development, including color matching, fabric inspection, 3D body scanning, computer-aided design and prototyping. Part Two covers automation in garment production, from handling, spreading and cutting, through to finishing and pressing techniques. Final chapters discuss advanced tools for assessing productivity in manufacturing, logistics and supply-chain management. This book is a key resource for all those engaged in textile and apparel development and production, and is also ideal for academics engaged in research on textile science and technology. Delivers theoretical and practical guidance on automated processes that benefit anyone developing or manufacturing textile products Offers a range of perspectives on manufacturing from an international team of authors Provides systematic and comprehensive coverage of the topic, from fabric construction, through product development, to current and potential applications
Download or read book Endocrinology of Aging written by John E. Morley and published by Springer Science & Business Media. This book was released on 1999-11-05 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Distinguished physicians critically review the clinical consequences of the endocrinological changes that occur with aging-in both men and women-and examine the use of hormonal therapy to reduce them. Topics range from bone disease and water balance in all older people, to androgen deficiency in aging males, gynecomastia, and menopause. The authors also discuss Type II diabetes in persons over 65, emphasizing the cognitive benefits of good glycemia control, and the interaction of nutrition and metabolism, focusing on hypocholesterolemia, obesity, the anorexia of aging, trace elements, and vitamins. The aging of the sympathetic nervous system and its impact on hypertension in the elderly is also covered. Timely and authoritative, Endocrinology of Aging offers endocrinologists, geriatricians, and primary care physicians critical insight into the endocrine problems of our rapidly growing elderly population.
Download or read book History of Cooper County Missouri written by William Foreman Johnson and published by . This book was released on 1919 with total page 1470 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Battles and Leaders of the Civil War written by Peter Cozzens and published by University of Illinois Press. This book was released on 2004 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 6 brings readers more of the best first-person accounts of marches, encampments, skirmishes, and full-blown battles, as seen by participants on both sides of the conflict. Alongside the experiences of lower-ranking officers and enlisted men are accounts from key personalities including General John Gibbon, General John C. Lee, and seven prominent generals from both sides offering views on "why the Confederacy failed." This volume includes 120 illustrations, including 16 previously uncollected maps of battlefields, troop movements, and fortifications.
Download or read book Green and Smart Technology with Sensor Applications written by Hyun-seob Cho and published by Springer. This book was released on 2012-11-07 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprises the refereed proceedings of the two International Conference on Green and Smart Technology, GST 2012, and on Sensor and Its Applications, SIA 2012, held in Jeju Island, Korea, in November/December 2012. The papers presented were carefully reviewed and selected from numerous submissions and focus on the various aspects of green and smart technology with sensor applications.
Download or read book Three Pioneer Rapides Families written by G. M. Stafford and published by Claitors Pub Division. This book was released on 1968-06-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Computing and Communications Part I written by Ajith Abraham and published by Springer. This book was released on 2011-07-08 with total page 771 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the first part of a four-volume set (CCIS 190, CCIS 191, CCIS 192, CCIS 193), which constitutes the refereed proceedings of the First International Conference on Computing and Communications, ACC 2011, held in Kochi, India, in July 2011. The 68 revised full papers presented in this volume were carefully reviewed and selected from a large number of submissions. The papers are organized in topical sections on ad hoc networks; advanced micro architecture techniques; autonomic and context-aware computing; bioinformatics and bio-computing; cloud, cluster, grid and P2P computing; cognitive radio and cognitive networks; cyber forensics; database and information systems.
