Download or read book The Life of Isaac Newton written by Richard S. Westfall and published by Cambridge University Press. This book was released on 2015-09-29 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Isaac Newton was indisputably one of the greatest scientists in history. His achievements in mathematics and physics marked the culmination of the movement that brought modern science into being. Richard Westfall's biography captures in engaging detail both his private life and scientific career, presenting a complex picture of Newton the man, and as scientist, philosopher, theologian, alchemist, public figure, President of the Royal Society, and Warden of the Royal Mint. An abridged version of his magisterial study Never at Rest (Cambridge, 1980), this concise biography makes Westfall's highly acclaimed portrait of Newton newly accessible to general readers.
Download or read book I Asimov written by Isaac Asimov and published by Bantam. This book was released on 2009-12-23 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arguably the greatest science fiction writer who ever lived, Isaac Asimov also possessed one of the most brilliant and original minds of our time. His accessible style and far-reaching interests in subjects ranging from science to humor to history earned him the nickname “the Great Explainer.” I. Asimov is his personal story—vivid, open, and honest—as only Asimov himself could tell it. Here is the story of the paradoxical genius who wrote of travel to the stars yet refused to fly in airplanes; who imagined alien universes and vast galactic civilizations while staying home to write; who compulsively authored more than 470 books yet still found the time to share his ideas with some of the great minds of our century. Here are his wide-ranging thoughts and sharp-eyed observations on everything from religion to politics, love and divorce, friendship and Hollywood, fame and mortality. Here, too, is a riveting behind-the-scenes look at the varied personalities—Campbell, Ellison, Heinlein, Clarke, del Rey, Silverberg, and others—who along with Asimov helped shape science fiction. As unique and irrepressible as the man himself, I. Asimov is the candid memoir of an incomparable talent who entertained readers for nearly half a century and whose work will surely endure into the future he so vividly envisioned.
Download or read book Never at Rest written by Richard S. Westfall and published by Cambridge University Press. This book was released on 1983-04-29 with total page 934 pages. Available in PDF, EPUB and Kindle. Book excerpt: This richly detailed 1981 biography captures both the personal life and the scientific career of Isaac Newton, presenting a fully rounded picture of Newton the man, the scientist, the philosopher, the theologian, and the public figure. Professor Westfall treats all aspects of Newton's career, but his account centres on a full description of Newton's achievements in science. Thus the core of the work describes the development of the calculus, the experimentation that altered the direction of the science of optics, and especially the investigations in celestial dynamics that led to the law of universal gravitation.
Download or read book Plant Cell Electroporation And Electrofusion Protocols written by Jac A. Nickoloff and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene transfer is an essential technology for improving our under standing of gene structure and function. Although there are many meth ods by which DNA may be introduced into cells—including heat and chemical treatments, and microinjection—electroporation has been found to be the most versatile gene transfer technique. Electroporation is effective with a wide variety of cell types, including those that are difficult to transform by other means. For many cell types, electroporation is either the most efficient or the only means known to effect gene transfer. The early and broad success of electric field-medi ated DNA transfer soon prompted researchers to investigate electroporation for transferring other types of molecules into cells, in cluding RNA, enzymes, antibodies, and analytic dyes. The first section of Plant Cell Electroporation and Electrofusion Protocols includes two chapters that serve as a guide to theoretical and practical aspects of electroporation, and will be of particular interest to those developing protocols for as yet untested species or cell types, and a third chapter that describes commercially available electroporation instruments. The remaining chapters describe well-tested protocols for DNA electrotransfection, electroporation of other biomolecules, or cell electrofusion. These chapters also include brief discussions of alterna tives to electric field-based methods, citing the advantages and limita tions of the various methods for achieving specific goals.
Download or read book Antibody Engineering Protocols written by Sudhir Paul and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive collection of recently developed methods for producing new antibody reagents by immunization and recombinant DNA techniques contains ready-to-use protocols that illuminate current areas of research on antibody structure, functions, and applications. The methods can be applied in basic immunological studies involving antibody specificity, catalysis, and evolution, and in the isolation of rare antibodies by phage display technology and the engineering of new antibodies by mutagenesis. They offer insight into new ways of developing clinically useful antibody reagents. Antibody Engineering Protocols constitutes a single-source volume for laboratory investigators who want to minimize extensive literature and methodology searches and to work productively in their fields with reproducible step-by-step protocols.
Download or read book Capillary Electrophoresis Guidebook written by Kevin D. Altria and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended to be a working guide to the operation of capillary electrophoresis (CE) instrumentation. Since CE is still a rap idly maturing technique, detailed validated protocols are not widely established. Therefore, extensive experimental procedures are not pro vided for individual analyses. The intention is to provide general guide lines on the principles and practice of CE and to give an overview of the specific technologies and important application areas. Part I provides operating instructions for standard commercially available instruments. Guidelines are included for activities such as changing capillaries, method development, quantitative procedures, optimization of precision and sensitivity, and the validation of meth ods, fraction collection, and troubleshooting, as well as a quick guide to running a separation. The application range of CE is possibly the most diverse of all analytical techniques and ranges from large, complex macromolecules, such as proteins and nucleic acids, to small solutes, such as organic drugs and inorganic anions and cations.
Download or read book Computer Analysis of Sequence Data Part II written by Annette M. Griffin and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA sequencing has become increasingly efficient over the years, resulting in an enormous increase in the amount of data gener ated. In recent years, the focus of sequencing has shifted, from being the endpoint of a project, to being a starting point. This is especially true for such major initiatives as the human genome project, where vast tracts of DNA of unknown function are sequenced. This sheer volume of available data makes advanced computer methods essen tial to analysis, and a familiarity with computers and sequence analy sis software a vital requirement for the researcher involved with DNA sequencing. Even for nonsequencers, a familiarity with sequence analysis software can be important. For instance, gene sequences already present in the databases can be extremely useful in the design of cloning and genetic manipulation experiments. This two-part work on Computer Analysis of Sequence Data is designed to be a practical aid to the researcher who uses computers for the acquisition, storage, or analysis of nucleic acid (and/or pro tein) sequences. Each chapter is written such that a competent scien tist with basic computer literacy can carry out the procedure successfully at the first attempt by simply following the detailed prac tical instructions that have been described by the author. A Notes section, which is included at the end of each chapter, provides advice on overcoming the common problems and pitfalls sometimes encoun tered by users of the sequence analysis software.
Download or read book Immunocytochemical Methods and Protocols written by Lorette C. Javois and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: The principle that antibodies can be used as cytochemical agents provided they are tagged with suitable markers has been evident for over 50 years. During this time the use of immunocytochemical meth ods has spread to a wide array of biological disciplines. Early applica tions focused on the detection of microbial antigens in tissues, while more recent applications have used monoclonal antibodies to study cell differentiation during embryonic development. For a select few disci plines, volumes have been published focusing on the specific applica tion of immunocytochemical techniques to that discipline. What distinguishes the present book, Immunocytochemical Meth ods and Protocols, from earlier books is its broad appeal to researchers in all disciplines, including those in both research and clinical settings. The methods and protocols presented here are designed to be general in their application and the accompanying "Notes" provide invaluable assistance in adapting or troubleshooting the protocols. Interspersed throughout the book are chapters providing overviews of select topics related to immunocytochemistry.
Download or read book Fisheries Review written by and published by . This book was released on 1994 with total page 888 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Electroporation Protocols for Microorganisms written by Jac A. Nickoloff and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electroporation is one of the most widespread techniques used in modem molecular genetics. It is most commonly used to introduce DNA into cells for investigations of gene structure and function, and in this regard, electroporation is both highly versatile, being effective with nearly all species and cell types, and highly efficient. For many cell types, electroporation is either the most efficient or the only means known to effect gene transfer. However, exposure of cells to brief, hi- intensity electric fields has found broad application in other aspects of biological research, and is now routinely used to introduce other types of biological and analytic molecules into cells, to induce cell-cell fusion, and to transfer DNA directly between different species. The first seven chapters of Electroporation Protocols for Micro organisms describe the underlying theory of electroporation, the com mercially available instrumentation, and a number of specialized electroporation applications, such as cDNA library construction and interspecies DNA electrotransfer. Each of the remaining chapters pre sents a well developed method for electrotransformation of a particular bacterial, fungal, or protist species. These chapters also serve to intro duce those new to the field the important research questions that are currently being addressed with particular organisms, highlighting both the major advantages and limitations of each species as a model organ ism, and explaining the roles that electroporation has played in the development of the molecular genetic systems currently in use.
Download or read book Radical and Marxist Theories of Crime written by Paul B. Stretesky and published by Routledge. This book was released on 2017-03-02 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: The essays selected for this volume show how radical and Marxist criminology has established itself as an influential critique since it emerged in the late 1960s. Unlike orthodox criminology which emphasizes individual level explanations of criminal behavior, radical and Marxist criminology emphasizes power inequality and structures, especially those related to class, as key factors in crime, law and justice. This collection of essays draws attention to the way in which structural forces shape and influence both individual and institutional (for example, governmental) behavior; highlights neglected crime (corporate, governmental, state-corporate and environmental) which causes more extensive damage than the street crimes examined by orthodox criminology; and discusses the ways in which law and criminal justice processes reinforce power structures and contribute to class control.
Download or read book Mennonite Family History Index 1992 1996 written by Lois Ann Mast and published by Masthof Press & Bookstore. This book was released on with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Social Development and Public Policy written by D. Ghai and published by Springer. This book was released on 1999-12-07 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book shows, through in-depth case studies, how some low income countries have made enormous strides in overcoming problems of adult literacy, lack of schooling, high child mortality, rapid population growth, mass poverty and gender inequalities. With contributions from outstanding scholars, the book analyses the experiences with social development and public policy of Chile, China, Costa Rica, Cuba, Kerala, Sri Lanka and Vietnam. Using a holistic approach, it draws lessons and evaluates their relevance for other countries interested in emulating their achievements.
Download or read book Water Balances in the Eastern Mediterranean written by International Development Research Centre (Canada) and published by IDRC. This book was released on 2000 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Water Balances in the Eastern Mediterranean
Download or read book Meat Eating and Human Evolution written by Craig B. Stanford and published by Oxford University Press. This book was released on 2001-06-14 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: When, why, and how early humans began to eat meat are three of the most fundamental unresolved questions in the study of human origins. Before 2.5 million years ago the presence and importance of meat in the hominid diet is unknown. After stone tools appear in the fossil record it seems clear that meat was eaten in increasing quantities, but whether it was obtained through hunting or scavenging remains a topic of intense debate. This book takes a novel and strongly interdisciplinary approach to the role of meat in the early hominid diet, inviting well-known researchers who study the human fossil record, modern hunter-gatherers, and nonhuman primates to contribute chapters to a volume that integrates these three perspectives. Stanford's research has been on the ecology of hunting by wild chimpanzees. Bunn is an archaeologist who has worked on both the fossil record and modern foraging people. This will be a reconsideration of the role of hunting, scavenging, and the uses of meat in light of recent data and modern evolutionary theory. There is currently no other book, nor has there ever been, that occupies the niche this book will create for itself.
Download or read book Protein Purification Protocols written by Shawn Doonan and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hans Neurath has written that this is the second golden era of enzymology {Protein Science [1994], vol. 3, pp. 1734—1739); he could with justice have been more general and referred to the second golden age of protein chemistry. The last two decades have seen enormous advances in our understanding of the structures and functions of pro teins arising on the one hand from improvements and developments in analytical techniques {see the companion volume, Basic Protein and Peptide Protocols, in this series) and on the other hand from the tech nologies of molecular genetics. Far from turning the focus away from protein science, the ability to isolate, analyze, and express genes has increased interest in proteins as gene products. Hence, many laborato ries are now getting involved in protein isolation for the first time, either as an essential adjunct to their work in molecular genetics or because of a curiosity to know more about the products of the genes that they have been studying. Protein Purification Protocols is aimed mainly at these newcom ers to protein purification, but it is hoped that it will also be of value to established practitioners who may find here techniques that they have not tried, but which might well be most applicable in their work. With the exception mainly of the first and last chapters, the format of the contributions to the present book conform to the established format of the Methods in Molecular Biology series.
Download or read book Sacred Darkness written by Holley Moyes and published by University Press of Colorado. This book was released on 2012-04-15 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Caves have been used in various ways across human society, but despite the persistence within popular culture of the iconic caveman, deep caves were never used primarily as habitation sites for early humans. Rather, in both ancient and contemporary contexts, caves have served primarily as ritual spaces. In Sacred Darkness, contributors use archaeological evidence as well as ethnographic studies of modern ritual practices to envision the cave as place of spiritual and ideological power that emerges as a potent venue for ritual practice. Covering the ritual use of caves in Europe, Asia, Australia, Africa, Mesoamerica, and the US Southwest and Eastern woodlands, this book brings together case studies by prominent scholars whose research spans from the Paleolithic period to the present day. These contributions demonstrate that cave sites are as fruitful as surface contexts in promoting the understanding of both ancient and modern religious beliefs and practices. This state-of-the-art survey of ritual cave use will be one of the most valuable resources for understanding the role of caves in studies of religion, sacred landscape, or cosmology and a must-read for any archaeologist interested in caves.
