Download or read book IRM fonctionnelle chez le rat written by Sébastien Reyt and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: L'imagerie par résonance magnétique fonctionnelle (IRMf ) permet de détecter sur le cerveau entier des activations neuronales en réponse à un stimulus, par le biais de l'observation des modifications hémodynamiques occasionnées. En particulier, l'IRMf est un outil de choix pour l'étude des mécanismes de la stimulation cérébrale profonde et de la stimulation du nerf vague qui sont encore mal connus. Cependant, cette technique n'est pas facilement utilisable chez l'homme en raison des problèmes de sécurité vis-à-vis de l'action des champs magnétiques intenses utilisés en IRM au niveau des électrodes implantées. Les développements méthodologiques chez l'animal sont donc nécessaires. L'objectif principal de cette thèse est l'étude des mécanismes à distance de la stimulation du système nerveux central et périphérique par IRMf chez le rat. Nous présentons dans un premier temps les séquences IRM rapides utilisées en IRMf, comme l'Echo-Planar Imaging multishot, permettant d'imager le cerveau entier en 1 à 2 secondes seulement, ainsi que les différents problèmes posés par l'utilisation de ces séquences, comme les artefacts de susceptibilité magnétique. Le couplage des séquences développées durant cette thèse avec des mesures électrophysiologiques a notamment permis l'imagerie des réseaux épileptiques chez le rat. Dans un second temps, nous développons les problèmes posés par la préparation animale, particulière en IRMf de par le fait que le couplage neurovasculaire doit être préservé sous anesthésie afin de préserver les activations neuronales. Après comparaison avec les anesthésies à l'isoflurane et la kétamine, nous avons déduit que la médétomidine constituait un anesthésique de choix pour l'IRMf du rongeur, et précisons le protocole de préparation animale utilisé pour l'imagerie. De plus, les électrodes utilisées en stimulation intracérébrale induisent des artefacts importants en imagerie, et des électrodes constituées de matériaux amagnétiques sont nécessaires. Nous expliquons pourquoi nous avons choisi des électrodes en carbone, et présentons le protocole de fabrication utilisé. Nous avons ensuite validé ces développements méthodologiques par des expériences d'IRMf de challenges hypercapniques et de stimulation de la patte chez le rat. Puis nous avons conduit une étude IRMf approfondie des mécanismes d'action de la stimulation du nerf vague, en s'intéressant à la distinction entre activations neuronales et effets cardiovasculaires confondants par modélisation causale dynamique. Nous présentons aussi des résultats en IRMf de la stimulation électrique intracérébrale chez le rat. Plusieurs cibles ont été stimulées (noyau géniculé dorso-latéral, gyrus dentelé, striatum et thalamus), et des activations ont été obtenues à distance de l'électrode, conformément aux connaissances actuelles sur les connexions neuroanatomiques de ces noyaux. Ainsi, nous avons mis au point et validé l'IRMf du rat et son application à la stimulation électrique du système nerveux périphérique et central.
Download or read book Imagerie Par R sonance Magn tique Fonctionnelle Du Rat 7T written by Vincent Méthot and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Geometries Of Nature Living Systems And Human Cognition New Interactions Of Mathematics With Natural Sciences And Humanities written by Luciano Boi and published by World Scientific. This book was released on 2005-11-02 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: The collection of papers forming this volume is intended to provide a deeper study of some mathematical and physical subjects which are at the core of recent developments in the natural and living sciences. The book explores some far-reaching interfaces where mathematics, theoretical physics, and natural sciences seem to interact profoundly. The main goal is to show that an accomplished movement of geometrisation has enabled the discovery of a great variety of amazing structures and behaviors in physical reality and in living matter. The diverse group of expert mathematicians, physicists and natural scientists present numerous new results and original ideas, methods and techniques. Both academic and interdisciplinary, the book investigates a number of important connections between mathematics, theoretical physics and natural sciences including biology.
Download or read book Biomedical Research in the Drugs Field written by Richard Muscat and published by Council of Europe. This book was released on 2006-01-01 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why is it that certain people use drugs in the first place and then why do some become dependent following repeated use while others do not? What are the possible implications of the current state of affairs of research from a biomedical or more aptly put, a Neuroscience perspective, including an ethical point of view? These are questions the author attempts to answer as the biomedical or neuroscience research in the drug field is a fast moving area with ethical implications that have arisen as a result of the conduct of such research.
Download or read book Olfaction Taste and Cognition written by Catherine Rouby and published by Cambridge University Press. This book was released on 2002-10-28 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human body has developed complex sensory processing systems which manifest themselves in our emotions, memory, and language. This book examines such olfactory and gustatory cognition. Leading experts have written chapters on many facets of taste and smell, including odor memory, genetic variation in taste, and the hedonistic dimensions of odors.
Download or read book Modern Trends in Aging Research written by Y. Courtois and published by Scientific & Medical Publications of France, Incorporated. This book was released on 1986 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Index Medicus written by and published by . This book was released on 2002 with total page 1788 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Leksell Radiosurgery written by A. Niranjan and published by Karger Medical and Scientific Publishers. This book was released on 2019-05-20 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its introduction 52 years ago, Leksell radiosurgery has become a widely applied technique for the management of a diverse group of vascular, neoplastic, and functional disorders. This publication presents an update on state-of-the-art radiosurgery technology, including outcomes, by the pioneers in the field. Experts have contributed chapters on various topics. They provide a history of the development of Leksell Gamma Knife and its evolution from frame-based to the inclusion of mask-based radiosurgery in the latest Gamma Knife model. For beginners, there is valuable information related to imaging, quality assurance, patient care, anesthesia, and regulatory requirements. Advance users will appreciate the summary of the long-term outcome of important indications. Additional chapters on cavernous malformation, orbital, uveal, and ocular disorders clarify the role of radiosurgery. This book is a concise overview for physicians interested in radiosurgery. It will be of great value to neurosurgeons, radiation oncologists, and medical physicists concerned with learning about the indications of radiosurgery.
Download or read book Cerebral Blood Flow and Metabolism written by Lars Edvinsson and published by . This book was released on 2002 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written and edited by the world's foremost authorities, the Second Edition of this landmark work is a current, comprehensive reference on cerebral blood flow and metabolism. The book covers the entire field in a systematic and coherent way and synthesizes the diverse body of basic science and clinical literature. The reader will gain a complete understanding of the anatomical, physiological, and pharmacological bases of the cerebral circulation, its regulation in health and disease, and the pathophysiological disturbances occurring in cerebrovascular disorders. Coverage includes stimulating discussions of future directions for research and therapeutic intervention.
Download or read book Atlas of Regional Anatomy of the Brain Using MRI written by Jean C. Tamraz and published by Springer Science & Business Media. This book was released on 2006-02-08 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique review of the essential topographical anatomy of the brain from an MRI perspective, correlating high-quality anatomical plates with high-resolution MRI images. The book includes a historical review of brain mapping and an analysis of the essential reference planes used. It provides a detailed review of the sulcal and the gyral anatomy of the human cortex, guiding readers through an interpretation of the individual brain atlas provided by high-resolution MRI. The relationship between brain structure and function is approached in a topographical fashion with an analysis of the necessary imaging methodology and displayed anatomy. An extensive coronal atlas rounds off the book.
Download or read book Syndromes pileptiques de l enfant et de l adolescent 5eme edition written by Bureau Michelle and published by John Libbey Eurotext. This book was released on 2013-09-11 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: Un DVD inclus avec des séquences vidéos inédites pour chaque chapitre ! L’épileptologie change, et les approches syndromiques sont maintenant complétées par une approche étiologique fondée sur les progrès considérables en génétique. Une approche purement « électro-clinique » n’est plus adaptée aujourd’hui dans bien des cas. Cette 5e édition du « Guide bleu » fait le point sur les plus récents progrès. Ainsi, la structure du livre a un peu évolué, laissant plus de place aux approches : - physiologiques - épidémiologiques - génétiques - thérapeutique Néanmoins, la description des syndromes épileptiques reste au cœur de cet ouvrage. La diversité des contributeurs – coordinateurs et auteurs – confère à ce livre des qualités d’objectivité et de sérieux qui en font la réputation depuis maintenant près de 30 ans.
Download or read book Pain 2014 Refresher Courses written by Srinivasa N. Raja and published by Lippincott Williams & Wilkins. This book was released on 2015-06-01 with total page 1122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every two years, the International Association for the Study of Pain publishes a compendium of benchmark papers that summarize the current status of pain research, treatment, and management throughout the world. Presented at the 15th World Congress on Pain in Buenos Aires in October 2014, these papers represent the thinking of the world's top pain scientists and clinicians. IASP distributes this book to participants in the Refresher Courses, and it is now available to pain researchers and clinicians who were unable to attend the Congress.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1995 with total page 1520 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The biology of Latimeria chalumnae and evolution of coelacanths written by J.A. Musick and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Postnatal Development of the Human Hippocampal Formation written by Ricardo Insausti and published by Springer Science & Business Media. This book was released on 2010 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: The postnatal development of the human hippocampal formation (HF) is subject of increasing interest due to its implication in important pathologies that hamper the normal development of children. In this work, the authors present a glimpse of the main events that constitute important milestones in the development and shaping of some of the most important psychological capabilities such as autobiographical memory. Although they examined some cases in the last trimester of gestation, their description starts at birth, around 40 gestational weeks. Serial sections with thionin for Nissl analysis revealed that all fields of the HF were present and identifiable at birth. However, the relative growth of the cortical mantle was much higher relative to the HF. The main structural changes took place during the first postnatal year, in particular in the dentate gyrus and in the entorhinal cortex. At subsequent ages, a growth in size was noted in all components of the HF. This growth was more evident at the body and tail of the hippocampus, as evidenced by measurements of the neuroanatomical series. In addition, the authors examined in some cases the MRI appearance of the HF at different postnatal ages obtained by post-mortem imaging. MRI neuroanatomical series provided anatomically identified landmarks useful for the MRI identification of different components of the HF during postnatal development.
Download or read book Medical Imaging Based on Magnetic Fields and Ultrasounds written by Hervé Fanet and published by John Wiley & Sons. This book was released on 2014-03-06 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the different principles and equipment used in medical imaging. The importance of medical imaging for diagnostics is rapidly increasing. A good working knowledge of all the different possible physical principles involved in medical imaging is now imperative. This book covers many of these principles including matter photon interactions, the principles of detectors, detectors and information processing for radiology, X-ray tomography, positron tomography, single photon tomography and optical tomography.
