Download or read book Iridium Catalyzed C H Borylation written by Behnaz Ghaffari and published by . This book was released on 2016 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Iridium Catalysis written by Pher G. Andersson and published by Springer Science & Business Media. This book was released on 2011-01-05 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the contents: Robert H Crabtree: Introduction and History. - Montserrat Diéguez, Oscar Pàmies and Carmen Claver: Iridium-catalysed hydrogenation using phosphorous ligands. - David H. Woodmansee and Andreas Pfaltz: Iridium Catalyzed Asymmetric Hydrogenation of Olefins with Chiral N,P and C,N Ligands. - Ourida Saidi and Jonathan M J Williams: Iridium-catalyzed Hydrogen Transfer Reactions. - John F. Bower and Michael J. Krische: Formation of C-C Bonds via Iridium Catalyzed Hydrogenation and Transfer Hydrogenation. - Jongwook Choi, Alan S. Goldman: Ir-Catalyzed Functionalization of CH Bonds. - Mark P. Pouy and John F. Hartwig: Iridium-Catalyzed Allylic Substitution. - Daniel Carmona and Luis A. Oro: Iridium-catalyzed 1.3-dipolar cycloadditions.

Download or read book Remote C H Bond Functionalizations written by Debabrata Maiti and published by John Wiley & Sons. This book was released on 2021-04-26 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to contemporary advancements in the field of distal C-H functionalizations An important and dynamic topic within the modern field of organic synthesis, selective functionalization of C-H bonds can be used in a variety of applications across the pharmaceutical and agrochemical industries. Remote C-H Bond Functionalizations presents an inclusive account of the most recent developments and potential applications of performing variegated functionalizations selectively at the distal positions of organic compounds. Featuring contributions by an international team of experts, this authoritative volume provides deep insight into distal functionalizations, including detailed discussion of mechanisms, the engineering of templates, and the design of strategies. The text covers a diverse range of topics including C-H functionalization of palladium/norbornene catalysis, ruthenium-catalyzed remote functionalization, the non-directed distal C(sp2)-H, functionalization, transition metal catalyzed distal para-selective C-H functionalization, and much more. Reviewing contemporary advancements in the field while laying the foundation for future research, this important resource: Provides the most recent research and thorough coverage of the subject available in a single volume Offers practical information on C-H functionalizations in various industries Includes an up-to-date introduction to distal C-H functionalizations Remote C-H Bond Functionalizations is a must-read for every synthetic chemist, including chemists working with organometallics, organic chemists and researchers, and industrial chemists.

Download or read book Iridium Catalyzed C H Borylation written by Kristin Anne Gore and published by . This book was released on 2017 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Frontiers in Iridium Catalyzed C H Borylation written by Matthew Alan Larsen and published by . This book was released on 2016 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: The following dissertation discusses the development of novel methodology for the catalytic borylation of C-H bonds and includes in-depth studies on the mechanism and selectivity of these synthetic transformations. These methods include the borylation of heteroaryl C-H bonds, the selective borylation of benzylic C-H bonds, and the directed and undirected borylation of unactivated alkyl C-H bonds. Chapter 1 contains a comprehensive review of C-H borylation methodology. This review focuses on the initial development of catalytic C-H borylation and on the state-of- the-art of methodology for the undirected and directed borylation of aryl, benzylic, and alkyl C-H bonds. Additionally, this review highlights knowledge gaps and unsolved challenges. Furthermore, this review provides the author's opinion on future directions for research on the borylation of C-H bonds. Chapter 2 describes the study of the iridium-catalyzed borylation of heteroaryl C- H bonds. Contained is an examination of the scope of the borylation of heterocycles containing more than one heteroatom and rules for predicting the site-selectivity of this reaction. Also included are experimental and computational studies that reveal the mechanism of this reaction and the origins of the observed regioselectivity. Chapter 3 discusses the development of the selective borylation of the primary benzylic C-H bonds of methylarenes. Key to this development was the discovery that the combination of a novel iridium catalyst and a silylborane allows for the selective borylation of benzylic C-H bonds over aryl C-H bonds. Experimental and computational studies that investigate the origins of this selectivity are also discussed. Chapter 4 discusses the development of the iridium-catalyzed, hydrosilyl-directed borylation of alkyl C-H bonds. This methodology allows for the diastereoselective borylation of secondary alkyl C-H bonds under relatively mild conditions. Chapter 5 explores the effect of ligand structure on the rates of alkyl C-H borylation catalyzed by Ir-phenanthroline complexes. Experimental and computational studies reveal that in addition to the relative electron-donating ability of phenanthrolines, weak interactions involving the phenanthroline in the transition state of the turnover- limiting step for the borylation of alkyl C-H bonds can have a large impact on the relative rates of alkyl C-H borylation catalyzed by various Ir-phenanthroline complexes.

Download or read book Advances in Cross Coupling Reactions written by José Pérez Sestelo and published by MDPI. This book was released on 2020-12-03 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this Special Issue, recent advances in cross-coupling reactions are presented in the form of original research articles, reviews, and short communications. These contributions cover different topics in this area, including novel coupling reactions, reaction conditions, synthetic alternatives, metal ligands, and applications for new pharmaceutical compounds and organic materials. In particular, the reviews deal with methodologies such as the synthesis of diarylketones through palladium catalysis and the most relevant examples of Suzuki–Miyaura and Buchwald–Hartwig coupling reactions in the synthesis of bioactive compounds. The synthetic utility of cross-coupling reactions for the synthesis of medium-size rings and the utility of Stille and Suzuki coupling reactions for the synthesis of new molecular machines based on sterically hindered anthracenyl trypticenyl units are also summarized. The original research articles present the synthesis of 2-alkynylpyrrols by inverse Sonogashira coupling and the synthesis of indoles under oxidative dearomative cross-dehydrogenative conditions. The efficient combination of iridium-catalyzed C–H borylation of aryl halides with the Sonogashira coupling and a sequential iridium-catalyzed borylation of NH-free pyrroles followed by a Suzuki–Miyaura reaction are included. The synthesis of aryl propionic acids, a common structural motif in medicinal chemistry, and the synthesis of new organic dyes are also covered.

Download or read book Synthetic Applications of Iridium catalyzed Aromatic C H Borylation written by Feng Shi and published by . This book was released on 2007 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Stereoselective Synthesis written by Gary A. Molander and published by Thieme Chemistry. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbonyl and imino groups are two of the most integral functional groups employed in organic synthesis. Specific topics discussed: reduction, alkylation, alkenylation, and arylation of these groups, as well as asymmetric aldol, Mannich, and Morita-Bayliss-Hillman reactions. This volume is part of a 3-volume set: Science of Synthesis Stereoselective Synthesis Workbench Edition Further information about Stereoselective Synthesis (including sample pages and the table of contents)

Download or read book Synthetic Applications written by Rajender S. Varma and published by Walter de Gruyter GmbH & Co KG. This book was released on 2022-05-09 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic nanocatalysts are becoming an important tool for greener catalytic processes in chemical transformations in view of the ease of their removal from a reaction medium. This book explores assorted magnetic nanocatalysts, their deployment in synthesis, chemical transformation and their recovery and reuse. Various thematic topics embodied include magnetic nanocatalysts for S-S bond formation, N-heterocycle formation, C-heteroatom bond formation, silica-supported catalysts, multicomponent reactions, including their recyclability; another available volume emphasizes the utility of magnetic nanocatalysts in industrial appliances.

Download or read book Supramolecular Catalysis written by Piet W.N.M. van Leeuwen and published by John Wiley & Sons. This book was released on 2021-12-31 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supramolecular Catalysis Provides a timely and detailed overview of the expanding field of supramolecular catalysis The subdiscpline of supramolecular catalysis has expanded in recent years, benefiting from the development of homogeneous catalysis and supramolecular chemistry. Supramolecular catalysis allows chemists to design custom-tailored metal and organic catalysts by devising non-covalent interactions between the various components of the reaction. Edited by two world-renowned researchers, Supramolecular Catalysis: New Directions and Developments summarizes the most significant developments in the dynamic, interdisciplinary field. Contributions from an international panel of more than forty experts address a broad range of topics covering both organic and metal catalysts, including emergent catalysis by self-replicating molecules, switchable catalysis using allosteric effects, supramolecular helical catalysts, and transition metal catalysis in confined spaces. This authoritative and up-to-date volume: Covers ligand-ligand interactions, assembled multi-component catalysts, ligand-substrate interactions, and supramolecular organocatalysis and non-classical interactions Presents recent work on supramolecular catalysis in water, supramolecular allosteric catalysis, and catalysis promoted by discrete cages, capsules, and other confined environments Highlights current research trends and discusses the future of supramolecular catalysis Includes full references and numerous figures, tables, and color illustrations Supramolecular Catalysis: New Directions and Developments is essential reading for catalytic chemists, complex chemists, biochemists, polymer chemists, spectroscopists, and chemists working with organometallics.

Download or read book Pincer Compounds written by David Morales-Morales and published by Elsevier. This book was released on 2018-04-11 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pincer Compounds: Chemistry and Applications offers valuable state-of-the-art coverage highlighting highly active areas of research—from mechanistic work to synthesis and characterization. The book focuses on small molecule activation chemistry (particularly H2 and hydrogenation), earth abundant metals (such as Fe), actinides, carbene-pincers, chiral catalysis, and alternative solvent usage. The book covers the current state of the field, featuring chapters from renowned contributors, covering four continents and ranging from still-active pioneers to new names emerging as creative strong contributors to this fascinating and promising area. Over a decade since the publication of Morales-Morales and Jensen’s The Chemistry of Pincer Compounds (Elsevier 2007), research in this unique area has flourished, finding a plethora of applications in almost every single branch of chemistry—from their traditional application as very robust and active catalysts all the way to potential biological and pharmaceutical applications. Describes the chemistry and applications of this important class of organometallic and coordination compounds Includes contributions from global leaders in the field, featuring pioneers in the area as well as emerging experts conducting exciting research on pincer complexes Highlights areas of promising and active research, including small molecule activation, earth abundant metals, and actinide chemistry

Download or read book Borane Reagents written by Andrew Pelter and published by . This book was released on 1988 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Part A written by Susanne L. Miller and published by . This book was released on 2017 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis and Application of Organoboron Compounds written by Elena Fernández and published by Springer. This book was released on 2015-03-04 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics in pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors.

Download or read book Regioselective Iridium Catalyzed C H Activation borylation of 2 substituted Indoles written by Sulagna Paul and published by . This book was released on 2007 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Overcoming Regioselectivity Challenges in Iridium Catalyzed C h Borylation Via Noncovalent Interactions and Advances on Cross Coupling Reactions of Aryl Imidazolylsulfonates written by Jose Raul Montero Bastidas and published by . This book was released on 2021 with total page 879 pages. Available in PDF, EPUB and Kindle. Book excerpt: Direct functionalization of C0́2H bonds reduces the number of synthetic steps for a target molecule enhancing efficiency and avoiding undesired waste material. Iridium catalyzed C-H activation-borylation (CHB) is an established method to access aryl boronic esters. Regioselectivity challenges can arise when multiple hydrogens are present in the molecule. This thesis describes the design of novel strategies to selective direct the CHB to one specific position.Ortho selective CHB has the challenge to go against the traditional CHB selectivity dictated by steric effects. Previously, our group reported a strategy for highly ortho-selective CHB of anilines by using a small B2eg2 (eg = ethanediol) as the borylating reagent. However, the products were unstable and transesterification with pinacol was needed. Chapter 2 builds upon this issue and presents a solution based on the modulation of the size of the boron partner. Small diboron partners retain the high ortho regioselectivity for CHB of aniline but larger borylating reagents generate more stable products. In our estimation, B2bg2 (bg = 1,2-butanediol) represents the best balance of reactivity, regioselectivity and stability.Remote functionalization including para selective reactions are difficult because a potential directing group would be far from the desired reactive site. Chapter 3 details how para CHB of tetraalkylammonium sulfates and sulfamates have been achieved using bipyridine-ligated Ir boryl catalysts. Selectivities can be modulated by both the length of the alkyl groups in the tetraalkylammonium cations and the substituents on the bipyridine ligands. Ion pairing, where the alkyl groups of the cation shield the meta C8́2H bonds in the counteranions, is proposed to account for para selectivity. The 4,4'-dimethoxy-2,2'-bipyridine ligand gave superior selectivities.The next chapter describes how intramolecular hydrogen bonding (IMHB) can lead to steric shielding effects that can direct CHB regiochemistry. Bpin/arene IMHB can promote remote borylations of N-borylated anilines, 2-amino-N-alkylpyridine, tetrahydroquinolines, indoles and 1-borylated naphthalenes. Our studies support molecular geometries with the Bpin orientation controlled by a C-H0́Ø0́Ø0́ØO IMHB. Calculated rotation barriers to displace the Bpin group are above 4 kcal/mol, suggesting that the planar ground conformation of the borylated arenes is retained during CHB. This study informs researchers to evaluate not only inter- but also intramolecular noncovalent interactions as potential drivers of remote CHB regioselectivity.The borylated products from CHB can be further manipulated in Suzuki-Miyaura cross-coupling (SMC) with aryl halides as the typical electrophilic partner. Aryl imidazolylsulfonates are nongenotoxic electrophiles that can be used in palladium catalyzed SMC to avoid halogenated materials. Chapter 5 shows the efforts towards a nickel-catalyzed SMC of aryl imidazolyl-sulfonates. Results show considerable amounts of the corresponding diarylsulfate formed during the reaction. Interestingly, the diaryl sulfa byproducts were found to be competent electrophilic partners for both palladium and nickel-catalyzed SMC.In summary, this thesis presents novel methodologies to access challenging transformations as the para borylations of phenols, anilines and benzyl alcohols. This was possible by the analysis of the different components of the catalytic system: design of ligands, diboron partners and substrate directing groups and how they interact during the reaction. Finally, the potential of aryl imidazolylsulfonates as nongenotoxic pseudohalides in nickel-catalyzed SMC was evaluated.

Download or read book Iridium Catalyzed C H Activation borylation of Aromatic heteroaromatic Substrates and Its Application in Small Molecule Synthesis written by Venkata Apparao Kallepalli and published by . This book was released on 2010 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: