Download or read book Ion Channels of Nociception written by Rashid Giniatullin and published by MDPI. This book was released on 2020-12-02 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Special Issue “Ion Channels of Nociception” contains 13 articles united by a focus on the peripheral mechanisms of pain. The content covers the mechanisms of neuropathic, inflammatory, and dental pain as well as pain in migraine and diabetes; nociceptive roles of P2X3, ASIC, Piezo and TRP channels; pain control through GPCRs and pharmacological agents; and nonpharmacological treatment with electroacupuncture.
Download or read book Ion Channels of Nociception written by Rashid Giniatullin and published by . This book was released on 2020 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Special Issue “Ion Channels of Nociception” contains 13 articles united by a focus on the peripheral mechanisms of pain. The content covers the mechanisms of neuropathic, inflammatory, and dental pain as well as pain in migraine and diabetes; nociceptive roles of P2X3, ASIC, Piezo and TRP channels; pain control through GPCRs and pharmacological agents; and nonpharmacological treatment with electroacupuncture.
Download or read book TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades written by Wolfgang B. Liedtke, MD, PH.D. and published by CRC Press. This book was released on 2006-09-29 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st
Download or read book Voltage Gated Sodium Channels written by Peter C. Ruben and published by Springer Science & Business Media. This book was released on 2014-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Download or read book The Nociceptive Membrane written by and published by Elsevier. This book was released on 2011-09-21 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membranes are essential cellular organelles. They not only define cells and other organelles, but also are critical in the cell function by selectively regulating the passage of molecules by acting as a matrix for other signaling molecules, and as conduits of information transfer between the external environment and the cell interior. This series was originally added in 1970 and has since provided a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include History of Ion Channels in the Pain Sensory System; Historical Overview; TRPV1, a Polymodal Sensor in the Nociceptor Terminal; Nociceptive Signals to TRPV1 and its Clinical Potential; Gating, Sensitization and Desensitization of TRPV1; TRP Channels as Thermosensors; ASIC Channels; P2X Receptors in Sensory Neurons; Voltage-Gated Sodium Channels and Neuropathic Pain; Voltage-Gated Potassium Channels in Sensory Neurons.
Download or read book Sodium Channels Pain and Analgesia written by Kevin Coward and published by Springer Science & Business Media. This book was released on 2006-01-17 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervous system sodium channels and reviews why sodium channel sub-types are potentially important drug targets in the treatment of pain. The roles of sodium channels in dental and visceral pain are also addressed. The emerging role of sodium channel Nav1.3 in neuropathic states is another important theme. Authors from the pharmaceutical industry discuss pharmacological approaches to the drug targeting of sodium channels, and in particular Nav1.8, exclusively expressed in nociceptive neurons. The final chapter highlights the functional diversity of sodium channels in part provided by post-transcriptional processing and the insights into sodium channel function that are being provided by tissue specific and inducible gene knock-out technology.
Download or read book The Essence of Analgesia and Analgesics written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2010-10-14 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.
Download or read book Nociceptors the cells that sense pain written by and published by Nociceptors. This book was released on with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Acute Pain Management written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2009-04-27 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.
Download or read book Ion Channels in Health and Sickness written by Fatima Shad Kaneez and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.
Download or read book Textbook of Ion Channels Volume III written by Jie Zheng and published by CRC Press. This book was released on 2023-06-28 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Textbook of Ion Channels is a set of three volumes that provides a wide-ranging reference source on ion channels for students, instructors and researchers. Ion channels are mem- brane proteins that control the electrical properties of neurons and cardiac cells; medi- ate the detection and response to sensory stimuli like light, sound, odor, and taste; and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical appli- cations. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs. Volume III includes coverage of key ion channel regulators and their mechanisms, the role of ion channels working in concert in selected physiological systems, and examples of ion channel mutations and dysfunction in a selection of diseases. Chapters on ion channel regulation include splice variants, calcium–calmodulin regulation, regulation by G pro- teins, and lipids. A selection of ion channels in physiological systems includes ion chan- nels of the heart, ion channels in immune cells and their role in pancreatic beta cells and regulation of insulin secretion, and the role of channels in sperm and eggs. While disease mechanisms are integrated into the chapters of Volume II, Volume III offers special consid- eration of ion channels in epilepsy, cystic fibrosis and pain syndromes. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and includecoverage of key examples of regulatory, physiological, and disease roles for ion channels.
Download or read book Pain Management written by Rajesh Gupta and published by Springer. This book was released on 2014-07-16 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain management is a vast subject and is changing rapidly. Finding a good resource for learning, however, is difficult. This book covers the entire curriculum relating to pain management and will make it easy to learn all aspects of the subject by covering key concepts in a reader-friendly manner. It comprises nine concise and simple chapters that aim to impart the maximum information within a limited space. These chapters address anatomy, assessment of pain, diagnosis of pain, pharmacology, non-pharmacological pain management, acute and chronic pain management, pain management in special groups, and special techniques. Pain Management: Essential Topics for Examinations will be an ideal resource for those who plan to sit for examinations, wherever they are based in the world. In addition, it will be an invaluable reference for higher and advanced pain trainees, residents, and physicians working in chronic pain.
Download or read book Mechanisms of Activation and Regulation of the Nociceptive Ion Channels TRPV1 and ASIC written by Milena Studer and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fundamentals of Anaesthesia written by Colin Pinnock and published by Cambridge University Press. This book was released on 2002-12 with total page 990 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Fundamentals of Anaesthesia builds upon the success of the first edition, and encapsulates the modern practice of anaesthesia in a single volume. Written and edited by a team of expert contributors, it provides a comprehensive but easily readable account of all of the information required by the FRCA Primary examination candidate and has been expanded to include more detail on all topics and to include new topics now covered in the examination. As with the previous edition, presentation of information is clear and concise, with the use of lists, tables, summary boxes and line illustrations where necessary to highlight important information and aid the understanding of complex topics. Great care has been taken to ensure an unrivalled consistency of style and presentation throughout.
Download or read book Nonclassical Ion Channels in the Nervous System written by Xu Tian-le and published by CRC Press. This book was released on 2021-08-05 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels generate bioelectricity. Recent findings have documented the biophysical properties, the structure, assembly and regulation, and function and dysfunction of nonclassical nervous system ion channels. This book reviews nonclassical ion channel research, ranging from the basic biology, structure, regulations to their functions not only in normal physiology but also neurological disorders, using a variety of cutting-edge techniques and novel animal models.
Download or read book Molecular and Cell Biology of Pain written by and published by Academic Press. This book was released on 2015-03-02 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain is the number one reason that people seek medical attention but pain is still under- and poorly-treated world-wide. The purpose of this book is to give an up to date picture of what causes pain, how pain becomes chronic and what pharmacological targets might be manipulated to alleviate acute and chronic pain. The book will cover a wide array of topics from gene polymorphisms to voltage-gated ion channels moving from cellular biology to whole animal physiology. Written by future leaders in the pain field Covers a wide range of targets Contains provocative ideas about the future direction of the pain field.
Download or read book Ion Channels written by James N. C. Kew and published by . This book was released on 2010 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent is often involved, either as the cause or the effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts. Part one is an introductory overview of the ion channel superfamily and the generic aspects of ion channel function. This part also reviews the methodologies by which ion channel function can be studied from the perspective of performing detailed biophysical characterization through to the deployment of high throughput approaches for identifying novel ion channel ligands. Part two of the book provides an in-depth review of the individual ion channel subfamilies and, as such, is subdivided into four broad sections: Voltage-Gated Ion Channels, Extracellular Ligand-Gated Ion Channels, Intracellular Ligand-Gated Ion Channels, and Polymodal-Gated Ion Channels, with each chapter focused on specific family members. These chapters have been written by world leading experts and provide a detailed overview of the structure, biophysics, localization, pharmacology, physiology, and disease relevance of each particular ion channel subfamily. Reviewing both the basic principles of ion channel function and providing a detailed up-to-date review of the phsyiological and pharmacological aspects of individual ion channel sub-families, this book constitutes both an excellent introduction to the field for non-specialists, as well as a highly valuable reference text for experienced researchers already working in the ion channel area.
