Download or read book Investigation of Advanced Clinical PET System Designs written by Fan-Chung Hsu and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Positron emission tomography (PET) is a functional radionuclide imaging modality commonly used for managing diseases such as cancer. High-resolution, high-sensitivity, quantitative PET imaging could open up potential new uses in early stage cancer management such as guiding biopsy or surgical resection. Locoregional PET systems with reconfigurable field-of-views (FOV) can further increase the sensitivity and resolution for a specific organ of interest. We will start this thesis by introducing the physics and basic detector designs of PET systems. It will then discuss design and performance of whole-body and locoregional PET system designs that are being investigated in the field. Then, the thesis will describe in detail a 1 mm resolution clinical locoregional PET scanner that is being constructed at Stanford. The design choices and electronics of this system will be discussed, and then system calibrations and performance test results will be shown. Finally, we will discuss additional data correction algorithms specific to this system, such as randoms correction and limited angle tomography image artifact correction algorithms. The results presented in this thesis show that the prototype subsystem of the 1 mm resolution clinical locoregional PET system can achieve spatial resolution of 0.73 mm at the center of the FOV, energy resolution of 11.34%, and coincident timing resolution (CTR) of 13.92 ns. The unique 3D position sensitive scintillation (3D-PSS) detectors used in the system allows for intercrystal scatter positioning algorithms that can be used to improve contrast-to-noise ratio (CNR) by 8.4%, or reduce the patient dose by 12% while maintaining the same image quality. This thesis may be useful for readers that are interested in the physics, electronics, and image quality of high-resolution PET scanners with small scintillation crystal elements. Interesting topics include investigations of detector signal multiplexing across a system, limited angle tomography effects in the reconstructed image, and ICS positioning in a system with multiplexed detectors.
Download or read book Advances in PET written by Jun Zhang and published by Springer Nature. This book was released on 2020-05-11 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a guide to new and emerging PET technology, instrumentation, and its place in clinical practice. PET technology is currently moving from the conventional photomultiplier tube (PMT) detector based PET to the new generation, solid state light sensor detector. This is a technological leap and holds significant implications for the use of PET imaging. This book introduces and describes the emerging and new generation of PET instrumentations and technologies across manufactures, focusing on solid-state PET detector designs, system characteristics, and clinical practices as well as future advanced Time-of-Flight (TOF) PET technologies. Organized into three sections, the basics of PET imaging; solid state digital PET instrumentation, technology, and clinical practice; and a look to the future of PET imaging, chapters present a full picture of PET imaging, where we are and where we will be. Nuclear medicine physicians, physicists, and technologists can use this book to better understand future PET systems, novel PET technologies, and potential game changes of clinical PET practice.
Download or read book Mathematics and Physics of Emerging Biomedical Imaging written by Committee on the Mathematics and Physics of Emerging Dynamic Biomedical Imaging and published by National Academies Press. This book was released on 1996-03-13 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cross-disciplinary book documents the key research challenges in the mathematical sciences and physics that could enable the economical development of novel biomedical imaging devices. It is hoped that the infusion of new insights from mathematical scientists and physicists will accelerate progress in imaging. Incorporating input from dozens of biomedical researchers who described what they perceived as key open problems of imaging that are amenable to attack by mathematical scientists and physicists, this book introduces the frontiers of biomedical imaging, especially the imaging of dynamic physiological functions, to the educated nonspecialist. Ten imaging modalities are covered, from the well-established (e.g., CAT scanning, MRI) to the more speculative (e.g., electrical and magnetic source imaging). For each modality, mathematics and physics research challenges are identified and a short list of suggested reading offered. Two additional chapters offer visions of the next generation of surgical and interventional techniques and of image processing. A final chapter provides an overview of mathematical issues that cut across the various modalities.
Download or read book Physics of PET and SPECT Imaging written by Magnus Dahlbom and published by CRC Press. This book was released on 2017-02-17 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: PET and SPECT imaging has improved to such a level that they are opening up exciting new horizons in medical diagnosis and treatment. This book provides a complete introduction to fundamentals and the latest progress in the field, including an overview of new scintillator materials and innovations in photodetector development, as well as the latest system designs and image reconstruction algorithms. It begins with basics of PET and SPECT physics, followed by technology advances and computing methods, quantitative techniques, multimodality imaging, instrumentation, pre-clinical and clinical imaging applications.
Download or read book PET MRI in Oncology written by Andrei Iagaru and published by Springer. This book was released on 2018-01-23 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, experts from premier institutions across the world with extensive experience in the field clearly and succinctly describe the current and anticipated uses of PET/MRI in oncology. The book also includes detailed presentations of the MRI and PET technologies as they apply to the combined PET/MRI scanners. The applications of PET/MRI in a wide range of oncological settings are well documented, highlighting characteristic findings, advantages of this dual-modality technique, and pitfalls. Whole-body PET/MRI applications and pediatric oncology are discussed separately. In addition, information is provided on PET technology designs and MR hardware for PET/MRI, MR pulse sequences and contrast agents, attenuation and motion correction, the reliability of standardized uptake value measurements, and safety considerations. The balanced presentation of clinical topics and technical aspects will ensure that the book is of wide appeal. It will serve as a reference for specialists in nuclear medicine and radiology and oncologists and will also be of interest for residents in these fields and technologists.
Download or read book Principles and Advanced Methods in Medical Imaging and Image Analysis written by Atam P. Dhawan and published by World Scientific. This book was released on 2008 with total page 869 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computerized medical imaging and image analysis have been the central focus in diagnostic radiology. They provide revolutionalizing tools for the visualization of physiology as well as the understanding and quantitative measurement of physiological parameters. This book offers in-depth knowledge of medical imaging instrumentation and techniques as well as multidimensional image analysis and classification methods for research, education, and applications in computer-aided diagnostic radiology. Internationally renowned researchers and experts in their respective areas provide detailed descriptions of the basic foundation as well as the most recent developments in medical imaging, thus helping readers to understand theoretical and advanced concepts for important research and clinical applications. Sample Chapter(s). Sample Chapter(s). Chapter 1: Introduction to Medical Imaging and Image Analysis: A Multidisciplinary Paradigm (60 KB). Contents: Principles of Medical Imaging and Image Analysis; Recent Advances in Medical Imaging and Image Analysis; Medical Imaging Applications, Case Studies and Future Trends. Readership: Graduate-level readers in medical imaging and medical image processing.
Download or read book PET MRI written by Ignasi Carrio and published by Springer Science & Business Media. This book was released on 2013-12-09 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: In compiling this textbook on the exciting novel imaging modality of PET/MRI, the editors have brought together a truly international group of experts in the field. The book is divided into two parts. The first part covers methodology and equipment and includes chapters on basic molecular medicine, contrast agents, MR attenuation and validation, and quantitative MRI and PET motion correction. The second part of the book focuses on clinical applications in oncology, cardiology, and neurology. Imaging of major neoplasms is covered in a series of individual chapters. Further chapters address functional and metabolic cardiovascular examinations and major central nervous system applications such as brain tumors and dementias. This book will be of interest to all radiologists and nuclear medicine physicians who wish to learn more about the latest developments in this important emerging imaging modality and its applications.
Download or read book Clinical PET and PET CT written by E. Edmund Kim and published by Springer Science & Business Media. This book was released on 2012-12-09 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical PET and PET/CT, 2nd Edition presents a valuable overview of the basic principles and clinical applications of PET and PET/CT. Emphasis is placed on the familiarization of normal distribution, artifacts, and common imaging agents such as FDG in conjunction with CT, MRI, and US to establish the clinical effectiveness of PET and PET/CT. Practical information about updated PET and PET/CT scanners, imaging processing, correlation, and quantification of PET and PET/CT measurements is also presented. This book is divided into two sections, the first half dealing with the basic principles of PET and PET/CT for instrumentation, fusion, radiopharmaceuticals, radiosynthesis, safety, and cost analysis. The second part of this volume presents chapters on the clinical techniques and applications of PET and PET/CT for common oncologic, cardiologic, and neurologic diseases. Numerous full color images provide comprehensive coverage on essential clinical PET and PET/CT studies.
Download or read book Atlas of PET MR Imaging in Oncology written by Osman Ratib and published by Springer Science & Business Media. This book was released on 2013-05-17 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new project on PET-MR imaging in oncology includes digital interactive software matching the cases in the book. The interactive version of the atlas is based on the latest web standard, HTML5, ensuring compatibility with any computer operating system as well as a dedicated version for Apple iPad. The book opens with an introduction to the principles of hybrid imaging that pays particular attention to PET/MR imaging and standard PET/MR acquisition protocols. A wide range of illustrated clinical case reports are then presented. Each case study includes a short clinical history, findings, and teaching points, followed by illustrations, legends, and comments. The multimedia version of the book includes dynamic movies that allow the reader to browse through series of rotating 3D images (MIP or volume rendered), display blending between PET and MR, and dynamic visualization of 3D image volumes. The movies can be played either continuously or sequentially for better exploration of sets of images. The editors of this state-of-the-art publication are key opinion leaders in the field of multimodality imaging. Professor Osman Ratib (Geneva) and Professor Markus Schwaiger (Munich) were the first in Europe to initiate the clinical adoption of PET/MR imaging. Professor Thomas Beyer (Zurich) is an internationally renowned pioneering physicist in the field of hybrid imaging. Individual clinical cases presented in this book are co-authored by leading international radiologists and nuclear physicians experts in the use of PET and MRI.
Download or read book Advanced Nanomaterials for Point of Care Diagnosis and Therapy written by Sushma Dave and published by Elsevier. This book was released on 2022-03-11 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Nanomaterials for Point of Care Diagnosis and Therapy provides an overview of technological and emerging novel trends in how point-of-care diagnostic devices are designed, miniaturized built, and delivered at different healthcare set ups. It describes the significant technological advances in fundamental diagnostic components and recent advances in fully integrated devices designed for specific clinical use. The book covers state-of-the-art fabrication of advances materials with broad spectrum therapeutic applications. It includes drug delivery, biosensing, bioimaging and targeting, and outlines the development of inexpensive, effective and portable in vitro diagnostics tools for any purpose that can be used onsite. Sections also discuss drug delivery, biosensing, bioimaging and targeting and various metal, metal oxide and non-metal-based nanomaterials that are developed, surface modified, and are being explored for diagnosis, targeting, drug delivery, drug release and imaging. The book concludes with current needs and future challenges in the field. Outlines the needs and challenges of point-of-care diagnostics Describes the fundamentals of application of nanomaterials as interesting building blocks for biosensing Overviews the different detection methods offered by using nanomaterials Explains the advantages and drawbacks of nanomaterial-based sensing strategies Describes the opportunities offered by technology as a cost-efficient biosensing platform
Download or read book Neurobiology and Physiology of the Endocannabinoid System written by Vinood B. Patel and published by Elsevier. This book was released on 2023-06-02 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurobiology and Physiology of the Endocannabinoid System offers readers a comprehensive reference on the neurobiology of this system and the use of cannabimimetic compounds to induce neurological changes and confer symptom relief. With sections on both natural and synthetic compounds, the book's broad coverage allows readers to learn about their use with multiple conditions, as well as the working biology of the endocannabinoid system, its receptors and its ligands. This volume provides a platform for research on the effects of this system and its modulation in brain function and neurological dysfunction. Summarizes research on the working neurobiology of the endocannabinoid system Contains chapter abstracts, key facts, a dictionary and a summary Covers both natural cannabinoids and synthetic or exogenous cannabimimetics Includes conditions like headache, anxiety, stress and neuroinflammation Discusses system modulation in the context of pain, traumatic brain injury and obesity
Download or read book Targeted Drug Delivery Concepts and Design written by Padma V. Devarajan and published by Springer. This book was released on 2014-12-08 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.
Download or read book Advanced X ray Detector Technologies written by Krzysztof (Kris) Iniewski and published by Springer Nature. This book was released on 2022-01-10 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers readers an overview of some of the most recent advances in the field of detectors for X-ray imaging. Coverage includes both technology and applications, with an in-depth review of the research topics from leading specialists in the field. Emphasis is on high-Z materials like CdTe, CZT and perovskites, since they offer the best implementation possibilities for direct conversion X-ray detectors. Authors discuss material challenges, detector operation physics and technology and readout integrated circuits required to detect signals processes by high-Z sensors.
Download or read book Biomedical Index to PHS supported Research written by and published by . This book was released on 1989 with total page 912 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Positron Emission Tomography written by Sandro Misciagna and published by BoD – Books on Demand. This book was released on 2013-12-18 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Positron Emission Tomography is a nuclear medicine technique first used to study the brain. Several decades ago, PET scanners design and performance have improved considerably: number of detectors has increased from 20 to 20,0000, axial field of view from 2 to 20 cm, spatial resolution has improved from 25 to 5 mm, sensitivity has increased of about 1000 fold. At the same time, clinical applications have grown dramatically. In the first section of this book the authors review some of developments in PET instrumentation, with emphasis on data acquisition, processing and image formation. In the second section authors expose examples of applications in human research. In the last section authors describe applications in assessment and prediction of oncological treatment response.
Download or read book Quantification in Nuclear Medicine Imaging written by Ivo Rausch and published by Frontiers Media SA. This book was released on 2022-01-20 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Secretary s Annual Report to Congress written by United States. Department of Energy and published by . This book was released on 1991 with total page 1096 pages. Available in PDF, EPUB and Kindle. Book excerpt:
