Download or read book Intrinsic Immunity written by Bryan R. Cullen and published by Springer Science & Business Media. This book was released on 2013-05-17 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted.
Download or read book Cellular Primary Immunodeficiencies written by Mario Milco D'Elios and published by Springer Nature. This book was released on 2021-06-10 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of the series Rare Diseases of the Immune System presents detailed state of the art knowledge on the cellular primary immunodeficiencies; it includes extensive coverage of both basic science discoveries and the latest clinical advances in the field. The book is structured in accordance with the most recent classification of PIDs and also covers updates on the T cell immunological synapse. Readers will find comprehensive, in-depth descriptions of novel cellular PID genes and related clinical applications, mucosal T cells, and the various clinical phenotypes of cellular PIDs. Cellular Primary Immunodeficiencies will be of high value for immunologists, pediatricians, rheumatologists, oncologists, internists, and infectious disease specialists and will also be informative for MD, Master and PhD students.
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Download or read book Inborn Errors of Immunity written by Asghar Aghamohammadi and published by Academic Press. This book was released on 2021-01-22 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Awareness among clinicians about PIDs, which consist of more than 400 different entities, plays an important role in ensuring that patients receive a timely diagnosis. Furthermore, clinicians who are educated about PIDs can give their patients access to optimal management of their condition, thus helping the patient achieve a better quality-of-life and long-term prognosis. Inborn Errors of Immunity: A Practical Guide provides the most up-to-date information for busy students, nurses, clinical residents, practicing physicians, and even basic researchers. Readers will benefit from a well-structured breakdown of complicated PID diseases, including approaches to their clinical signs/symptoms and immunologic/laboratory findings. Presents valuable contribution of more than 40 expert chapter authors, from top centers spanning five continents, each in a specific PID field Covers various aspects of PID using updated clinical guidelines and standard stepwise pipelines Focuses on the latest developments in the molecular diagnosis and pathogenesis of diseases, with easy explanation and schematic representation of defective signaling pathways Includes dedicated sections for clinical features and immunological tests with carefully-curated figures of PID manifestations, imaging, and histological/pathological illustrations to create the first PID medial-color atlas Summarizes the updated conventional and specific treatments and follow-up notes for different PID diseases
Download or read book Establishing a Role for Intrinsic Immunity to Influenza A Virus Infection written by Matthew Charman and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Retroviruses written by Source Wikipedia and published by University-Press.org. This book was released on 2013-09 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Pages: 28. Chapters: Intrinsic immunity, PtERV1, Retrovirus.
Download or read book Prenylation in Cell intrinsic Innate Immunity to Positive strand RNA Viruses written by Frank William Soveg and published by . This book was released on 2021 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell intrinsic antiviral immunity is a critical facet of the innate immune response to viruses. Since virtually every subcellular compartment can be utilized by viruses for replication, antiviral factors must also be positioned in these compartments to effectively interact with various viral threats. In this thesis, we explored the impact organelle membrane targeting through protein prenylation has on the antiviral specificity of innate immune RNA binding proteins in the context of positive-strand RNA virus infection. Since positive-strand RNA viruses use host organelle membranes to construct niches for RNA replication, we hypothesized antiviral RNA binding proteins that localize to organelle membranes might have enhanced access to viral RNA generated by these viruses during infection. We focused on two antiviral RNA binding proteins: zinc finger antiviral protein (ZAP) and oligoadenylate synthetase 1 (OAS1). The long isoform of ZAP, ZAP-L, is prenylated and targeted to endosomes and lysosomes. This localization is critical for its antiviral activity against alphaviruses, which use those compartments for RNA replication. The cytosolic short isoform of ZAP, ZAP-S, regulates interferon RNA. Similarly, the p46 isoform of OAS1 is prenylated and localizes primarily to the Golgi apparatus and the endoplasmic reticulum. Localization to these compartments bestows p46 with enhanced antiviral activity against viruses that use ER and Golgi membranes for RNA replication, including picornaviruses, flaviviruses, and coronaviruses. Overall, prenylation can target innate immune antiviral RNA binding proteins to subcellular compartments where positive-strand RNA viruses sequester their RNA.
Download or read book Inactivation of a Daxx mediated Cellular Intrinsic Immune Defense Against Human Cytomegalovirus Contributes to Viral Gene Expression written by Ryan Thomas Saffert and published by . This book was released on 2008 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Interplay Between Innate Immunity And Herpesviruses written by Santo Landolfo and published by Frontiers Media SA. This book was released on 2021-12-03 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book APOBEC3 Mediated Intrinsic Immunity to Retroviral Infection written by Brian P. Doehle and published by . This book was released on 2006 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ecoimmunology written by Gregory Demas and published by OUP USA. This book was released on 2012-01-05 with total page 649 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book critically reviews recent advances in ecoimmunology, a newly emergent, interdisciplinary research field that examines interactions among host physiology and disease ecology in a wide range of environmentally relevant contexts.
Download or read book Bioprocess and Analytics Development for Virus based Advanced Therapeutics and Medicinal Products ATMPs written by Saurabh Gautam and published by Springer Nature. This book was released on 2023-08-10 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the knowledge, methods and available techniques in the rapidly advancing field of virus based vaccines and gene therapeutics. It also highlights new innovative tools and interdisciplinary techniques for bioprocess development and analytics of viruses and viral vectors. As such, it provides a timely and highly relevant resource, since current advances in pharmaceutical research have seen the rise of vaccines and advanced therapeutics and medicinal products (ATMPs), that rely on the power of viruses. However, developing bioprocesses and analytics required to create this often called “magic bullet” (i.e. gene therapy) remains an extremely challenging and costly task. This book offers strategies for overcoming hurdles and difficulties within in all the necessary steps of viral vector development - from scalability to purification methods and quality control. The book is intended for researchers working in academia or industry, as well as graduate students pursuing a career in virology.
Download or read book Military Strategies for Sustainment of Nutrition and Immune Function in the Field written by Institute of Medicine and published by National Academies Press. This book was released on 1999-05-13 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.
Download or read book Neonatal Hematology written by Pedro A. de Alarcón and published by Cambridge University Press. This book was released on 2021-02-18 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential guide to the pathogenesis, diagnosis and management of hematologic problems in the neonate, covering erythrocyte disorders, leukocyte disorders, immunologic disorders and hemostatic disorders. Guidance is practical, including blood test interpretation, advice on transfusions and reference ranges for hematological values.
Download or read book T Cell intrinsic PHD Proteins Regulate Pulmonary Immunity written by David Cameron Clever and published by . This book was released on 2016 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Plasma Medical Science written by Shinya Toyokuni and published by Academic Press. This book was released on 2018-07-06 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plasma Medical Science describes the progress that has been made in the field over the past five years, illustrating what readers must know to be successful. As non-thermal, atmospheric pressure plasma has been applied for a wide variety of medical fields, including wound healing, blood coagulation, and cancer therapy, this book is a timely resource on the topics discussed. Provides a dedicated reference for this emerging topic Discusses the state-of-the-art developments in plasma technology Introduces topics of plasma biophysics and biochemistry that are required to understand the application of the technology for plasma medicine Brings together diverse experience in this field in one reference text Provides a roadmap for future developments in the area
