Download or read book Innate Immunity in Health and Disease written by Shailendra K. Saxena and published by BoD – Books on Demand. This book was released on 2021-08-25 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. Throughout this book, we examine the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases. Written by experts in the field, the volume discusses the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. Chapters cover such topics as the fate of differentiated macrophages and the molecular pathways that are important for the pathologic role of macrophages.
Download or read book Interferon and Cancer written by Florence S. Karlsberg and published by . This book was released on 1984 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Interferon and Cancer written by Karol Sikora and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interferon was first discovered in 1957. Over the last five years it has become almost a household word. Many believe it to be a drug with already proven efficacy against cancer and viral infection. The media has distorted any cool scientific view of the data available. We have learned much about the complexity of the interferon system. We know some of the switches involved in interferon gene expression and its secretion by virally and immune stimulated cells. We also know that it binds to a cell surface receptor, mediating its complex effects on target cells by a series of second messengers. The advent of the new techniques of modern molecular biology, such as monoclonal antibodies and gene cloning, has had tremendous impact on the rate of acquisition of knowledge. Such techniques have provided us with almost unlimited quantities of highly purified interferon for clinical trial in patients with a spectrum of infectious and malignant diseases. The information we have gathered raises many more questions. Why should there be several families of interferon genes? What is their true physiolo gical role? How are they interrelated functionally? Interferon is clearly a cellular hormone providing a means of communication between cells. ~fhether it has clinical value in the management of patients with diseased cells remains to be seen. This book sum marises our current knowledge of interferons as possible an- cancer agents. It is clear interferon is no penicillin for cancer.
Download or read book Interferons Mechanisms of Action and Role in Cancer Therapy written by Derek Crowther and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: A great deal of new information has been obtained during the past four years, and this monograph provides a clear and well reviewed update on biochemical mechanisms and the results of important new clinical studies using the interferons. Reviews include what is presently known about the biosynthesis, physiological role and mechanisms of action of the interferons (alpha, beta, gamma). New biochemical information on interferon-receptor interactions and signalling pathways is provided. The pharmacokinetic considerations in treating leukemia, lymphoma, myeloma, neuroendocrine tumors and other solid tumors are reviewed with special emphasis on studies of adjuvant chemotherapy in malignancies of the immune system.
Download or read book Interferon written by Mike Edelhart and published by . This book was released on 1981 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Interferon and Cancer written by Karol Sikora and published by Springer. This book was released on 1983-06 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interferon was first discovered in 1957. Over the last five years it has become almost a household word. Many believe it to be a drug with already proven efficacy against cancer and viral infection. The media has distorted any cool scientific view of the data available. We have learned much about the complexity of the interferon system. We know some of the switches involved in interferon gene expression and its secretion by virally and immune stimulated cells. We also know that it binds to a cell surface receptor, mediating its complex effects on target cells by a series of second messengers. The advent of the new techniques of modern molecular biology, such as monoclonal antibodies and gene cloning, has had tremendous impact on the rate of acquisition of knowledge. Such techniques have provided us with almost unlimited quantities of highly purified interferon for clinical trial in patients with a spectrum of infectious and malignant diseases. The information we have gathered raises many more questions. Why should there be several families of interferon genes? What is their true physiolo gical role? How are they interrelated functionally? Interferon is clearly a cellular hormone providing a means of communication between cells. ~fhether it has clinical value in the management of patients with diseased cells remains to be seen. This book sum marises our current knowledge of interferons as possible an- cancer agents. It is clear interferon is no penicillin for cancer.
Download or read book Case for Interferon written by Joseph Cummins and published by Simon and Schuster. This book was released on 2021-01-05 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Touted as a potential breakthrough cancer therapy in the 1980s by the scientific community and publications such as TIME and Newsweek magazine, the reputation of interferon has not lived up to its early promise. Interferons are small proteins with anti-viral and anti-cancer effects, which have the power to modulate the functioning of the immune system. But Dr. Joseph Cummins, an early interferon pioneer, holder of sixteen US medical patents, author of more than sixty scientific publications, as well as having taught veterinary medicine at the University of Missouri, University of Illinois, and Texas A & M University, argues that the current thinking on interferon is fundamentally flawed. Interferon is created in small quantities in the body in response to infection, and seems to work best at these low dosages. However, the public health cowboys, working under the assumption that anything good in tiny amounts must be better in massive amounts, pursued exactly the wrong strategy. High-dose interferon does not work in the body and may even cause problems. The first remarkable results for interferon and the flu were reported by the Soviets in the 1970s, but Western medicine discounted these findings because they believed the dosages were so low they couldn’t possibly be effective. In the 1980s, when interferon was expensive to produce and only small quantities could be manufactured, the results were remarkable. Dr. Cummins was an early pioneer of low-dose interferon, and his remarkable findings among animals led to collaborations with medical doctors for human trials, even going so far as Africa at the height of the HIV-AIDS epidemic. Cummins reviews the evidence for this inexpensive, safe treatment and makes an eloquent argument for medical science to take another look at interferon to tackle today’s most challenging health conditions, including COVID-19.
Download or read book Biological Modulation of Solid Tumours by Interferons written by Karl Pummer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the 1960s, it was reported that interferons have antitumour activity in different experimental models. Since that time, numerous studies have been performed to elucidate the various mechanisms of action that have been proposed. However, there is much controversy in the literature and promising preclinical findings failed to translate into substantial clinical progress. The present book gives a critical overview of current knowledge of how interferons act in solid tumours. For this purpose, after two chapters of general aspects of interferon action and interaction, selected solid tumours which are commonly considered difficult to treat in advanced stages are discussed with respect to both preclinical data and clinical experience.
Download or read book Basal Cell Carcinoma written by Michael R. Migden and published by Springer Nature. This book was released on 2019-12-17 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basal Cell Carcinoma: Advances in Treatment and Research provides a comprehensive overview of evidence-based treatment approaches for the most common cancer worldwide - basal cell carcinoma. The first part of this book details the epidemiology, risk factors, pathophysiology, and different histologic subtypes of basal cell carcinoma highlighted with high-resolution histopathology images. The second part of the book provides an in-depth review of different treatment modalities including topical therapy, local immunotherapy with interferon, cryotherapy, electrodesiccation and curettage, radiotherapy, and surgical approaches with Mohs micrographic surgery, head and neck surgery, and oculoplastic surgery. The final part of book highlights the utilization of innovative technology such as photodynamic therapy and laser for the treatment of basal cell carcinoma while providing excellent cosmetic outcome as well as emerging systemic therapeutic options utilizing hedgehog pathway inhibitors and immunotherapy for the difficult-to-treat disease state, advanced basal cell carcinoma. Meant for a multi-disciplinary audience of dermatologists, Mohs Surgeons, oncologists, head and neck surgeons, oculoplastic surgeons, radiation oncologists, this book serves as an informative practical guide for physicians, mid-level providers and trainees. Basal Cell Carcinoma, is edited and written by leaders with expertise in cutaneous oncology, pathology, dermatology, Mohs micrographic surgery, plastic surgery, and many more specialties.
Download or read book Interferons in Oncology written by John F. Smyth and published by Springer. This book was released on 1987 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Principles and Practice of the Biologic Therapy of Cancer written by Steven A. Rosenberg and published by . This book was released on 2000 with total page 916 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference on the biologic therapy of cancer provides scientific and practical information to both researchers and clinicians involved in the development and application of new cancer treatments. Major sections of the book cover: cytokines; cell transfer therapy; monoclonal antibodies; cancer vaccines; gene therapy; and antiangiogenesis therapy. Each section begins with basic principles and preclinical studies, and proceeds to clinical applications. The clinical chapters present comprehensive analyses of clinical data, emphasizing the indications for treatment and the practical guidelines necessary to safely apply these new approaches.
Download or read book Interferons in Cancer Treatment written by Hulbert Keyes Belford Silver and published by Mississauga, Ont. : MES Medical Education Services (Canada). This book was released on 1986 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Cancer Research written by and published by Academic Press. This book was released on 1986-05-15 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research
Download or read book Interferons written by Carlo Aul and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interferons were among the first cytokines to be studied clinically in recombinant form in the 1980s, beginning a new era of pharmacotherapy in internal medicine. Interferons were soon employed in the treatment of tumors and it was shown that those hematopoietic neoplasias which had been difficult to treat with chemotherapy responded well to interferon treatment. In the present volume, renowned international authors update the importance of interferons in various fields of internal medicine, dermatology, and urology. The book also contains a general introduction into the classification, structure, and mode of action of interferons. Further chapters discuss the range of side effects of these substances and point out possible focuses of further clinical interferon research.
Download or read book Human Monocytes written by Marek Zembala and published by . This book was released on 1989 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monocytes represent one of the major types of white blood cells in man which prevent infection by ingesting and killing invading pathogens and by releasing factors which stimulate and regulate lymphocytes. Monocytes "purify" the blood, removing immune complexes, mediating inflammatory responses, and initiating tissue repair. Human Monocytes represents an up-to-date, definitive account of this important cell. It covers the cells biochemical, immunological, and inflammatory functionsand its role in many diseases, including asthma, atherosclerosis, rheumatoid arthritis, and AIDS.
Download or read book Interferon Alpha 2 Pre Clinical and Clinical Evaluation written by Daniel L. Kisner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interferon alpha-2 is a genetically engineered, highly purified pharmaceutical agent that has undergone extensive phase I and phase II clinical study in more than 1000 patients. The material has biological activity by intravenous, intramus cular and subcutaneous routes. Clinical toxicity principally involves the 'influen za like' syndrome previously seen with native interferons. Other important toxi cities include anorexia, hepatitis, confusion and myelosuppression. Tolerable doses in multiple schedules and routes of administration have been determined. Phase II clinical trials with multiple routes and schedules of administration have been performed. Significant clinical activity has been found in non Hodgkin's lymphomas (both low grade and high grade), refractory and relapsing multiple myeloma, hairy cell leukemia, Kaposi's sarcoma, with suggestions of activity in Hodgkin's disease, renal cell carcinoma, and melanoma. The studies performed to date have for the most part involved small numbers of heavily pre-treated patients. Large-scale clinical trials in some of these disea ses are now warranted in populations of patients with as little bulk disease and prior treatment as is feasible for each tumour type. This is particularly the case in . Hodgkin's disease and subcategories of the non-Hodgkin's lymphomas. Alterna tely, interferon alpha-2 might be used to maintain remissions induced by other modalities (i. e. , in NHL, multiple myeloma, ovarian cancer). In some advanced disease settings, combinations of interferon alpha-2 with chemotherapeutic agents should now be investigated.
Download or read book National Cancer Institute Clinical Trials of Interferon written by Florence S. Karlsberg and published by . This book was released on 1985 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:
