Download or read book Interactions of Charged and Superparamagnetic Nanoparticles with Lipid Model Membranes written by Janez Ivan Pavlič and published by . This book was released on 2010 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Interaction Between Silver Nanoparticles and Model Cell Membranes written by Mona Kavianipour and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "The use of nanoparticles (NPs) in research and technology is rapidly expanding; NPs have become part of our daily life in medical, cosmetic, or food products. Since exposure of cells to some biofunctional NPs might be fatal if the NPs are toxic, applying NPs with minimal cytotoxicity should be considered. In this study, we investigated the effect of Ag NPs on model cell membranes, namely, suspended unilamellar vesicles (SUVs) using the fluorescent probe, 1-N-phenylnaphthylamine (NPN) that fluoresces in a hydrophobic environment such as the internal region of the lipid bilayer. A multi-well plate reader was used to record fluorescence spectra of neutral, and negatively charged vesicles exposed to different concentrations of NPs; in this technique, a loss in fluorescence intensity corresponds to disruption of the model cell membrane. To provide insight into the fate of Ag NPs and their impact on cell membrane permeability, the interaction of Ag NPs and Ag ions (AgNO3) with two component model membranes (neutral and negatively-charged SUVs) was analyzed. We observed an 83% reduction in the fluorescence intensity of negatively-charged vesicles interacting with 40 mM Ag ions. A lower level of membrane disruption (50% reduction in fluorescence intensity) was observed for the neutrally charged SUVs indicating that electrostatic interactions play an important role. Since the phase behavior of a phospholipid bilayer influences vesicle properties, the effect of temperature was also examined. Furthermore, we investigated the effect of NP surface coating on NP-vesicle interaction as the properties of the NPs can be significantly altered through their surface modification, and we observed different behavior for PVP- and citrate-coated silver NPs. The role of NP type on NP-vesicle interaction was examined using 50-nm-PVP coated gold and silver NPs. Dynamic light scattering was used to measure the size distribution, surface potential of the SUVs, and the likelihood of aggregation over time. The measurements revealed that by increasing the Ag ion concentration, the aggregation of vesicles increased. More SUV aggregation was observed for negatively charged vesicles in comparison to neutral ones. Nanoparticle tracking analysis was also utilized to determine the lipid vesicle size. The amount of dissolved silver was determined for both PVP- and citrate-coated NPs using inductively couple plasma mass spectrometry in a single particle mode. Overall, this study demonstrates a novel approach to study the disruption of model cell membranes by metal ions and NPs. " --
Download or read book Sensing and Characterizing Interactions with Lipid Membranes written by Simou Sun and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Herein, interactions between lipid membranes and physiologically important species, from divalent cations to viral proteins, are sensed and characterized in model membrane systems. By applying vibrational sum frequency generation spectroscopy (VSFS), we show that Ca2+, Mg2+ and Zn2+ bind to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) in different binding modes, which lead to distinct effects on lipid headgroup orientation and membrane chemical and physical properties. For example, Ca2+-PI(4,5)P2 interactions inhibit protein binding to the lipid, however, Mg2+ can hardly do so. Also, Zn2+ induces lipid domain formation and lipid monolayer phase transition more easily than both Ca2+ and Mg2+. Next, by means of pH modulation fluorescence sensing assay, we demonstrate that the commonly consumed small molecule drug, ibuprofen, interacts with the lipid membrane in three consecutive steps. In each step, the drug has distinct influence on the biophysical properties of the membrane. Further, the interactions between lipid membranes and antimicrobial peptides, viral proteins are studied with the sensing assay. We find that favorable like-charge pairing is formed between nonaarginine (R9) peptides. As such, R9 is able to bind to lipid membranes more strongly and cooperatively than nonalysine (K9), which explains at the molecular level why arginine-rich peptides are better antimicrobial agents than lysine-rich peptides. Also, we are able to identify a new phosphatidylinositide binding site on poliovirus 3C protein, which also acts as the viral RNA binding site. By correlating the fluorescence signal change in the pH modulation sensing assay with the change of membrane surface potential, a mathematic model was built to calculate the surface coverage of divalent cations when binding to negatively charged lipid membranes. As such, we can report accurate binding stoichiometry between Ca2+, Mg2+, Zn2+ and three different anionic lipids. Another aspect of this work is to understand the interactions between PI(4,5)P2 supported lipid bilayers (SLBs) and the solid support, as well as the interleaflet distribution of PI(4,5)P2s in the SLB. We developed a novel analytical assay to separate the two leaflets of a SLB at ambient condition. In this way, we characterized the time-dependent PI(4,5)P2 distribution in the SLBs by directly demonstrating defect-mediated PI(4,5)P2 flipping. Also, we reveal that the strong interaction between PI(4,5)P2 and the underlying glass substrate is due to water-mediated hydrogen bonding.
Download or read book Interaction of Amphphilic Nanoparticles with Model and Bacterial Membranes written by Jared Thomas Wiemann and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this doctoral work, we aimed to understand how amphiphilic nanoparticles, especially those with anisotropic surface chemistry, interact with biological membranes. Specifically, our overall goal was to elucidate the cytotoxic and antibacterial properties of anisotropic particles relative to amphiphilic nanoparticles with uniform surface chemistry. Nanoparticles with anisotropic surface chemistry have been synthesized for uses in sensing and immunotherapy, among other uses. In our early studies, we evaluated the impact of amphiphilic particles against free-standing biomimetic membranes to assess their potential cytotoxicity. Using “two-faced” amphiphilic Janus nanoparticles, which display separated hydrophobic and hydrophilic sides, we observed that anisotropic surface chemistry enhances the binding of particles to lipid membranes which leads to poration, membrane wrinkling, protrusions, and even collapse of entire membranes. Building upon these findings, we further observed that Janus nanoparticles selectively bind to liquid disordered domains in phase-separated lipid membranes. Extraction of lipids from liquid disordered domains to the hydrophobic nanoparticle hemispheres led to membrane compression and bulging of liquid ordered domains. These studies revealed the distinct consequences of anisotropic amphiphilic nanoparticles on lipid membrane integrity and structure. In the final part of this work, we investigated the antimicrobial properties of amphiphilic Janus nanoparticles. As more multidrug resistant bacteria emerge and fewer antibiotics are developed for clinical use, antibiotic resistance remains an increasing threat to public health. Researchers have since turned to nanomaterials with tailored surface chemistry to evade mechanisms of antibiotic resistance by directly disrupting lipid membranes and cell walls, often times using uniform coatings of cationic or amphiphilic ligands on particle surfaces. Given the potential enhanced antibiotic properties of Janus nanoparticles based on our first works, we fabricated “two-faced” amphiphilic Janus nanoparticles with one hemisphere of the Janus nanoparticles functionalized with hydrophobic alkyl chains and the other hemisphere of the nanoparticles functionalized with either a cationic antibiotic drug, colistin, or a cationic poly(amidoamine) (PAMAM) dendrimer that is not an antibiotic drug. We show that both the colistin/hydrophobic Janus nanoparticles and dendrimer/hydrophobic Janus nanoparticles effectively inhibit the growth of both Gram-negative and Gram-positive bacteria at picomolar concentrations. The half-maximum effective concentrations (EC50) of those cationic/hydrophobic Janus nanoparticles against a variety of bacteria are in the picomolar range and significantly lower than those of conventional nanoparticles with uniform surface chemistry. The Janus nanoparticles inhibit bacterial growth by disrupting bacterial membranes and by inducing reactive oxygen species (ROS). Our results demonstrate that the design of the segregated hydrophobic and cationic charges on the nanoparticle surface is key for their antibiotic potency. The antibiotic potency of the Janus nanoparticles is applicable to cationic ligands and not limited to cationic antibiotic molecules. Those anisotropic amphiphilic Janus nanoparticles are promising new broad-spectrum antibiotic nanoparticles.
Download or read book Interaction of Amphiphilic Nanoparticles with Model and Bacterial Membranes written by Jared Thomas Wiemann and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this doctoral work, we aimed to understand how amphiphilic nanoparticles, especially those with anisotropic surface chemistry, interact with biological membranes. Specifically, our overall goal was to elucidate the cytotoxic and antibacterial properties of anisotropic particles relative to amphiphilic nanoparticles with uniform surface chemistry. Nanoparticles with anisotropic surface chemistry have been synthesized for uses in sensing and immunotherapy, among other uses. In our early studies, we evaluated the impact of amphiphilic particles against free-standing biomimetic membranes to assess their potential cytotoxicity. Using "two-faced" amphiphilic Janus nanoparticles, which display separated hydrophobic and hydrophilic sides, we observed that anisotropic surface chemistry enhances the binding of particles to lipid membranes which leads to poration, membrane wrinkling, protrusions, and even collapse of entire membranes. Building upon these findings, we further observed that Janus nanoparticles selectively bind to liquid disordered domains in phase-separated lipid membranes. Extraction of lipids from liquid disordered domains to the hydrophobic nanoparticle hemispheres led to membrane compression and bulging of liquid ordered domains. These studies revealed the distinct consequences of anisotropic amphiphilic nanoparticles on lipid membrane integrity and structure. In the final part of this work, we investigated the antimicrobial properties of amphiphilic Janus nanoparticles. As more multidrug resistant bacteria emerge and fewer antibiotics are developed for clinical use, antibiotic resistance remains an increasing threat to public health. Researchers have since turned to nanomaterials with tailored surface chemistry to evade mechanisms of antibiotic resistance by directly disrupting lipid membranes and cell walls, often times using uniform coatings of cationic or amphiphilic ligands on particle surfaces. Given the potential enhanced antibiotic properties of Janus nanoparticles based on our first works, we fabricated "two-faced" amphiphilic Janus nanoparticles with one hemisphere of the Janus nanoparticles functionalized with hydrophobic alkyl chains and the other hemisphere of the nanoparticles functionalized with either a cationic antibiotic drug, colistin, or a cationic poly(amidoamine) (PAMAM) dendrimer that is not an antibiotic drug. We show that both the colistin/hydrophobic Janus nanoparticles and dendrimer/hydrophobic Janus nanoparticles effectively inhibit the growth of both Gram-negative and Gram-positive bacteria at picomolar concentrations. The half-maximum effective concentrations (EC50) of those cationic/hydrophobic Janus nanoparticles against a variety of bacteria are in the picomolar range and significantly lower than those of conventional nanoparticles with uniform surface chemistry. The Janus nanoparticles inhibit bacterial growth by disrupting bacterial membranes and by inducing reactive oxygen species (ROS). Our results demonstrate that the design of the segregated hydrophobic and cationic charges on the nanoparticle surface is key for their antibiotic potency. The antibiotic potency of the Janus nanoparticles is applicable to cationic ligands and not limited to cationic antibiotic molecules. Those anisotropic amphiphilic Janus nanoparticles are promising new broad-spectrum antibiotic nanoparticles.
Download or read book Protein Nanoparticle Interactions written by Masoud Rahman and published by Springer Science & Business Media. This book was released on 2013-06-24 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a “biological identity” to their surfaces (referred to as a “corona”), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called “bio-nano interface,” has been very rarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts.
Download or read book Magnetic Nanomaterials written by Yanglong Hou and published by John Wiley & Sons. This book was released on 2017-10-23 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: Timely and comprehensive, this book presents recent advances in magnetic nanomaterials research, covering the latest developments, including the design and preparation of magnetic nanoparticles, their physical and chemical properties as well as their applications in different fields, including biomedicine, magnetic energy storage, wave-absorbing and water remediation. By allowing researchers to get to the forefront developments related to magnetic nanomaterials in various disciplines, this is invaluable reading for the nano, magnetic, energy, medical, and environmental communities.
Download or read book Unraveling the Safety Profile of Nanoscale Particles and Materials written by Andreia Ferreira de Castro Gomes and published by BoD – Books on Demand. This book was released on 2018-03-21 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: As nanomaterials become increasingly present in our daily lives, pertinent questions regarding their safety arise. Nanomaterial risk assessment, as in other areas, directs much of the effort worldwide in defining guidelines that may be translated into national or international directives. Nanomaterials encompass different entities, from nanoparticles to nanostructured materials, with specific effects over cells, tissues, organisms and ecosystems depending on their biophysical characteristics. Such interactions will directly affect the impact of novel nanotechnologies. This book aims to provide the reader with a comprehensive overview of the current state of the art in nanotoxicology, featuring the most important developments and critical issues regarding the use of and exposure to nanoparticles.
Download or read book Nanopharmaceuticals Principles and Applications Vol 3 written by Vinod Kumar Yata and published by Springer Nature. This book was released on 2020-08-19 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.
Download or read book Lipids in Nanotechnology written by Moghis U. Ahmad and published by Elsevier. This book was released on 2015-08-15 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology is a rapidly expanding field which includes fundamental nanoscale phenomena and processes, nanomaterials, nanoscale devices and systems, nanomanufacturing, and benefits and risks of nanotechnology. This book serves as a valuable reference and resource for those interested in the field of nanotechnology – from basic research to engineering aspects of nanoparticles. It covers thermodynamics to engineering aspects of nanoparticles or nanoemulsions; synthesis and applications of surface active lipids to food and cosmetics; and pharmaceutical applications to nanomedicine. Lipids in Nanotechnology will be useful to scholars, scientists, and technologists who are interested in the field of lipid nanotechnology. - Discusses an overview of the opportunities and challenges of lipids in nanotechnology - Presents applications of nanotechnology for use in drug delivery, nanomedicine, and pharmaceutical developments - Explores the potential for lipids to act as encapsulation agents or delivery vehicles of bioactive compounds
Download or read book Surface and Interface Science Volumes 7 and 8 written by Klaus Wandelt and published by John Wiley & Sons. This book was released on 2020-03-30 with total page 1002 pages. Available in PDF, EPUB and Kindle. Book excerpt: In ten volumes, this unique handbook covers all fundamental aspects of surface and interface science and offers a comprehensive overview of this research area for scientists working in the field, as well as an introduction for newcomers. Volume 1: Concepts and Methods Volume 2: Properties of Elemental Surfaces Volume 3: Properties of Composite Surfaces: Alloys, Compounds, Semiconductors Volume 4: Solid-Solid Interfaces and Thin Films Volume 5: Solid-Gas Interfaces I Volume 6: Solid-Gas Interfaces II Volume 7: Liquid and Biological Interfaces Volume 8: Interfacial Electrochemistry Volume 9: Applications of Surface Science I Volume 10: Applications of Surface Science II Content of Volumes 7 & 8: * Probing Liquid/Solid Interfaces at the Molecular Level * Structure and Dynamics of Liquid-Solid Interfaces * Adsorption of Biomolecules * Liquid Surfaces * Surfaces of Ionic Liquids * Superhydrophobicity * Cell Penetrating Peptides Targeting and Distorting Biological Membranes * Theory of Solid/Electrolyte Interfaces * Metal/Electrolyte Interfaces: An Atomic View * X-Ray Spectroscopy at Electro-Catalytic Interfaces * Fundamental Aspects of Electro-Catalysis * Non-Linear Processes at Solid/Liquid Interfaces
Download or read book Inorganic Nanoparticles written by Claudia Altavilla and published by CRC Press. This book was released on 2017-12-19 with total page 885 pages. Available in PDF, EPUB and Kindle. Book excerpt: Among the various nanomaterials, inorganic nanoparticles are extremely important in modern technologies. They can be easily and cheaply synthesized and mass produced, and for this reason, they can also be more readily integrated into applications. Inorganic Nanoparticles: Synthesis, Applications, and Perspectives presents an overview of these special materials and explores the myriad ways in which they are used. It addresses a wide range of topics, including: Application of nanoparticles in magnetic storage media Use of metal and oxide nanoparticles to improve performance of oxide thin films as conducting media in commercial gas and vapor sensors Advances in semiconductors for light-emitting devices and other areas related to the energy sector, such as solar energy and energy storage devices (fuel cells, rechargeable batteries, etc.) The expanding role of nanosized particles in the field of catalysis, art conservation, and biomedicine The book’s contributors address the growing global interest in the application of inorganic nanoparticles in various technological sectors. Discussing advances in materials, device fabrication, and large-scale production—all of which are urgently required to reduce global energy demands—they cover innovations in areas such as solid-state lighting, detailing how it still offers higher efficiency but higher costs, compared to conventional lighting. They also address the impact of nanotechnology in the biomedical field, focusing on topics such as quantum dots for bioimaging, nanoparticle-based cancer therapy, drug delivery, antibacterial agents, and more. Fills the informational gap on the wide range of applications for inorganic nanoparticles in areas including biomedicine, electronics, storage media, conservation of cultural heritage, optics, textiles, and cosmetics Assembling work from an array of experts at the top of their respective fields, this book delivers a useful analysis of the vast scope of existing and potential applications for inorganic nanoparticles. Versatile as either a professional research resource or textbook, this effective tool elucidates fundamentals and current advances associated with design, characterization, and application development of this promising and ever-evolving device.
Download or read book Bioelectrochemistry written by Philip N. Bartlett and published by John Wiley & Sons. This book was released on 2008-05-27 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioelectrochemistry: Fundamentals, Experimental Techniques and Application, covers the fundamental aspects of the chemistry, physics and biology which underlie this subject area. It describes some of the different experimental techniques that can be used to study bioelectrochemical problems and it describes various applications of biolelectrochemisty including amperometric biosensors, immunoassays, electrochemistry of DNA, biofuel cells, whole cell biosensors, in vivo applications and bioelectrosynthesis. By bringing together these different aspects, this work provides a unique source of information in this area, approaching the subject from a cross-disciplinary viewpoint.
Download or read book Nanooncology written by Gil Gonçalves and published by Springer. This book was released on 2018-06-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a systematic overview of the most relevant nanomaterials and their respective intrinsic properties that have been highly explored by the scientific community and pharmaceutical companies in several different modalities for cancer therapy and bioimaging. The chapters explore the synergistic effects provided by the different nanostructured materials and highlight the main in vitro and in vivo therapeutic achievements on cancer. This work also provides relevant discussion about the recent progresses and future challenges that nanotechnology faces on the conception of more efficient nanoformulations against primary tumors, circulating cancer cells and metastases.
Download or read book Surface Chemistry of Nanobiomaterials written by Alexandru Grumezescu and published by William Andrew. This book was released on 2016-02-03 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface Chemistry of Nanobiomaterials brings together the most recent findings regarding the surface modification of currently used nanomaterials, which is a field that has become increasingly important during the last decade. This book enables the results of current research to reach those who wish to use this knowledge in an applied setting. Leading researchers from around the world present various types of nanobiomaterials, such as quantum dots (QDs), carbon nanotubes, silver nanoparticles, copper oxide, zinc oxide, magnesium oxide, magnetite, hydroxyapatite and graphene, and discuss their related functionalization strategies. This book will be of interest to postdoctoral researchers, professors and students engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians. - An up-to-date and highly structured reference source for researchers, practitioners and students working in biomedical, biotechnological and engineering fields - A valuable guide to recent scientific developments, covering major and emerging applications of nanomaterials in the biomedical field - Proposes novel opportunities and ideas for developing or improving technologies in nanomedicine and nanobiology
Download or read book Characterization of Pharmaceutical Nano and Microsystems written by Leena Peltonen and published by John Wiley & Sons. This book was released on 2020-12-21 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn about the analytical tools used to characterize particulate drug delivery systems with this comprehensive overview Edited by a leading expert in the field, Characterization of Pharmaceutical Nano- and Microsystems provides a complete description of the analytical techniques used to characterize particulate drug systems on the micro- and nanoscale. The book offers readers a full understanding of the basic physicochemical characteristics, material properties and differences between micro- and nanosystems. It explains how and why greater experience and more reliable measurement techniques are required as particle size shrinks, and the measured phenomena grow weaker. Characterization of Pharmaceutical Nano- and Microsystems deals with a wide variety of topics relevant to chemical and solid-state analysis of drug delivery systems, including drug release, permeation, cell interaction, and safety. It is a complete resource for those interested in the development and manufacture of new medicines, the drug development process, and the translation of those drugs into life-enriching and lifesaving medicines. Characterization of Pharmaceutical Nano- and Microsystems covers all of the following topics: An introduction to the analytical tools applied to determine particle size, morphology, and shape Common chemical approaches to drug system characterization A description of solid-state characterization of drug systems Drug release and permeation studies Toxicity and safety issues The interaction of drug particles with cells Perfect for pharmaceutical chemists and engineers, as well as all other industry professionals and researchers who deal with drug delivery systems on a regular basis, Characterization of Pharmaceutical Nano- and Microsystems also belongs on bookshelves of interested students and faculty who interact with this topic.
Download or read book Magnetic Nanoparticles in Human Health and Medicine written by Costica Caizer and published by John Wiley & Sons. This book was released on 2021-09-08 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Nanoparticles in Human Health and Medicine Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine. Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer therapeutics—featuring discussion of current problems, proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume: Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.
