Download or read book Integrative Pharmacology based Research on Traditional Medicine Methodologies Medical and Pharmacological Applications written by Hai Yu Xu and published by Frontiers Media SA. This book was released on 2023-09-19 with total page 1019 pages. Available in PDF, EPUB and Kindle. Book excerpt: ntegrative Pharmacology can be used to determine the multi-pharmacological effects of traditional medicines such as traditional Chinese medicine (TCM), Kampo, Sa-sang, Ayurveda, etc.). Through qualitative and quantitative pharmacokinetic-pharmacodynamic (PK-PD) correlations among multi-constituents and multi-targets, integrating chemical profiling, ADME/PK processes, molecular network calculation and resulting experimental validation, the use of Integrative Pharmacology has become widespread. The data has provided a novel paradigm to evaluate the druggability of bioactive ingredients of herbs or formulae, to decipher the pharmacological mechanisms of drug action and to screen potentially new indications for approved drugs and previously unidentified adverse events. On this basis, Integrative Pharmacology may offer an effective way to test the potential scientific basis for traditional medicines and to assess what roles of traditional medicine can and cannot play in pharmaceuticals.
Download or read book Integrative Pharmacology written by Greg Sperber and published by . This book was released on 2016 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Quantitative Pharmacology written by Johan Gabrielsson and published by Swedish Pharmaceutical Press. This book was released on 2012-05-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: PKPD awareness is vital if we are to attempt to relate preclinical results to the acute and long term consequences in humans. The debate on whether preclinical findings can be translated to the human usage is still engaging scientists across industry, academia and regulatory bodies. Pharmacokinetics (PK) and pharmacodynamics (PD) comprise traditionally distinct disciplines within pharmacology, the study of the interaction of drugs with the body. It is our intention to show that by deliberately, intimately and systematically integrate these disciplines our understanding of drugs and the efficiency and effectiveness of drug discovery and development may be greatly enhanced. The book is therefore written with a broad audience in mind and focuses on concepts. Pharmacologists of all sorts, safety scientists, pharmacokineticists, medicinal chemists, clinicians, statisticians, veterinarians, animal science professionals, project leaders and students of medical, pharmaceutical and veterinary sciences are the primary targets. This textbook Introduces the basics of PK and PD concepts Outlines the implications of integrating PK and PD analysis Introduces the principles behind different biomarkers and inter-species scaling Discusses experimental design of PK, PD and safety studies in non-human species Covers numerous real life Case Studies from the drug discovery arena
Download or read book Integrated Pharmacology written by Greg Sperber and published by Blue Poppy Enterprises, Inc.. This book was released on 2007 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrated Pharmacology: Combining Modern Pharmacology with Chinese Medicine, by Dr Greg Sperber, gives you basic information about each common class of Western pharmaceuticals. For each category of drug, Dr Sperber gives us the generic names, pronunciation, and registered proprietary versions, an explanation of function, mechanism of action, dosages for adults, children, and the elderly, possible adverse affects, red flags, and the most up-to-the-minute information on specific drug-drug and drug-herb interactions that may affect your patients. Additionally, the book includes commentary by Bob Flaws on a three-part system for evaluating Western meds using Chinese medical principles and a Chinese medical analysis of each class of drugs using this three-part system. This book has Over 130 illustrations showing the functions and mechanisms of each type of drug as well as a page-by-page glossary of potentially difficult terms throughout the book.
Download or read book Polypharmacology written by Zhiguo Wang and published by Springer Nature. This book was released on 2022-08-01 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology that is needed. This book aims to meet the needs making Polypharmacology a new sub-discipline of Pharmacology, not only being a hot area of pharmacological research and education but also a new paradigm for drug discovery. It contains the contents covering the entire scope of Polypharmacology including systemic in-depth exposition of basic knowledge, novel concepts, innovative technologies, and translational and clinical applications by showcasing state-of-the-art strategies and step-by-step instructions of cutting-edge methods. The contents of this book targets broad readerships including scientists in pharmacology research and drug development, and university teachers and graduates in medical school or school of pharmacy.
Download or read book Integrative Nursing written by Andrew Weil and published by Oxford University Press, USA. This book was released on 2018-11-27 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of "Integrative Nursing" is a complete roadmap to integrative patient care, providing a guide to the whole person/whole systems assessment and clinical interventions for individuals, families, and communities. Treatment strategies described in this version employ the full complement of evidence-informed methodologies in a tailored, person-centered approach to care. Integrative medicine is defined as healing-oriented medicine that takes account of the whole person (body, mind, and spirit) as well as all aspects of the lifestyle; it emphasizes the therapeutic relationship and makes use of appropriate therapies, but conventional and alternative. -- From publisher's description
Download or read book Regenerative Pharmacology written by George J. Christ and published by Cambridge University Press. This book was released on 2013-04-15 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state-of-the-art primer on the role of pharmacological sciences in regenerative medicine, for advanced students, postdoctoral fellows, and researchers.
Download or read book Network Pharmacology written by Shao Li and published by Springer Nature. This book was released on 2021-09-29 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.
Download or read book Drug Repositioning Current Advances and Future Perspectives written by Yuhei Nishimura and published by Frontiers Media SA. This book was released on 2019-01-11 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically, drug repositioning has been realized through serendipitous clinical observations or improved understanding of disease mechanisms. However, recent technological advances have enabled a more systematic approach to drug repositioning. This eBook collects 16 articles from 112 authors, providing readers with current advances and future perspectives of drug repositioning.
Download or read book Principles of Safety Pharmacology written by Michael K. Pugsley and published by Springer. This book was released on 2015-06-19 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.
Download or read book Insights in Ethnopharmacology 2021 written by Michael Heinrich and published by Frontiers Media SA. This book was released on 2022-11-04 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Discovery Toxicology written by Yvonne Will and published by John Wiley & Sons. This book was released on 2016-03-22 with total page 899 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices
Download or read book Early Drug Development written by Fabrizio Giordanetto and published by John Wiley & Sons. This book was released on 2018-06-11 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to pharmacology to intellectual property issues. After introducing the overall early development workflow, the critical steps of early drug development are described in a sequential and enabling order: the availability of the drug substance and that of the drug product, the prediction of pharmacokinetics and -dynamics, as well as that of drug safety. The final section focuses on intellectual property aspects during early clinical development. The emphasis throughout is on recent case studies to exemplify salient points, resulting in an abundance of practice-oriented information that is usually not available from other sources. Aimed at medicinal chemists in industry as well as academia, this invaluable reference enables readers to understand and navigate the challenges in developing clinical candidate molecules that can be successfully used in phase one clinical trials.
Download or read book A Pharmacology Primer written by Terry P. Kenakin and published by Academic Press. This book was released on 2018-10-26 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition features the latest ideas and research regarding the application of pharmacology to the process of drug discovery. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This updated edition has been thoroughly revised to include material on quantifying drug efficacy through bias and cluster analysis, the impact of molecular dynamics and protein structural analysis, the real time kinetic analysis of drug effect, virtual screening for new drug chemical scaffolds, and much more. With full color illustrations and new examples throughout, this book remains a top reference for all industry and academic scientists that is also ideal for students directly involved in drug discovery or pharmacologic research. - Highlights changes surrounding strategies for drug discovery, providing a comprehensive reference and featuring advances in the methods involved - Includes multiple new sections, such as development and utilization of models in pharmacology, de-orphanization of new drug targets, predicting impact of disease on drug pharmacokinetics, and the impact of enzyme kinetics on drug-drug interactions - Illustrates the application of rapid inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data
Download or read book Medical Pharmacology and Therapeutics E Book written by Derek G. Waller and published by Elsevier Health Sciences. This book was released on 2017-06-04 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical Pharmacology & Therapeutics, now in its fifth edition, offers medical students all they need to know to become safe and effective prescribers. It forms a complete, integrated resource for basic pharmaceutical science, pathophysiology, clinical pharmacology, and therapeutics. The fifth edition has been extensively revised and updated throughout. Key features include: - Clear, disease-based approach. - Presentation of how drugs are used in clinical practice. - Succinct explanations of the major pathogenic mechanisms of each disease and consequent clinical signs and symptoms. - Comprehensive reviews of major drug classes relevant to each disease. - Structured approach to the principles of disease management – outlining core principles of drug choice and planning a therapeutic regimen for common diseases. - Quick-reference drug compendia illustrating key similarities and differences among all BNF-listed drugs in each class. - Comes with free e-book on StudentConsult. - New sections on key and evolving topics, including prescribing safety and pharmacovigilance. - Updated figures to further clarify complex areas. - Over 800 revised multiple-choice and case-based questions for self-assessment.
Download or read book Holistic Healthcare written by Anne George and published by CRC Press. This book was released on 2017-03-16 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new book focuses on recent trends in holistic medicine, the art of maintaining proper balance between one’s physical health and mental well-being. The books highlights the importance of maintaining a healthy life style for physical well-being and examines the advantages of using traditional medicine to combat multi-drug-resistance problems caused by modern-day antibiotics. It details the advantages of using holistic approaches to treat infectious diseases with relevant clinical data.
Download or read book Graduate Programs in the Biological Biomedical Sciences Health Related Medical Professions 2014 Grad 3 written by Peterson's and published by Peterson's. This book was released on 2013-12-20 with total page 4553 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peterson's Graduate Programs in the Biological/Biomedical Sciences & Health-Related Medical Professions 2014 contains comprehensive profiles of nearly 6,800 graduate programs in disciplines such as, allied health, biological & biomedical sciences, biophysics, cell, molecular, & structural biology, microbiological sciences, neuroscience & neurobiology, nursing, pharmacy & pharmaceutical sciences, physiology, public health, and more. Up-to-date data, collected through Peterson's Annual Survey of Graduate and Professional Institutions, provides valuable information on degree offerings, professional accreditation, jointly offered degrees, part-time and evening/weekend programs, postbaccalaureate distance degrees, faculty, students, requirements, expenses, financial support, faculty research, and unit head and application contact information. There are helpful links to in-depth descriptions about a specific graduate program or department, faculty members and their research, and more. There are also valuable articles on financial assistance, the graduate admissions process, advice for international and minority students, and facts about accreditation, with a current list of accrediting agencies.
