Download or read book Insights Into Dioxygen Bond Activation and Formation by Small Biomimetic Complexes written by Maksym A. Dedushko and published by . This book was released on 2020 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Formation of an O-O bond is a crucial step in the biological oxidation of water to produce molecular O2. Its microscopic reverse, namely the activation of an O-O bond, is an essential step in key oxidative transformations during metabolism. Both of the reactions are employed by Nature to garner energy, synthesize, and degrade biomolecules in order to sustain life. A common feature of these two seemingly opposite, yet intimately interlinked, reactions in biological systems is that they are catalyzed by first-row transition metals such as manganese, iron, and copper. Both types of reactions are proposed to proceed through several reactive intermediates. Among them, metal-(hydro)peroxo and high-valent metal-oxo are common to both an O-O bond activation and formation step. Iron-containing metalloenzymes that utilize O2 as an oxidant perform a wide variety of biologically important chemical transformations. Cysteine-ligated iron metalloenzymes are of particular interest due to the unique properties that thiolates impart on transition metal ions. Thiolate (RS−) ligands form highly-covalent metal-ligand bonds, lower the activation energy barrier to O2 binding and one-electron reduction, facilitate an O-O bond activation. This dissertation describes a cis-thiolate ligated [FeII(SMeN4(tren))]+ complex that reacts with O2 to afford a series of metastable intermediates such as Fe111-superoxo, Mu-peroxo Fe111 dimer, Fe1v-oxo, and Fe111-hydroxo at low temperature, (Chapters 2 - 3). Remarkably, addition of oxo-atom donors (OAD) to [Fe11(SMeN4(tren))]+ affords an identical metastable Mu-peroxo Fe111 dimeric species, suggesting that a reversible O-O bond formation can occur, (Chapter 4). Chapter 5 describes the structure and properties of a O2-derived thiolate-ligated, Mu-peroxo-bridged CoIII dimer and provides a comparison with structurally analogous Mu-peroxo-bridged Mn111 dimers. And lastly, Chapter 6 provides a detailed description of a successfully developed, versatile synthetic procedure to the Schiff-based precursors en route to heterobimetallic Robson-type target complexes. Moreover, a heterobimetallic NaMn3O4 cubane complex relevant to the oxygen-evolving complex (OEC) has been synthesized and crystallographically characterized.
Download or read book Effect of Coordination Environment on Transition Metal mediated Dioxygen Bond Formation Stabilization and Cleavage written by Kuheli Dutta and published by . This book was released on 2024* with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Englische Version: Transition metal-oxo, -peroxo, -oxyl intermediates have been proposed as key reactive intermediates in biochemical transformations relevant to dioxygen bond formation and cleavage. Biomimetic studies of relevant enzyme active sites help us to understand the different mechanistic pathways operating in biological systems. Moreover, biomimetic studies also provide us with unique insights into the effect of subtle changes in the coordination environment that can influence the product-selectivity, catalytic efficiency and reaction mechanism. The generation and characterization of these crucial reactive intermediates, therefore, provide a valuable tool for mechanistic understanding and consequently, aid in the development of new and improved catalysts for dioxygen bond formation and cleavage. Therefore, in this thesis, we show how subtle changes in the ligand framework or reaction medium can greatly influence the fate of the dioxygen bond, its formation, stabilization and cleavage.
Download or read book Physical Methods in Bioinorganic Chemistry written by Lawrence Que and published by Sterling Publishing Company. This book was released on 2000 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides detailed coverage of physical methods used in bioinorganic chemistry. By integrating theory with experimentation, and providing a more biological orientation, the book aims to serve as a major textbook for students of bioinorganic chemistry.
Download or read book Activation of Small Molecules written by William B. Tolman and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first to combine both the bioinorganic and the organometallic view, this handbook provides all the necessary knowledge in one convenient volume. Alongside a look at CO2 and N2 reduction, the authors discuss O2, NO and N2O binding and reduction, activation of H2 and the oxidation catalysis of O2. Edited by the highly renowned William Tolman, who has won several awards for his research in the field.
Download or read book Modern Techniques of Surface Science written by D. P. Woodruff and published by Cambridge University Press. This book was released on 1994-03-03 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revised and expanded second edition of the standard work on new techniques for studying solid surfaces.
Download or read book Activation and Functionalization of C H Bonds written by Karen I. Goldberg and published by ACS Symposium. This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Activation and Functionalization of C-H Bonds explores recent developments in the reaction chemistry of solution-phase transition-metal based systems with simple hydrocarbons and with more complex organic molecules. More than 20 internationally leading research groups contributed to this volume, and their chapters cover such topics as fundamental theoretical and mechanistic studies of C-H bond activation by metal complexes, catalytic systems for alkane functionalization, and new applications in synthetic organic chemistry. An introductory chapter offers an overview of stoichiometric and catalytic reactions of C-H bonds with transition metal complexes. The C-H bond is the most widespread linkage in organic chemistry, present in virtually every organic molecule. Unfortunately, C-H bonds are famously resistant to selective chemical transformations. The development of methods for their selective transformations has enormous potential value in fields ranging from the chemistry of fuels (for example, the conversion of methane to methanol) to the synthesis of the most complex organic molecules.
Download or read book On Biomimetics written by Lilyana Pramatarova and published by BoD – Books on Demand. This book was released on 2011-08-29 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bio-mimicry is fundamental idea "How to mimic the Nature" by various methodologies as well as new ideas or suggestions on the creation of novel materials and functions. This book comprises seven sections on various perspectives of bio-mimicry in our life; Section 1 gives an overview of modeling of biomimetic materials; Section 2 presents a processing and design of biomaterials; Section 3 presents various aspects of design and application of biomimetic polymers and composites are discussed; Section 4 presents a general characterization of biomaterials; Section 5 proposes new examples for biomimetic systems; Section 6 summarizes chapters, concerning cells behavior through mimicry; Section 7 presents various applications of biomimetic materials are presented. Aimed at physicists, chemists and biologists interested in biomineralization, biochemistry, kinetics, solution chemistry. This book is also relevant to engineers and doctors interested in research and construction of biomimetic systems.
Download or read book Anion Receptor Chemistry written by Jonathan L Sessler and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anion recognition plays a critical role in a range of biological processes, and a variety of receptors and carriers can be found throughout the natural world. Chemists working in the area of supramolecular chemistry have created a range of anion receptors, drawing inspiration from nature as well as their own inventive processes. This book traces the origins of anion recognition chemistry as a unique sub-field in supramolecular chemistry while illustrating the basic approaches currently being used to effect receptor design. The combination of biological overview and summary of current synthetic approaches provides a coverage that is both comprehensive and comprehensible. First, the authors detail the key design motifs that have been used to generate synthetic receptors and which are likely to provide the basis for further developments. They also highlight briefly some of the features that are present in naturally occurring anion recognition and transport systems and summarise the applications of anion recognition chemistry. Providing as it does a detailed review for practitioners in the field and a concise introduction to the topic for newcomers, Anion Receptor Chemistry reflects the current state of the art. Fully referenced and illustrated in colour, it is a welcome addition to the literature.
Download or read book Iron containing Enzymes written by Sam P. De Visser and published by Royal Society of Chemistry. This book was released on 2011 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mononuclear iron containing enzymes are important intermediates in bioprocesses and have potential in the industrial biosynthesis of specific products. This book features topical review chapters by leaders in this field and its various sub-disciplines.
Download or read book Comprehensive Inorganic Chemistry II written by and published by Newnes. This book was released on 2013-07-23 with total page 7694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Inorganic Chemistry II, Nine Volume Set reviews and examines topics of relevance to today’s inorganic chemists. Covering more interdisciplinary and high impact areas, Comprehensive Inorganic Chemistry II includes biological inorganic chemistry, solid state chemistry, materials chemistry, and nanoscience. The work is designed to follow on, with a different viewpoint and format, from our 1973 work, Comprehensive Inorganic Chemistry, edited by Bailar, Emeléus, Nyholm, and Trotman-Dickenson, which has received over 2,000 citations. The new work will also complement other recent Elsevier works in this area, Comprehensive Coordination Chemistry and Comprehensive Organometallic Chemistry, to form a trio of works covering the whole of modern inorganic chemistry. Chapters are designed to provide a valuable, long-standing scientific resource for both advanced students new to an area and researchers who need further background or answers to a particular problem on the elements, their compounds, or applications. Chapters are written by teams of leading experts, under the guidance of the Volume Editors and the Editors-in-Chief. The articles are written at a level that allows undergraduate students to understand the material, while providing active researchers with a ready reference resource for information in the field. The chapters will not provide basic data on the elements, which is available from many sources (and the original work), but instead concentrate on applications of the elements and their compounds. Provides a comprehensive review which serves to put many advances in perspective and allows the reader to make connections to related fields, such as: biological inorganic chemistry, materials chemistry, solid state chemistry and nanoscience Inorganic chemistry is rapidly developing, which brings about the need for a reference resource such as this that summarise recent developments and simultaneously provide background information Forms the new definitive source for researchers interested in elements and their applications; completely replacing the highly cited first edition, which published in 1973
Download or read book Challenges in Computational Enzymology written by Vicent Moliner and published by Frontiers Media SA. This book was released on 2019-12-31 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Amide Bond Activation written by Michal Szostak and published by MDPI. This book was released on 2019-07-12 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. These developments cover an impressive range of catalytic N–C bond activation in electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This monograph on amide bonds offers a broad survey of recent advances in activation of amides and addresses various approaches in the field.
Download or read book C H Activation for Asymmetric Synthesis written by Françoise Colobert and published by John Wiley & Sons. This book was released on 2019-11-11 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides, in one handbook, comprehensive coverage of one of the hottest topics in stereoselective chemistry Written by leading international authors in the field, this book introduces readers to C-H activation in asymmetric synthesis along with all of its facets. It presents stereoselective C-H functionalization with a broad coverage, from outer-sphere to inner-sphere C-H bond activation, and from the control of olefin geometry to the induction of point, planar and axial chirality. Moreover, methods wherein asymmetry is introduced either during the C-H activation or in a different elementary step are discussed. Presented in two parts?asymmetric activation of C(sp3)-H bonds and stereoselective synthesis implying activation of C(sp2)-H bonds?CH-Activation for Asymmetric Synthesis showcases the diversity of stereogenic elements, which can now be constructed by C-H activation methods. Chapters in Part 1 cover: C(sp3)-H bond insertion by metal carbenoids and nitrenoids; stereoselective C-C bond and C-N bond forming reactions through C(sp3)?H bond insertion of metal nitrenoids; enantioselective intra- and intermolecular couplings; and more. Part 2 looks at: C-H activation involved in stereodiscriminant step; planar chirality; diastereoselective formation of alkenes through C(sp2)?H bond activation; amongst other methods. -Covers one of the most rapidly developing fields in organic synthesis and catalysis -Clearly structured in two parts (activation of sp3- and activation of sp2-H bonds) -Edited by two leading experts in C-H activation in asymmetric synthesis CH-Activation for Asymmetric Synthesis will be of high interest to chemists in academia, as well as those in the pharmaceutical and agrochemical industry.
Download or read book Bioinspired Chemistry From Enzymes To Synthetic Models written by Balaban Teodor Silviu and published by World Scientific. This book was released on 2019-03-08 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: The observation of Nature is an inexhaustible source of inspiration to promote innovations in chemistry. The bioinspired approach is a revolution in our paradigms because it is not based on what we can take to nature, but on what we can learn from it. Enzymatic systems involved in solar energy conversion (photosystem), hydrogen production (hydrogenases), dioxygen activation (oxydases et oxygenases), CO₂ reduction (CO dehydrogenase) use abundant and cheap starting material such as O₂, H₂O and CO₂. Inspiration of these biological systems is a solution to make our chemical processes greener. These are some of the many challenges that bioinspired chemistry is able to take up.A number of the recent developments in bioinspired chemistry are discussed, including some descriptions on the biological systems that are the source of inspiration. This book is a guide to where bioinspired chemistry will be in the near future and provides a thoughtful perspective on how bioinspiration could change our world.
Download or read book Physical Inorganic Chemistry written by Andreja Bakac and published by John Wiley & Sons. This book was released on 2010-04-22 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physical Inorganic Chemistry contains the fundamentals of physical inorganic chemistry, including information on reaction types, and treatments of reaction mechanisms. Additionally, the text explores complex reactions and processes in terms of energy, environment, and health. This valuable resource closely examines mechanisms, an under-discussed topic. Divided into two sections, researchers, professors, and students will find the wide range of topics, including the most cutting edge topics in chemistry, like the future of solar energy, catalysis, environmental issues, climate changes atmosphere, and human health, essential to understanding chemistry.
Download or read book Cytochrome P450 written by Paul R. Ortiz de Montellano and published by Springer Science & Business Media. This book was released on 2007-02-05 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years.
Download or read book Copper Oxygen Chemistry written by Kenneth D. Karlin and published by John Wiley & Sons. This book was released on 2011-08-24 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers the vastly expanding subject of oxidative processes mediated by copper ions within biological systems Copper-mediated biological oxidations offer a broad range of fundamentally important and potentially practical chemical processes that cross many chemical and pharmaceutical disciplines. This newest volume in the Wiley Series on Reactive Intermediates in Chemistry and Biology is divided into three logical areas within the topic of copper/oxygen chemistry— biological systems, theory, and bioinorganic models and applications—to explore the biosphere for its highly evolved and thus efficient oxidative transformations in the discovery of new types of interactions between molecular oxygen and copper ion. Featuring a diverse collection of subject matter unified in one complete and comprehensive resource, Copper-Oxygen Chemistry probes the fundamental aspects of copper coordination chemistry, synthetic organic chemistry, and biological chemistry to reveal both the biological and chemical aspects driving the current exciting research efforts behind copper-oxygen chemistry. In addition, Copper-Oxygen Chemistry: Addresses the significantly increasing literature on oxygen-atom insertion and carbon-carbon bond-forming reactions as well as enantioselective oxidation chemistries Progresses from biological systems to spectroscopy and theory, and onward to bioinorganic models and applications Covers a wide array of reaction types such as insertion and dehydrogenation reactions that utilize the cheap, abundant, and energy-containing O2 molecule With thorough coverage by prominent authors and researchers shaping innovations in this growing field, this valuable reference is essential reading for bioinorganic chemists, as well as organic, synthetic, and pharmaceutical chemists in academia and industry.
