Download or read book Influence of Maternal High Fat Diet Stress and Cocaine on Neural Mechanisms of Reward and Anxiety in Rat Offspring written by Aya Sasaki and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Maternal obesity has important health consequences for the mother and her offspring. Experiments presented in this dissertation explored the role of maternal overnutrition with a high fat diet (HFD) on several aspects of offspring phenotype: reward- and stress-related behaviours, the endocrine stress response, and associated neural gene expression. First, I examined maternal HFD effects on offspring phenotype in stress-related brain regions. Maternal HFD was associated with altered expression of stress-related genes, a heightened endocrine stress response and increased anxiety behaviour in adult offspring. Genes central to stress and drug addiction (TH and CRF) were upregulated in HFD offspring, suggesting that maternal HFD alters neural systems underlying related processes. Second, I investigated the role of maternal HFD on offspring phenotype following chronic cocaine exposure. Maternal HFD increased anxiety in saline-treated control females, reduced anxiety in cocaine-treated females, but did not interact with cocaine-primed locomotor activity or neural gene expression. These findings suggest that maternal HFD modulates offspring anxiety behavior with chronic cocaine exposure. Third, I investigated the role of maternal HFD and maternal stress on offspring phenotype given acute cocaine exposure. Maternal HFD did not interact with cocaine at the level of behavior or gene expression. However, there was an increase in locomotor activity in males exposed to maternal HFD, and with maternal stress at a high dose of cocaine. These findings suggest that, overall, maternal HFD and stress increase cocaine-induced locomotor activity in offspring through common but not identical neural mechanisms. Finally, in parallel I investigated the role of pre-gestational cocaine on offspring phenotype, and demonstrated an effect on the locomotor activating effects of cocaine in adult male offspring, as well as dopamine receptor 1 expression in the medial prefrontal cortex. These findings suggest increased sensitivity to cocaine in the male offspring of mothers given pre-gestational cocaine. The collective findings are discussed within a framework of maternal influences on cocaine sensitivity in offspring, wherein maternal HFD and pre-gestational cocaine confer increased sensitivity of stress- and reward-related responses in offspring.
Download or read book Obesogenic Environmental Conditions Affect Neurodevelopment and Neurodegeneration written by Gustavo Pacheco-Lopez and published by Frontiers Media SA. This book was released on 2021-09-23 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fat Detection written by Jean-Pierre Montmayeur and published by CRC Press. This book was released on 2009-09-14 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the State-of-the-Art in Fat Taste TransductionA bite of cheese, a few potato chips, a delectable piece of bacon - a small taste of high-fat foods often draws you back for more. But why are fatty foods so appealing? Why do we crave them? Fat Detection: Taste, Texture, and Post Ingestive Effects covers the many factors responsible for the se
Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.
Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Download or read book The Two Way Link between Eating Behavior and Brain Metabolism written by Tanya Zilberter and published by Frontiers Media SA. This book was released on 2016-01-13 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: This research topic collected and connected information concerning both the underlying metabolic mechanisms and consequences of eating behaviors. These two aspects are tremendously important for a better understanding of eating behavior abnormalities as well as for improving education on eating disorders and behaviors.
Download or read book Translational Research Models and Methods for Mother Infant Interactions and Developmental Studies written by Josephine Johns and published by Frontiers Media SA. This book was released on 2012-10-01 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The disruption of mother-infant interactions can have life-long detrimental consequences for offspring and mothers. This topic of Frontiers will focus on maternal-infant interactions including factors that may affect or alter infant or child development and maternal response capability in clinical and preclinical (animal) populations. Articles may highlight topics such as drug abuse, maternal neglect, altered reward systems, stress, biological and neural system development, child and infant behavioral development, genetics/epigenetics and intergenerational studies. Submissions can include research methods papers, reviews, original research articles, techniques and opinion articles that address the topics of interest. This Research Topic will highlight translational research including common measures and results found in both animal and human studies. Please contact one of the Editors for submission proposals or for additional information.
Download or read book Programming HPA axis by early life experience Mechanisms of stress susceptibility and adaptation written by Rachel Yehuda and published by Frontiers Media SA. This book was released on 2015-03-16 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming.
Download or read book Stress Disorders Among Vietnam Veterans Theory Research written by Charles R. Figley and published by Routledge. This book was released on 2014-07-22 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1978. This book represents a unique accomplishment in pulling together in one place the broadest collection of material yet published on the psychological problems of veterans of the Vietnam war. It will provide not only an important historical document, but an invaluable resource in detailing many of the issues involved. This book should lay to rest many of the misconceptions about the Vietnam Veteran.
Download or read book Food Addiction Obesity and Disorders of Overeating written by Claire E. Wilcox and published by Springer Nature. This book was released on 2021-09-30 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is written for providers of broad training backgrounds, and aims to help those who care for people with EDs, overweight and obesity provide evidence-based care. The goal of the book is to provide these providers with a straightforward resource summarizing the current standard of care. However, it goes further by also introducing the concept of food addiction (FA) as a model to understand some forms of overeating. This book discusses the pros and cons of embracing FA and reviews the evidence for and against the validity and utility of FA. By doing so, the chapters convey a “middle ground” approach to help people with obesity, BED, and bulimia nervosa plus FA symptomatology who also want to lose weight. The text discusses FA by reviewing several of the main ongoing controversies associated with the construct. It reviews both the clinical and neuroscientific evidence that some individuals’ eating behavior mirrors that seen in substance use disorders (SUD), such as how their relationship with food appears to be “addictive”. Chapters also discuss how many of the mechanisms known to underlie SUDs appear to drive overeating in animal models and humans. Finally, the text argues that the similarities between the brain mechanisms of addictive disorders and overeating behavior has the potential to open up new avenues for current treatment and treatment development. Food Addiction, Obesity and Disorders of Overeating: An Evidence-Based Assessment and Clinical Guide is suited for both medical and mental health practitioners, including physicians in primary care or psychiatry, nurses, psychologists, social workers, medical students and medical residents. It could also be utilized by researchers in obesity and ED fields, stimulating ideas for future research and study design.
Download or read book Toxicological Profile for Toluene written by and published by . This book was released on 2000 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Reducing Risks for Mental Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 1994-01-01 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: The understanding of how to reduce risk factors for mental disorders has expanded remarkably as a result of recent scientific advances. This study, mandated by Congress, reviews those advances in the context of current research and provides a targeted definition of prevention and a conceptual framework that emphasizes risk reduction. Highlighting opportunities for and barriers to interventions, the book draws on successful models for the prevention of cardiovascular disease, injuries, and smoking. In addition, it reviews the risk factors associated with Alzheimer's disease, schizophrenia, alcohol abuse and dependence, depressive disorders, and conduct disorders and evaluates current illustrative prevention programs. The models and examination provide a framework for the design, application, and evaluation of interventions intended to prevent mental disorders and the transfer of knowledge about prevention from research to clinical practice. The book presents a focused research agenda, with recommendations on how to develop effective intervention programs, create a cadre of prevention researchers, and improve coordination among federal agencies.
Download or read book Developmental Psychopathology Volume 2 written by Dante Cicchetti and published by John Wiley & Sons. This book was released on 2006-03-31 with total page 896 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developmental Psychopathology, Second Edition, contains in three volumes the most complete and current research on every aspect of developmental psychopathology. This seminal reference work features contributions from national and international expert researchers and clinicians who bring together an array of interdisciplinary work to ascertain how multiple levels of analysis may influence individual differences, the continuity or discontinuity of patterns and the pathways by which the same developmental outcomes may be achieved. This volume addresses theoretical perspectives and methodological.
Download or read book The Cambridge Handbook of Play written by Peter K. Smith and published by Cambridge University Press. This book was released on 2018-11-15 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Play takes up much of the time budget of young children, and many animals, but its importance in development remains contested. This comprehensive collection brings together multidisciplinary and developmental perspectives on the forms and functions of play in animals, children in different societies, and through the lifespan. The Cambridge Handbook of Play covers the evolution of play in animals, especially mammals; the development of play from infancy through childhood and into adulthood; historical and anthropological perspectives on play; theories and methodologies; the role of play in children's learning; play in special groups such as children with impairments, or suffering political violence; and the practical applications of playwork and play therapy. Written by an international team of scholars from diverse disciplines such as psychology, education, neuroscience, sociology, evolutionary biology and anthropology, this essential reference presents the current state of the field in play research.
Download or read book Building Better Health written by C. David Jenkins and published by Pan American Health Org. This book was released on 2003 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This manual provides guidance on proven disease prevention strategies and practical behavioral science principles for health workers involved in all levels of planning and operating local and regional health programmes. Issues discussed include: basic disease prevention principles; community health intervention strategies; improving health throughout the life cycle; leading forms of death and disability including brain and behavioural disorders, cardiovascular diseases, strokes and cancers; and successful strategies for behavioural change.
Download or read book Science And Human Behavior written by B.F Skinner and published by Simon and Schuster. This book was released on 2012-12-18 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: The psychology classic—a detailed study of scientific theories of human nature and the possible ways in which human behavior can be predicted and controlled—from one of the most influential behaviorists of the twentieth century and the author of Walden Two. “This is an important book, exceptionally well written, and logically consistent with the basic premise of the unitary nature of science. Many students of society and culture would take violent issue with most of the things that Skinner has to say, but even those who disagree most will find this a stimulating book.” —Samuel M. Strong, The American Journal of Sociology “This is a remarkable book—remarkable in that it presents a strong, consistent, and all but exhaustive case for a natural science of human behavior…It ought to be…valuable for those whose preferences lie with, as well as those whose preferences stand against, a behavioristic approach to human activity.” —Harry Prosch, Ethics
Download or read book Stress and Cardiovascular Disease written by Paul Hjemdahl and published by Springer Science & Business Media. This book was released on 2011-10-01 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main aim of this book is to evaluate the concept of stress and provide tools for physicians to identify patients who might benefit from stress management. This will incorporate a detailed description of the physiological and pathophysiological consequences of acute and chronic stress that might lead to cardiovascular disease. The book will aim to critically evaluate interventional research (behavioural and other therapies) and provide evidence based recommendations on how to manage stress in the cardiovascular patient. Our intentions are to define and highlight stress as an etiological factor for cardiovascular disease, and to describe an evidence based "tool box" that physicians may use to identify and manage patients in whom stress may be an important contributing factor for their disease and their risk of suffering cardiovascular complications.
