Download or read book In Vivo EPR ESR written by Lawrence J. Berliner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Vivo EPR (ESR) is a textbook on this relatively new subject in biomedical electron spin resonance. While a few chapters have appeared in special topics volumes in this series, this book covers the principles and theory, instrumentation as well as the latest applications at the time of its writing. The authors are world-renowned experts and pioneers in their fields. This book is divided into two major sections dealing with theory and instrumentation, and aspects of biochemistry, in vitro and in vivo applications. A significant amount of detail is devoted to clinical applications and the problems and pitfalls encountered in in vivo spectroscopy and imaging. Key Features: -History of In Vivo EPR, -Principles of Imaging-Theory and Instrumentation, -Time-domain Radio Frequency EPR Imaging, -The Measurement of Oxygen In Vivo Using In Vivo EPR Techniques, -Potential Medical (Clinical) Applications of EPR, -Combining NMR and EPR/ESR for In Vivo Experiments.
Download or read book EPR IMAGING and IN VIVO EPR written by Gareth R. Eaton and published by CRC Press. This book was released on 2018-01-18 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a detailed examination of the physical basis for EPR imaging and in vivo EPR spectroscopy, experimental arrangements, and data analysis. The EPR imaging methods described include continuous wave, spin-echo-detected and ENDOR-detected EPR with constant, stepped, modulated, and pulsed magnetic field gradients. Applications described include inhomogeneous materials, diffusion kinetics, reaction kinetics, orientation of liquid crystals, microwave distributions, magnetic field distributions, superconductors, radiation damage, and defects in solids. The book also covers other topics important to in vivo studies, including in vivo EPR spectroscopy, low-frequency EPR, state-of-the-art low-frequency EPR instruments, achievable sensitivity, and spin labels. The book will be of great interest to graduate students, researchers, and medical instrument developers who use EPR, as well as clinicians and chemists interested in the relationship between in vivo radicals (such as superoxide and diseases).
Download or read book Magnetic Resonance Imaging in Tissue Engineering written by Mrignayani Kotecha and published by John Wiley & Sons. This book was released on 2017-03-06 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Resonance Imaging in Tissue Engineering provides a unique overview of the field of non-invasive MRI assessment of tissue engineering and regenerative medicine Establish a dialogue between the tissue-engineering scientists and imaging experts and serves as a guide for tissue engineers and biomaterial developers alike Provides comprehensive details of magnetic resonance imaging (MRI) techniques used to assess a variety of engineered and regenerating tissues and organs Covers cell-based therapies, engineered cartilage, bone, meniscus, tendon, ligaments, cardiovascular, liver and bladder tissue engineering and regeneration assessed by MRI Includes a chapter on oxygen imaging method that predominantly is used for assessing hypoxia in solid tumors for improving radiation therapy but has the ability to provide information on design strategies and cellular viability in tissue engineering regenerative medicine
Download or read book EPR IMAGING and IN VIVO EPR written by Gareth R. Eaton and published by CRC Press. This book was released on 2018-01-18 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a detailed examination of the physical basis for EPR imaging and in vivo EPR spectroscopy, experimental arrangements, and data analysis. The EPR imaging methods described include continuous wave, spin-echo-detected and ENDOR-detected EPR with constant, stepped, modulated, and pulsed magnetic field gradients. Applications described include inhomogeneous materials, diffusion kinetics, reaction kinetics, orientation of liquid crystals, microwave distributions, magnetic field distributions, superconductors, radiation damage, and defects in solids. The book also covers other topics important to in vivo studies, including in vivo EPR spectroscopy, low-frequency EPR, state-of-the-art low-frequency EPR instruments, achievable sensitivity, and spin labels. The book will be of great interest to graduate students, researchers, and medical instrument developers who use EPR, as well as clinicians and chemists interested in the relationship between in vivo radicals (such as superoxide and diseases).
Download or read book Measuring Oxidants and Oxidative Stress in Biological Systems written by Lawrence J. Berliner and published by Springer Nature. This book was released on 2020-08-08 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.
Download or read book Very High Frequency VHF ESR EPR written by Oleg Grinberg and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of Very High Frequency EPR (VHF EPR) or sometimes called Very High Field EPR (conveniently, also abbreviated as VHF EPR) has blossomed during the past decade, especially after the original pioneering work of Ya. S. Lebedev and his group at the Institute of Chemical Physics, Russian Academy of Sciences in Moscow. Although Lebedev suffered heavily under the economic constraints of the communist Soviet Union and then succumbed to cancer at the peak of his scientific career, his groundbreaking work from the 1970's is still considered today to be the 'gold standard' by researchers practicing EPR at high magnetic fields. A stimulus for the production of this book is the legacy of Yakov Levedev in his students now residing in academic positions in the US and elsewhere. The aim of this book is to highlight the state of this growing field. This is an attempt to cover the full scope of VHF EPR in a single volume. The idea for this volume came to the editors at the 2001 Rocky Mountain Analytical Conference during the 24th International EPR Symposium chaired by Sandra and Gareth Eaton. VHF EPR was presented as an independent research field at a workshop organized by LC BruneI and supported by the National High Magnetic Field Laboratory, a National Science Foundation funded facility at Florida State University.
Download or read book Biomedical EPR Part A Free Radicals Metals Medicine and Physiology written by Sandra S. Eaton and published by Springer Science & Business Media. This book was released on 2006-01-20 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical EPR – Part A focuses on applications of EPR spectroscopy in the areas of free radicals, metals, medicine, and physiology. The book celebrates the 70th birthday of Prof. James S. Hyde, Medical College of Wisconsin, and his contributions to this field. Chapters are written to provide introductory material for new-comers to the field which lead into up-to-date reviews that provide perspective on the wide range of questions that can be addressed by EPR. Key Features: Free Radicals in Medicine Radicals in vivo and in Model Systems, and their Study by Spin Trapping In vivo EPR, including Oximetry and Imaging Time Domain EPR at Radio Frequencies EPR of Copper Complexes: Motion and Frequency Dependence Time Domain EPR and Electron Spin Echo Envelope Modulation
Download or read book Foundations of Modern EPR written by Gareth R. Eaton and published by World Scientific. This book was released on 1998 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its inception 50 years ago, electron paramagnetic resonance (EPR, also called ESR or EMR) has become a major tool in diverse fields ranging from biology and chemistry to solid state physics and materials science. This important book includes personal descriptions of early experiments by pioneers who laid the foundations for the field, perspectives on the state of the art, and glimpses of future opportunities. It presents a broad view of the foundations of EPR and its applications, and will therefore appeal to scientists in many fields. Even the expert will find here history not previously recorded and provocative views of future directions.
Download or read book Biomedical EPR Part B Methodology Instrumentation and Dynamics written by Sandra S. Eaton and published by Springer Science & Business Media. This book was released on 2004 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical EPR – Part A focuses on applications of EPR spectroscopy in the areas of free radicals, metals, medicine, and physiology. The book celebrates the 70th birthday of Prof. James S. Hyde, Medical College of Wisconsin, and his contributions to this field. Chapters are written to provide introductory material for new-comers to the field which lead into up-to-date reviews that provide perspective on the wide range of questions that can be addressed by EPR. Key Features:Free Radicals in Medicine Radicals in vivo and in Model Systems, and their Study by Spin Trapping In vivo EPR, including Oximetry and Imaging Time Domain EPR at Radio Frequencies EPR of Copper Complexes: Motion and Frequency Dependence Time Domain EPR and Electron Spin Echo Envelope Modulation About the Editors: Prof. Sandra S. Eaton is John Evans Professor in the Department of Chemistry and Biochemistry at the University of Denver. Her research interests include distance measurements in proteins, EPR of metal ions in biological systems, electron spin relaxation times, and EPR instrumentation. The Eatons co-organize an annual EPR Symposium in Denver. Prof. Gareth R. Eaton is John Evans Professor in the Department of Chemistry and Biochemistry at the University of Denver. His research interests include EPR instrumentation, distance measurements in proteins, EPR of metal ions in biological systems, and electron spin relaxation times. Dr. Lawrence J. Berliner is currently Professor and Chair of the Department of Chemistry and Biochemistry at the University of Denver after retiring from Ohio State University, where he spent a 32-year career in the area of biological magnetic resonance (EPR and NMR). He is the Series Editor for Biological Magnetic Resonance, which he launched in 1979.
Download or read book Computational and Instrumental Methods in EPR written by Christopher J. Bender and published by Springer Science & Business Media. This book was released on 2007-12-27 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational and Instrumental Methods in EPR is devoted to both instrumentation and computation aspects of EPR, while addressing applications such as spin relaxation time measurements. However, this is the first comprehensive volume to offer practical, non-invasive spectroscopic methods of analyzing the rheology of biopolymers: comparative studies of polymer fluidity using traditional methods (e.g. viscosity) and nuclear magnetic resonance.
Download or read book High Resolution EPR written by Graeme Hanson and published by Springer Science & Business Media. This book was released on 2009-06-19 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metalloproteins comprise approximately 30% of all known proteins, and are involved in a variety of biologically important processes, including oxygen transport, biosynthesis, electron transfer, biodegradation, drug metabolism, proteolysis, and hydrolysis of amides and esters, environmental sulfur and nitrogen cycles, and disease mechanisms. EPR spectroscopy has an important role in not only the geometric structural characterization of the redox cofactors in metalloproteins but also their electronic structure, as this is crucial for their reactivity. The advent of x-ray crystallographic snapshots of the active site redox cofactors in metalloenzymes in conjunction with high-resolution EPR spectroscopy has provided detailed structural insights into their catalytic mechanisms. This volume was conceived in 2005 at the Rocky Mountain Conference on Analytical Chemistry (EPR Symposium) to highlight the importance of high-resolution EPR spectroscopy to the structural (geometric and electronic) characterization of redox active cofactors in metalloproteins. We have been fortunate to have enlisted internationally recognized experts in this joint venture to provide the scientific community with an overview of high-resolution EPR and its application to metals in biology. This volume, High-Resolution EPR: Applications to Metalloenzymes and Metals in Medicine, covers high-resolution EPR methods, iron proteins, nickel and copper enzymes, and metals in medicine. An eloquent synopsis of each chapter is provided by John Pilbrow in the Introduction. A second volume, Metals in Biology: Applications of High-Resolution EPR to Metalloenzymes, will appear later this year covering the complement of other metalloproteins. One of the pioneers in the development of pulsed EPR and its application to metalloproteins was Arthur Schweiger, whose contribution we include in this volume. Unfortunately, he passed away suddenly during the preparation of this volume. The editors and coauthors are extremely honored to dedicate this volume to the memory of Arthur Schweiger in recognition of his technical advances and insights into pulsed EPR and its application to metalloproteins. Arthur was extremely humble and treated everyone with equal respect. He was a gifted educator with an ability to explain complex phenomena in terms of simple intuitive pictures, had a delightful personality, and continues to be sadly missed by the community. It is an honor for the editors to facilitate the dissemination of these excellent contributions to the scientific community. Suggestions for future volumes are always appreciated.
Download or read book Biomedical EPR Part B Methodology Instrumentation and Dynamics written by Sandra S. Eaton and published by Springer Science & Business Media. This book was released on 2006-05-06 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical EPR – Part B focuses on applications of EPR techniques and instrumentation, with applications to dynamics. The book celebrates the 70th birthday of Prof. James S. Hyde, Medical College of Wisconsin, and his contributions to this field. Chapters are written to provide introductory material for new-comers to the field that lead into up-to-date reviews that provide perspective on the wide range of questions that can be addressed by EPR. Key Features: EPR Techniques including Saturation Recovery, ENDOR, ELDOR, and Saturation Transfer Instrumentation Innovations including Loop Gap Resonators, Rapid Mixing, and Time Locked Sub-Sampling Motion in Biological Membranes Applications to Structure Determination in Proteins Discussion of Trends in EPR Technology and Prognosis for the Future
Download or read book Distance Measurements in Biological Systems by EPR written by Lawrence J. Berliner and published by Springer Science & Business Media. This book was released on 2006-02-20 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: Distance measurements in biological systems by EPR The foundation for understanding function and dynamics of biological systems is knowledge of their structure. Many experimental methodologies are used for determination of structure, each with special utility. Volumes in this series on Biological Magnetic Resonance emphasize the methods that involve magnetic resonance. This volume seeks to provide a critical evaluation of EPR methods for determining the distances between two unpaired electrons. The editors invited the authors to make this a very practical book, with specific numerical examples of how experimental data is worked up to produce a distance estimate, and realistic assessments of uncertainties and of the range of applicability, along with examples of the power of the technique to answer biological problems. The first chapter is an overview, by two of the editors, of EPR methods to determine distances, with a focus on the range of applicability. The next chapter, also by the Batons, reviews what is known about electron spin relaxation times that are needed in estimating distances between spins or in selecting appropriate temperatures for particular experiments. Albert Beth and Eric Hustedt describe the information about spin-spin interaction that one can obtain by simulating CW EPR line shapes of nitroxyl radicals. The information in fluid solution CW EPR spectra of dual-spin labeled proteins is illustrated by Hassane Mchaourab and Eduardo Perozo.
Download or read book EPR in the 21st Century written by Asako Kawamori and published by Elsevier. This book was released on 2002-07-01 with total page 853 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Proceedings in this volume are a refereed selection of presentations from The Third Asia-Pacific EPR/ESR Symposium (APES'01), held in Kobe, Japan from October 29 to November 1, 2001. Participants from 20 countries from Asia, Australia, Europe, North and South America presented 210 papers, of which 132 are included here. These Proceedings are also a blueprint for development of electron paramagnetic resonance (EPR) / electron spin resonance (ESR) in the Asia-Pacific region in the 21st century. The Symposium reflected a variety of research fields developed over half a century and focuses especially on the most recent developments, such as high-field and high-frequency EPR, which are envisaged to be further developed and applied to various fields in the 21st century. All sessions consisted of Plenary, Invited and Contributed presentations. The Plenary presentations aimed at summarizing the overall developments. Invited presentations, reviewing the most recent developments, and Contributed ones, dealing with original research recently carried out in the EPR/ESR area, were given in one of three parallel sessions. The unique research works presented cover various fields and reflect the existing diversity of applications of the EPR/ESR techniques.
Download or read book Tumor Markers Research Perspective written by Geoffrey A. Sinise and published by Nova Publishers. This book was released on 2007 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumour markers are molecules occurring in blood or tissue that are associated with cancer, and whose measurement or identification is useful in patient diagnosis or clinical management. This book analyses potential signals of cancerous tumours, otherwise known as markers or indicators. This includes, direct and rapid determination of cancer antigen, potential tumour markers for cholangiocarcinoma, melanoma inhibitory activity, metastatic uveal melanoma, measurement of tumour oxygenation, bladder cancer markers, epithelial cell adhesion and progression markers in prostate tumours.
Download or read book Quantitative EPR written by Gareth R. Eaton and published by Springer Science & Business Media. This book was released on 2010-04-10 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a growing need in both industrial and academic research to obtain accurate quantitative results from continuous wave (CW) electron paramagnetic resonance (EPR) experiments. This book describes various sample-related, instrument-related and software-related aspects of obtaining quantitative results from EPR expe- ments. Some speci?c items to be discussed include: selection of a reference standard, resonator considerations (Q, B ,B ), power saturation, sample position- 1 m ing, and ?nally, the blending of all the factors together to provide a calculation model for obtaining an accurate spin concentration of a sample. This book might, at ?rst glance, appear to be a step back from some of the more advanced pulsed methods discussed in recent EPR texts, but actually quantitative “routine CW EPR” is a challenging technique, and requires a thorough understa- ing of the spectrometer and the spin system. Quantitation of CW EPR can be subdivided into two main categories: (1) intensity and (2) magnetic ?eld/mic- wave frequency measurement. Intensity is important for spin counting. Both re- tive intensity quantitation of EPR samples and their absolute spin concentration of samples are often of interest. This information is important for kinetics, mechanism elucidation, and commercial applications where EPR serves as a detection system for free radicals produced in an industrial process. It is also important for the study of magnetic properties. Magnetic ?eld/microwave frequency is important for g and nuclear hyper?ne coupling measurements that re?ect the electronic structure of the radicals or metal ions.
Download or read book Ultra High Field Magnetic Resonance Imaging written by Pierre-Marie Robitaille and published by Springer Science & Business Media. This book was released on 2007-12-31 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: The foundation for understanding the function and dynamics of biological systems is not only knowledge of their structure, but the new methodologies and applications used to determine that structure. This volume in Biological Magnetic Resonance emphasizes the methods that involve Ultra High Field Magnetic Resonance Imaging. It will interest researchers working in the field of imaging.
