Download or read book Targeted Drug Delivery Concepts and Design written by Padma V. Devarajan and published by Springer. This book was released on 2014-12-08 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.
Download or read book Fundamentals of Protein Structure and Function written by Engelbert Buxbaum and published by Springer. This book was released on 2015-11-27 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, taking into account the physiological, pharmacological and medical significance of this often neglected topic. This is followed by thorough coverage of hæmoglobin and myoglobin, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins to various cell compartments and solute transport across biological membranes. Proteins in the laboratory are also covered, including a detailed description of the purification and determination of proteins, as well as their characterisation for size and shape, structure and molecular interactions. The book emphasises the link between protein structure, physiological function and medical significance. This book can be used for graduate and advanced undergraduate classes covering protein structure and function and as an introductory text for researchers in protein biochemistry, molecular and cell biology, chemistry, biophysics, biomedicine and related courses. About the author: Dr. Buxbaum is a biochemist with interest in enzymology and protein science. He has been working on the biochemistry of membrane transport proteins for nearly thirty years and has taught courses in biochemistry and biomedicine at several universities.
Download or read book Antimalarial Chemotherapy written by Philip J. Rosenthal and published by Springer Science & Business Media. This book was released on 2001-04-01 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.
Download or read book Bioprobes written by H. Osada and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid advances in the study of the molecular basis of mammalian cell proliferation, differentiation, and apoptosis have made it possible to develop new screening systems for isolating from microbial metabolites specific inhibitors of mammalian cell functions. "Bioprobes" is the term used to describe these inhibitors, which are extremely useful agents in investigating the molecular and chemical regulation of eukaryotic cell function and apoptosis. Another area where bioprobes are playing an important role is research into immune cell function. This book is the first to present the groundbreaking applications of bioprobes as tools for biochemical research. A large appendix contains the chemical structure, origin, function, key references, and other essential data for more than 80 important bioprobes. The information for each bioprobe is shown in a two-page display, in an easy-to-use format for identifying specific bioprobes for investigation of cell function.
Download or read book Bioactive Essential Oils and Cancer written by Damião Pergentino de Sousa and published by Springer. This book was released on 2015-09-10 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a general overview of the therapeutic potential of the essential oils in cancer and highlights some promising future directions. It integrates chemistry, pharmacology, and medicine while discussing bioactive essential oils in experimental models and clinical studies of cancer. The book is a valuable resource for all engaged in the study of natural products and their synthetic derivatives, particularly for those interested in academic research and pharmaceutical and food industries dedicated in the discovery of useful agents for the therapy or prevention of cancer.
Download or read book Endosymbiosis written by Wolfgang Löffelhardt and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: The origin of energy-conserving organelles, the mitochondria of all aerobic eukaryotes and the plastids of plants and algae, is commonly thought to be the result of endosymbiosis, where a primitive eukaryote engulfed a respiring α-proteobacterium or a phototrophic cyanobacterium, respectively. While present-day heterotrophic protists can serve as a model for the host in plastid endosymbiosis, the situation is more difficult with regard to (the preceding) mitochondrial origin: Two chapters describe these processes and theories and inherent controversies. However, the emphasis is placed on the evolution of phototrophic eukaryotes: Here, intermediate stages can be studied and the enormous diversity of algal species can be explained by multiple secondary and tertiary (eukaryote-eukaryote) endosymbioses superimposed to the single primary endosymbiotic event. Steps crucial for the establishment of a stable, mutualistic relationship between host and endosymbiont, as metabolic symbiosis, recruitment of suitable metabolite transporters, massive gene transfer to the nucleus, development of specific translocases for the re-import of endosymbiont proteins, etc. are discussed in individual chapters. Experts, dealing with biochemical, genetic and bioinformatic approaches provide insight into the state of the art of one of the central themes of biology. The book is written for graduate students, postdocs and scientists working in evolutionary biology, phycology, and phylogenetics.
Download or read book Encyclopedia of Molecular Pharmacology written by Stefan Offermanns and published by Springer Science & Business Media. This book was released on 2008-08-14 with total page 1515 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.
Download or read book Protein Folding in the Cell written by and published by Elsevier. This book was released on 2002-02-20 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Advances in Protein Chemistry provides a broad, yet deep look at the cellular components that assist protein folding in the cell. This area of research is relatively new--10 years ago these components were barely recognized, so this book is a particularly timely compilation of current information. Topics covered include a review of the structure and mechanism of the major chaperone components, prion formation in yeast, and the use of microarrays in studying stress response. Outlines preceding each chapter allow the reader to quickly access the subjects of greatest interest. The information presented in this book should appeal to biochemists, cell biologists, and structural biologists.
Download or read book The Chloroplast written by Anna Stina Sandelius and published by Springer Science & Business Media. This book was released on 2008-12-11 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chloroplasts are vital for life as we know it. At the leaf cell level, it is common knowledge that a chloroplast interacts with its surroundings – but this knowledge is often limited to the benefits of oxygenic photosynthesis and that chloroplasts provide reduced carbon, nitrogen and sulphur. This book presents the intricate interplay between chloroplasts and their immediate and more distant environments. The topic is explored in chapters covering aspects of evolution, the chloroplast/cytoplasm barrier, transport, division, motility and bidirectional signalling. Taken together, the contributed chapters provide an exciting insight into the complexity of how chloroplast functions are related to cellular and plant-level functions. The recent rapid advances in the presented research areas, largely made possible by the development of molecular techniques and genetic screens of an increasing number of plant model systems, make this interaction a topical issue.
Download or read book Molecular Biology of Steroid and Nuclear Hormone Receptors written by Leonard Freedman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intracellular Receptors: New Instruments for a Symphony of Signals In the late eighteenth century, it was proposed on theoretical grounds that each of the body's organs, beginning with the brain, must be "a factory and laboratory of a specific humor which it returns to the blood", and that these circulating signals "are indispensable for the life of the whole" (Bordeu 1775). During the nineteenth cen tury, some remarkable physiological experiments revealed the actions of humoral factors that affected the for and function of multiple tissues, organs and organ sys tems within the body (Berthold 1849); much later, the chemical and molecular na ture of some of those factors was determined. Against this deep historical backdrop of the founding studies of intercellular signaling, molecular biology sprang into existence a mere forty years ago, rooted in the revelation of regulable gene expression in bacteria. But contemporaneous with those classical analyses of transcriptional regulation of the lactose operon, the mod em era of signal transduction was inaugurated by the identification of cAMP as a second messenger -- an intracellular mediator of hormonal activation of glycogen catabolism (Sutherland and RaIl 1960). Later in that same decade, it emerged that cAMP is a critical signal not only in metazoans, but even in bacteria, where it serves an analogous function as a critical switch that activates expression of genes re quired for catabolism of complex carbon sources, including those of the lactose operon.
Download or read book Hsp90 in Cancer Beyond the Usual Suspects written by and published by Academic Press. This book was released on 2016-02-23 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hsp90 in Cancer: Beyond the Usual Suspects, the latest volume in the Advances in Cancer Research series, focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins and discusses some of the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression. - Focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins - Highlights the rapidly evolving understanding of the fundamental roles of Hsp90 in cancer biology - Discusses the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression
Download or read book Literary Studies in English written by Tess Clarke and published by . This book was released on 2016-06-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to examine multiple literary texts and works by applying various cultural and literary theories & criticism. The application of these theories helps in deciphering novel meanings and understanding of the textual elements. The book encompasses texts and articles from the literary canon as well as contemporary literature from around the world which offer a broader perspective on the interaction between various socio-cultural elements that shape literary works. It aims to understand the formation of new meanings and paradigms that emerge out these literary analyses and reviews. This book is a great resource for all the students, academicians and critics who are looking for recent perspectives on different literary texts and works.
Download or read book Phosphoinositides I Enzymes of Synthesis and Degradation written by Tamas Balla and published by Springer Science & Business Media. This book was released on 2012-03-08 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.
Download or read book Protein Misassembly written by and published by Academic Press. This book was released on 1997-10-22 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role that primary amino acid sequences plays in influencing the partitioning of polypeptides between productive folding and irreversible aggregation pathways has introduced a whole new dimension to the folding problem. The volume deals with the structures of the products of protein misassembly and the role of amino acid sequences in favoring these structures.
Download or read book Her Lifeline written by L. A. Casey and published by Montlake Romance. This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: From New York Times bestselling author L.A. Casey comes an irresistible tale of first love and second chances. Erin has had a crush on her brother's best friend Ward for as long as she can remember. But eleven years ago he disappeared from their lives--breaking Erin's trust, and her heart. When the person they both love most--Erin's brother Tommy--is nearly killed in a terrible crash, she and Ward are thrown back together for the first time. Their lives couldn't be further apart. Erin still lives at home, working two jobs and dealing with a series of family disasters. Ward, now a multibillionaire entrepreneur and a household name, seems determined to make amends--but it may just be too little too late. And while Erin can't deny feeling a spark at the sight of Ward, is it a spark of love or burning resentment? At odds with one another but forced to share their heartache, have Erin and Ward really drifted apart forever, or have they finally found the anchor they both so desperately need?
