Download or read book Improved Brain PET Quantification Using Partial Volume Correction Techniques written by Benjamin Aneurin Thomas and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Improved Brain PET Quantification Using Partial Volume Correction Techniques written by B. A. Thomas and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Positron emission tomography (PET) suffers from a degradation in quantitative accuracy due to a phenomenon known as the partial volume effect (PVE). The effects are due to the limited spatial resolution of the scanner. Methods that correct for PVEs are known as partial volume correction (PVC) techniques and are either data-driven or make use of anatomical information from other modalities such as magnetic resonance (MR) imaging. This thesis reports investigations into PVC techniques for improving the quantification of brain amyloid PET tracers. These tracers image amyloid plaque aggregation in-vivo, which is a pathological hallmark of Alzheimer's disease. An extension to existing anatomy-based PVC methods is reported. Region-based voxelwise (RBV) correction has been shown to reduce PVE-induced regional bias and variance when compared to commonly applied PVC techniques. This has been proven in phantom studies and observed in clinical data. In addition, RBV has been used to demonstrate that white matter variability exists in two different amyloid tracers. This finding has implications for the application of PVC in amyloid imaging and also how scans should be normalised. Alternative reference regions were investigated in two amyloid PET tracers. The brain stem, in combination with PVC, was found to result in the strongest agreement between tracers. Anatomy-based PVC techniques rely on parcellations of structural images. These parcellations are not necessarily representative of the PET data. A further extension to RBV is proposed which iteratively modifies the parcellations to find an optimal PVC in terms of the observed PET data. This novel technique reduces quantification errors due to PET-MR mismatch and has the potential to provide an additional parameter of 'functional volume change' in longitudinal studies.

Download or read book Quantitative Functional Brain Imaging with Positron Emission Tomography written by Richard E. Carson and published by Elsevier. This book was released on 1998-09-08 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest scientific developments in the field of positron emission tomography (PET) dealing with data acquisition, image processing, applications, statistical analysis, tracer development, parameter estimation, and kinetic modeling. It covers improved methodology and the application of existing techniques to new areas. The text also describes new approaches in scanner design and image processing, and the latest techniques for modeling and statistical analyses. This volume will be a useful reference for the active brain PET scientist, as well as a valuable introduction for students and researchers who wish to take advantage of the capabilities of PET to study the normal and diseased brain. Authored by international authorities in PET Provides the latest up-to-date techniques and applications Covers all fundamental disciplines of PET in one volume A comprehensive resource for students, clinicians, and new PET researchers

Download or read book Basic Science of PET Imaging written by Magdy M. Khalil and published by Springer. This book was released on 2016-11-07 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a wide-ranging and up-to-date overview of the basic science underlying PET and its preclinical and clinical applications in modern medicine. In addition, it provides the reader with a sound understanding of the scientific principles and use of PET in routine practice and biomedical imaging research. The opening sections address the fundamental physics, radiation safety, CT scanning dosimetry, and dosimetry of PET radiotracers, chemistry and regulation of PET radiopharmaceuticals, with information on labeling strategies, tracer quality control, and regulation of radiopharmaceutical production in Europe and the United States. PET physics and instrumentation are then discussed, covering the basic principles of PET and PET scanning systems, hybrid PET/CT and PET/MR imaging, system calibration, acceptance testing, and quality control. Subsequent sections focus on image reconstruction, processing, and quantitation in PET and hybrid PET and on imaging artifacts and correction techniques, with particular attention to partial volume correction and motion artifacts. The book closes by examining clinical applications of PET and hybrid PET and their physiological and/or molecular basis in conjunction with technical foundations in the disciplines of oncology, cardiology and neurology, PET in pediatric malignancy and its role in radiotherapy treatment planning. Basic Science of PET Imaging will meet the needs of nuclear medicine practitioners, other radiology specialists, and trainees in these fields.

Download or read book Quantitative Analysis in Nuclear Medicine Imaging written by Habib Zaidi and published by Springer Science & Business Media. This book was released on 2006-07-11 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a review of image analysis techniques as they are applied in the field of diagnostic and therapeutic nuclear medicine. Driven in part by the remarkable sophistication of nuclear medicine instrumentation and - crease in computing power and its ready and inexpensive availability, this is a relatively new yet rapidly expanding field. Likewise, although the use of nuclear imaging for diagnosis and therapy has origins dating back almost to the pioneering work of Dr G. de Hevesy, quantitative imaging has only recently emerged as a promising approach for diagnosis and therapy of many diseases. An effort has, therefore, been made to place the reviews provided in this book in a broader context. The effort to do this is reflected by the inclusion of introductory chapters that address basic principles of nuclear medicine instrumentation and dual-modality imaging, followed by overview of issues that are closely related to quantitative nuclear imaging and its potential role in diagnostic and therapeutic applications. A brief overview of each chapter is provided below. Chapter 1 presents a general overview of nuclear medicine imaging physics and instrumentation including planar scintigraphy, single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Nowadays, patients’ diagnosis and therapy is rarely done without the use of imaging technology. As such, imaging considerations are incorporated in almost every chapter of the book. The development of dual-modality - aging systems is an emerging research field, which is addressed in chapter 2.

Download or read book Quantification of Brain Function Using PET written by and published by Elsevier. This book was released on 1996-07-17 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional imaging of the brain is one of the most rapidly advancing areas of neuroscience and Positron Emission Tomography (PET) plays a major role in this progress. This book provides a comprehensive overview of the current status of PET and state-of-the-art neuroimaging. It is comprised of summaries of the presentations by experts in the field. Topics covered include radiotracer selection, advances in instrumentation, image reconstruction and data analysis, and statistical mapping of brain activity. This book focuses on the accuracy of the functional image and the strategies for addressing clinical, scientific, and diagnostic questions. Covers the PET imaging process from tracer selection to analysis and interpretation Contains 79 concise reports with abundant illustrations The definitive state-of-the-art book for functional neuroscience with PET

Download or read book MR Guided PET Image Restoration for Neurological Applications written by Marzieh S. Tahaei and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "PET and MR provide complementary information for diagnosis and treatment planning for patients as well as for studying the biological and pathological processes in the human brain. Therefore many PET studies are also coupled with MR imaging. PET images suffer from high noise and low spatial resolution compared to T1-weighted images. The main objective of this dissertation is to develop methods that use superior anatomical information inherent in the subject’s T1-weighted MR image to help reduce noise and improve spatial resolution in PET images.To this end, we first propose a PET reconstruction method in which the PET image is re-parameterized using patch-based basis functions, learned from the subject's T1-weighted MR image. Also, a reconstruction algorithm that imposes sparsity on the parameters is proposed and used to find a sparse set of coefficients for the MR-based basis functions. The results suggest that the proposed method can provide considerable improvement in the quality of reconstructed images compared to the standard penalized likelihood framework.Post reconstruction methods are of great interest in the analysis of PET data as they can be applied to large multicentre datasets in which raw measurement data is not available. Therefore, as the second objective of this dissertation, we develop a dual re-parameterization that restores PET images after they are reconstructed using a conventional method. This dual re-parameterization uses kernels extracted from the T1-weighted MR image without segmentation and the median filtered PET image to represent the restored image. An algorithm for estimating the coefficients of these basis functions is proposed. Moreover, a fast non-iterative method that uses guided filtering to restore PET images. The proposed methods are compared to other denoising methods and the results show improvement in the image quality in terms of the error within the brain and the bias and variance of PET-specific lesions.The accuracy of denoising and partial volume correction methods depends on the correct tuning of hyperparameters which are usually sensitive to the noise level and the amount of blurring in the image. For large multicentre datasets, this information may not be available. In this context, as the third objective of the thesis, a blind PET image restoration method is proposed. In the proposed framework, a deep neural network is trained on simulated PET images with different characteristics such as activity level, amount of smoothing, and the number of reconstruction iterations. Two models are trained, one with and one without a T1-weighted MR image as input. In addition, data inherent uncertainty is estimated in the proposed model. The resulting uncertainty map can be used to predict regions that may have a higher amount of error in the reconstructed image. The results of the test simulation data show significant improvement in image quality compared to the proposed guided filtering method. The application of the proposed method to real data shows promising generalizability across scanners and radiotracers"--

Download or read book Neuroimaging of Sleep and Sleep Disorders written by Eric Nofzinger and published by Cambridge University Press. This book was released on 2013-03-07 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: An up-to-date, superbly illustrated practical guide to the effective use of neuroimaging in the patient with sleep disorders. The only book to date to provide comprehensive coverage of this topic. A must for all healthcare workers interested in understanding the causes, consequences and treatment of sleep disorders.

Download or read book Instrumentation an Issue of Pet Clinics written by Habib Zaidi and published by Saunders. This book was released on 2008-03 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently there is no shortage of challenges and opportunities for PET instrumentation and quantitative imaging techniques. Molecular imaging technologies are leading to a revolutionary paradigm shift in health care and clinical practice. This issue reviews recent advances in PET instrumentation as well as volume correction strategies and strategies for motion tracking and correction, scatter compensation techniques, and attenuation correction techniques.

Download or read book Positron Emission Tomography written by Dale L. Bailey and published by Springer Science & Business Media. This book was released on 2006-07-06 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential for students, science and medical graduates who want to understand the basic science of Positron Emission Tomography (PET), this book describes the physics, chemistry, technology and overview of the clinical uses behind the science of PET and the imaging techniques it uses. In recent years, PET has moved from high-end research imaging tool used by the highly specialized to an essential component of clinical evaluation in the clinic, especially in cancer management. Previously being the realm of scientists, this book explains PET instrumentation, radiochemistry, PET data acquisition and image formation, integration of structural and functional images, radiation dosimetry and protection, and applications in dedicated areas such as drug development, oncology, and gene expression imaging. The technologist, the science, engineering or chemistry graduate seeking further detailed information about PET, or the medical advanced trainee wishing to gain insight into the basic science of PET will find this book invaluable. This book is primarily repackaged content from the Basic Science section of the 'big' Valk book on PET. It contains new, completely revised and unchanged chapters covering the "basic sciences" section of the main book - total 18 chapters: 2 new (chapters 1, 16) 8 completely revised (chapters 4, 5, 8, 13, 14, 15, 17, 18) 3 minor corrections (chapters 2, 6, 11) 5 unchanged (chapters 3, 7, 9, 10, 12)

Download or read book Statistical Parametric Mapping The Analysis of Functional Brain Images written by William D. Penny and published by Elsevier. This book was released on 2011-04-28 with total page 689 pages. Available in PDF, EPUB and Kindle. Book excerpt: In an age where the amount of data collected from brain imaging is increasing constantly, it is of critical importance to analyse those data within an accepted framework to ensure proper integration and comparison of the information collected. This book describes the ideas and procedures that underlie the analysis of signals produced by the brain. The aim is to understand how the brain works, in terms of its functional architecture and dynamics. This book provides the background and methodology for the analysis of all types of brain imaging data, from functional magnetic resonance imaging to magnetoencephalography. Critically, Statistical Parametric Mapping provides a widely accepted conceptual framework which allows treatment of all these different modalities. This rests on an understanding of the brain's functional anatomy and the way that measured signals are caused experimentally. The book takes the reader from the basic concepts underlying the analysis of neuroimaging data to cutting edge approaches that would be difficult to find in any other source. Critically, the material is presented in an incremental way so that the reader can understand the precedents for each new development. This book will be particularly useful to neuroscientists engaged in any form of brain mapping; who have to contend with the real-world problems of data analysis and understanding the techniques they are using. It is primarily a scientific treatment and a didactic introduction to the analysis of brain imaging data. It can be used as both a textbook for students and scientists starting to use the techniques, as well as a reference for practicing neuroscientists. The book also serves as a companion to the software packages that have been developed for brain imaging data analysis. An essential reference and companion for users of the SPM software Provides a complete description of the concepts and procedures entailed by the analysis of brain images Offers full didactic treatment of the basic mathematics behind the analysis of brain imaging data Stands as a compendium of all the advances in neuroimaging data analysis over the past decade Adopts an easy to understand and incremental approach that takes the reader from basic statistics to state of the art approaches such as Variational Bayes Structured treatment of data analysis issues that links different modalities and models Includes a series of appendices and tutorial-style chapters that makes even the most sophisticated approaches accessible

Download or read book Cerebrovascular Reactivity written by Jean Chen and published by Humana. This book was released on 2021-11-06 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive overview of the methodology, physiology, and contemporary and novel applications of cerebrovascular reactivity (CVR) measurements. The chapters in this book cover topics such as an introduction of the neurophysiology, neuroimaging, and clinical methods for CVR measurement; the use of CVR methods in the study of aging, cerebrovascular dysfunction, dementia, and brain tumors; and recommendations for measurement protocols and future applications in clinical translation. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your research center and clinical investigation. Thorough and comprehensive, Cerebrovascular Reactivity: Methodological Advances and Clinical Applications is a valuable tool that provides researchers in neuroscience and neurology with the latest resources on the measurement, interpretation, and application of CVR measurement.

Download or read book Progress in Brain Research written by J. P. Schadé and published by . This book was released on 1963 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Neuroimaging and Neurophysiology in Psychiatry written by David Linden and published by Oxford University Press. This book was released on 2016 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroimaging and Neurophysiology in Psychiatry is an invaluable guide through the methods and applications of neuroimaging and neurophysiology.

Download or read book Hybrid Cardiac Imaging written by Stephan G. Nekolla and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This clinically oriented book provides an up-to-date review on the various hybrid imaging modalities that may be employed for the purpose of cardiac imaging. After discussion of generic aspects of hybrid imaging, SPECT/CT, PET/CT, and PET/MRI are each considered in depth. In addition, information is provided on upcoming technologies, such as dedicated so-called fast cardiac cameras (CZT detector technology) and novel probes and radiotracers. A wide variety of topics are addressed, including important technological aspects, possible applications, imaging protocols, peculiarities of the available modalities, radiation exposure, and dose reduction. Last but not least, an estimation of the cost efficiency of dedicated and hybrid imaging devices in cardiology is provided and possible scenarios with respect to health care economics are envisioned. Hybrid Cardiac Imaging will be of particular value for nuclear medicine specialists, cardiologists, and radiologists and will also be of interest to medical physicists, medical technicians, and cardiothoracic surgeons. .

Download or read book Emission Tomography written by Miles N. Wernick and published by Elsevier. This book was released on 2004-12-07 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: PET and SPECT are two of today’s most important medical-imaging methods, providing images that reveal subtle information about physiological processes in humans and animals. Emission Tomography: The Fundamentals of PET and SPECT explains the physics and engineering principles of these important functional-imaging methods. The technology of emission tomography is covered in detail, including historical origins, scientific and mathematical foundations, imaging systems and their components, image reconstruction and analysis, simulation techniques, and clinical and laboratory applications. The book describes the state of the art of emission tomography, including all facets of conventional SPECT and PET, as well as contemporary topics such as iterative image reconstruction, small-animal imaging, and PET/CT systems. This book is intended as a textbook and reference resource for graduate students, researchers, medical physicists, biomedical engineers, and professional engineers and physicists in the medical-imaging industry. Thorough tutorials of fundamental and advanced topics are presented by dozens of the leading researchers in PET and SPECT. SPECT has long been a mainstay of clinical imaging, and PET is now one of the world’s fastest growing medical imaging techniques, owing to its dramatic contributions to cancer imaging and other applications. Emission Tomography: The Fundamentals of PET and SPECT is an essential resource for understanding the technology of SPECT and PET, the most widely used forms of molecular imaging. *Contains thorough tutorial treatments, coupled with coverage of advanced topics *Three of the four holders of the prestigious Institute of Electrical and Electronics Engineers Medical Imaging Scientist Award are chapter contributors *Include color artwork

Download or read book Advances in PET written by Jun Zhang and published by Springer Nature. This book was released on 2020-05-11 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a guide to new and emerging PET technology, instrumentation, and its place in clinical practice. PET technology is currently moving from the conventional photomultiplier tube (PMT) detector based PET to the new generation, solid state light sensor detector. This is a technological leap and holds significant implications for the use of PET imaging. This book introduces and describes the emerging and new generation of PET instrumentations and technologies across manufactures, focusing on solid-state PET detector designs, system characteristics, and clinical practices as well as future advanced Time-of-Flight (TOF) PET technologies. Organized into three sections, the basics of PET imaging; solid state digital PET instrumentation, technology, and clinical practice; and a look to the future of PET imaging, chapters present a full picture of PET imaging, where we are and where we will be. Nuclear medicine physicians, physicists, and technologists can use this book to better understand future PET systems, novel PET technologies, and potential game changes of clinical PET practice.