Download or read book Immunology of Milk and the Neonate written by Jiri Mestecky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the course of history, humans have attempted to interrupt the physiological and psychological bond formed between a nursing mother and her child by substituting breastfeeding with artificial formulas. A growing body of evidence indicates that breast milk, quite apart from its unsurpassed nutritive value, contains a large number of substances that protect the offspring from common infectious agents and allergens and promote the maturation of the gastrointestinal tract and the immune system. In addition to well described milk antibodies and soluble mediators of innate immunity, milk cells and pluripotent secreted factors - cytokines - are currently in the forefront of extensive research with respect to their importance in milk immunology. The purpose of this conference was to critically evaluate the current state of our knowledge concerning the protective role of immune agents found in milk, to provide up-to-date information of milk factors with respect to their role in the maturation of immunological defense systems in the neonate, and to reassess the importance of breastfeeding in the prevention of allergies in formula-fed infants. We hope that the work presented by international participants will prompt many new ideas and stimulate further research in this important area. This conference was sponsored primarily by the National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD. We would like to thank Drs. Sumner Yaffe and Delbert Dayton for their efforts with the organization, planning, and support of this conference.
Download or read book Milk Mucosal Immunity and the Microbiome Impact on the Neonate written by P.L. Ogra and published by S. Karger. This book was released on 2020-04-24 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considerable advances have been made in science in order to understand the varied mixture of bioactive components in human milk. The 94th Nestlé Nutrition Institute Workshop was designed to provide a comprehensive overview of the latest findings in human milk research and its potential to modulate mucosal immunity, the microbiome, and its impact on the neonate. The publication provides a balanced state-of-the-art update on the current knowledge about milk, mucosal immunity, and the microbiome as well as their impact on breastfeeding in mammalian neonates. The first part reviews data on the immunology of milk and lactation from a historical perspective to the latest scientific findings. The second part discusses the microbiology of human milk and lactation in detail, with a focus on premature infants and necrotizing enterocolitis. And finally, in the third part, light is shed on the protective factors in human milk and their role in influencing the neonate’s immune system. Important new insights will provide great scientific support for all people seeking a deeper understanding of human milk and its immunological properties and will enlarge the knowledge of those who have already specialized in human milk research.
Download or read book Immunology of Breast Milk written by Pearay L. Ogra and published by Raven Press (ID). This book was released on 1979 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: The mechanisms of immunity transfer to newborns through breast milk are not clearly understood. Biochemists exchanged information relevant to the systemic and local muscosal immunity system provided to the newborn by the mammary gland and its secretions. Topics include the functions of the mucosal immune system and the gut-associated and bronchial-associated lymphoid tissues, the transfer of maternal antibodies to fetus or newborn, andthe constituents of human colostrum and milk, such as immunoglobulins M, G, A, E and D, and cells B, T, NK and K. Questions which remain unanswered include stimulus and location of B-cell switching; the origin and acquisition of T-cell recognition patterns; cell migration and binding; maternal cell colonization of the infant; the presence of lymphokines and monokines; and the roles of basophils, most cells and esinophils.
Download or read book Infant Formula written by Institute of Medicine and published by National Academies Press. This book was released on 2004-06-10 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infant formulas are unique because they are the only source of nutrition for many infants during the first 4 to 6 months of life. They are critical to infant health since they must safely support growth and development during a period when the consequences on inadequate nutrition are most severe. Existing guidelines and regulations for evaluating the safety of conventional food ingredients (e.g., vitamins and minerals) added to infant formulas have worked well in the past; however they are not sufficient to address the diversity of potential new ingredients proposed by manufacturers to develop formulas that mimic the perceived and potential benefits of human milk. This book, prepared at the request of the Food and Drug Administration (FDA) and Health Canada, addresses the regulatory and research issues that are critical in assessing the safety of the addition of new ingredients to infants.
Download or read book The Immunology of Infant Feeding written by A. W. Wilkinson and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Though much thought is given to nutritional aspects of infant feeding, the complex immunological aspects have not been considered adequately, not only in the acceptance of the change to artificial feeding during this century, but also in developing feeds for total or supplementary feeding which will do minimal immunological damage. Besides food, mother's milk gives an orchestra of complex interacting bacteriostatic, bactericidal and anti-viral substances which contribute to the establishment of the normal intestinal flora. These mechanisms probably explain the many reports that breast fed babies get fewer infections than those fed artificially; deprivation from this effect of artificial feeding can be devastating in developing countries, with limited hygienic facilities, bad water supplies and sanitation. Infection is also more frequent in artificially fed infants in developed countries. Ingesting antigens is an important step in initiating the immune response, but the reSponse to such antigens is a controlled one, and besides antibody and cell mediated responses, partial tolerance, and immune exclusion (reduction of subsequent entry of antigen) occur. It is likely that food allergy, grossly neglected until recently, arises from disturbance of such mechanisms in the genetically vulnerable (immunodeficient) child.
Download or read book Protecting Infants through Human Milk written by Larry K. Pickering and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protecting Infants through Human Milk: Advancing the Scientific Evidence provides a forum in which basic scientists, clinicians, epidemiologists, and policy makers exchange the latest findings regarding the effects of human milk and breastfeeding on infant and maternal health, thereby fostering new and promising collaborations. This volume also integrates data from animal and in vitro laboratory studies with clinical and population studies to examine human milk production and composition, the mechanisms of infant protection and/or risk from human milk feeding, and proposed interventions related to infant feeding practices. Additionally, it stimulates critical evaluation of, and advances in, the scientific evidence base and research methods, and identifies the research priorities in various areas.
Download or read book Immunity in Compromised Newborns written by Per T. Sangild and published by Frontiers Media SA. This book was released on 2021-09-14 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Integrating Population Outcomes Biological Mechanisms and Research Methods in the Study of Human Milk and Lactation written by Margarett K. Davis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrating Population Outcomes, Biological Mechanisms and Research Methods in the Study of Human Milk and Lactation is the product of the 10th Conference of the International Society for Research on Human Milk and Lactation, held on September 15-19, 2000, in Tucson, Arizona. The presented sessions at the meeting are as diverse as the volume itself. These sessions include the impact of micronutrient deficiencies during lactation on maternal and infant health, the premature infant, developmental immunology, breastfeeding in the industrialized world, and viral transmission in milk. Whenever possible, the sessions were organized to include human population research, research showing the biological underpinnings of the effects on human health, and important methodological issues. This volume is a contemporary and influential tool for human milk biologists, breastfeeding epidemiologists, biochemists, immunologists, clinical specialists, and all professionals and researchers in the field.
Download or read book Human Milk in the Feeding of Preterm Infants Established and Debated Aspects written by Guido Eugenio Moro and published by Frontiers Media SA. This book was released on 2020-10-23 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Secretory Immunity and Infection written by Jerry R. McGhee and published by . This book was released on 1978 with total page 936 pages. Available in PDF, EPUB and Kindle. Book excerpt: An International Symposium concerning the secretory immune system and caries immunity was hosted by the Institute of Dental Research and The School of Dentistry at The University of Alabama in Birmingham, Alabama. Particular emphasis was given to aspects of secretory immunity including, the induction of an immune response, cellular events involved in differentiation and function of mucosal antibodies. Major emphasis was also given to the most recent advances in studies of bacterial antigens of importance in ecology, pathogenesis and immunity. Encouraging results from several laboratories indicate that the major goal - induction of protective immunity in external secretions - is attainable. This particularly concerns immunity to dental caries, the gastrointestinal enteropathies, and respiratory and urogenital infections. As a result of this meeting, the summation committee suggested future avenues of most relevant and productive research in the field of secretory immunity and infection.
Download or read book Immunobiology of Human Milk written by Lars A. Hanson and published by Hale Pub L P. This book was released on 2004-01-01 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunobiology of Human Milk provides a thorough understanding of the wondrous biology of the immune components in human milk and how they protect the breastfed infant. In this book, Dr. Hanson describes the elaborate systems that have developed to protect the infant against infections and to promote the infant's growth and neurodevelopment. Dr. Hanson has been studying the immunobiology of breastmilk since 1955, publishing 650 scientific papers and editing/contributing to 19 books. He is one of the most highly respected immunobiologists/pediatricians in the world. Features included in this book include the bacterial colonization of the newborn, components of host defense, host defense of the growing baby, the pregnant mother's support of host defense in the fetus, the breastfeeding mother's support of host defense, protection against disease provided by breastfeeding, and infectious agents in breastmilk and their impact on breastfeeding.
Download or read book Neonatal Nutrition for Inflammatory Disorders and Necrotizing Enterocolitis written by Misty Good and published by MDPI. This book was released on 2020-11-19 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Nutrients Special Issue focuses on neonatal nutritional advances for inflammatory disorders affecting infants such as necrotizing enterocolitis (NEC). Nutrition can significantly impact the development of certain diseases that afflict infants. This Special Issue aims to bring together the latest research on the role of nutrition in preventing or impacting neonatal disorders. Specifically, this Special Issue focuses on the role of breast milk or donor breast milk and the various components in milk that have been demonstrated to protect against NEC and other inflammatory diseases. This issue provides a comprehensive composite of the advances in nutritional strategies that can modulate or prevent neonatal intestinal disorders.
Download or read book Human Milk and Infant Development written by Margit Hamosh and published by S. Karger AG (Switzerland). This book was released on 1998-01-01 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue presents the most recent information on bioactive functions of human milk and its role in infant growth and development. Reviews provide new data on differences in growth patterns between breast-fed and formula-fed infants and on some of the unique nutritional characteristics of human milk. The role of long-chain polyunsaturated fatty acids (present in human milk but absent in most infant formulas) in neonatal development is discussed. Some chapters are dedicated to the protective functions of human milk, dealing with immune protection as well as nonimmune protection against a variety of microorganisms including viruses, bacteria and protozoa. Also emphasized are the mechanisms of protection provided by milk glycoproteins, proteins and lipids, as well as the immunomodulating function of the cytokines present in human milk. The discussion is rounded off by a chapter examining the short-term (during infancy) and long-term effects of breast-feeding. This useful publication is of interest for the practicing physician as well as the basic scientist concerned with neonatology, pediatrics, nutrition, immunology, molecular biology or community and preventive medicine.
Download or read book The Neonatal Immune System A Unique Host Microbial Interface written by Joseph M. Bliss and published by Frontiers Media SA. This book was released on 2018-01-25 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging from the protective environment of the uterus, the newborn is exposed to a myriad of microbes, and quickly establishes a complex microbiome that shapes the infant’s biology in ways that are only now beginning to come to light. Among these exposures are a number of potential pathogens. The host responses to these pathogens in the neonatal period are unique, reflecting a developing immune system even with delivery at term. Preterm infants are delivered at a time when host defense mechanisms are even less developed and therefore face additional risk. As such, the organisms that cause disease in this period are different from the pathogens that are common in other age groups, or the disease they cause manifests in more severe fashion. Developmental alterations in both innate and adaptive immune responses in neonates have been documented among many cell types and pathways over the last several decades. Contemporary insights into the human immune system and methodologies that allow an “omics” approach to these questions have continued to provide new information regarding the mechanisms that underlie the human neonate as an “immunocompromised host.” This Research Topic highlights studies related to this unique host-pathogen interface. Contributions include those related to the innate or adaptive immune system of neonates, their response to microbial colonization or infection, and/or the pathogenesis of microbes causing disease in neonates.
Download or read book Advances in Nutritional Research Volume 10 written by Bill Woodward and published by Taylor & Francis US. This book was released on 2001-11-30 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines various aspects of milk, with regard to allergies, immunology, toxicology, and general health, reflecting developments and research in these areas.
Download or read book Bioactive Components of Human Milk written by David S. Newburg and published by Springer Science & Business Media. This book was released on 2001-12-31 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major emphasis in this book is a compilation and definition of what is known about components of human milk, including glycoconjugates, that inhibit common pathogens of the infant. Also discussed are other bioactive constituents whose relevant biological roles are also beginning to be defined. Hormonal and cytokine activity, immunomodulating and autoinflammatory agents, xenobiotics, and conditionally essential nutrients in milk could have roles in the protection of the infant, but may also participate in digestive processes, maternal--infant communication, maturation of the gut, central nervous system, and other components of infant growth and development. Like the protective activities, these are discussed in terms of their presence in milk, structures, potential functions, and structure/function relationship. Components whose role is nutritional support during early development of the infant are also included.
Download or read book Neonatal Hematology written by Pedro A. de Alarcón and published by Cambridge University Press. This book was released on 2021-02-18 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential guide to the pathogenesis, diagnosis and management of hematologic problems in the neonate, covering erythrocyte disorders, leukocyte disorders, immunologic disorders and hemostatic disorders. Guidance is practical, including blood test interpretation, advice on transfusions and reference ranges for hematological values.
