Download or read book Immunological Control of Fertility Using Synthetic Peptide based Vaccines written by Nektaria Dimopoulos and published by . This book was released on 1997 with total page 43 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immunological Approaches to Contraception and Promotion of Fertility written by Gursaran Talwar and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contraceptive research has entered the new age of vaccines. Realistic prospects exist for the development of an entirely new battery of vaccines for use in human and veterinary medicine. Among them may be anti-fertility vaccines, based on physiological mechanisms applicable to either the female or male. This volume is a comprehensive review - a status report - of the subjects including fundamental work on the search for useful epitopes and ranging to applied vaccinology. One vaccine to prevent pregnancy, for use by women, has already been studied extensively. G.P. Talwar, the volume's editor and his colleagues in New Oelhi, India, published in 1976 a landmark series of papers describing the immunological properties of a preparation consisting of the alum-precipitated beta-subunit of human chorionic gonadotropin (hCG) chemically linked to tetanus toxoid. The principle of enhancing antigenicity of a self-protein by linkage of the epitope to a carrier protein was employed and tested clinically. These trials, carried out under the auspices of the Indian Council for Medical Research, were the first application of the carrier protein concept for a vaccine for human use. The encouraging results stimulated a wave of research not only on the use of hCG-based vaccines, but on other antigens as well.
Download or read book Recombinant and Synthetic Vaccines written by G. P. Talwar and published by Springer. This book was released on 1994 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccines have historically been the most cost effective agents for the prevention of human and animal diseases. This volume gives a state-of-the-art description of the recombinant and synthetic vaccines for animal use as well as for hepatitis, HIV, measles, etc. Extensively covered are Malaria and vaccines for the control of fertility. Also described are new recombinant vaccines for anti-tuberculosis immunity and hantavirus hemmorrhagic fever, the development of genetic toxoids for pertussis and cholera and new technologies enabling the delivery of multiple doses of vaccines at a single contact point. This volume with contributions by numerous experts will be a valuable addition in this rapidly developing field.
Download or read book Immunological Control of Fertility written by Mark P. Bradley and published by . This book was released on 1994 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Contraceptive Research and Development written by Institute of Medicine and published by National Academies Press. This book was released on 1996-11-04 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: The "contraceptive revolution" of the 1960s and 1970s introduced totally new contraceptive options and launched an era of research and product development. Yet by the late 1980s, conditions had changed and improvements in contraceptive products, while very important in relation to improved oral contraceptives, IUDs, implants, and injectables, had become primarily incremental. Is it time for a second contraceptive revolution and how might it happen? Contraceptive Research and Development explores the frontiers of science where the contraceptives of the future are likely to be found and lays out criteria for deciding where to make the next R&D investments. The book comprehensively examines today's contraceptive needs, identifies "niches" in those needs that seem most readily translatable into market terms, and scrutinizes issues that shape the market: method side effects and contraceptive failure, the challenge of HIV/AIDS and other sexually transmitted diseases, and the implications of the "women's agenda." Contraceptive Research and Development analyzes the response of the pharmaceutical industry to current dynamics in regulation, liability, public opinion, and the economics of the health sector and offers an integrated set of recommendations for public- and private-sector action to meet a whole new generation of demand.
Download or read book Antibodies Against Spermatozoal Surface written by Hans Jakob Ingerslev and published by . This book was released on 1981 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Using Science to Improve the BLM Wild Horse and Burro Program written by National Research Council and published by National Academies Press. This book was released on 2013-10-04 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using Science to Improve the BLM Wild Horse and Burro Program: A Way Forward reviews the science that underpins the Bureau of Land Management's oversight of free-ranging horses and burros on federal public lands in the western United States, concluding that constructive changes could be implemented. The Wild Horse and Burro Program has not used scientifically rigorous methods to estimate the population sizes of horses and burros, to model the effects of management actions on the animals, or to assess the availability and use of forage on rangelands. Evidence suggests that horse populations are growing by 15 to 20 percent each year, a level that is unsustainable for maintaining healthy horse populations as well as healthy ecosystems. Promising fertility-control methods are available to help limit this population growth, however. In addition, science-based methods exist for improving population estimates, predicting the effects of management practices in order to maintain genetically diverse, healthy populations, and estimating the productivity of rangelands. Greater transparency in how science-based methods are used to inform management decisions may help increase public confidence in the Wild Horse and Burro Program.
Download or read book Birth Control Vaccines written by G. P. Talwar and published by R G Landes Company. This book was released on 1995 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: For researchers and clinicians, explores the regulation of fertility with vaccines that act by mobilizing internal processes within the body, and so do not entail the continuous pharmacological intake of synthetic compounds. The idea of using vaccines against specifically targeted antigens in the bo
Download or read book 100 Years of Human Chorionic Gonadotropin written by Laurence A. Cole and published by Elsevier. This book was released on 2020-02-07 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: 100 years of Human Chorionic Gonadotropin: Reviews and New Perspectives is a collection of articles written by some of the world’s leading experts on the pregnancy hormone and cancer marker hCG. In 2019 it is difficult to ignore the effect that our understanding of hCG has had on the lives of millions of people worldwide. The hCG immunoassay, in one form or another, is now one of the most common medical tests conducted and is often the first indication that a mother-to-be is pregnant. Not only a marker of pregnancy, hCG is utilized in the diagnosis and monitoring in oncology and presents a potential target for novel cancer therapeutics. 100 years ago, in 1919, Hirose was demonstrating gonadotropic functions which resulted from a chorionic factor. Over the last century this factor has become defined as hCG and more recently explored as not one molecule but a group of molecules with variable structure and variable functions in both pregnancy and cancer. hCG is a multi-faceted molecule that has clinical and therapeutic implications but can be a challenging topic for researchers and physicians alike. This text covers the different structures and functions of hCG exploring the genes and evolution of the molecule, the different protein and glycosylation structures which can exist and their effect on structure, detection and quantification. 100 Years of hCG is not an attempt to recount the history of every publication on hCG, but rather a collection of reviews and new perspectives by "hCG-ologists", the term used by Hussa to describe biochemists working on HCG in the first book written on the topic over 30 years ago. Some of the authors have been around a while, some not so long, but others are just beginning their journey with a most beguiling molecule. Provides updated information on a complex and changing subject in five sections Reviews historical perspectives and developments over the last 100 years Includes novel insights into the structure, function and detection of hCG in pregnancy and cancer Includes chapters on the use of mass spectrometry to detect and quantify hCG as well as traditional immunoassays and over the counter pregnancy tests Describes the role of hCG in pregnancy, endometrial receptivity and embryo implantation and the use in fertility treatment Addresses the specific hyperglycosylated hCG test that can distinguish a normal term from a failing pregnancy and also screen for preeclampsia and gestational hypertension in pregnancy as well as its use as a marker and treatment target in cancer. Includes chapters on the development and use of hCG vaccines Includes a section on hCG and in subunits in cancer
Download or read book Immune Infertility written by Walter K.H. Krause and published by Springer. This book was released on 2016-11-02 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers comprehensive coverage of both basic and clinical aspects of immune reactions responsible for infertility. It has four sections focusing on Sperm antigens, Antisperm antibodies (ASAs), Clinical impact of ASAs, and Immune contraception, and include contributions from leading experts in these fields. This new edition of the book offers a comprehensive update that reflects the very significant advances in reproductive immunology that have been achieved over the past five years, especially related to the sperm proteome, sperm-egg binding/fusion proteins, gene knockout studies, and immunocontraception. Reproductive immunology continues to be a fast-growing discipline in which new knowledge is emerging almost every day. Immune Infertility is a model source of vital and reliable information on the latest scientific developments in the field. It will be of value for clinicians, scientists, students, residents, and fellows working in reproductive biology, obstetrics and gynecology, and urology.
Download or read book Reproductive Immunology written by Satish Kumar Gupta and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reproductive Immunology is a compilation of research articles presented during the VII International Congress of Reproductive Immunology which was held in New Delhi, India on 27-30 October 1998. The articles pertain to the following six major themes: Molecular and Immunological Aspects of Sperm-Egg Interaction Embryonic-Endometrial Cross-Talk Immunobiology of Pregnancy Autoantibodies and Infertility Immunocontraception Mucosal Immunology and Reproductive Tract Infections . The first section deals with our current understanding of various steps involved in fertilization. The functional significance of sperm surface mannosidase and glutathione S-transferases to bind zona pellucida is described. The role of zona pellucida glycoproteins in the binding of sperm, induction of acrosome reactions and avoidance of polyspermy is discussed. In the second section, the role of various cytokines, growth factors and immunomodulatory agents in implantation of embryos is described. In the field of reproductive immunology, one of the major issues is to explore the successful gestation of the histoincompatible fetus in the uterus of an immunologically competent mother. The Proceedings presents the issues of paternal antigens at the feto-maternal interface and shows that Th2-type of immunity is involved in normal successful conception. The role of membrane-bound and soluble HLA-G in protecting the fetus from the lytic activities of maternal uterine and peripheral blood natural killer (NK) cells is also presented. Nature's experiments suggest that antibodies against sperm-specific antigens are responsible for infertility in some women. The possibility that an immunogenetic background contributes to production of sperm-immobilizing antibodies in infertile women is discussed in the section on autoantibodies and infertility. The Proceedings presents the issue of Th1-type cytokines in inducing recurrent spontaneous abortions of unexplained etiology. The roles of β2-glycoprotein 1 (β2-GP1)-dependent anticardiolipin antibody, lupus anticoagulant, antiphospholipids, anti-thyroid antibody and anti-nuclear antibody in miscarriages are also described. The rising global human population, particularly in the developing countries, has driven the need for new and safer methods of contraception. Fertility regulation by vaccines is thus an interesting proposition. The section on contraceptive vaccines discusses the latest advances in this area and describes the current status of vaccines based on βhCG, sperm antigens, zona pellucida glycoproteins, and riboflavin carrier proteins. The issues of mucosal immunity and strategies for enhancing local genital immune responses to combat HIV infection is discussed. The role of inflammatory and related cytokines in chorioamnionitis is described. The contents of this Proceedings describes various facets of reproductive immunology which will help us to design strategies to combat genital infections and miscarriages caused by immunological etiology. Descriptions of the molecular basis of gamete recognition, implantation and survival of the allogenic fetus will help in designing strategies for overcoming infertility and also new contraceptive approaches. The Proceedings will be useful to researchers and clinicians involved in basic or applied research in the disciplines of reproductive biology, reproductive immunology, and obstetrics and gynecology.
Download or read book Vaccine Design written by Michael F. Powell and published by Springer. This book was released on 2012-12-06 with total page 977 pages. Available in PDF, EPUB and Kindle. Book excerpt: When my interest was first drawn to the phenomenon of vaccination for virus diseases in the late 1930s, the state of the art and the science of vaccine design was not far advanced beyond the time of Jenner at the end of the 18th century and of Pasteur a century later. In the 1930s it was still believed that for the induction of immunity to a virus-caused disease the experience of infection was required, but not for a toxin-caused disease such as diphtheria or tetanus, for which a chemically detoxified antigen was effective for immu nization. This prompted the question as to whether it might be possible to produce a similar effect for virus diseases using nonreplicating antigens. When in the 1930s and 1940s it was found possible to propagate influenza viruses in the chick embryo, protective effects could be induced without the need to experience infection by the use of a sufficient dose of a noninfectious influenza virus preparation. Later in the 1940s, it became possible to propagate polio and other viruses in cultures of human and monkey tissue and to immunize against other virus diseases in the same way. Later, with the advent of the era of molecular biology and genetic engineering, antigens and vaccines could be produced in new and creative ways, using either replicating or nonreplicating forms of the appropriate antigens for inducing a dose-related protective state.
Download or read book Gamete Immunology written by Hiroaki Shibahara and published by Springer Nature. This book was released on 2022-08-26 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the biology, diagnosis, treatment and the latest research on anti-sperm antibody (ASA) and anti-zona pellucida antibody (AZPA) produced in some infertile patients. It summarizes ASA in both men and women, and presents new research to serve as a guideline for medical treatment, which currently varies considerably. It also discusses the recently identified target antigens of these antibodies, and the latest immunocontraceptive development projects. The book features chapters on AZPA explaining the biological structure and function of the zona pellucida, and describing the abnormality and the antibody. It also provides insights into their evolution, presenting the differences in taxonomy, mammalian physiological functions and the morphologically and immunologically unique human zona pellucida. Gamete Immunology is a valuable resource for researchers, and postdocs who are curious about new research on ASA and AZPA. It offers clinicians and embryologists who are interested in gamete immunology diverse perspectives as well as the basis for new ideas to treat the antibodies and develop contraceptive vaccinogens.
Download or read book Fertility Control written by S.L. Corson and published by CRC Press. This book was released on 1995-12-15 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second edition of Corson, Derman, and Tyrer's complete medical textbook on fertility control. It has been revised and fully updated to include details about oral contraceptives and new progestins, the female condom, hormonal implantation, new information about IUDs, and the biochemistry, biological effects, and uses of mifepristone (RU-486).
Download or read book Immunological Aspects of Reproduction in Mammals written by D. B. Crighton and published by Butterworth-Heinemann. This book was released on 2014-05-20 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunological Aspects of Reproduction in Mammals contains papers presented during a symposium at the University of Nottingham Easter School. The scholarly presentations provide a wealth of information on the field of reproductive immunology and indicate just how complex this field is and how many questions still remain to be answered. The book begins with reviews of the current status of the complexities and uncertainties of the cellular basis of the immune response and the structure and function of antibodies. This is followed by separate chapters on the assessment and interpretation of the phenomena surrounding autoimmune and isoimmune reactions to spermatozoa; advances in defining the distribution and degree of exposure of major histocompatibility antigens; the reproductive immunology of the mouse, horse, and sheep; and fetal and neonatal immunity. Subsequent chapters present studies of immunization of several species with either the hypothalamic hormone LH-RH, pituitary gonadotrophins, or ovarian steroids; and studies directed towards efforts to enhance animal production by either active or passive immunization of female farm animals against steroid hormones. This book will be a valuable reference text for those already involved in the field and a stimulus for others to enter this complex and fascinating area of research.
Download or read book The Journal of Immunology written by and published by . This book was released on 2002 with total page 1430 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Veterinary Vaccinology written by Paul-Pierre Pastoret and published by Elsevier Science & Technology. This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. Vaccination is widely recognised as one of the most efficient tools in public health, showing obvious cost-benefit advantages for all target populations involved.Vaccines in the veterinary field can contribute greatly to the welfare of domestic and wild animals and, indirectly, to environmental protection. The aim of animal vaccination will increasingly be to prevent dissemination of zoonoses (such as rabies, taeniosis, salmonellosis, etc.) rather than to protect the animal itself, especially when infection or infestation is not harmful to the reservoir (cysticercosis)At present there is insufficient overall understanding of some important aspects of veterinary vaccines. Literature on the subject exists, but often consists of either research communications or 'catalogue-type' descriptive works. This unique book fills a gap within the already available literature. The scope is broad and covers all aspects of vaccines and vaccination in the
