Download or read book Immunological Aspects of Rheumatology written by G. Dick and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an exciting era in medicine and in science. Successive waves of advance in knowledge gather, break and recede uncovering fresh challenges and new opportunities. Each plays its part in eroding the tidemark of yesterday's ignorance. Many involved in the day-to-day management of patients, ill prepared and ill-equipped by the training which they received as under graduate students, find it difficult to retain contact with the advances in medical science and feel uncomfortable on the shifting sands of uncertainty upon which we now stand. Which of the new ideas is sound ? Upon which data may we rely? How may we distinguish the real from the unreal, the true from the false, recent advances from recent retreats? These are the anxieties, often either unstated or alternatively expressed in terms of an attitude of total opposition to 'all of this research rubbish' which are widespread in medical circles today. It is for these individuals who are not themselves directly involved in the immunology of rheumatic diseases but who, nevertheless, recognize the importance of this subject to their patients and, in particular, to tomorrow's patients, that this book has been written. There are two points that I believe to be of central concern. Firstly, I think it important to recognize that the intellectual basis of most of the research work being generated today is actually extremely simple.
Download or read book Immunological Aspects of Rheumatoid Arthritis written by J. Clot and published by S. Karger AG (Switzerland). This book was released on 1975 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immunological Aspects of Rheumatoid Arthritis written by Jacques Clot and published by . This book was released on 1975 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book IMMUNOLOGICAL ASPECTS OF RHEUMATOID ARTHRITIS PROCEEDINGS OF AN INTERNATIONAL SYMPOSIUM written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Case Studies in Immunology Rheumatoid Arthritis written by Raif Geha and published by Garland Science. This book was released on 2010-01-01 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents case histories that are chosen for two purposes: to illustrate in a clinical context essential points about the mechanisms of immunity; and to describe and explain some of the immunological problems often seen in the clinic.
Download or read book Immunological Aspects of Rheumatoid Arthritis written by and published by . This book was released on 1975 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cellular Inflammation in Arthritis written by Dan C. E. Nordström and published by . This book was released on 1989 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immunological Aspects of Rheumatoid Arthritis written by Jacques Clot and published by . This book was released on 1975 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Rheumatoid Arthritis written by Josef S. Smolen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many advances have occurred in the last 5 years especially in understanding genetic susceptibility factors, the role of immune response in chronic arthritis and the relationship between cellular processes that underlie inflammation and tissue damage. All these are dealt with in depth in the individual contributions. Genetics studies included illustrate how studies of HLA genes and genes controlling the autoantibody repertoire may be involved. Environmental factors are believed to be important and studies both in humans and in experimental models on the role of viral and bacterial agents are covered. The fascinating relationship between microbes, dysregulated immune responses and oncogenes are also examined. Since autoimmunity is the key aspect of the immunological response in rheumatoid arthritis, the role of antigens is re-examined as is the part played by immune T and B cells. New areas of clinical application of basic science is well presented in this book, forexample, in examining how markers of cartilage destruction may become important in monitoring disease activity. A chapter reviewing possible future novel therapies is included.
Download or read book Sj gren s Syndrome written by Norman Talal and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: I have been a student of Sjogren's syndrome for virtually all of my professional life. My education in this disease began in 1962 when I arrived at the National Institutes of Health to begin a Clinical Asso ciateship with Dr. Joseph J. Bunim. Bunim introduced me to a pat ient with Sjogren's syndrome of 8 years duration who had devel oped malignant lymphoma 6 months previously. He told me that there were other such patients. I obtained serum samples from these patients and studied them by the then new technique of immuno electrophoresis. We observed that an initial hypergammaglobulin emia could progressively decline to hypogammaglobulinemia with loss of autoantibodies. One patient in this initial series had macrog lobulinemia. We published this report and suggested that the auto immunity predisposed to the malignant transformation. Thus began my love affair with this disease. In those days many rheumatologists considered Sjogren's syn drome simply a variant of rheumatoid arthritis. It's curious that two decades ago there was little confusion between Sjogren's syndrome and systemic lupus erythematosus, whereas today there is great con fusion. There is still a great need for internationally agreed upon di agnostic criteria, which merely illustrates once again the difficulty of accurate diagnosis in our profession. The multidisciplinary aspects of Sjogren's syndrome require au thorities in several areas of medicine. The various chapter contribu tors are experts in their field and have often put aside other respon sibilities to complete their contributions and not delay publication.
Download or read book Case Studies in Immunology Rheumatoid Arthritis written by Raif Geha and published by Garland Science. This book was released on 2010-01-01 with total page 35 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents case histories that are chosen for two purposes: to illustrate in a clinical context essential points about the mechanisms of immunity; and to describe and explain some of the immunological problems often seen in the clinic.
Download or read book Immunology of the Rheumatic Diseases written by R. N. Maini and published by Hodder Education. This book was released on 1977 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunologie / Rahumatismus.
Download or read book New Developments in the Pathogenesis of Rheumatoid Arthritis written by Lazaros Sakkas and published by BoD – Books on Demand. This book was released on 2017-02-22 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. HLA class II alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (ACPAs), along with the effectiveness of biological treatments targeting cytokines, such as TNF-?, IL-6, and also T cells and B cells, reinforced the pathogenetic role of the respective factors. ACPAs, induced by cigarette smoking and periodontitis in individuals with HLA-DRB1 shared epitope, appear to be autoantigens that initiate the inflammatory immune response in RA. MicroRNAs, part of epigenetic mechanisms, which also include DNA methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book.
Download or read book Papers Presented at the International Workshop on Immunological Aspects of Rheumatoid Arthritis and Related Diseases written by International Workshop on Immunological Aspects of Rheumatoid Arthritis and Related Diseases and published by . This book was released on 1984 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms and Models in Rheumatoid Arthritis written by B. Henderson and published by Academic Press. This book was released on 1995-03-16 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rheumatoid arthritis is a bewilderingly complex disease involving the interactions of many, and varied, cell populations and multiple families of low and high molecular mass mediators. We are only slowly beginning to understand the mechanisms that produce the local and systematic pathology clinically recognized as rheumatoid arthritis. Increasingly, use is being made of experimental models of this disease in an effort to test hypotheses about putative pathological mechanisms and to investigate the effect of novel therapeutic agents. A major section of this book covers these experimental models in great detail from their development through to reviews of the most recent information on each model.Mechanisms and Models in Rheumatoid Arthritis brings together a group of eminent researchers from the fields of clinical rheumatology, pathology, experimental pathology, immunology, connective tissue biochemistry, microbiology, pharmacology and developmental biology to describe the current views of the cellular and humoral mechanisms that drive the pathology of rheumatoid arthritis and experimental models of rheumatoid arthritis. Key Features:* The book is divided into five sections:* The clinical spectrum, aetiopathogenesis, the role of microbial superantigens in pathology and the present and future therapies for rheumatoid arthritis* The pathology of rheumatoid arthritis, the development and role of synovial pannus and the use of immunohistochemistry in defining synovial pathology* Cell populations involved in synovitis with chapters on synovial cells, chondrocytes, bone cells, leukocytes and leukocyte trafficking* Mediators, with coverage of: cytokines and cytokine inhibitors, growth factors, free radicals and inflammatory lipid mediators, neuropeptides and proteases* Current studies on experimental models of rheumatoid arthritis
Download or read book Immunology of Rheumatic Diseases written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 916 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent developments in basic science and clinical rheumatology make it appropriate at this time to create a volume devoted to the immunology of rheumatic diseases. The impact of molecular biology, gene cloning, and new technologies for establishing hybridomas and T-cell lines in the laboratory is now beginning to be felt in clinical medicine. There is a general air of excitement and a feeling that we stand on the threshold of a new era in molecular medicine and clinical science. It is this excitement that we have tried to capture in this book. This volume is divided into five sections entitled Basic Mechanisms, Autoimmunity, Classical Concepts of Rheumatic Diseases, Pathogenetic Mechanisms, and Therapy. This is not an arbitrary arrangement but represents our belief that from an understanding of basic mechanisms of disease pathogenesis will come new and more successful forms of treatment for the sufferers of rheumatic disorders. We have tried in the selection of authors to choose internationally recognized experts who have both a scientific and a clinical orientation to their subjects. We believe the marriage of clinical and basic disciplines represents the best hope for rapid knowledge transfer from the laboratory to the clinic, where such knowledge can be used to improve patient health.
Download or read book Papers Presented at the International Workshop on Immunological Aspects of Rheumatoid Arthritis and Related Diseases Erlangen FRG written by and published by . This book was released on 1985 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:
