Download or read book Immuno epidemiological Studies of Antibody Responses to Variant Surface Antigens of Plasmodium Falciparum in African Individuals written by Gerardo Cabrera Orozco and published by . This book was released on 2004 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies of Naturally Acquired Antibody Responses to Plasmodium Falciparum Merozoite Surface Proteins in Malaria Endemic Populations written by Simon Weisman and published by . This book was released on 2003 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Antibodies to Variant Surface Antigens of Plasmodium Falciparum and Protection from Malaria in an Area of Low and Seasonal Transmission written by Trine Staalsø and published by . This book was released on 2001 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Antibodies to Plasmodium Falciparum Variant Surface Antigens and Malaria During Pregnancy and in Childhood written by Michael Fokuo Ofori and published by . This book was released on 2005 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Rodent Malaria written by R. Killick-Kendrick and published by Elsevier. This book was released on 2012-12-02 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rodent Malaria reviews significant findings concerning malaria parasites of rodents, including their taxonomy, zoogeography, and evolution, along with life cycles and morphology; genetics and biochemistry; and concomitant infections. This volume is organized into eight chapters and begins by sketching out the history of the discovery of rodent as well as aspects of parasitology, immunology, and chemotherapy. These concepts are investigated two decades following Ignace Vincke's major discovery and Meir Yoeli's successful establishment of the method of cyclical transmission of the parasite. The following chapters focus on the taxonomy and systematics of the subgenus Vinckeia, with reference to the concepts of species and subspecies of animals and the degree to which they apply to malaria parasites, in particular to those of rodents. The discussion then shifts to how the rodent malaria parasites provide a unique insight into the subcellular organization of Plasmodium species, the use of rodent malaria as an experimental model to study immunological responses, and infectious agents that interact with malaria parasites. The book concludes with a chapter on malaria chemotherapy, with emphasis on the value of rodent malaria in antimalarial drug screening and the use of antimalarial drugs as biological probes. This book will be of interest to protozoologists and physicians as well as those from other disciplines including biochemistry, immunology, pharmacology, cell biology, and genetics.
Download or read book Naturally Occurring Antibodies NAbs written by Hans U. Lutz and published by Springer Science & Business Media. This book was released on 2012-08-19 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume illustrates the functional properties of NAbs. Authors from pioneering groups report in their chapters on the tissue homeostatic, tissue regenerating and regulatory properties of NAbs and NAbs in pooled human IgG. Scientists interested in the regulation and modulation of components of the immune system found a whole variety of NAbs to cytokines with regulatory and protective functions and NAbs that modulate, e.g., dendritic cells, regulatory T cells, B cells and granulocytes. Considering the large plasma pools and initial difficulties in preparing IVIG that does not induce adverse effects upon infusion into recipients, this volume ends with a historical chapter on how pooled human plasma was fractionated and the IgG component pretreated for a safe intravenous application.
Download or read book Antibody Responses to Plasmodium Falciparum Antigens Before and After Acute Infection in African Children written by and published by . This book was released on 2015 with total page 71 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Patterns of Antibody Acquisition to the Major Variant Surface Antigen of Plasmodium Falciparum written by Sofonias Kifle Tessema and published by . This book was released on 2016 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Malaria Research written by Deepak Gaur and published by John Wiley & Sons. This book was released on 2016-12-27 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly reviews our current understanding of malarial biology Explores the subject with insights from post-genomic technologies Looks broadly at the disease, vectors of infection, and treatment and prevention strategies A timely publication with chapters written by global researchers leaders
Download or read book Human Antibody Responses to Antigens on the Surface of Plasmodium Falciparum Gemetocyte infected Erythrocytes and Their Relation with Gametocytaemia written by Bismarck Dinko and published by . This book was released on 2013 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bead based Chemistries to Quantitate Antibody Responses to Multiple Plasmodium Falciparum and Plasmodium Vivax Antigens written by Sonam Kaur Ghag and published by . This book was released on 2019 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each year malaria impacts approximately 219 million people and causes over 400,000 deaths. The worldwide parasite burden remains high, even with the availability of efficacious antimalarial drugs and vector control tools such as insecticides and bed nets. Despite large investments in malaria vaccine development, there is currently no deployable vaccine for malaria. However, individuals who live in malaria endemic regions develop naturally acquired immunity (NAI). Thus, good vaccine candidates may be identified by studying serum antibody responses in malaria patients who live in endemic areas. Protein arrays, which interrogate patient serum antibody binding to many proteins simultaneously, are the primary method of antigen prioritization. However, protein arrays are fabricated by generating unpurified malaria antigens in bacteria and directly spotting lysates onto slides without validation of correct antigen folding or purification. Results from protein arrays can be affected by the sample impurity where positive binding events may be masked by background protein interactions or unrecognizable epitope presentation. Thus, technical improvements are needed to control protein production and protein exposure to patient sera. More recently, multiplexing bead-based assays have been applied to investigate malaria patient immune responses where spectrally distinct bead sets are coated with unique antigens of interest. For such assays, antigens traditionally are individually purified before coupling onto beads. To produce a more high-throughput method of patient immune response dissection using a large panel of antigens, bead-based chemistries were developed to modify multiplexing beads with a small linker molecule or with antigen capturing antibody. These modified beads capture malaria antigens directly from translation lysates, essentially purifying antigens in a single step. Both chemistries utilized the capture of recombinant antigens via a highly specific protein tag, HaloTag or C-tag. Although both systems successfully capture tagged antigens from translation lysates, the C-tag capture system proved to be more reliable and reproducible. Using recombinant malaria antigen merozoite surface protein 1 (MSP1)-coated beads and standard anti-MSP1 detecting antibodies, a 105-fold signal increase was observed in comparison to green fluorescence protein (GFP)-coated beads. Malaria patient sera responses to recombinant MSP1 were also measured. When assessed against MSP1-coated beads, serum from a high immune responsive patient gave an 8.5-fold increase in comparison to GFP-coated beads, while a low immune responsive patient gave a 2-fold increase. These results agree with previously reported protein microarray dissection of the same patient serum samples. The bead chemistries developed here make it possible to interrogate multiple malaria antigens simultaneously without demanding timely antigen purification. Furthermore, the multiplexing assay present antigen epitopes in a more accessible configuration while utilizing small amount of precious patient sera. The platform developed here will provide a high-throughput method of identifying specific patient antibody-antigen binding events and has the potential to customize bead arrays to model populations with high antigenic variation.
Download or read book Malaria Immunology written by Peter Perlmann and published by Karger Medical and Scientific Publishers. This book was released on 2002-01-01 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite extensive efforts to control it, malaria is still one of the most devastating infectious diseases worldwide. This book, now in its second edition, provides a broad and up-to-date overview of the rapidly expanding field of malaria immunology and its importance in the control of this disease. The first section deals with the malaria parasite and its interactions with both the vertebrate host and the mosquitoes which transmit the disease. In the second part, the mechanisms of immunity and their regulation by environmental and genetic factors are discussed. Finally, this volume contains several chapters on malaria vaccine development, describing the application of the most recent vaccine technologies as well as ongoing and planned vaccine trials. Authored by well-recognized experts, this volume not only demonstrates the rapid progress being made in the search for vaccines against malaria, but also broadens our understanding of immunity to infection in general. It is therefore highly recommended reading for all scientists and professionals in the fields of immunology, infection and vaccine development.
Download or read book Immunoepidemiology written by Peter J. Krause and published by Springer Nature. This book was released on 2019-10-24 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook focuses on the nascent field of Immunoepidemiology that addresses how differences in immune responses among individuals affect the epidemiology of infectious diseases, cancer, hypersensitivity, and autoimmunity. The idea for the book originated from a course entitled “Immunology for Epidemiologists“ at the Yale School of Public Health. While many fine textbooks are available that address the immunological responses of individuals to pathogens, these provided very little information regarding how immunological variation among populations affects the epidemiology of disease. And yet, it has long been recognized that there is great immunologic diversity among people, which can have a profound effect on the epidemiology of disease. Careful review of the immunologic and epidemiologic literature revealed that there have been relatively few publications concerning immunoepidemiology and that no textbook is available on the subject. This textbook therefore aims to fill this void by providing a much-needed tool to comprehensively and efficiently teach immunoepidemiology. The book includes a section on the basic principles of immunology, and then applies them to particular examples of disease in human populations. The target audience for this text book are Masters of Public Health students. Others who should also find it of interest include PhD students in epidemiology, immunology, medical students, generalists, and specialists in immunology, infectious diseases, cancer, and rheumatology.
Download or read book Human monoclonal antibody assisted characterization of Plasmodium falciparum variant surface antigens written by Jorid Birkelund Sørli and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Acquisition of Variant specific Humoral Immunity to Malaria written by Lasse S. Vestergaard and published by . This book was released on 2005 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Agglutination Studies written by Ferne F. Loomis and published by . This book was released on 1926 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immunology and Evolution of Infectious Disease written by Steven A. Frank and published by Princeton University Press. This book was released on 2002-07-21 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher Description
