Download or read book IGFs Local Repair and Survival Factors Throughout Life Span written by David Clemmons and published by Springer Science & Business Media. This book was released on 2009-12-01 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.
Download or read book Igfs written by Dr David Clemmons, PhD and published by Springer. This book was released on 2016-05-01 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insulin-like growth factors (IGFs) continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodeling and metabolic regulation. This book takes a close look at IGFs.
Download or read book Oxidative Stress in Aquatic Ecosystems written by Doris Abele and published by John Wiley & Sons. This book was released on 2011-11-03 with total page 818 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reactive oxygen species (ROS) are increasingly appreciated as down-stream effectors of cellular damage and dysfunction under natural and anthropogenic stress scenarios in aquatic systems. This comprehensive volume describes oxidative stress phenomena in different climatic zones and groups of organisms, taking into account specific habitat conditions and how they affect susceptibility to ROS damage. A comprehensive and detailed methods section is included which supplies complete protocols for analyzing ROS production, oxidative damage, and antioxidant systems. Methods are also evaluated with respect to applicability and constraints for different types of research. The authors are all internationally recognized experts in particular fields of oxidative stress research. This comprehensive reference volume is essential for students, researchers, and technicians in the field of ROS research, and also contains information useful for veterinarians, environmental health professionals, and decision makers.
Download or read book Handbook of Hormones written by Yoshio Takei and published by Academic Press. This book was released on 2015-08-26 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research collates fundamental information about the structure and function of hormones from basic biology to clinical use. The handbook offers a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors and signalling pathways, and the biological activities they regulate. The evolution of hormones and gene families is also covered both in the text and in online ancillaries. Users will find simple and visual ways to learn key molecular information. Chapters and online ancillary resources integrate additional sections, providing a comparative molecular, functional, and evolutionary consideration. - Provides the only single resource available with concise, yet informative descriptions of hormones in vertebrates, invertebrates, and plants - Presents hormones in groups according to their origin, so that readers can easily understand their inter-relation - Includes comparative information on the structures and functions of hormones enabling readers to understand both general and specific actions in and across species - Ancillary website hosts additional information, including sequence data, comparative data, figures, and tables
Download or read book The Coming of Age of Insulin Signalling in Insects written by Colin G.H. Steel and published by Frontiers E-books. This book was released on 2015-01-28 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new millennium has seen a major paradigm shift in insect endocrinology. Great advancements are being made which establish that nutrition and growth play a central role in diverse cellular and physiological phenomena during insect development and reproduction. Nutrition affects rates of growth and is mainly regulated by the function of the pathway of insulin/insulin-like growth factor signalling. This pathway is highly conserved across species and ultimately regulates rates of cell growth and proliferation in growing organs. Insulin and insulin-like peptides (ILPs) are some of the best studied hormones in the animal kingdom and all share a common structural motif and initiate a wide range of closely similar physiological processes in higher organisms. In insects, nutrition, via circulating sugar, promotes release of ILPs from brain neurosecretory cells into the haemolymph, which act on peripheral tissues and stimulate protein synthesis and cell growth. Therefore, insect ILPs are common mediators between nutrition and growth in insects and are functionally analogous to mammalian insulin. The 1980s and 1990s witnessed great progress in elucidation of the physiological and molecular mechanism of action of numerous insect hormones involved in regulation of growth, development, reproduction and metabolism. But the signals for the initiation or termination of controlled events remained largely unknown. ILPs were first identified from the silkmoth Bombyx mori and were named bombyxins, but related peptides were soon found in numerous species and their functions elucidated. The insulin signalling pathway is now recognized as a central factor in the timing of cell proliferation, growth, longevity, reproduction, and reproductive diapause, as well as social behaviour. Recent work has revealed that the insulin signalling pathway is closely integrated with that of various other hormones, including ecdysteroids, the juvenile hormones and neuropeptide(s) such a prothoracicotropic hormone. In addition, the pathway is also linked with both circadian (daily) and photoperiodic (seasonal) clocks potentially providing a basis for its timing function. This Research Topic aims to provide the only current collection of recent advances on insect ILPs. We encouraged submissions on all areas related to identification, characterization, regulation and physiological functions of insect ILPs. We welcomed both full and short reviews and original research articles.
Download or read book Development Strategies and Biodiversity written by David Costantini and published by Springer Nature. This book was released on 2022-02-15 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Development is a complex and highly dynamic process involving the cross talk among genes, maternal effects and environmental circumstances. Widespread evidence from plant to animal species show that variation in developmental conditions can modulate life history trajectories and influence key traits, such as growth, reproduction, and senescence. These effects are not limited to a single generation but can also be passed on future generations. This book aims to bring together studies of early life effects from the fields of evolutionary biology, global change biology, and biomedicine to synthesise and improve current knowledge of the mechanisms involved, and how variation in early life conditions translates into Darwinian fitness outcomes. Relying on examples of organisms’ responses to the ongoing and future environmental challenges of the Anthropocene, this book takes a novel approach to address the adaptive meaning of early life effects. The book has a broad scientific approach, targeting eco-evolutionary biologists, behavioural biologists, eco-physiologists, eco-toxicologists, as well as epidemiologists and biomedical scientists.
Download or read book Oxford Textbook of Endocrinology and Diabetes written by John A.H. Wass and published by Oxford University Press, USA. This book was released on 2011-07-28 with total page 2158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its second edition, the Oxford Textbook of Endocrinology and Diabetes is a fully comprehensive, evidence-based, and highly-valued reference work combining basic science with clinical guidance, and providing first rate advice on diagnosis and treatment.
Download or read book Handbook of Biologically Active Peptides written by Abba Kastin and published by Academic Press. This book was released on 2013-01-26 with total page 2033 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Biologically Active Peptides, Second Edition, is the definitive, indispensable reference for peptide researchers, biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and endocrinologists. Its chapters are designed to be a source for workers in the field and enable researchers working in a specific area to examine related areas outside their expertise. Peptides play a crucial role in many physiological processes, including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The second edition of Handbook of Biologically Active Peptides presents this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. - Presents all aspects of biologically active peptides in one resource - Features more than 20 sections spanning plant, bacterial, fungal, venom, and invertebrate peptides to general peptides - Includes immunological, inflammatory, cancer, vaccine, and neurotrophic peptides - Discusses peptide precursors, mRNA distribution, processing, and receptors, not just pathophysiological implications
Download or read book IGF and Nutrition in Health and Disease written by M. Sue Houston and published by Springer Science & Business Media. This book was released on 2004-08-04 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: A benchmark review on how specific nutrients or adverse nutritional states impact the components of the IGF (Insulin-like Growth Factor) system and affect human health and disease. The authors describe the fundamentals of the IGF system, explain its basic mechanisms of action, illuminate its essential role in physical development across the life span, and highlight the link between normal and abnormal cellular growth resulting in tumor formation. They also fully examine the clinical aspects of nutrition and IGF, from pre- and postnatal development through old age, in the maintenance of normal metabolism, bone, and muscle health, and their role in pathological states. Special attention is given to critical illness, diabetes, gastrointestinal diseases, kidney failure, endocrine dysfunctions, cardiovascular disease, neurological disorders, and cancer, as well as to their potential for IGF therapy.
Download or read book Physiology at a Glance written by Jeremy P. T. Ward and published by John Wiley & Sons. This book was released on 2017-02-27 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensively revised and updated, this fourth edition of Physiology at a Glance continues to provide a thorough introduction to human physiology, covering a wealth of topics in a comprehensive yet succinct manner. This concise guide breaks this often complex subject down into its core components, dealing with structures of the body from the cellular level to composite systems. New to this edition are three chapters on cell signalling, thermoregulation, and altitude and aerospace physiology, as well as a glossary of terms to aid medical, dental, health science and biomedical students at all levels of their training. Featuring clear, full-colour illustrations, memorable data tables, and easy-to-read text, Physiology at a Glance is ideal as both a revision guide and as a resource to assist basic understanding of key concepts.
Download or read book Oral and Maxillofacial Surgery written by Lars Andersson and published by John Wiley & Sons. This book was released on 2012-01-10 with total page 1316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral and Maxillofacial Surgery Oral and Maxillofacial Surgery Edited by Lars Andersson, Karl-Erik Kahnberg and M. Anthony Pogrel Oral and Maxillofacial Surgery is a comprehensive reference for all trainees and specialists in oral and maxillofacial surgery, oral surgery, and surgical dentistry. This landmark new resource draws together current research, practice and developments in the field, as expressed by world authorities. The book’s aim is to cover the full scope of oral and maxillofacial surgery, incorporating recent technical and biological developments within the specialty. It provides a uniquely international and contemporary approach, reflecting the exciting developments of technique and instrumentation within this surgical field, built on technical innovation and medical and dental research. Oral and Maxillofacial Surgery coalesces impressively broad and deep coverage of this surgical specialty into a cohesive and readable resource, identifying commonalities and shedding light on controversies through reasoned discussion and balanced presentation of the evidence. The Editors are joined by over 50 international experts, offering a truly global perspective on the full spectrum of issues in oral and maxillofacial surgery. The book’s coverage extends from basic principles such as patient evaluation, dental anesthesia, wound healing, infection control, and surgical instruments, to coverage of the complex areas of dentoalveolar surgery, oral pathologic lesions, trauma, implant surgery, dentofacial deformities, temporomandibular joint disorders, and salivary gland disorders. Where relevant, the book provides separate coverage of topics where practice differs significantly from region to region, such as general anesthesia. Comprehensive reference covering full scope of oral and maxillofacial surgery Covers state-of-art clinical practice, and the basic principles that underpin it Promotes an intellectually and internationally inclusive approach to oral and maxillofacial surgery Nearly 100 expert contributors brought together under the aegis of a renowned international editorial team Richly illustrated with medical artwork and clinical images ALSO OF INTEREST Clinical Periodontology and Implant Dentistry, Fifth Edition Edited by Jan Lindhe, Niklaus P. Lang, Thorkild Karring • ISBN: 9781405160995 Textbook and Color Atlas of Traumatic Injuries to the Teeth, Fourth Edition Edited by Jens Andreasen, Frances Andreasen, Lars Andersson • ISBN: 9781405129541
Download or read book Dairy in Human Health and Disease across the Lifespan written by Ronald Ross Watson and published by Academic Press. This book was released on 2017-06-19 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dairy in Human Health and Disease across the Lifespan addresses the contribution of milk to the human diet and health throughout the life span. This comprehensive book is divided into three sections and presents a balanced overview of dairy's impact on nutrition from infancy to adulthood. Summaries capture the most salient points of each chapter, and the book provides coverage of dairy as a functional food in health and disease. - Presents various dairy products and their impact on health specific to various stages in the lifespan - Provides information to identify which food and diet constituents should be used as dietary supplements based on modification of health and nutrition - Incorporates contributions from an international team of authors with varying areas of expertise related to dairy and nutrition
Download or read book Regenerative Medicine in China written by Xiaobing Fu and published by Springer Nature. This book was released on 2021-08-01 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes major issues in wound tissue repair and regeneration in 14 chapters. The topics start from cytological basis, molecular and genetic basis, skin development, to the tissue repair, visceral injury and tissue engineering. In the second part, it introduces Chinese researchers’ contribution in wound repair and regeneration. Specially, it has 3 chapters discussing new technologies in tissue repair and regeneration, and 1 chapter in Traditional Chinese Medicine.
Download or read book Angiogenesis in Health Disease and Malignancy written by Ali Salajegheh and published by Springer. This book was released on 2016-03-10 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about “Angiogenesis”. A process in which new vasculature is formed from pre-existing capillaries. Angiogenesis process is associated with the proliferation and growth of both physiologically normal and neoplastic tissues, through the formation of vascular supply, essential for delivering growth requirements such as oxygen and nutrients. The book describes more than 100 genes and their key regulatory functions in the context of normal healthy condition, disease and malignancy, cancer proliferation and progression. New insights into the role of angiogenesis and the therapeutic inhibition of its regulators are investigated, due to the great potential for exploitation in the development of a novel treatment for cancer. New scientists, junior researchers and biomedical science students will find this book an invaluable introductory reference to their insight about angiogenesis and angiogenic role of more than 100 angiogenes and their role in healthy, disease and malignant conditions.
Download or read book The Somatotrophic Axis in Brain Function written by Fred Nyberg and published by Elsevier. This book was released on 2005-12-12 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: The somatotropic axis is one of the major hormonal systems regulating postnatal growth in mammals. It interacts with the central nervous system on several levels. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) receptors are expressed in many brain areas including the hippocampus, pituitary and hypothalamus. GH and IGF-I are important factors in the development and differentiation of the CNS and have protective properties in dementia, as well as in traumatic and ischaemic injury of the CNS. Also GH has an important impact on mood and well-being with GH secretory capacity being reduced in depression.This volume will include chapters (1) on basic knowledge on GH/IGF-1, (2) on localization of GH/IGF-1 and their receptors in the CNS, including blood brain barrier transport of both hormones, (3) on actions of the two hormones on CNS function (basic science), (4) on clinical aspects of GH/IGF-1 in relation to various CNS functions and disorders, and finally (5) on some future perspectives in this area of science.Contents are well balanced and cover a variety of relevant topics from basic to clinical researchInternational selection of authors, with a good representation of the research on growth hormonesA timely publication which will be useful to scientists in both basic and clinical research
Download or read book Adult Stem Cells written by Kursad Turksen and published by Springer Science & Business. This book was released on 2014-04-16 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adult Stem Cells, second edition, takes a critical look at issues concerning the developmental or differentiation potential for a variety of tissue types and for specific adult stem cell types. Since the first edition appeared a decade ago, our understanding of adult stem cells, and more specifically tissue-specific adult stem cells, has advanced tremendously. And an increased interest in regenerative medicine and potential stem cell applications has driven a quest for better understanding of stem cell biology. In turn, this has spawned much activity on generation and utilization of more and better reagents to identify and isolate stem cells and stem cell-like subpopulations, and on assays elucidating their developmental or differentiation potential and functional integration with host tissues and organs. In this fully updated new edition, chapters cover topics ranging from signaling pathways maintaining stemness in hematopoietic cells to regeneration after injury and endocrine mechanisms underlying the stem cell theory of aging. Other chapters cover stem cells by organ or system including pituitary, cardiac, epithelial, teeth, lung, ovary, prostate, liver, and many more. Importantly, the authors of the chapters have not only summarized their successes, but have also summarized some of the difficulties that each particular field is still facing with respect to maximizing the utility of stem cells in clinical settings. Collectively, they impart both the excitement and challenges facing stem cell utilization for repair and regeneration making this book essential reading for those involved in stem cell research as well as those involved in clinical assays.
Download or read book Bio Systems Engineering for Regulating Nerve Regeneration written by Srinivas Madduri and published by Frontiers Media SA. This book was released on 2022-04-29 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt:
