Download or read book Identification of Genetic Changes in Ovarian Serous Epithelial Carcinoma Associated with Resistance to Chemotherapy microform written by Marcus Bernardini and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 2004 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this project was to use high resolution microarray comparative genomic hybridization (CGH) to identify differentiating regions of genomic imbalance between epithelial ovarian tumors resistant and sensitive to chemotherapy. Our analysis has confirmed the presence of copy number alterations At specific chromosomal loci in these tumors. Gains at 1q, 3q, 8q, 12p and 20q as well as losses at 1p, 4q, 6q, 8p, 9q, 13q, 16q 17p, 18q, are consistent with reported changes in the literature. The improved resolution of array CGH has further allowed us to determine important discriminating regions in these two tumor sets. These regions include 1q42.3, 6q25.3, 13q12.3 and 17q25.3. Two of these regions have been identified in previous work and another contains a gene identified as playing a role in chemotherapy response. Once refined, these regions may be used as markers to identify resistance to chemotherapy prior to initiation of treatment.
Download or read book Advances in Epithelial Ovarian Cancer Model Systems Microenvironmental Influences Therapy and Origins written by Viive Maarika Howell and published by Frontiers Media SA. This book was released on 2016-02-03 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook provides a compendium of the current state-of-the-art in research tools for, and understanding of, the critical research areas in epithelial ovarian cancer (EOC) with a strong emphasis on (HG-SOC). Research areas covered include therapy response and development, microenvironmental influences and the etiology and progression of EOC. Ten articles detail established and novel in vivo and in vitro model systems. These include primary and immortalized cell culture in 2D and 3D as well as genetically engineered, transgenic, spontaneous, syngeneic, classical xenograft and patient derived xenograft mouse models. The generation of genetically engineered mouse models of HG-SOC has been a major dilemma as models with the oncogenic aberrations common in the human malignancy do not accurately recapitulate HG-SOC. Conversely, commonly used HG-SOC cell lines have been found to not harbor the expected genetic changes. These issues as well as the rapid acceptance of patient derived xenograft models are reviewed. Five articles discuss different aspects of the tumor microenvironment including its role in therapy resistance, disease progression and metastasis. Mutation of BRCA1/2 continues to be the best defined risk factor for HG-SOC. Three articles discuss BRCA-loss in the context of disease development, targeted therapies and changes in preventative measures proposed for mutation carriers in light of the recent advances in knowledge regarding the origins of this malignancy. An image of HG-SOC with reduced BRCA1 expression is featured on the cover (image by VM Howell). A major clinical issue for patients with HG-SOC is the development of therapy resistance. Five articles focus on therapy resistance and different ways to overcome resistance. Overall, this eBook is an outstanding resource to aid researchers design their programs of research and determine the most appropriate and up-to-date EOC model systems to address their research questions.
Download or read book Integrated Functional and Genomic Analysis of High Grade Serous Ovarian Cancer written by Mauricio Medrano and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Epithelial ovarian cancer is the fifth-leading cause of cancer-related death for women in North America and is responsible for over 100 000 deaths/year worldwide (Ferlay et al., 2015). High-grade serous ovarian cancer (HGSC) is the most common and lethal subtype and the vast majority of women are diagnosed with advanced stage disease (Bowtell, 2010). The current standard treatment is aggressive surgery combined with adjuvant and/or neo-adjuvant platinum/taxane-based chemotherapy. Despite initial efficacy of standard therapy, resistant cancer recurs and 70% of patients die within 5 years after initial diagnosis (Bast et al., 2009). Further understanding of the molecular and cellular features that promote HGSC progression may assist in identifying new opportunities for therapeutic intervention and ultimately improve the prognosis of women with HGSC. My research has generated an extensive functional and genomic characterization of serous ovarian cancer cell lines and provides a framework for identifying vulnerabilities associated with distinct molecular features. Using this dataset, I have focused on the identification of genes encoding for highly expressed cell surface molecules. I have identified a novel role of the tetraspanin CD151 in serous ovarian cancer. I have found that CD151 depletion impairs survival, proliferation and tumor growth in murine models of a subset of HGSC cell lines. In search of the mechanism underlying CD151-dependency, I have uncovered a novel association for CD151-dependency in cancer cells with mesenchymal features. In particular, high ZEB1 and ZEB2 expression is tightly coupled with CD151-dependency and thus, may be used as biomarkers for stratifying tumors requiring CD151 for growth. Moreover, CD151-binding antibodies block the migratory capacity of CD151-dependent cells, thereby implicating CD151 in metastasis and dissemination of HGSC tumors. These studies provide a resource of characterized HGSC cell lines and suggest that CD151 may be a biological target in HGSC tumors.
Download or read book Characterization of Novel Epigenetic Targets in Ovarian Cancer written by Zhi Qiang Wang and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Signs in MR Mammography written by Werner A. Kaiser and published by Springer Science & Business Media. This book was released on 2008-11-27 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is the leading cause of cancer-related deaths in women, and its prevalence has been steadily rising in recent decades. This book describes morphologic and kinetic signs that are important in the analysis of breast MR images before and after contrast administration and in various pulse sequences. It will help broaden the clinical application of MRM so that as many physicians as possible can make more accurate diagnoses.
Download or read book PET in Clinical Oncology written by Helmut J. Wieler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: A description of positron emission tomography in the diagnosis and management of malignant tumors. Experts from Germany and the United States present basics, technical details, and clinical aspects for both standard and new PET techniques, illustrating the importance of PET in comparison to other imaging techniques. Generously supplemented with charts, tables, and illustrations, each chapter provides readers with well-delineated descriptions, from the basic technical situation through the clinical use of PET.
Download or read book Cytopathology of Infectious Diseases written by PANTANOWITZ LIRON and published by Springer Science & Business Media. This book was released on 2011-12-02 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytopathology of Infectious Diseases is the first book of its kind to focus entirely on the cytopathology of infectious diseases. It contains all of the pertinent information about the cytology of infectious diseases and microorganisms and will serve as an ideal handy reference. This unique volume covers the cytomorphology of various microorganisms and the host reactions they elicit, and also incorporates an update on advances in the field. Newly recognized infections such as the recent discovery of the Merkel Cell Polyomavirus (MCV) are included, as well as the utility of new immunostains (e.g. CM2B4 for MCV) and the role of molecular techniques that assist in the identification, classification and even quantification of microorganisms. Each chapter is succinctly written and concisely referenced with key published articles and resources. The volume includes practical pointers, useful diagnostic criteria, differential diagnoses and potential pitfalls. Many color images of high resolution that illustrate microorganisms (e.g. branching hyphae) and host reactions (e.g. viral cytopathic effect) are included throughout. Relevant tables with diagrams that provide quick reference guides are incorporated. Cytopathology of Infectious Diseases will serve as a valuable reference tool for cytopathologists, anatomical/clinical pathologists, cytotechnologists, pathology residents and cytopathology fellows.
Download or read book Clinical Embryology written by Robert Carachi and published by Springer. This book was released on 2019-05-07 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive atlas is unique in combining information on the embryological development of the human with detailed presentation of the congenital malformations encountered in clinical practice. As a consequence it will not only assist practitioners and trainees in recognizing and evaluating malformations, but also enable them to understand how a malformation has developed and to explain the mystery of congenital malformations to relatives and patients. The book is organized according to anatomic region, with additional chapters on hernias, tumors, lymphogenesis and lymphatic malformations. According to WHO statistics, each year congenital anomalies result in approximately 3.2 million birth defect-related disabilities worldwide. All too often, however, training in embryology is now a neglected area, and medical graduates frequently lack confidence in their knowledge of the field. Clinical Embryology: An Atlas of Congenital Malformations will help to rectify this deficit and to ensure that malformations are comprehended and managed appropriately. It will be of value for postgraduate trainees in pediatric surgery, pediatrics, and neonatology, undergraduate medical students, and general practitioners/family physicians.
Download or read book Fine Needle Aspiration Cytology written by Gabrijela Kocjan and published by Springer Science & Business Media. This book was released on 2006-02-23 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Histopathologists all over the world have to report cytopathology during the course of their work and it is then that they find themselves facing diagnostic dilemmas. This practical, well-illustrated book, explicitly dedicated to this readership will serve their needs and meets their requirements in daily practice.
Download or read book Imaging of Orbital and Visual Pathway Pathology written by Wibke S. Müller-Forell and published by Springer Science & Business Media. This book was released on 2005-12-29 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Deals with imaging of pathology of the visual system. This book is divided into two parts, general and special. In the general part, important basics of modern imaging methods are discussed. The knowledge on the indication, technique, and results of functional MR imaging is also presented.
Download or read book Neuropathology Review written by Richard A. Prayson and published by Springer Science & Business Media. This book was released on 2007-12-26 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scope of neuropathology continues to expand and the ever-increasing amount of information to assimilate and master can be daunting. Neuropathology Review, Second Edition summarizes in simple outline form the essentials of neuropathology. It has been updated to reflect the newest information and ideas in this constantly changing field.
Download or read book Imaging of Kidney Cancer written by Ali Guermazi and published by Springer Science & Business Media. This book was released on 2005-10-05 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is one of the first books to deal specifically with diagnostic imaging of the entire spectrum of kidney cancers. Both new and conventional imaging modalities are fully considered. After an introductory chapter on the histopathological classification of kidney cancers, the advantages and disadvantages of the various imaging modalities used in the diagnosis and assessment of disease extension are documented. Subsequent chapters offer an exhaustive description of the radiological features of the different histological subtypes of kidney cancer, with radiological and histological illustrations and tables. The latest innovations in interventional and minimally invasive procedures are also well covered. The book benefits from carefully chosen and technically excellent images. Each of the 24 chapters is written by an internationally acclaimed expert, making this book the most current and complete treatment of the subject available. It should be of great interest to radiologists, oncologists, and urologists.
Download or read book Peritoneal Adhesions written by Karl-Heinz Treutner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adhesions can cause a wide range of problems, complaints and hazards, even after simple abdominal procedures, such as appendectomy, with complications ranging from recurrent discomfort and pain to intestinal obstruction. Postsurgical adhesions increase the risk of following operations of the abdominal and thoracic cavity. They impair peritoneal dialysis and chemotherapy and play a crucial part in laparoscopic procedures. Adhesion-related problems account for a large amount of clinical work and have a significant socioeconomic impact. This book presents the current knowledge on the aetiopathogenesis of adhesion formation as well as the available methods for their prevention and control. Experts in the field contribute to clinical standards for preventive measures to control the formation of postoperative adhesions
Download or read book Molecular Imaging in Oncology written by E. Edmund Kim and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a report on updated techniques, instrumentation and clinical application of PET, MRI and MRS in cancer management.
Download or read book Head and Neck Cancer Imaging written by Robert Hermans and published by Springer Science & Business Media. This book was released on 2012-01-20 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imaging is crucial in the multidisciplinary approach to head and neck cancer management. The rapid technological development of recent years makes it necessary for all members of the multidisciplinary team to understand the potential applications, limitations, and advantages of existing and evolving imaging technologies. It is equally important that the radiologist has sufficient clinical background knowledge to understand the clinical significance of imaging findings. This book provides an overview of the findings obtained using different imaging techniques during the evaluation of head and neck neoplasms, both before and after therapy. All anatomic areas in the head and neck are covered, and the impact of imaging on patient management is discussed in detail. The authors are recognized experts in the field, and numerous high-quality images are included. This second edition provides information on the latest imaging developments in this area, including the application of PET-CT and diffusion-weighted magnetic resonance imaging.
Download or read book Basics of Oncology written by Frederick O Stephens and published by Springer Science & Business Media. This book was released on 2009-04-29 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Basics of Oncology" provides an easily understood and general overview of the basic medical, scientific and clinical aspects of cancer. Causes, pathology, clinical features, diagnostic investigations, treatments and outcomes are all carefully explained and discussed, both for cancers in general and for the common cancers in individual countries. The reader will thereby be provided with an understanding of how and why people develop cancer, how the body reacts to cancer, what can be done to prevent the disease, and how the various cancers are best diagnosed and treated. The book will serve as a sound basis for the more detailed or specific studies that may be needed in different areas of practice and in different countries. It will be invaluable for students of medicine, nurse oncologists, students of medical sciences and other health professionals in all parts of the world.
Download or read book Color Atlas of Chemical Peels written by Antonella Tosti and published by Springer Science & Business Media. This book was released on 2006-01-16 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: First atlas to cover latest advances in chemical peel techniques Fully illustrated to support step-by-step procedures Ideal reference tool for dermatologists focusing on cosmetology
