Download or read book Identification Characterization of Potential Mediators Mechanisms Invloved in Neuropathic Pain written by Amin Boroujerdi and published by . This book was released on 2010 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain is defined as an unpleasant sensation and emotional experience associated with actual or potential tissue injury. Everyone at some point has experienced a painful sensation. Pain can cause unwanted physical, emotional and social anguish throughout one's daily life. According to the American Chronic Pain Association, pain is the number one cause of adult disability in the U.S. costing an estimated $80 billion annually in medical bills and lost productivity. Unfortunately, over the past decades, our understanding of pain mechanisms and efforts to control pain are not adequate. So as a consequence, current medications for pain managements, especially that for chronic pain, are not efficacious, and often associated with intolerable side effects. Therefore, target specific, mechanism based therapeutic medications for effective, and safe pain control is an unmet medical need. In my dissertation I have focused on characterizing the role of two proteins involved in mediating neuropathic pain, a form of chronic pain. I provide evidence showing that the auxiliary subunit of the voltage gated calcium channel alpha 2 delta-1 protein is upregulated in the dorsal spinal cord (DSC) due to peripheral nerve injury. This upregulation can be pervented by blocking ectopic discharges at the site of injury or using intrathecal calcium channel alpha 2 delta-1 antisense oligodeoxynucleotide preemptively. This inhibition of calcium channel alpha 2 delta-1 levels in DSC result in delay in the development of neuropathic pain, suggesting elevated levels of calcium channel alpha 2 delta-1 in the DSC mediates the initiation of peripheral nerve injury induced neuropathic pain. I have also determined that the calcium channel alpha 2 delta-1 protein plays a role in central neuropathic pain. I observed an upregulation of the calcium channel alpha 2 delta-1 protein in the DSC of spinal cord injured (SCI) rats with neuropathic pain states, and both neuropathic pain states and calcium channel alpha 2 delta-1 protein levels could be reversed by intrathecal calcium channel alpha 2 delta-1 antisense oligodeoxynucleotides. Lastly, I contributed to identifying thrombospondin-4 (TSP4) protein, a synapse inducer, as a novel mediator in the development of neuropathic pain. Similar to the calcium channel alpha 2 delta-1 protein, TSP4 protein levels were also upregulated in DSC of peripheral nerve injury induced neuropathic pain models that correlated with pain states, . Various pharmacological agents could alter both the TSP4 levels in DSC and behavioral hypersensitivity supporting the notion that TSP4 plays a novel role in neuropathic pain. I was also able to show using immunohistchemistry that enhanced levels of TSP4 colocalized with calcium channel alpha 2 delta-1 and presynaptic marker synaptic vesicle-2 protein (sv2) in the DSC, suggesting that interaction of these two proteins plays a possible role in spinal synaptogenesis, leading to neuropathic pain transmission. These findings provide a greater understanding in the mechanism of chronic pain, which can ultimately contribute to development of new target specific medications for alleviating this debilitating disease state.
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Download or read book Pain Modulation written by Howard L. Fields and published by Elsevier Publishing Company. This book was released on 1988-01-01 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents edited material that was presented at a conference on brainstem modulation of spinal nociception held in Beaune, France during July, 1987. Pain Modulation, Volume 77 in the series Progress in Brain Research reviews, analyses and suggests new research strategies on several relevant topics including: the endogenous opioid peptides; sites of action of opiates; the role of biogenic animes and non-opioid peptides in analgesia; dorsal horn circuitry; behavioural factors in the activation of pain modulating networks and clinical studies of nociceptive modulation.
Download or read book The Oxford Handbook of the Neurobiology of Pain written by John N. Wood and published by Oxford University Press, USA. This book was released on 2020 with total page 939 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is currently in development, with individual articles publishing online in advance of print publication. At this time, we cannot add information about unpublished articles in this handbook, however the table of contents will continue to grow as additional articles pass through the review process and are added to the site. Please note that the online publication date for this handbook is the date that the first article in the title was published online.
Download or read book Acute Pain Management written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2009-04-27 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.
Download or read book Wall and Melzack s Textbook of Pain written by Patrick David Wall and published by Churchill Livingstone. This book was released on 2006 with total page 1239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combining theoretical and practical aspects of pain, from basic scientific concepts to specific strategies of therapeutic management, this book serves as a guide to current concepts of pain and should appeal to both clinicians and researchers.
Download or read book Cytokines and Pain written by L.R. Watkins and published by Springer Science & Business Media. This book was released on 1999 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to examine immune-to-brain communication from the viewpoint of its effect on pain processing, and to clarify the major role that substances released by immune cells play in pain modulation. In these chapters, contributed by major laboratories whose focus is understanding how cytokines modulate pain, the perspectives examined range from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans. -- book cover.
Download or read book The Essence of Analgesia and Analgesics written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2010-10-14 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.
Download or read book Voltage Gated Sodium Channels written by Peter C. Ruben and published by Springer Science & Business Media. This book was released on 2014-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
Download or read book Neuropathic Pain written by Cory Toth and published by Cambridge University Press. This book was released on 2013-11-07 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Central or peripheral neuropathic pain can be caused by a wide range of injuries, infections and diseases such as: spinal cord injury, multiple sclerosis, stroke, herpes zoster, diabetes and cancer. Many of these pain syndromes are difficult to treat, representing a challenge for many neurologists not routinely trained in pain management. Written by an international team of experts in the field, Neuropathic Pain: Causes, Management and Understanding gives readers an in-depth understanding of the multitude of conditions causing neuropathic pain. Epidemiology, clinical diagnosis, pathophysiology, outcome measurement and the best evidence-based management of individual and general neuropathic pain conditions are also described in depth. A unique chapter, written from a patient's viewpoint, gives new insight into how chronic neuropathic pain affects the lives of those patients with the condition. This book is essential reading for all pain specialists, neurologists, psychiatrists and anesthesiologists who wish to better understand their patients' neuropathic pain.
Download or read book Sickle Cell Pain written by Samir K. Ballas and published by IASP Press. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sickle Cell Pain is a panoramic, in-depth exploration of every scientific, human, and social dimension of this cruel disease. This comprehensive, definitive work is unique in that it is the only book devoted to sickle cell pain, as opposed to general aspects of the disease. The 752-page book links sickle cell pain to basic, clinical, and translational research, addressing various aspects of sickle pain from molecular biology to the psychosocial aspects of the disease. Supplemented with patient narratives, case studies, and visual art, Sickle Cell Pain's scientific rigor extends through its discussion of analgesic pharmacology, including abuse-deterrent formulations. The book also addresses in great detail inequities in access to care, stereotyping and stigmatization of patients, the implications of rapidly evolving models of care, and recent legislation and litigation and their consequences.
Download or read book Fundamentals of Anaesthesia written by Colin Pinnock and published by Cambridge University Press. This book was released on 2002-01-12 with total page 990 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive but easily readable account of all of the information required by the FRCA Primary examination candidate.
Download or read book The Genetics of Pain written by Jeffrey Steven Mogil and published by Progress in Pain Research and. This book was released on 2004 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics more than any other biological approach can explain why some people experience more pain than others and receive less benefit from existing analgesics. Sixteen scholarly articles from international contributors describe the application of genetic techniques to the problem of pain and consider the knowledge that has so far resulted. Three themed sections review the techniques that are allowing the study of pain mechanisms at the genetic level; describe the progress being made in lab animals and humans in identifying the genes responsible for individual differences; and explore the practical and ethical issues that face pain researchers. The editor is associated with the Centre for Research on Pain, McGill U., Montreal. Annotation : 2004 Book News, Inc., Portland, OR (booknews.com).
Download or read book Textbook of Pain written by Patrick D. Wall and published by Edinburgh : Churchill Livingstone. This book was released on 1989-01-01 with total page 1064 pages. Available in PDF, EPUB and Kindle. Book excerpt: The New Edition of the most comprehensive and scholarly reference book on pain research and management has been completely revised and updated. Covers all aspects of the understanding and management of pain.
Download or read book Acute Pain Management written by Pamela E. Macintyre and published by . This book was released on 2010-01-01 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Theranostics of CNS Injuries and Diseases From Basic Research to Clinical Practice written by Bo Li and published by Frontiers Media SA. This book was released on 2023-09-07 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:
