Download or read book RNA Infrastructure and Networks written by Lesley J. Collins and published by Springer Science & Business Media. This book was released on 2011-09-15 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNAs form complexes with proteins and other RNAs. The RNA‐infrastructure represents the spatiotemporal interaction of these proteins and RNAs in a cell‐wide network. RNA Infrastructure and Networks brings together these ideas to illustrate the scope of RNA‐based biology, and how connecting RNA mechanisms is a powerful tool to investigate regulatory pathways. This book is but a taste of the wide range of RNA‐based mechanisms that connect in the RNA infrastructure.
Download or read book Developmental Timing written by and published by Academic Press. This book was released on 2013-09-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Current Topics in Developmental Biology covers developmental timing, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as the timing of developmental programs in Drosophila, temporal patterning of neural progenitors, and environmental modulation of developmental timing.
Download or read book Methods in Molecular Biology written by Peter B. Becker and published by . This book was released on 1999 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nematodes as Model Organisms written by Itamar Glazer and published by Cab International. This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Nematodes, especially Caenorhabditis elegans have been used as a model for research in molecular biology since the 1960's. This is a much-needed update on research on fundamental processes in areas such as genetics, developmental biology, nutrition, toxicology, ecology, pharmacology and medicine"--
Download or read book Transformations of Lamarckism written by Snait Gissis and published by MIT Press. This book was released on 2011 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: A reappraisal of Lamarckism--its historical impact and contemporary significance.
Download or read book RNAi written by Gregory J. Hannon and published by CSHL Press. This book was released on 2003 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past three years, the use of double-stranded RNA to silence gene activity has become widely and rapidly adopted. RNA interference is highly specific and remarkably potent, and it acts on cells and tissues far removed from the site of introduction. The principles behind RNAi are just being uncovered, but this laboratory technique has been applied effectively in a wide variety of animal and plant species. Variations on RNAi are revolutionizing many approaches to experimental biology, complementing traditional genetic technologies with a quicker and less expensive way of mimicking the effects of mutations both in cell cultures and in living animals. Recent advances in the use of RNAi to engineer heritable silencing in mammals, to alter stem cells for organ reconstitution, and to alter the course of disease in model systems indicate that RNAi may have a future in disease therapy. Written by pioneers in this new field and edited by Gregory Hannon, one of its leading figures, RNAi: A Guide to Gene Silencing presents the principles of RNAi and reliable protocols for its laboratory use in Caenorhabditis elegans, Drosophila, plants, avian embryos, mammalian cells, mouse oocytes, and more. This important and unique book is an essential laboratory resource for scientists studying gene regulation and for all experimental biologists interested in the emerging practical applications of RNAi.
Download or read book Beyond the Gene written by Jan Sapp and published by Oxford University Press. This book was released on 1987-05-14 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scope and significance of cytoplasmic inheritance has been the subject of one of the longest controversies in the history of genetics. In the first major book on the history of this subject, Jan Sapp analyses the persistent attempts of investigators of non-Mendelian inheritance to establish their claims in the face of strong resistance from nucleo-centric geneticists and classical neo-Darwinians. A new perspective on the history of genetics is offered as he explores the conflicts which have shaped theoretical thinking about heredity and evolution throughout the century: materialism vs. vitalism, reductionism vs. holism, preformation vs. epigenesis, neo-Darwinism vs. new-Lamarckism, and gradualism vs. saltationism. In so doing, Sapp highlights competitive struggles for power among individuals and disciplinary groups. He accepts that political interests and general social contexts may directly affect scientific ideas, but develops the stronger thesis that social interests inside science itself are always involved in the content of scientific knowledge. He goes on to show that there are no neutral judges in scientific controversies and investigates the social strategies and methodological rhetoric used by scientists when they defend or oppose a particular theory. At the same time, Sapp illustrates the social constraints that ensure the high cost and risk of entertaining unorthodox theories in the sciences.
Download or read book C elegans written by Kevin Strange and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular biology has driven a powerful reductionist, or “molecule-c- tric,” approach to biological research in the last half of the 20th century. Red- tionism is the attempt to explain complex phenomena by defining the functional properties of the individual components of the system. Bloom (1) has referred to the post-genome sequencing era as the end of “naïve reductionism. ” Red- tionist methods will continue to be an essential element of all biological research efforts, but “naïve reductionism,” the belief that reductionism alone can lead to a complete understanding of living organisms, is not tenable. Organisms are clearly much more than the sum of their parts, and the behavior of complex physiological processes cannot be understood simply by knowing how the parts work in isolation. Systems biology has emerged in the wake of genome sequencing as the s- cessor to reductionism (2–5). The “systems” of systems biology are defined over a wide span of complexity ranging from two macromolecules that interact to carry out a specific task to whole organisms. Systems biology is integrative and seeks to understand and predict the behavior or “emergent” properties of complex, multicomponent biological processes. A systems-level characteri- tion of a biological process addresses the following three main questions: (1) What are the parts of the system (i. e.
Download or read book Current Protocols Essential Laboratory Techniques written by Sean R. Gallagher and published by John Wiley & Sons. This book was released on 2012-03-19 with total page 679 pages. Available in PDF, EPUB and Kindle. Book excerpt: The latest title from the acclaimed Current Protocols series, Current Protocols Essential Laboratory Techniques, 2e provides the new researcher with the skills and understanding of the fundamental laboratory procedures necessary to run successful experiments, solve problems, and become a productive member of the modern life science laboratory. From covering the basic skills such as measurement, preparation of reagents and use of basic instrumentation to the more advanced techniques such as blotting, chromatography and real-time PCR, this book will serve as a practical reference manual for any life science researcher. Written by a combination of distinguished investigators and outstanding faculty, Current Protocols Essential Laboratory Techniques, 2e is the cornerstone on which the beginning scientist can develop the skills for a successful research career.
Download or read book Chloroplast Biogenesis written by Udaya C. Biswal and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chloroplast is the organelle where the life-giving process photosynthesis takes place; it is the site where plants and algae produce food and oxygen that sustain our life. The story of how it originates from proplastids, and how it ultimately dies is beautifully portrayed by three authorities in the field: Basanti Biswal, Udaya Biswal and M. K. Raval. I consider it a great privilege and honor to have been asked to write this foreword. The book ' Chloroplast biogenesis: from proplastid to gerontoplast' goes much beyond photosynthesis. The character of the book is different from that of many currently available books because it provides an integrated approach to cover the entire life span of the organelle including its senescence and death. The books available are mostly confined to the topics relating to the 'build up' or development of chloroplast during greening. The story of organelle biogenesis without description of the events associated with its regulated dismantling during genetically programmed senescence is incomplete. A large volume of literature is available in this area of chloroplast senescence accumulated during the last 20 years. Although some of the findings in this field have been organized in the form of reviews, the data in the book are generalized and integrated with simple text and graphics. This book describes the structural features of prop las tid and its transformation to fully mature chloroplast, which is subsequently transformed into gerontoplast exhibiting senescence syndrome. The book consists of five major chapters.
Download or read book RNAi Technology written by R. K. Gaur and published by CRC Press. This book was released on 2016-04-19 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNAi technology is used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. Introducing new technology in the study of RNA
Download or read book Caenorhabditis Elegans written by Henry F. Epstein and published by Academic Press. This book was released on 1995 with total page 687 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this laboratory handbook emphasizes diverse methods and technologies needed to investigate C. elegans, both as an integrated organism and as a model system for research inquiries in cell, developmental, and molecular biology, as well as in genetics and pharmacology. Four primary sections--Genetic and Culture Methods, Neurobiology, Cell and Molecular Biology, and Genomics and Informatics--reflect the cross-disciplinary nature of C. elegans research. Because C. elegans is a simple and malleable organism with a small genome and few cell types, it provides an elegant demonstr.
Download or read book Genetically Engineered Crops written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-01-28 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetically engineered (GE) crops were first introduced commercially in the 1990s. After two decades of production, some groups and individuals remain critical of the technology based on their concerns about possible adverse effects on human health, the environment, and ethical considerations. At the same time, others are concerned that the technology is not reaching its potential to improve human health and the environment because of stringent regulations and reduced public funding to develop products offering more benefits to society. While the debate about these and other questions related to the genetic engineering techniques of the first 20 years goes on, emerging genetic-engineering technologies are adding new complexities to the conversation. Genetically Engineered Crops builds on previous related Academies reports published between 1987 and 2010 by undertaking a retrospective examination of the purported positive and adverse effects of GE crops and to anticipate what emerging genetic-engineering technologies hold for the future. This report indicates where there are uncertainties about the economic, agronomic, health, safety, or other impacts of GE crops and food, and makes recommendations to fill gaps in safety assessments, increase regulatory clarity, and improve innovations in and access to GE technology.
Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Download or read book The Neuronal Ceroid Lipofuscinoses Batten Disease written by Sara Mole and published by OUP Oxford. This book was released on 2011-03-10 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt: The neuronal ceroid lipofuscinoses are an extremely rare group of inherited neurodegenerative diseases that primarily affect children. Core symptoms of these conditions typically include epilepsy, cognitive decline and visual failure. These diseases are so rare that professionals who come into contact with them need a consultative reference work that enables them to become expert, or identify who to contact for more details. Fully updated and revised, this second edition continues to be the definitive volume on this devastating group of disorders. Written by an international collection of authorities in the field, it provides invaluable advice on their diagnosis, patient care, and new treatments that are available. This new edition of the definitive reference text on the neuronal ceroid lipofuscinoses will prove useful for clinicians, family physicians, research scientists, diagnostic laboratories, families affected by the disease as well as by workers in industry planning translational research.
Download or read book Gene Drives on the Horizon written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-08-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.
Download or read book Mitochondrial Function written by William S. Allison and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
