Download or read book Cystogenesis written by Jong Hoon Park and published by Springer. This book was released on 2016-10-12 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Download or read book Pediatric Nephrology written by Ellis D. Avner and published by Springer Science & Business Media. This book was released on 2009-08-20 with total page 2059 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases.
Download or read book Every Tool s a Hammer written by Adam Savage and published by Atria Books. This book was released on 2020-10-27 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this New York Times bestselling “imperative how-to for creativity” (Nick Offerman), Adam Savage—star of Discovery Channel’s Mythbusters—shares his golden rules of creativity, from finding inspiration to following through and successfully making your idea a reality. Every Tool’s a Hammer is a chronicle of my life as a maker. It’s an exploration of making, but it’s also a permission slip of sorts from me to you. Permission to grab hold of the things you’re interested in, that fascinate you, and to dive deeper into them to see where they lead you. Through stories from forty-plus years of making and molding, building and breaking, along with the lessons I learned along the way, this book is meant to be a toolbox of problem solving, complete with a shop’s worth of notes on the tools, techniques, and materials that I use most often. Things like: In Every Tool There Is a Hammer—don’t wait until everything is perfect to begin a project, and if you don’t have the exact right tool for a task, just use whatever’s handy; Increase Your Loose Tolerance—making is messy and filled with screwups, but that’s okay, as creativity is a path with twists and turns and not a straight line to be found; Use More Cooling Fluid—it prolongs the life of blades and bits, and it prevents tool failure, but beyond that it’s a reminder to slow down and reduce the friction in your work and relationships; Screw Before You Glue—mechanical fasteners allow you to change and modify a project while glue is forever but sometimes you just need the right glue, so I dig into which ones will do the job with the least harm and best effects. This toolbox also includes lessons from many other incredible makers and creators, including: Jamie Hyneman, Nick Offerman, Pixar director Andrew Stanton, Oscar-winner Guillermo del Toro, artist Tom Sachs, and chef Traci Des Jardins. And if everything goes well, we will hopefully save you a few mistakes (and maybe fingers) as well as help you turn your curiosities into creations. I hope this book serves as “creative rocket fuel” (Ed Helms) to build, make, invent, explore, and—most of all—enjoy the thrills of being a creator.
Download or read book Stardust Dads written by Josephine C. George and published by iUniverse. This book was released on 2008-10-17 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The e-mail Danny and Allison read on their new computer in 1996 looks no different from the millions of others received by Web users around the world, with one glaring exception--it was sent by their dads who died during the 1970s. While residing in the afterworld at an amenity-laden paradise called Midway Manor, guitar-strumming Mickey Parks and piano-playing Lloyd Wallace monitor and manipulate the lives of their adult children on earth from the mid-'70s through the 1990s. Tampering with the facility's sophisticated computer, the dads thrust Mickey's daughter Allison and Lloyd's son Danny into a passionate but sometimes stormy relationship-a relationship steeped in Danny's heavy drinking and entangled in the often-zany world of men's adventure magazine publishing. After carefully implementing a plan to send their son and daughter a gift of knowledge that could enrich their lives forever, the dads' brief contact is cut short. They are banished to another destination in the afterworld, but not before they impart indisputable proof of life after death--and unwittingly put Danny's and Allison's earthbound lives on the line.
Download or read book The Pleasant Profession of Robert A Heinlein written by Farah Mendlesohn and published by Unbound Publishing. This book was released on 2019-03-07 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Robert A. Heinlein began publishing in the 1940s at the dawn of the Golden Age of science fiction, and today he is considered one of the genre's 'big three' alongside Arthur C. Clarke and Isaac Asimov. His short stories were instrumental in developing its structure and rhetoric, while novels such as Stranger in a Strange Land and Starship Troopers demonstrated that such writing could be a vehicle for political argument. Heinlein’s influence remains strong, but his legacy is fiercely contested. His vision of the future was sometimes radical, sometimes deeply conservative, and arguments have flared up recently about which faction has the most significant claim on his ideas. In this major critical study, Hugo Award-winner Farah Mendlesohn carries out a close reading of Heinlein’s work, including unpublished stories, essays, and speeches. It sets out not to interpret a single book, but to think through the arguments Heinlein made over a lifetime about the nature of science fiction, about American politics, and about himself.
Download or read book Medical Surgical Nursing Single Volume Text and Elsevier Adaptive Learning Package written by Sharon L. Lewis and published by Elsevier. This book was released on 2014-06-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Corresponding chapter-by-chapter to Medical-Surgical Nursing, 9e, Elsevier Adaptive Learning combines the power of brain science with sophisticated, patented Cerego algorithms to help you learn faster and remember longer. It's fun; it's engaging; and it's constantly tracking your performance and adapting to deliver content precisely when it's needed to ensure core information is transformed into lasting knowledge. Please refer to the individual product pages for the duration of access to these products. An individual study schedule reduces cognitive workload and helps you become a more effective learner by automatically guiding the learning and review process. The mobile app offers a seamless learning experience between your smartphone and the web with your memory profile maintained and managed in the cloud. UNIQUE! Your memory strength is profiled at the course, chapter, and item level to identify personal learning and forgetting patterns. UNIQUE! Material is re-presented just before you would naturally forget it to counteract memory decay. A personalized learning pathway is established based on your learning profile, memory map, and time required to demonstrate information mastery. The comprehensive student dashboard allows you to view your personal learning progress.
Download or read book Mathematicians in Love written by Rudy Rucker and published by Macmillan. This book was released on 2008-07-08 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: A riveting new science fiction novel from the writer who twice won the Philip K. Dick Award for best SF novel.Bela and Paul, two wild young mathematicians, are friends and roommates, and in love with the same woman, who happens to be Alma, Bela's girlfriend. They fight it out by changing reality using cutting edge math, to change who gets the girl. The contemporary world they live in is not quite this one, but much like Berkeley, California, and the two graduate students are trying to finish their degrees and get jobs. It doesn't help that their unpredictable advisor Roland is a mad mathematical genius who has figured out a way to predict isolated and specific bits of the future that can cause a lot of trouble. . .and he's starting to see monsters in mirrors. Bela and Paul start to mess around with reality, and when that happens, all heaven and hell break loose. Those monsters of Roland's were really there, but who are they? This novel is a romantic comedy with a whole corkscrew of SF twists. At the publisher's request, this title is being sold without Digital Rights Management software (DRM) applied.
Download or read book Medical Terminology in a Flash written by Sharon Eagle and published by F A Davis Company. This book was released on 2006 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides students with a foundation of knowledge they can build on as they pursue a career in healthcare. This work is written in a user-friendly style.
Download or read book The Math Gene written by Keith Devlin and published by Basic Books. This book was released on 2001-05-17 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: If people are endowed with a "number instinct" similar to the "language instinct" -- as recent research suggests -- then why can't everyone do math? In The Math Gene, mathematician and popular writer Keith Devlin attacks both sides of this question. Devlin offers a breathtakingly new theory of language development that describes how language evolved in two stages and how its main purpose was not communication. Devlin goes on to show that the ability to think mathematically arose out of the same symbol-manipulating ability that was so crucial to the very first emergence of true language. Why, then, can't we do math as well as we speak? The answer, says Devlin, is that we can and do -- we just don't recognize when we're using mathematical reasoning.
Download or read book Clinical Nephrotoxins written by Marc E. de Broe and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: To you the reader, the joy of discovery begins, for We continue in our goal of providing a text which us the job is done. In this edition, we have corrected is useful, not only to the clinician, but of equal interest past deficiencies, added new topics, expanded infor- to the investigator. The selection of content has been mation regarding the pediatric age group, provided directed at topics of current interest rather than those up to date (March 2003) references, while remaining of historic contribution. We have stressed the cont- true to our concept of a multi-national author book. bution of cell biology and pathophysiology, were it We continue to believe that scientific information is an exists, believing it provides both a better understa- international commodity whose interpretation and ap- ing of toxic injury when known, and a rational dir- plication are strongly influenced by both the cultural tion for therapy and prevention. and ethnic background of the observer. The oppor- nity to share in the rich diversity of the international We are encouraged by the accumulation of rec- scientific community remains a fundamental goal of nized risk factors, which allow pre-treatment strati- this endeavor. To participate as equals leads to mu- cation of our patients’ relative risk and allow us to - tual respect and peer appreciation. The sharing of in- cus our preventative techniques on the individuals tellectual resources fostered by this effort should and most likely to gain the greatest benefit.
Download or read book Research on Women s Health written by and published by . This book was released on 1997 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Clinical Diagnostics written by Xue-Hong Wan and published by Springer Nature. This book was released on 2019-08-26 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book covers basic theories, basic knowledge and basic skills on clinical diagnosis, basic requirements for doctors’ ethical conduct, clinical reasoning and documentation of medical records during the process of making a diagnosis. It consists of six parts, including ‘Symptoms’, ‘History Taking’, ‘Physical Examination’, ‘Supplementary Examination’, ‘Common Clinical Diagnosis Techniques’, and ‘Diagnostic Process and Clinical Reasoning’. A vocabulary index is included for easy reference at the end of the book. This book is compiled by authors of 14 Chinese medical schools and universities, whose years of experience in clinical diagnostics, rich overseas learning and working experiences. This book is included in the first round of English textbooks series for clinical medicine major of China's higher medical colleges; and is among "13th Five-Year" planning textbooks of National Health Commission of the People’s Republic of China. It is also an ideal textbook for MBBS (Bachelor of Medicine and Bachelor of Surgery) student It is a co-publication book with People's Medical Publishing House (PMPH). The ISBN of PMPH version in China is 978-7-117-23852-6.
Download or read book Approaches to Chronic Kidney Disease written by Jerry McCauley and published by Springer Nature. This book was released on 2021-10-18 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic kidney disease (CKD) is a major global public health problem, affecting nearly one in seven adults in the United States alone. It is a disease that integrates chronic illness at several levels, and the progressive condition is associated with high rates of co-morbidity. This text provides a comprehensive, current state-of-the art review of this field, serving as a valuable resource for primary care providers and non-nephrology clinicians that treat patients with CKD. It is comprised of 24 chapters focused on specific aspects of the disease. The first 2 chapters provide a bit of background on the disease, describing the anatomy and physiology of the kidney as well as the definition and epidemiology of the disease. The following 3 chapters discuss the detection, prevention and progression of the disease. The next 6 chapters describe the relationship of the disease with other conditions and most common co-morbidities such as diabetes and hypertension. The chapters, that follow focus on the CKD associated complications and the CKD within special populations such as the elderly and minorities as well as dietary restrictions and drug dosing. The book concludes with discussion on preparation for renal replacement therapy and preemptive organ transplantation as an alternative to dialysis in the management of the advanced CKD. Written by experts in the field, Approach to Chronic Kidney Disease is a comprehensive guide for clinicians, especially primary care providers including residents and fellows in training, who take care of chronic kidney disease patients. It is also a useful tool for researchers dealing with this challenging field.
Download or read book Fetal Neonatal Secrets written by Richard Polin and published by Elsevier Health Sciences. This book was released on 2013-10-01 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fetal and Neonatal Secrets by Drs. Richard Polin and Alan Spitzer, uses the success formula of the highly popular Secrets Series to offer fast answers to the most essential clinical questions in fetal and neonatal medicine. With its user-friendly Q&A format, practical tips from neonatologists and fetal medicine experts, and "Key Points" boxes, this portable and easy-to-read medical reference book provides rapid access to the practical knowledge you need to succeed both in practice and on board and recertification exams. "Fetal and Neonatal Secrets is a book with an alternative setup that offers answers to a wide spectrum of clinical questions in the field of fetal and neonatal medicine. The book covers both fetal and neonatal medicine, and could be relevant for junior doctors aiming to become obstetricians or pediatricians." Reviewed by: Acta Obstetricia et Gynecologica Scandinavica, January 2015 - Get the evidence-based guidance you need to provide optimal care for your fetal and neonatal patients. - Zero in on key fetal and neonatal information with a question and answer format, bulleted lists, mnemonics, and practical tips from the authors. - Enhance your reference power with a two-color page layout, "Key Points" boxes, and lists of useful websites. - Review essential material efficiently with the "Top 100 Secrets in Fetal and Neonatal Medicine" – perfect for last-minute study or self-assessment. - Apply all the latest pediatric advances in clinical fetal neonatology techniques, technology, and pharmacology
Download or read book Embryo and Fetal Pathology written by Enid Gilbert-Barness and published by Cambridge University Press. This book was released on 2004-05-31 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exhaustively illustrated in color with over 1000 photographs, figures, histopathology slides, and sonographs, this uniquely authoritative atlas provides the clinician with a visual guide to diagnosing congenital anomalies, both common and rare, in every organ system in the human fetus. It covers the full range of embryo and fetal pathology, from point of death, autopsy and ultrasound, through specific syndromes, intrauterine problems, organ and system defects to multiple births and conjoined twins. Gross pathologic findings are correlated with sonographic features in order that the reader may confirm visually the diagnosis of congenital abnormalities for all organ systems. Obstetricians, perinatologists, neonatologists, geneticists, anatomic pathologists, and all practitioners of maternal-fetal medicine will find this atlas an invaluable resource.
Download or read book Critical Care Nephrology and Renal Replacement Therapy in Children written by Akash Deep and published by Springer. This book was released on 2018-08-17 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents an invaluable resource for professionals for the diagnosis and treatment of acute kidney injury (AKI) in children and how to select and deliver the appropriate form of renal replacement therapy (RRT). Experts from all over the globe have come together to share their wide experience in the field of Critical Care Nephrology in children. Paediatric critical care nephrology is a complex and highly specialised field, presenting challenges and management strategies that are often quite distinct from those seen in adult practice. Therefore, it is high time to address all the topics in the field of critical care nephrology in children in a unique book which is the first of its kind. This book covers the basics as well as advances in the field of Critical Care Nephrology. Each chapter is dedicated to practical aspects of a particular topic elucidating various management decision points. Each chapter is also accompanied with algorithms, figures and protocols in tabulated format. Information on how to manage specific conditions are contextualized with relevant background anatomy, physiology and biochemistry and practical examples. At the end of the chapter, there are key learning points. Paediatricians, nephrologists and paediatric intensivists, as well as paediatric critical care and nephrology nurses in all countries will find this book an invaluable reference text.
Download or read book Case Files Neurology Third Edition written by Eugene C. Toy and published by McGraw Hill Professional. This book was released on 2017-11-10 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: The innovative case-based way to learn neurology – completely revised for today’s shelf exam Medical students need exposure to cases to pass the USMLE® and shelf exams, and this is exactly what Case Files: Neurology, Third Edition offers. Written by experienced educators, it teaches students how to think through diagnosis and management when confronting neurological clinical problems. Sixty high-yield clinical cases focus on the core competencies for the neurology clerkship. Each case includes extended discussion, definition of key terms, clinical pearls, and USMLE-style review questions. This interactive learning system helps students learn instead of memorize. The Third Edition has been completely revised with new questions, enhanced discussions, and better alignment with the challenging shelf exam to give students an unmatched review and learning tool. • Clinical pearls highlight key points • Reflects the most recent clerkship guidelines and core curriculum • Helps students learn in the context of real patients