Download or read book Cooking Well written by Jacob Taylor and published by . This book was released on 2016-06-15 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cookbook tailored for those with Polycystic Kidney Disease
Download or read book Cystogenesis written by Jong Hoon Park and published by Springer. This book was released on 2016-10-12 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Download or read book Pediatric Nephrology written by Ellis D. Avner and published by Springer Science & Business Media. This book was released on 2009-08-20 with total page 2059 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases.
Download or read book What If Our World Is Their Heaven written by Gwen Lee and published by ABRAMS. This book was released on 2002-12-31 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interviews with the genius behind The Man in the High Castle and countless other science fiction classics. In the field of science fiction, Philip K. Dick is unparalleled. His novel Do Androids Dream of Electric Sheep? became the classic film Blade Runner. His short story “The Minority Report” was adapted for the screen by Steven Spielberg. The Man in the High Castle has become a hit series on Amazon, and those titles represent only a small fraction of his work. In November 1982, six months before the author’s untimely death, journalist Gwen Lee recorded the first of several in-depth discussions with Philip K. Dick that continued over the course of the next three months. This transcription is a fascinating read for anyone interested in the field of science fiction. “These transcripts bring fresh insights—notably, into the imaginative biotech plot line of the unwritten The Owl in Daylight . . . Dick also discusses music, writing, philosophers and his 1974–1975 mystical visions, when the revelation of his son’s undiagnosed birth defect—‘down to anatomical details’—saved the child’s life . . . Fans will rejoice.” —Publishers Weekly
Download or read book In Pursuit of a Better Quality Life written by Risa Simon and published by Createspace Independent Publishing Platform. This book was released on 2017 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: You're in need of a living kidney donor, but you're not sure how to go about the process. You've been told to share your story with family and friends-but striking up a conversation about your need for a kidney transplant (and search for a living kidney donor) is the most nerve-racking conversation you can imagine. Whether you're trying to avoid dialysis or be "free of the machine," this book can help get you there. In Pursuit of a Better Life provides communication principles, campaign strategies, template letters and old fashion relationship skills that can instantly create a desire to help. In this book, the author shares strategies taught in her motivational seminars and webinars, and with her mentoring and coaching clients. Living her best life possible as a preemptive (live-donor) kidney transplant recipient, the author invites her readers to proactively engage as their own best advocate and "join her at the top," where dreams do come true. Known as the quintessential marketing plan for finding living kidney donors, this book reveals strategies rarely discussed in your doctor's office or transplant center. Uncover this wildly successful path for attracting potential kidney donors today! ABOUT THE AUTHOR The highlight of Risa Simon's life was the day an unexpected, unrelated, living kidney donor offered to give her a kidney and tests revealed a sister-like match. That day didn't come easy-and it might never have if she wasn't willing to become a proactive contender, competing for her best life possible. Risa knows all too well what it's like to be a kidney patient trapped in a hopeless sinkhole headed towards dialysis. As she watched her renal function numbers decline, her emotions escalated. The thought of surrendering her sense of control over her future consumed her thoughts and immobilized her dreams. Unwittingly, she discovered a new paradigm after attending a kidney patient conference. The presentation she attended caused an awakening that compelled her to stand before her disease and use her voice to proactively secure her best choice - a transplant before dialysis. Today, Risa is living her best life ever as a preemptive (live-donor) transplant recipient. Her passion for helping others reflects in the names of her principal firms, The Proactive Path and the TransplantFirst Academy, a non-profit (501c3) organization leading the way to better outcomes. As an enthusiastic "positive-disruptor," she's dedicated her life to inspiring eligible kidney patients to bypass dialysis (or become dialysis-free) by proactively seeking live-donor transplant opportunities. Known for her trailblazing patient empowerment strategies, she invites her fans and followers to "join her at the top" - where dreams can come true.
Download or read book The Family Tree Guide to DNA Testing and Genetic Genealogy written by Blaine T. Bettinger and published by Penguin. This book was released on 2019-08-13 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unlock the family secrets in your DNA! Discover the answers to your family history mysteries using the most cutting edge tool available. This plain-English guide (newly updated and expanded to include th latest DNA developments) will teach you what DNA tests are available; the pros and cons of the major testing companies; and how to choose the right test to answer your specific genealogy questions. And once you've taken a DNA test, this guide will help you use your often-overwhelming results, with tips for understanding ethnicity estimates, navigating suggested cousin matches, and using third-party tools like GEDmatch to further analyze your data. The book features: · Colorful diagrams and expert definitions that explain key DNA terms and concepts such as haplogroups and DNA inheritance patterns · Detailed guides to each of the major kinds of DNA tests and tips for selecting the DNA test that can best help you solve your family mysteries, with case studies showing how each can be useful · Information about third-party tools you can use to more thoroughly analyze your test results once you've received them · Test comparison guides and research forms to help you select the most appropriate DNA test and organize your results · Insights into how adoptees and others who know little about their ancestry can benefit from DNA testing Whether you've just heard of DNA testing or you've tested at all three major companies, this guide will give you the tools you need to unpuzzle your DNA and discover what it can tell you about your family tree.
Download or read book Martian Time Slip written by Philip K Dick and published by Hachette UK. This book was released on 2011-03-24 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mars is a desolate world. Largely forgotten by Earth, the planet remains helpless in the stranglehold of Arnie Kott, who as boss of the plumbers' union has a monopoly over the vital water supply. Arnie Kott is obsessed by the past; the native Bleekmen, poverty-stricken wanderers, can see into the future; while to Manfred, an autistic boy, time apparently stops. When one of the colonists, Norbert Steiner, commits suicide, the repercussions are startling and bizarre.
Download or read book The Search for Philip K Dick written by Anne R Dick and published by Tachyon Publications. This book was released on 2010-11-01 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering an intimate perspective on the life of an important, prolific author, this revealing biography uncovers the inner workings of a cult figure through his tumultuous relationship with his third wife. Brilliant and charismatic, Philip K. Dick was known as a loyal friend, father, and husband, as well as a talented science fiction writer. His six-year marriage to the woman he described as “the love of his life” and his intellectual equal was full of passion—the meeting of soul mates. But behind the façade of an untroubled life was a man struggling with his demons, unable to trust anyone, and reliant upon his charm to navigate his increasingly dark reality and descent into drugs and madness. Exposing personal details of their married life as well as the ways he continued to haunt her even after their relationship collapsed, Anne Dick provides thorough research combined with personal memories of this mysterious man.
Download or read book Kidney Disease written by Walter A. Hunt and published by Johns Hopkins University Press. This book was released on 2011-06-01 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: By understanding kidney failure—what causes it, how it may affect their lives, and what treatment options they have—people with the disease can improve their quality of life and achieve the best possible outcome.
Download or read book Primary Cilia written by and published by Academic Press. This book was released on 2009-11-30 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the role of cilia in the study of health, development and disease has been increasingly clear, and new discoveries have made this an exciting and important field of research. This comprehensive volume, a complement to the new three-volume treatment of cilia and flagella by King and Pazour, presents easy-to-follow protocols and detailed background information for researchers working with cilia and flagella. - Covers protocols for primary cilia across several systems and species - Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time - Relevant to clinicians and scientists working in a wide range of fields
Download or read book Cutaneous T Cell Lymphoma written by Herschel S. Zackheim and published by CRC Press. This book was released on 2004-10-28 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cutaneous T-cell lymphoma (CTCL) is a general term for many lymphomas of the skin including mycosis Fungoides and Sezary syndrome. This book presents the state of the art in CTCL epidemiology, clinical features, pathology, immunochemistry, diagnostic molecular techniques, staging and prognosis, and treatment. Edited by one of the leading experts in the disease, Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sezary Syndrome provides comprehensive coverage of the disease and presents techniques for diagnosis and state-of-the-art treatment modalities, such as ultraviolet light, steroids, and topical chemotherapeutics.
Download or read book The Unconsoled written by Kazuo Ishiguro and published by Vintage. This book was released on 2012-09-05 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the universally acclaimed author of The Remains of the Day comes a mesmerizing novel of completely unexpected mood and matter--a seamless, fictional universe, both wholly unrecognizable and familiar. When the public, day-to-day reality of a renowned pianist takes on a life of its own, he finds himself traversing landscapes that are by turns eerie, comical, and strangely malleable.
Download or read book Clinical Management of Male Infertility written by Giorgio Cavallini and published by Springer. This book was released on 2014-10-20 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides andrologists and other practitioners with reliable, up-to-date information on all aspects of male infertility and is designed to assist in the clinical management of patients. Clear guidance is offered on classification of infertility, sperm analysis interpretation and diagnosis. The full range of types and causes of male infertility are then discussed in depth. Particular attention is devoted to poorly understood conditions such as unexplained couple infertility and idiopathic male infertility, but the roles of diverse disorders, health and lifestyle factors and environmental pollution are also fully explored. Research considered stimulating for the reader is highlighted, reflecting the fascinating and controversial nature of the field. International treatment guidelines are presented and the role of diet and dietary supplements is discussed in view of their increasing importance. Clinicians will find that the book’s straightforward approach ensures that it can be easily and rapidly consulted.
Download or read book Ambulatory Peritoneal Dialysis written by M.M. Avram and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fourth International Congress of Peritoneal Dialysis was held in Venice, Italy, June 29 to July 2, 1987. By this time peritoneal dialysis had emerged as a treatment for a substantial fraction of patients with end-stage renal disease and countless numbers of patients with acute renal failure. This treatment is now practiced worldwide and is the life-sustaining treatment for about 40,000 patients with chronic renal failure, representing 15 to 20% of dialysis therapy in about 1000 centers. It is not surprising, therefore, that the number of health professionals engaged in the investigation and the application of the treatment has also grown exponen tially. The First International Symposium on Peritoneal Dialysis, organized by Dr. A. Treviiio-Be cerra in Chapala, Mexico, in 1978, brought together a group of pioneers when continuous ambulatory peritoneal dialysis was in its infancy. In 1981, Dr. G. M. Gahl chaired the Second Symposium, in West Berlin, when the technique and professional interest were growing con siderably. By 1984, when Dr. 1. F. Winchester and I organized the Third Symposium, the pre sented papers exceeded 100 and there were about 1000 attendees. At that time, it was deemed appropriate to form a more organized group and the International Society for Peritoneal Dialy sis was founded. One of the first actions of the Society was to choose from among several applicants Dr.
Download or read book Robopocalypse written by Daniel H. Wilson and published by Vintage. This book was released on 2012-04-17 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this terrifying tale of humanity’s desperate stand against a robot uprising, Daniel H. Wilson has written the most entertaining sci-fi thriller in years. Not far into our future, the dazzling technology that runs our world turns against us. Controlled by a childlike—yet massively powerful—artificial intelligence known as Archos, the global network of machines on which our world has grown dependent suddenly becomes an implacable, deadly foe. At Zero Hour—the moment the robots attack—the human race is almost annihilated, but as its scattered remnants regroup, humanity for the first time unites in a determined effort to fight back. This is the oral history of that conflict, told by an international cast of survivors who experienced this long and bloody confrontation with the machines. Brilliantly conceived and amazingly detailed, Robopocalypse is an action-packed epic with chilling implications about the real technology that surrounds us.
Download or read book Clinical Nephrotoxins written by Marc E. de Broe and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: To you the reader, the joy of discovery begins, for We continue in our goal of providing a text which us the job is done. In this edition, we have corrected is useful, not only to the clinician, but of equal interest past deficiencies, added new topics, expanded infor- to the investigator. The selection of content has been mation regarding the pediatric age group, provided directed at topics of current interest rather than those up to date (March 2003) references, while remaining of historic contribution. We have stressed the cont- true to our concept of a multi-national author book. bution of cell biology and pathophysiology, were it We continue to believe that scientific information is an exists, believing it provides both a better understa- international commodity whose interpretation and ap- ing of toxic injury when known, and a rational dir- plication are strongly influenced by both the cultural tion for therapy and prevention. and ethnic background of the observer. The oppor- nity to share in the rich diversity of the international We are encouraged by the accumulation of rec- scientific community remains a fundamental goal of nized risk factors, which allow pre-treatment strati- this endeavor. To participate as equals leads to mu- cation of our patients’ relative risk and allow us to - tual respect and peer appreciation. The sharing of in- cus our preventative techniques on the individuals tellectual resources fostered by this effort should and most likely to gain the greatest benefit.
Download or read book Every Tool s a Hammer written by Adam Savage and published by Atria Books. This book was released on 2020-10-27 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this New York Times bestselling “imperative how-to for creativity” (Nick Offerman), Adam Savage—star of Discovery Channel’s Mythbusters—shares his golden rules of creativity, from finding inspiration to following through and successfully making your idea a reality. Every Tool’s a Hammer is a chronicle of my life as a maker. It’s an exploration of making, but it’s also a permission slip of sorts from me to you. Permission to grab hold of the things you’re interested in, that fascinate you, and to dive deeper into them to see where they lead you. Through stories from forty-plus years of making and molding, building and breaking, along with the lessons I learned along the way, this book is meant to be a toolbox of problem solving, complete with a shop’s worth of notes on the tools, techniques, and materials that I use most often. Things like: In Every Tool There Is a Hammer—don’t wait until everything is perfect to begin a project, and if you don’t have the exact right tool for a task, just use whatever’s handy; Increase Your Loose Tolerance—making is messy and filled with screwups, but that’s okay, as creativity is a path with twists and turns and not a straight line to be found; Use More Cooling Fluid—it prolongs the life of blades and bits, and it prevents tool failure, but beyond that it’s a reminder to slow down and reduce the friction in your work and relationships; Screw Before You Glue—mechanical fasteners allow you to change and modify a project while glue is forever but sometimes you just need the right glue, so I dig into which ones will do the job with the least harm and best effects. This toolbox also includes lessons from many other incredible makers and creators, including: Jamie Hyneman, Nick Offerman, Pixar director Andrew Stanton, Oscar-winner Guillermo del Toro, artist Tom Sachs, and chef Traci Des Jardins. And if everything goes well, we will hopefully save you a few mistakes (and maybe fingers) as well as help you turn your curiosities into creations. I hope this book serves as “creative rocket fuel” (Ed Helms) to build, make, invent, explore, and—most of all—enjoy the thrills of being a creator.
