Download or read book Non Motor Symptoms of Parkinson s Disease written by K. Ray Chaudhuri and published by Oxford University Press, USA. This book was released on 2014 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patients with Parkinson's disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the NMS of Parkinson's Disease, which are poorly recognized and inadequately treated by clinicians. The NMS of PD have a significant impact on patient quality of life and mortality and include neuropsychiatric, sleep-related, autonomic, gastrointestinal, and sensory symptoms. While some NMS can be improved with currently available treatments, others may be more refractory and will require research into novel (non-dopaminergic) drug therapies for the future. Edited by members of the UK Parkinson's Disease Non-Motor Group (PD-NMG) and with contributions from international experts, this new edition summarizes the current understanding of NMS symptoms in Parkinson's disease and points the way towards future research.

Download or read book I Have Parkinson s What Should I Do An Informative Practical Personal Guide to Living Positively with the Many Challenges of Parkinso written by Ann Andrews and published by ReadHowYouWant. This book was released on 2013-09-23 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: An informative, practical, personal guide to living positively with the many challenges of Parkinson's disease.

Download or read book Atypical Parkinsonian Disorders written by Irene Litvan and published by Springer Science & Business Media. This book was released on 2007-10-27 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of what is known not only about the cause and treatment of atypical parksonian disorders, but also the issues that clinicians, researchers, patients, and caregivers face in dealing with them. The authors cover the basic science (history, epidemiology, genetics, pathology, nosology, computer modeling, and animal models), detailed clinical and laboratory assessments, and available diagnostic tools, including neuropsychiatric, neurologic, neuropsychologic, speech, electrophysiologic, and imaging evaluations. Current and future therapeutic approaches are also detailed, along with extensive discussions about future research directions.

Download or read book The Complete Guide for People With Parkinson s Disease and Their Loved Ones written by Lianna Marie and published by Purdue University Press. This book was released on 2020-10-15 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: A diagnosis of Parkinson’s disease is as disorienting as it is devastating. The Complete Guide for People With Parkinson’s Disease and Their Loved Ones helps make sense of what comes next and what can be done, not just for those suffering from the disease but for their family and friends as well. A trained nurse and primary caregiver for her mother, who was diagnosed with Parkinson’s disease in 1991, Lianna Marie draws upon over twenty years of education, research, and direct experience. Written in straightforward and easily accessible language, this essential guide aims to help patients better understand their role in their treatment so that they may continue to lead happy and hopeful lives. Topics covered include nutrition and exercise, alternative and complementary therapies, medication and treatment, and what caregivers can do to help. Written by an international expert on Parkinson’s who has confronted the disease firsthand, The Complete Guide serves as the go-to book for comprehensive, easy-to-understand information for all Parkinson’s patients and their loved ones.

Download or read book I Have Parkinson s What Should I Do written by Ann Andrews and published by Turner Publishing Company. This book was released on 2011-10-30 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: A realistic, compassionate, supportive guide to living positively with a disease that is usually portrayed in depressing terms. Drawing on her own experience and that of others with early onset Parkinson's, the author combines clear information about the symptoms and treatments with practical strategies for adapting to the challenges of life with the disease.

Download or read book Ending Parkinson s Disease written by Ray Dorsey and published by PublicAffairs. This book was released on 2020-03-17 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this "must-read" guide (Lonnie Ali), four leading doctors and advocates offer a bold action plan to prevent, care for, and treat Parkinson's disease-one of the great health challenges of our time. Brain diseases are now the world's leading source of disability. The fastest growing of these is Parkinson's: the number of impacted patients has doubled to more than six million over the last twenty-five years and is projected to double again by 2040. Harmful pesticides that increase the risk of Parkinson's continue to proliferate, many people remain undiagnosed and untreated, research funding stagnates, and the most effective treatment is now a half century old. In Ending Parkinson's Disease, four top experts provide a plan to help prevent Parkinson's, improve care and treatment, and end the silence associated with this devastating disease.

Download or read book The New Parkinson s Disease Treatment Book written by J. Eric Ahlskog, PhD, MD and published by Oxford University Press. This book was released on 2015-08-03 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fundamental guide to the most effective treatments for Parkinson's Disease, from a Mayo Clinic doctor with thirty years of clinical and research experience. In this second edition follow-up to the extremely successful first edition, Dr. Ahlskog draws on thirty years of clinical experience to present the definitive guide to dealing with all aspects of Parkinson's Disease, from treatment options and side effects to the impact of the disease on caregivers and family. Dr. Ahlskog's goal is to educate patients so that they can better team up with their doctors to do battle with the disease, streamlining the decision-making process and enhancing their treatment. To do this, Dr. Ahlskog offers a gold mine of information, distilled from his years of experience treating people with Parkinson's at the Mayo Clinic. In addition to providing a comprehensive account of Parkinson's medications, this book also examines additional aspects of treatment, such as the role of nutrition, exercise, and physical therapy. Although many commendable texts have been written on the subject of Parkinson's Disease, their discussions of treatment have not been in depth. Dr. Ahlskog sifts through aspects of the disease in order to give the reader a comprehensive sense of Parkinson's and the best available treatment options. With a broader understanding of the disease and the available options, patients are able to make more informed choices, and doctors are able to provide more tailored care. This book delivers hopeful, helpful, and extensive information to all parties concerned: patients, caregivers, and doctors. The ultimate guide to symptoms and treatment, this thoroughly updated second edition is the first place patients should turn for reliable, easy-to-grasp information on Parkinson's Disease.

Download or read book Levodopa pharmacokinetics from stomach to brain written by Maria Nord and published by Linköping University Electronic Press. This book was released on 2019-01-07 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson’s disease (PD) is one of the most common neurodegenerative disorders and it is caused by a loss of dopamine (DA) producing neurons in the basal ganglia in the brain. The PD patient suffers from motor symptoms such as tremor, bradykinesia and rigidity and treatment with levodopa (LD), the precursor of DA, has positive effects on these symptoms. Several factors affect the availability of orally given LD. Gastric emptying (GE) is one factor and it has been shown to be delayed in PD patients resulting in impaired levodopa uptake. Different enzymes metabolize LD on its way from the gut to the brain resulting in less LD available in the brain and more side effects from the metabolites. By adding dopa decarboxylase inhibitors (carbidopa or benserazide) or COMT-inhibitors (e.g. entacapone) the bioavailability of LD increases significantly and more LD can pass the blood-brain-barrier and be converted to DA in the brain. It has been considered of importance to avoid high levodopa peaks in the brain because this seems to induce changes in postsynaptic dopaminergic neurons causing disabling motor complications in PD patients. More continuously given LD, e.g. duodenal or intravenous (IV) infusions, has been shown to improve these motor complications. Deep brain stimulation of the subthalamic nucleus (STN DBS) has also been proven to improve motor complications and to make it possible to reduce the LD dosage in PD patients. In this doctoral thesis the main purpose is to study the pharmacokinetics of LD in patients with PD and motor complications; in blood and subcutaneous tissue and study the effect of GE and PD stage on LD uptake and the effect of continuously given LD (CDS) on LD uptake and GE; in blood and cerebrospinal fluid (CSF) when adding the peripheral enzyme inhibitors entacapone and carbidopa to LD infusion IV; in brain during STN DBSand during oral or IV LD treatment. To conclude, LD uptake is more favorable in PD patients with less severe disease and GE is delayed in PD patients. No obvious relation between LD uptake and GE or between GE and PD stage is seen and CDS decreases the LD levels. Entacapone increases the maximal concentration of LD in blood and CSF. This is more evident with additional carbidopa and important to consider in avoiding high LD peaks in brain during PD treatment. LD in brain increases during both oral and IV LD treatment and the DA levels follows LD well indicating that PD patients still have capacity to metabolize LD to DA despite probable pronounced nigral degeneration. STN DBS seems to increase putaminal DA levels and together with IV LD treatment also increases LD in brain possibly explaining why it is possible to decrease LD medication after STN DBS surgery. Parkinsons sjukdom (PS) är en av de vanligaste s.k. neurodegenerativasjukdomarna och orsakas av förlust av dopamin(DA)producerande nervceller i hjärnan. Detta orsakar motoriska symptom såsom skakningar, stelhet och förlångsammade rörelser. Levodopa (LD) är ett ämne, som kan omvandlas till DA i hjärnan och ge symptomlindring och det är oftast förstahandsval vid behandling av patienter med PS. Flera faktorer påverkar tillgängligheten av LD, bl.a. den hastighet som magsäcken tömmer sig med och denna verkar förlångsammad hos personer med PS vilket ger sämre tillgänglighet av LD i blodet och därmed i hjärnan. LD bryts även ner i hög grad av olika enzym ute i kroppen vilket leder till mindre mängd LD som hamnar i hjärnan och till fler nedbrytningsprodukter som orsakar biverkningar. Tillägg av enzymhämmare leder till ökad mängd LD som kan nå hjärnan och omvandlas till DA. Det anses viktigt att undvika höga toppar av LD i hjärnan då dessa verkar bidra till utvecklandet av besvärliga motoriska komplikationer hos patienter med PS. Om LD ges mer kontinuerligt, exempelvis som en kontinuerlig infusion in i tarmen eller i blodet, så minskar dessa motoriska komplikationer. Inopererande av stimulatorer i vissa delar av hjärnan (DBS) har också visat sig minska dessa motoriska komplikationer och även resultera i att man kan minska LD-dosen. Huvudsyftet med den här avhandlingen är att studera LD hos patienter med PS; i blod och fettvävnad då LD ges i tablettform och se om det finns något samband med LD-upptag och hastigheten på magsäckstömningen (MT) och om kontinuerligt given LD påverkar LD-upptaget eller MT; i blod och i ryggmärgsvätska då enzymhämmarna entakapon och karbidopa tillsätts LD; i hjärna vid behandling med DBS och då LD ges både som tablett och som infusion i blodet. Sammanfattningsvis kan vi se att LD-upptaget är mer gynnsamt hos patienter med PS i tidigare skede av sjukdomens komplikationsfas. MT är förlångsammad hos patienter med PS och det är inget tydligt samband mellan LD-upptag och MT eller mellan MT och sjukdomsgrad. Kontinuerligt given LD minskar LDnivåerna. Enzymhämmaren entakapon ökar den maximala koncentrationen av LD i blod och ryggmärgsvätska och effekten är mer tydlig vid tillägg av karbidopa vilket är viktigt att ta i beaktande vid behandling av PS för att undvika höga toppar av LD i hjärnan. LD ökar i hjärnan då man behandlar med LD i tablettform och som infusion i blodet och DA-nivåerna i hjärnan följer LD väl vilket visar på att patienter med PS fortfarande kan omvandla LD till DA trots trolig uttalad brist av de DA-producerande nervcellerna i hjärnan. DBS verkar öka DA i vissa områden i hjärnan och tillsammans med LD-infusion i blodet verkar det även öka LD i hjärnan och det kan förklara varför man kan sänka LDdosen efter DBS-operation.

Download or read book An Essay on the Shaking Palsy written by James Parkinson and published by . This book was released on 1817 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Etiology of Parkinson s Disease written by Jonas H. Ellenberg and published by CRC Press. This book was released on 1995-03-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.

Download or read book Deep Brain Stimulation for Parkinson s Disease written by Gordon H. Baltuch and published by CRC Press. This book was released on 2007-03-19 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considered the largest breakthrough in the treatment of Parkinson's disease in the past 40 years, Deep Brain Stimulation (DBS) is a pioneering procedure of neurology and functional neurosurgery, forging enormous change and growth within the field. The first comprehensive text devoted to this surgical therapy, Deep Brain Stimulation for Parkinson's

Download or read book Parkinson s Disease written by Abraham N. Lieberman and published by Simon and Schuster. This book was released on 1993-02 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide for Parkinson patients and their caregivers that addresses the body and the spirit.

Download or read book Parkinson s Disease written by William J. Weiner and published by JHU Press. This book was released on 2006-11-13 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent innovations, including deep brain stimulation and new medications, have significantly improved the lives of people with Parkinson’s disease. Nevertheless, medical, emotional, and physical challenges remain. The second edition of this accessible and comprehensive guide provides crucial information for managing this complex condition, including details on the use of medications, diet, exercise, complementary therapies, and surgery. The second edition includes new information about: • The genetic and hereditary pattern of the disease • Medications and uses of established medications • Other approaches to treating the symptoms of Parkinson’s • Juvenile-onset Parkinson’s disease • Normal pressure hydrocephalus • The effects of fluctuating hormones on disease symptoms • Fetal cell transplants and porcine cell transplants • The nutritional supplement Co-Enzyme Q10

Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Download or read book Ferri s Clinical Advisor 2020 E Book written by Fred F. Ferri and published by Elsevier Health Sciences. This book was released on 2019-06-01 with total page 2136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significantly updated with the latest developments in diagnosis and treatment recommendations, Ferri’s Clinical Advisor 2020 features the popular "5 books in 1" format to organize vast amounts of information in a clinically relevant, user-friendly manner. This efficient, intuitive format provides quick access to answers on 1,000 common medical conditions, including diseases and disorders, differential diagnoses, and laboratory tests – all reviewed by experts in key clinical fields. Updated algorithms, along with hundreds of new figures, tables, and boxes, ensure that you stay current with today’s medical practice. Contains significant updates throughout, covering all aspects of current diagnosis and treatment. Features 27 all-new topics including chronic traumatic encephalopathy, medical marijuana, acute respiratory failure, gallbladder carcinoma, shift work disorder, radial tunnel syndrome, fertility preservation in women, fallopian tube cancer, primary chest wall cancer, large-bowel obstruction, inguinal hernia, and bundle branch block, among others. Includes a new appendix covering Physician Quality Reporting System (PQRS) Measures. Provides current ICD-10 insurance billing codes to help expedite insurance reimbursements. Patient Teaching Guides for many of the diseases and disorders are included, most available in both English and Spanish versions, which can be downloaded and printed for patients.

Download or read book Parkinson s Disease Guide for the Newly Diagnosed written by Peter LeWitt and published by Rockridge Press. This book was released on 2020-06-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Effective and modern treatment strategies for those newly diagnosed with Parkinson’s Whether it’s you or a family member, receiving a diagnosis of Parkinson’s disease can generate emotions of anger, frustration, sadness, and confusion—but you’re not in this fight alone. Parkinson’s Disease for the Newly Diagnosed is one of the most helpful Parkinson’s disease books, giving you the tools to conquer those feelings of being overwhelmed and helping you to be better prepared for life post-diagnosis. In one of the most extensive, up-to-date Parkinson’s disease books, you’ll find resources for maintaining realistic optimism while living with Parkinson’s disease. With helpful information and advice from how to build a community and patient-caregiver relationships, to assembling your primary care team and more, there’s practical advice for addressing what life will be like moving forward. This standout among Parkinson’s disease books includes: Set expectations—Go beyond other Parkinson’s disease books with an in-depth overview of all the stages from early to advanced. Tailored for you—Use strategies for managing your symptoms that are straightforward and specifically designed for the newly diagnosed. Positive, practical advice—Find out about support groups, how best to adapt your home, preserve your independence, and more in one of the most comprehensive Parkinson’s disease books available. If you’re looking for Parkinson’s disease books that help you understand and manage your symptoms, Parkinson’s Disease for the Newly Diagnosed delivers results.

Download or read book What Your Doctor May Not Tell You About TM Parkinson s Disease written by Mary J. Shomon and published by Grand Central Publishing. This book was released on 2003-02-01 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: From established, trusted doctors comes another groundbreaking "What Your Doctor May Not Tell You" book on Parkinson's Disease, a debilitating neurological disorder that affects over one million people in the U.S.​ Parkinson's patients can now choose from a variety of increasingly effective treatments, including new drugs, revolutionary surgical techniques, and cutting-edge alternative treatments such as intravenous glutathione therapy. The book covers not only the pros and cons of prescription drug and surgical treatments for Parkinson’s, but discusses the latest alternative therapies, including herbal treatments, traditional Chinese medicine, Ayurvedic medicine, diet, exercise, mind-body approaches like Tai Chi, and energy work. With special sections focusing on how patients can deal with persistent problems such as fatigue, depression, and balance problems, and unique chapters that specifically address the interests of the growing number of both caregivers and young-onset Parkinson’s patients, this book is a must for anyone looking to alleviate the disabilities caused by this devastating illness.