Download or read book I Design and Synthesis of Cysteine Protease Inhibitors II Total Synthesis of bafilomycin A1 III Studies Directed Towards the Total Synthesis of Apoptolidin written by Karl A. Scheidt and published by . This book was released on 1999 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Selected Studies in Asymmetric Synthesis written by William John Smith (III.) and published by . This book was released on 2002 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book American Doctoral Dissertations written by and published by . This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2000 with total page 992 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bioprobes written by H. Osada and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid advances in the study of the molecular basis of mammalian cell proliferation, differentiation, and apoptosis have made it possible to develop new screening systems for isolating from microbial metabolites specific inhibitors of mammalian cell functions. "Bioprobes" is the term used to describe these inhibitors, which are extremely useful agents in investigating the molecular and chemical regulation of eukaryotic cell function and apoptosis. Another area where bioprobes are playing an important role is research into immune cell function. This book is the first to present the groundbreaking applications of bioprobes as tools for biochemical research. A large appendix contains the chemical structure, origin, function, key references, and other essential data for more than 80 important bioprobes. The information for each bioprobe is shown in a two-page display, in an easy-to-use format for identifying specific bioprobes for investigation of cell function.
Download or read book Methods for Analysis of Golgi Complex Function written by and published by Elsevier. This book was released on 2013-11-26 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Cell Biology looks at methods for analyzing of golgi complex function. Chapters cover such topics as in vitro reconstitution systems, fluorescence-based analysis of trafficking in mammalian cells and high content screening. With cutting-edge material, this comprehensive collection is intended to guide researchers for years to come. - Covers sections on model systems and functional studies, imaging-based approaches and emerging studies - Chapters are written by experts in the field - Cutting-edge material
Download or read book Protein protein Interactions PPIs written by Clyde R. Montgomery and published by Nova Science Publishers. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein-protein interactions (PPIs) play an important role in vital biological processes such as metabolic and signaling pathways, cell cycle control, and DNA replication and transcription. This book discusses types, methods for detection and the analysis of PPIs. Chapter One describes two key nuclear magnetic resonance (NMR) methods for the investigation of protein-protein interactions, chemical shift perturbation, and residual dipolar coupling, with practical tips on the preparation of samples, NMR measurement, and analysis. Chapter Two describes the basic principles and provides a practical description of the recent technological developments in solution NMR spectroscopy for examining protein-protein interactions. Chapter Three focuses on identifying PPIs via many learning methods based on protein sequence information. Chapter Four examines the thermodynamics of PPIs by isothermal titration calorimetry. Chapter Five describes the general microscopic features of amyloid fibril structures and then discusses the macroscopic properties of protein aggregate with conformations such as packing, hydration, and enthalpy using thermodynamic variables in combination with densitometry and isothermal titration calorimetry. Chapter Six reviews the special case of protein self-association as a modulator of protein function.
Download or read book I Total Synthesis of Piericidin A1 and B1 and Key Analogues written by Martin John Schnermann and published by ProQuest. This book was released on 2008 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: The total synthesis of piericidin A1 and B1 and its extension to the preparation of a series of key analogues are described including ent -piericidin A1 (ent-1), 4'-deshydroxypiericidin A1 (58), 5'-desmethylpiericidin A1 (73), 4'-deshydroxy-5'-desmethylpiericidin A1 (75), and the corresponding analogues 51, 59, 76, and 77 bearing a simplified farnesyl side chain. The evaluation of these key analogues, along with those derived from their further functionalizations, permitted a scan of the key structural features providing new insights into the role of the substituents found in both the pyridyl core as well as the side chain. A strategic late stage heterobenzylic Stille cross-coupling reaction of the pyridyl core with the fully elaborated side chain permitted ready access to the analogues in which each half of the molecule could be systematically and divergently modified. The pyridyl cores were assembled enlisting inverse electron demand Diels-Alder reactions of N -sulfonyl-1-azabutadienes while key elements of side chain syntheses include an anti selective asymmetric aldol to install the C9 and C10 relative and absolute stereochemistry (for natural and ent-1) and a modified Julia olefination for formation of the C5-C6 trans double bond with convergent assemblage of the side chains. The studies directed toward enabling a highly novel approach towards the synthesis of vinblastine and velbanamine aryl analogues from an advanced [beta]-keto ester substrate are reported. A key chiral lactone compound 2.55 containing the C14'/C20' stereocenters of the natural product was generated through an Evan's alkylation, Sharpless dihydroxylation sequence. Following preliminary studies featuring an intramolecular epoxide opening reaction, the key 11-membered ring macrocycle needed for the [alpha]-arylation studies was generated from 2.55 through the use of a key RCM reaction to effectively deliver the [alpha]-arylation precursors 2.101 and 2.111. The [alpha]-arylation reaction with the simplified aryl lead reagent 2.106 was shown to only proceed in modest conversion and with no diastereoselectivity for the formation of C16' center fully saturated system 2.111, while the unsaturated enone system 2.101 underwent the [alpha]-arylation reaction in good conversion and with significant diastereoselectivity (3:1) for the desired C16' stereochemistry found in the natural products. Preliminary studies towards the generation of the indole substrate found in the natural product have been unsuccessful to date, however these studies have included the synthesis of the vinyl triflate 2.113, generated from the [alpha]-diketone 2.112, for use as cross coupling partner that should be integral as these efforts proceed. The key diketone 2.112 has been also been converted quinoxaline compound 2.114 and this intermediate has been carried forward to the bicyclic velbanamine structure 2.117. These studies have demonstrated the potential of this approach to generate advanced intermediates relevant for both the synthesis of vinblastine and novel key velbanamine aryl analogues.
