Download or read book Hydrogel Micro and Nanoparticles written by L. Andrew Lyon and published by John Wiley & Sons. This book was released on 2012-09-24 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides experienced as well as young researchers with a topical view of the vibrant field of soft nanotechnology. In addition to elucidating the underlying concepts and principles that drive continued innovation, major parts of each chapter are devoted to detailed discussions of potential and already realized applications of micro- and nanogel- based materials. Examples of the diverse areas impacted by these materials are biocompatible coatings for implants, films for controlled drug release, self-healing soft materials and responsive hydrogels that react to varying pH conditions, temperature or light.
Download or read book Nanostructured Polymer Blends written by Sérgio Roberto Montoro and published by Elsevier Inc. Chapters. This book was released on 2013-11-28 with total page 55 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymer systems can be developed into a variety of functional forms to meet industrial and scientific applications. In general, they are presented in four common physical forms: (1) linear free chains in solution, (2) covalently or physically cross-linked reversible gels, (3) micro and nanoparticles, and (4) chains adsorbed or in surface-grafted form. Hydrogels are polymeric particles consisting of water-soluble polymer chains, chemically or physically connected using, in general, a cross-linking agent. These materials do not dissolve in water but may swell considerably in aqueous medium, demonstrating an extraordinary ability (>20%) to absorb water into the reticulated structure. Such features make these materials promising tools in the biomedical field, especially as controlled drug release systems. This chapter describes recent progress in the development and applications of polymeric nanostructured hydrogels, mainly in the context of biomedical devices. Additionally, it reports the significant advances in synthesis and characterization strategies of these materials. Special attention is devoted to smart or stimuli-responsive bionanogels, which mimic the property of living systems responding to environmental changes such as pH, temperature, light, pressure, electric field, chemicals, or ionic strength, or a combination of different stimuli. Consequently, these bionanogels offer an efficient solution to various biomedical limitations in the field of drug administration.
Download or read book The Design of Multifunctional Hydrogel Nanoparticles for Drug Delivery written by Michael Hughes Smith and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Hydrogel micro- and nanoparticles (microgels and nanogels) are a promising class of drug delivery vehicles. Composed of hydrophilic polymers arranged into a cross-linked network structure, nanogels show several attractive features for the delivery of macromolecule therapeutics. For instance, the hydrated, porous internal cavity of the nanogel may serve as a high capacity compartment for loading macromolecules, whereas the periphery of the nanogel may be used as a scaffold for conjugating cell-specific targeting moieties. This dissertation presents recent investigations of nanogels as targeted delivery vehicles for oligonucleotides to cancer cells, while exploring new nanogel chemistries that enable future in vivo applications. For instance, synthetic efforts have produced particles capable of erosion into low molar mass constituents, providing a possible mechanism of particle clearance after repeated administration in vivo. In another example, the microgel network chemistry was tuned to promote the encapsulation of charged proteins. In parallel with those synthetic efforts, new light scattering methodologies were developed to accurately quantify the particle behaviors (e.g. loading, erosion). Using multiangle light scattering (MALS), changes in particle molar mass and radius were measured, providing a quantitative and direct approach for monitoring nanogel erosion and macromolecule encapsulation. The new particle chemistries demonstrated, together with enabling light scattering methods, will catalyze the development of improved delivery vehicles in the near future.
Download or read book Micro and Nanotechnologies Based Product Development written by Neelesh Kumar Mehra and published by CRC Press. This book was released on 2021-09-06 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive information of the nanotechnology-based pharmaceutical product development including a diverse range of arenas such as liposomes, nanoparticles, fullerenes, hydrogels, thermally responsive externally activated theranostics (TREAT), hydrogels, microspheres, micro- and nanoemulsions and carbon nanomaterials. It covers the micro- and nanotechnological aspects for pharmaceutical product development with the product development point of view and also covers the industrial aspects, novel technologies, stability studies, validation, safety and toxicity profiles, regulatory perspectives, scale-up technologies and fundamental concept in the development of products. Salient Features: Covers micro- and nanotechnology approaches with current trends with safety and efficacy in product development. Presents an overview of the recent progress of stability testing, reverse engineering, validation and regulatory perspectives as per regulatory requirements. Provides a comprehensive overview of the latest research related to micro- and nanotechnologies including designing, optimisation, validation and scale-up of micro- and nanotechnologies. Is edited by two well-known researchers by contribution of vivid chapters from renowned scientists across the globe in the field of pharmaceutical sciences. Dr. Neelesh Kumar Mehra is working as an Assistant Professor of Pharmaceutics & Biopharmaceutics at the Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, India. He received ‘TEAM AWARD’ for successful commercialisation of an ophthalmic suspension product. He has authored more than 60 peer-reviewed publications in highly reputed international journals and more than 10 book chapter contributions. He has filed patents on manufacturing process and composition to improved therapeutic efficacy for topical delivery. He guided PhD and MS students for their dissertations/research projects. He has received numerous outstanding awards including Young Scientist Award and Team Award for his research output. He recently published one edited book, ‘Dendrimers in Nanomedicine: Concept, Theory and Regulatory Perspectives’, in CRC Press. Currently, he is editing books on nano drug delivery-based products with Elsevier Pvt Ltd. He has rich research and teaching experience in the formulation and development of complex, innovative ophthalmic and injectable biopharmaceutical products including micro- and nanotechnologies for regulated market. Dr. Arvind Gulbake is working as an Assistant Professor at the Faculty of Pharmacy, School of Pharmaceutical & Population Health Informatics, at DIT University, Dehradun, India. He has authored more than 40 peer-reviewed publications in highly reputed international journals, four book chapters and a patent contribution. He has received outstanding awards including Young Scientist Award and BRG Travel Award for his research. He is an assistant editor for IJAP. He guided PhD and MS students for their dissertations/research projects. He has successfully completed extramural project funded by SERB, New Delhi, Government of India. He has more than 12 years of research and teaching experience in the formulation and development of nanopharmaceuticals.
Download or read book Novel Biomaterials for Regenerative Medicine written by Heung Jae Chun and published by Springer. This book was released on 2018-10-24 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores in depth a wide range of new biomaterials that hold great promise for applications in regenerative medicine. The opening two sections are devoted to biomaterials designed to direct stem cell fate and regulate signaling pathways. Diverse novel functional biomaterials, including injectable nanocomposite hydrogels, electrosprayed nanoparticles, and waterborne polyurethane-based materials, are then discussed. The fourth section focuses on inorganic biomaterials, such as nanobioceramics, hydroxyapatite, and titanium dioxide. Finally, up-to-date information is provided on a wide range of smart natural biomaterials, ranging from silk fibroin-based scaffolds and collagen type I to chitosan, mussel-inspired biomaterials, and natural polymeric scaffolds. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth the latest enabling technologies for regenerative medicine.
Download or read book Polymeric and Self Assembled Hydrogels written by Xian Jun Loh and published by Royal Society of Chemistry. This book was released on 2013 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only book to give a complete picture of current hydrogel research, covering all the major applications as well as the fundamental principles behind them.
Download or read book Hydrogels written by Vijay Kumar Thakur and published by Springer. This book was released on 2018-08-28 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses recent advances in hydrogels, including their generation and applications and presents a compendium of fundamental concepts. It highlights the most important hydrogel materials, including physical hydrogels, chemical hydrogels, and nanohydrogels and explores the development of hydrogel-based novel materials that respond to external stimuli, such as temperature, pressure, pH, light, biochemicals or magnetism, which represent a new class of intelligent materials. With their multiple cooperative functions, hydrogel-based materials exhibit different potential applications ranging from biomedical engineering to water purification systems. This book covers key topics including superabsorbent polymer hydrogel; intelligent hydrogels for drug delivery; hydrogels from catechol-conjugated materials; nanomaterials loaded hydrogel; electrospinning of hydrogels; biopolymers-based hydrogels; injectable hydrogels; interpenetrating-polymer-network hydrogels: radiation- and sonochemical synthesis of micro/nano/macroscopic hydrogels; DNA-based hydrogels; and multifunctional applications of hydrogels. It will prove a valuable resource for researchers working in industry and academia alike.
Download or read book Optically Induced Nanostructures written by Karsten König and published by Walter de Gruyter GmbH & Co KG. This book was released on 2015-05-19 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructuring of materials is a task at the heart of many modern disciplines in mechanical engineering, as well as optics, electronics, and the life sciences. This book includes an introduction to the relevant nonlinear optical processes associated with very short laser pulses for the generation of structures far below the classical optical diffraction limit of about 200 nanometers as well as coverage of state-of-the-art technical and biomedical applications. These applications include silicon and glass wafer processing, production of nanowires, laser transfection and cell reprogramming, optical cleaning, surface treatments of implants, nanowires, 3D nanoprinting, STED lithography, friction modification, and integrated optics. The book highlights also the use of modern femtosecond laser microscopes and nanoscopes as novel nanoprocessing tools.
Download or read book Synthesis and Characterisation of Hydrogel Nanoparticles Prepared Using Inverse Microemulsion Polymerisation Processes written by Sarah Eccleston and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell Microencapsulation written by Emmanuel C. Opara and published by Humana. This book was released on 2016-10-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a unique forum to review cell microencapsulation in a broad sense by exploring various cell types that have been encapsulated for different purposes, different approaches and devices used for microencapsulation, the biomaterials used in cell microencapsulation, the challenges to the technology, and the current status of its application in different clinical situations. This book is divided in five sections: Section I is an introductory part that discusses historical developments of the technology and its current challenges, as well as the various applications of cell microencapsulation; Section II discusses the main approaches and devices currently used in cell microencapsulation; Section III presents an overview of the various polymeric materials currently in use for cell microencapsulation and the enabling technologies to either monitor or enhance encapsulated cell function; Section IV gives specific examples of the methods used to encapsulate various cell types; and Section V provides an overview of the different clinical situations in which cell microencapsulation has been applied. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Cell Microencapsulation: Methods and Protocols is a valuable reference for researchers, engineers, clinicians, and other healthcare professionals, as well as food technologists who will find detailed descriptions of methods for the microencapsulation of specific cell types and their current of potential clinical and industrial applications. This volume also includes detailed information about the design and manufacture of different devices including large-scale production devices for use in cell microencapsulation.
Download or read book Stimuli Responsive Gels written by Dirk Kuckling and published by MDPI. This book was released on 2018-10-11 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Stimuli-Responsive Gels" that was published in Gels
Download or read book Handbook of Research on Nano Drug Delivery and Tissue Engineering written by Rajakumari Rajendran and published by CRC Press. This book was released on 2022-03-10 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions from leading researchers in the nanomedicine field from industry, academia, and government and private research institutions across the globe, the volume provides an up-to-date report on topical issues in nano-drug delivery and nanotechnological approaches to tissue engineering. The volume offers research on a variety of diverse nano-based drug delivery systems along with discussions of their efficacy, safety, toxicology, and applications for different purposes. Focusing on nanotechnology approaches to tissue engineering, this volume considers the use of hydrogel systems, nanoceria and micro- and nano-structured biomaterials for bone tissue engineering, mesenchymal stem cells, and more.
Download or read book Nano Micro Structured Materials for Energy and Biomedical Applications written by Bingbing Li and published by Springer. This book was released on 2018-02-08 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the latest developments of the synthesis, preparation, characterization, and applications of nano/microstructure-based materials in biomedical and energetic fields. It introduces several popular approaches to fabricating these materials, including template-assisted fabrication, electrospinning of organic/inorganic hybrid materials, biomineralization-mediated self-assembly, etc. The latest results in material evaluation for targeted applications are also presented. In particular, the book highlights the latest advances and future challenges in polymer nanodielectrics for energy storage applications. As such, it offers a valuable reference guide for scholars interested in the synthesis and evaluation of nano/microstructure-based materials, as well as their biomedical and energetic applications. It also provides essential insights for graduate students and scientists pursuing research in the broad fields of composite materials, polymers, organic/inorganic hybrid materials, nano-assembly, etc.
Download or read book Development and Evaluation of Enzymatically degradable Hydrogel Microparticles for Pulmonary Delivery of Nanoparticles and Biologics written by Prinda Wanakule and published by . This book was released on 2012 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: The emerging class of biologic drugs, including proteins, peptides, and gene therapies, are widely administered by injection, despite potential systemic side effects. Rational design of targeted carriers that can be delivered non-invasively, with reduced side effects, is essential for the success of these therapies, as well as for the improvement of patient compliance and quality of life. One potential approach is to take advantage of specific physiological cues, such as enzymes, which would trigger drug release from a drug carrier. Enzymatic cleavage is highly specific and could be tailored for certain diseased tissues where specific enzymes are up regulated. Enzymatically-degradable hydrogels, which incorporate an enzyme- cleavable peptide into the network structure, have been extensively reported for releasing drugs for tissue engineering applications. These studies showed that a rapid response and corresponding drug release occurs upon enzyme exposure, whereas minimal degradation occurs without enzyme. Recently, Michael addition reactions have been developed for the synthesis of such enzymatically-degradable hydrogels. Michael addition reactions occur under mild physiological conditions, making them ideally suited for polymerizing hydrogels with encapsulated biologic drugs without affecting its bioactivity, as in traditional polymerization and particle synthesis. The focus of my research was to create enzymatically-degradable hydrogel microparticles, using Michael addition chemistry, to evaluate for use as an inhalable, disease-responsive delivery system for biologic drugs and nanoparticles. In this dissertation, I utilize bioconjugation and Michael addition chemistries in the design and development of enzymatically-degradable hydrogels, which may be tailored to a multitude of disease applications. I then introduce a new method of hydrogel microparticle, or microgel, synthesis known as the Michael Addition During Emulsion (MADE) method. These microgel carriers were evaluated in vitro, and found to exhibit triggered release of encapsulated biologic drugs in response to enzyme, no significant cytotoxic effects, and the ability the avoid rapid clearance by macrophages. Lastly, in vivo studies in mice were conducted, and microgels were found to exhibit successful delivery to the deep lung, as well as prolonged pulmonary retention after intratracheal aerosol delivery. In conclusion, a new class of enzymatically-degradable microgels were successfully developed and characterized as a versatile and promising new system for pulmonary, disease-responsive delivery of biologic drugs.
Download or read book Nanostructured Polymer Blends written by Kokkarachedu Varaprasad and published by Elsevier Inc. Chapters. This book was released on 2013-11-28 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructured hydrogels represent a unique class of materials that synergizes the advantageous features of hydrogels. Research into nanostructured hydrogels for biomedical applications has seen great progress in recent years owing to their unlimited potential to advance human health. The development of nanotechnology provides opportunities to characterize, manipulate, and organize matter systematically at the nanometer scale. This is because nanostructured systems in general and nanostructured polymer hydrogels in particular have noble advantages as transporters for a wide range of drugs and tissue engineering scaffolds for biomedical (therapeutic) applications. This chapter explains the design and development of different nanostructured hydrogels and their applications in the biomedical field.
Download or read book Noble and Precious Metals written by Mohindar Seehra and published by BoD – Books on Demand. This book was released on 2018-07-04 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of copper, silver, gold and platinum in jewelry as a measure of wealth is well known. This book contains 19 chapters written by international authors on other uses and applications of noble and precious metals (copper, silver, gold, platinum, palladium, iridium, osmium, rhodium, ruthenium, and rhenium). The topics covered include surface-enhanced Raman scattering, quantum dots, synthesis and properties of nanostructures, and its applications in the diverse fields such as high-tech engineering, nanotechnology, catalysis, and biomedical applications. The basis for these applications is their high-free electron concentrations combined with high-temperature stability and corrosion resistance and methods developed for synthesizing nanostructures. Recent developments in all these areas with up-to-date references are emphasized.
Download or read book Chemical Design of Responsive Microgels written by Andrij Pich and published by Springer Science & Business Media. This book was released on 2010-10-08 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microgels by Precipitation Polymerization: Synthesis, Characterization, and Functionalization, by A. Pich and W. Richtering * Hydrogels in Miniemulsions, by K. Landfester and A. Musyanovych * Nano- and Microgels Through Addition Reactions of Functional Oligomers and Polymers, by K. Albrecht, M. Moeller, and J. Groll * Synthesis of Microgels by Radiation Methods, by F. Krahl and K.-F. Arndt * Microgels as Nanoreactors: Applications in Catalysis, by N. Welsch, M.s Ballauff, and Y. Lu
