Download or read book Human Papillomaviruses and Polyomaviruses in Skin Cancer written by Herbert Johannes Pfister and published by Frontiers Media SA. This book was released on 2019-02-06 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonmelanoma skin cancer (NMSC), more recently defined as keratinocyte carcinoma (KC), is the most frequent malignant tumor among Caucasians. This book deals with widely distributed cutaneous papillomaviruses and polyomaviruses, which are able to establish life-long persistent infections. They are frequently clinically inapparent in the general population, but can cause skin cancer in immunocompromised hosts or in the aging skin undergoing immunosenescence, thereby leading to major medical problems. The incidence of cutaneous squamous cell carcinoma (cSCC) in immunosuppressed organ transplant recipients is 60-250 times higher than that observed in the general population, which is highly suggestive of viral etiology. The treatment of metastatic melanoma with BRAF-inhibitors can induce cSCC formation within only 8-12 weeks. The clinicopathological characteristics of these tumors led to speculations on a possible involvement of oncogenic viruses. The evidence presented in this eBook indicates that high priority should be given to the implementation of a prophylactic and/or therapeutic vaccination program against cutaneous papillomaviruses to prevent NMSC in immunosuppressed allograft recipients.

Download or read book Editorial written by Herbert Johannes Pfister and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Human Polyomaviruses and Papillomaviruses written by Ugo Moens and published by MDPI. This book was released on 2018-09-21 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Human Polyomaviruses and Papillomaviruses" that was published in IJMS

Download or read book Non melanoma Skin Cancer in HIV Infection written by Sacha Imran Goolamali and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Papillomaviruses written by David Evered and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: A multidisciplinary volume presenting recent research relating to papillomaviruses and their association with certain types of malignant lesions. Presents up-to-date findings on their classification and their molecular biology and cell-virus interactions, including mode of entry, modification of genetic material and pathogenecity; their relationship to various kinds of skin conditions; their association with cervical carcinoma and carcinomas of the bladder and alimenatry tract, with descriptions of in vitro studies; and finally, their immunology and possible therapeutic agents, e.g., interferon and vaccination. The only comprehensive text on the subject, it brings together the work of many of the most prominent researchers in the field.

Download or read book The Papillomaviruses written by Robert Garcea and published by Springer Science & Business Media. This book was released on 2007-08-19 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume evaluates the carcinogenic risk to humans posed by infection with human papillomaviruses (HPVs). To date, more than 70 HPV types have been identified, of which over 15 have been reported in cervical cancer biopsies. Worldwide, cervical cancer is the second most common cancer in women. This book also considers the possible involvement of HPV infection in cancers at other sites of the human body.

Download or read book Biology of Skin Cancer excluding Melanomas written by O. D. Laerum and published by . This book was released on 1981 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Human Polyomaviruses and Papillomaviruses written by Ugo Moens (Ed.) and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Human Polyomaviruses and Papillomaviruses written by Ugo Moens and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The interest in human polyomaviruses (HPyV) has seen a renaissance because of new species that have been isolated and their previously unknown association with diseases. Likewise, the increasing evidence for the association of human papillomaviruses (HPV) with oropharyngeal cancer has sparked the attention of researchers and clinicians. The Special Issue "Human Polyomaviruses and Papillomaviruses" presents studies describing the nuclear egress of BK polyomavirus mediated by the viral agnoprotein and the cellular a-SNAP protein. In addition, a study examines the promoter activity of two different variants of human polyomavirus 9 in different cell lines. This Special Issue offers an interesting perspective on the epidemiology of HR-HPV in different cancers and on the mechanisms by which these viruses target host cell proteins to replicate their genome, express their genes, interfere with autophagy, and induce cancer. Other topics that are highlighted include the role of co-factors, such as smoking and co-infection, novel therapeutic strategies, and surface immunoregulatory proteins, chemokines, and cytokines as possible biomarkers to determine the stage of a tumor and to predict clinical outcomes.

Download or read book Polyomaviruses and Human Diseases written by Nasimul Ahsan and published by Springer Science & Business Media. This book was released on 2007-06-25 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science never solves apr oblem without creating ten more Geor ge Bernard Shaw How prophetic the above words prove to be when applied to the advances of 20th century medicine. Prior to Banting and Best, chnicians were unaware of the ravages of diabetes, patients simply wasted away and died. Following the purifica tion of insulin, clinicians now had to deal with diabetic retinopathy, diabetic neph ropathy and all the other complications of long-term diabetes. A little over 50 years ago, the first successful human kidney transplant was performed in Boston. The first 30 years of the experience had successes when compared to the alternative but were a constant struggle to get even 50% of the grafts from deceased donors to survive more than a year. However, the science continued to advance knowledge of the immune response. With this came more and increasingly powerful tools for the clinician. Suddenly, success rates of 80-90% at one year were attainable. With this success came new problems, new complications and clinicians now had to worry about the long-term consequences of their therapy as patients were surviving with functional grafts for extended periods. A particular infectious complication evolved with the application of ever more powerful immunosuppressant drugs. Astute clinicians noted that occasionally cellular rejections seemed to get worse with steroids. Despite their best efforts and the use of powerful drugs, patients lost their grafts to overwhelming interstitial infiltrates not seen before.

Download or read book The Role of Human Papillomaviruses and Their Replication in Nonmelanoma Skin Cancer written by Lorna J. Mackintosh and published by . This book was released on 2011 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonmelanoma skin cancer (NMSC) is the commonest cancer worldwide and is a significant and increasing burden on health care resources. NMSC aetiology is fundamentally linked to sun exposure although infection with oncogenic viruses including Human Papillomaviruses (HPV) is thought to be a cofactor. Fair skinned populations residing in geographical areas with high sun exposure have an increased incidence of NMSC and an excess of NMSC is also observed in certain patient groups including immunosuppressed organ transplant recipients. This thesis describes the epidemiology of NMSC in the immunosuppressed renal transplant population in the West of Scotland. Clinical samples from this population were investigated for the presence of HPV utilising a PCR reverse hybridisation technique. This assay specifically examined for HPV of the genus Beta that have been previously linked to NMSC. The effect of presence of HPV in these samples was evaluated through an investigation of the expression of cellular biomarkers. A biomarker expression pattern specific to HPV infected lesions would add further support to the link between HPV and NMSC. Samples were probed for Ki67, p16, p53, MCM2 and MCM5 antigens in addition to novel antigen, Topoisomerase II Beta Binding Protein 1 (TopBP1). TopBP1 is a host cellular protein that is involved in the DNA damage response and is an interacting partner for HPV thus making it a likely candidate for involvement in cutaneous carcinogenesis. A biomarker expression pattern specific to HPV infected NMSC was not identified although aberrant expression of TopBP1 was identified in a subset of skin cancers. To investigate this novel observation, a molecular investigation of the interaction between TopBP1 and the viral replication factor E2 was carried out, firstly in HPV-16 before extending the work to the cutaneous virus HPV-8. A mutant of HPV-16E2 that failed to bind TopBP1 was generated. Failure to bind TopBP1 resulted in a phenotype exhibiting compromised viral replication. The equivalent mutation generated in HPV-8E2 resulted in an even more compromised replicative phenotype. In addition to this work, gene targets of TopBP1 were also identified by a microarray analysis. This was carried out using MCF7 cells untreated or damaged by ultraviolet radiation (UVR) with endogenous TopBP1 depleted by SiRNA treatment. These studies showed that TopBP1 is involved in a number of cellular processes and is likely to be involved in controlling DNA damage targets following UVR induced DNA damage. The work described in this thesis provides further evidence supporting the role of HPV in the aetiology of nonmelanoma skin cancer. Generation of an E2 mutant that fails to bind TopBP1 and exhibits a compromised replication phenotype provides further evidence to support the hypothesis that the E2-TopBP1 interaction is essential for viral replication and therefore the viral life cycle. This work may facilitate the development of anti-viral therapies for HPV-associated disease by targeting HPV DNA replication through disruption of the E2/TopBP1 interaction.

Download or read book DNA Tumor Viruses written by Blossom Damania and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book focuses on the DNA viruses in the human population that are associated with cancers. It covers most of the viruses that are thought to contribute to human malignancy. This book represents a comprehensive review of the field of DNA tumor virology. Right now, while there are books out there that cover individual viruses that are also covered in this book, there is no single book that covers this topic comprehensively. This book is the first current, comprehensive review of its kind in the market.

Download or read book Papillomaviruses and Human Disease written by Kari J. Syrjänen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, papillomaviruses in general and human papillo maviruses in particular have been recognized as possible agents of important diseases, including some forms of human cancer. The purpose of this book is to present a concise panorama of the pre sent status of knowledge of this topic. This knowledge is as impor tant to molecular biologists and virologists as it is to clinicians and pathologists. To bridge the gap among these diverse groups of investigators, we conceived of a book covering a broad spectrum of the basic scientific, clinical, and pathological aspects of diseases associated with papillomaviruses. Although the principal thrust of this book is directed at human papillomaviruses, fundamental knowledge of animal viruses is essential to the current understand ing of the molecular mechanisms of cell transformation. For this reason, a chapter on animal viruses has also been included. Some of the experimental work having to do with the elucidation of transformation and other aspects of interaction between the virus and the cell cannot be based on human papillomaviruses because of a lack of suitable experimental models. Hence, some of the chapters dealing with fundamental aspects of viral molecular biol ogy are based on animal models. We were very fortunate in having persuaded a number of distin guished colleagues to contribute to this work.

Download or read book Molecular Virology of Human Pathogenic Viruses written by Wang-Shick Ryu and published by Academic Press. This book was released on 2016-03-30 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Virology of Human Pathogenic Viruses presents robust coverage of the key principles of molecular virology while emphasizing virus family structure and providing key context points for topical advances in the field. The book is organized in a logical manner to aid in student discoverability and comprehension and is based on the author’s more than 20 years of teaching experience. Each chapter will describe the viral life cycle covering the order of classification, virion and genome structure, viral proteins, life cycle, and the effect on host and an emphasis on virus-host interaction is conveyed throughout the text. Molecular Virology of Human Pathogenic Viruses provides essential information for students and professionals in virology, molecular biology, microbiology, infectious disease, and immunology and contains outstanding features such as study questions and recommended journal articles with perspectives at the end of each chapter to assist students with scientific inquiries and in reading primary literature. Presents viruses within their family structure Contains recommended journal articles with perspectives to put primary literature in context Includes integrated recommended reading references within each chapter Provides access to online ancillary package inclusive of annotated PowerPoint images, instructor’s manual, study guide, and test bank

Download or read book Essential Human Virology written by Jennifer Louten and published by Academic Press. This book was released on 2022-05-28 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential Human Virology, Second Edition focuses on the structure and classification of viruses, virus transmission and virus replication strategies based upon type of viral nucleic acid. Several chapters focus on notable and recognizable viruses and the diseases caused by them, including influenza, HIV, hepatitis viruses, poliovirus, herpesviruses and emerging and dangerous viruses. Additionally, how viruses cause disease (pathogenesis) is highlighted, along with discussions on immune response to viruses, vaccines, anti-viral drugs, gene therapy, the beneficial uses of viruses, research laboratory assays and viral diagnosis assays. Fully revised and updated with new chapters on coronaviruses, nonliving infectious agents, and notable non-human viruses, the book provides students with a solid foundation in virology. Focuses on human diseases and the cellular pathology that viruses cause Highlights current and cutting-edge technology and associated issues Presents real case studies and current news highlights in each chapter Features dynamic illustrations, chapter assessment questions, key terms, and a summary of concepts, as well as an instructor website with lecture slides, a test bank and recommended activities Updated and revised, with new chapters on coronaviruses, nonliving infectious agents, and notable non-human viruses

Download or read book Human Polyomaviruses written by Kamel Khalili and published by John Wiley & Sons. This book was released on 2004-03-24 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Polyomaviruses Molecular and Clinical perspectives Edited by Kamel Khalili and Gerald L. Stoner Our understanding of human polyomaviruses has evolved profoundly in the last fifteen years, creating an urgent need for an updated resource. Drs. Khalili and Stoner have collected the contributions of renowned researchers and clinicians in this cutting-edge volume. Human Polyomaviruses: Molecular and Clinical Perspectives presents in-depth analyses, comprehensive reviews, and timely assessments of recent discoveries and ongoing controversies focused on these important viral pathogens. Beginning with an historical perspective, this book covers up-to-date investigations into the molecular biology and pathogenesis of human polyomaviruses. All aspects of these persistent infections are subsequently covered, including clinical issues, from diagnosis to information on treatment and drug trials. Central topics are: BK virus JC virus Simian virus 40 (SV40) and its potential as a human pathogen Progressive multifocal leukoencephalopathy (PML) This reference is a superb indoctrination for graduate students, medical students, high-level undergraduates, and anyone engaged in the study of DNA viruses and their molecular biology, evolution, transmission, and pathological potential.

Download or read book Oral Head and Neck Oncology and Reconstructive Surgery E Book written by R. Bryan Bell and published by Elsevier Health Sciences. This book was released on 2017-08-25 with total page 967 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral, Head and Neck Oncology and Reconstructive Surgery is the first multidisciplinary text to provide readers with a system for managing adult head and neck cancers based upon stage. Using an evidence-based approach to the management and treatment of a wide variety of clinical conditions, the extensive experience of the author and contributors in head and neck surgery and oncology are highlighted throughout the text. This includes computer aided surgical simulation, intraoperative navigation, robotic surgery, endoscopic surgery, microvascular reconstructive surgery, molecular science, and tumor immunology. In addition, high quality photos and illustrations are included, which are easily accessible on mobile devices. Management protocols and outcomes assessment provide clear guidelines for managing problems related to adult head and neck oncology and reconstructive surgery. State-of-the art guidance by recognized experts details current techniques as well as technological advances in head and neck/cranio-maxillofacial surgery and oncology. Evidence-based content details the latest diagnostic and therapeutic options for treating a wide-variety of clinical problems with an emphasis on surgical technique and outcomes. Multidisciplinary approach reflects best practices in managing head and neck oncology and cranio-maxillofacial surgery. 900 highly detailed images clearly demonstrate pathologies and procedures. Designed for the modern classroom which lets you access important information anywhere through mobile tablets and smart phones.