Download or read book Homeostasis and Allostasis of Thyroid Function written by Johannes W. Dietrich and published by Frontiers Media SA. This book was released on 2018-08-29 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of the negative feedback of thyroid hormones on pituitary thyroid-stimulating hormone (TSH) secretion, a classical endocrine feedback control system, has shaped diagnosis and treatment of thyroid disease for the last decades. Based on this concept, a unique diagnostic category of subclinical thyroid disorders was introduced, being defined exclusively by an abnormal TSH response in the presence of thyroid hormone concentrations within the reference range. Although this approach was able to deliver a conceptually straightforward disease definition problems surfaced in clinical practice as neither the diagnostic reference range nor the appropriate threshold for initiating substitution treatment are universally agreed upon for subclinical thyroid disorders. The situation is further aggravated by the so-called syndrome T, which comprises a substantial but heterogeneous group of L-T4 treated patients with hypothyroidism with reduced quality of life despite “normal” TSH values. A limited understanding of the physiological relationships between TSH and thyroid hormones may be a main reason for clinical difficulties in dealing with the causes of syndrome T and tailoring substitution therapy for hypothyroid patients with subclinical thyroid disorders. Feedback regulation has recently been shown to be much more complex than previously assumed. The concept of homeostatic control has also been extended to include the lesser known but equally important allostatic thyroid regulation.The latter aims at adaptive homeostasis or stability through changing setpoints and modulating structural parameters of feedback control, as may be appropriate to adapt to a vast array of conditions spanning from fetal life, aging, pregnancy, exercise, starvation, obesity, psychiatric disorders to the severe non-thyroidal illness syndrome. A better understanding of homeostatic and allostatic mechanisms, which govern the behaviour of pituitary-thyroid feedback control, is on the horizon. This promises to improve the diagnostic utility of laboratory methods, laying the foundation for personalised methods to optimise dosage and modality of substitution therapy. The emerging new world of thyroid physiology is reflected on the side of clinical medicine in a new, relational paradigm for diagnosis and treatment. Considerable progress has been made in this respect in the following key areas: • the significance of complementary information processing structures within the feedback loop, in particular ultrashort feedback of TSH on its own secretion and the action of a TSH-T3 shunt unburdening the thyroid from T4 synthesis in imminent thyroid failure, • the unravelling of spatio-temporal dynamics of hormone concentrations ranging from ultradian to circannual rhythms and including hysteresis effects, • the emergence of “non-canonical” mechanisms of thyroid hormone signalling beyond transcriptional control of gene expression, • the physiological actions of thyronine metabolites, which have been previously regarded as biologically inactive, such as thyronamines and iodothyroacetates, • the characterisation of distinct patterns in the adaptive processes to stress and strain and their conclusive explanation through reactions to type 1 and type 2 allostatic load. This collective volume contains the contributions to the Research Topic “Homeostasis and Allostasis of Thyroid Function”, which was originally published by the journal Frontiers in Endocrinology. Authored by an international team of experts from three continents ,the book provides a comprehensive overview on thyroid control from recent research in basic, computational and clinical thyroidology. Many aspects addressed here can be expected to stimulate future research. A more comprehensive view and better integration of in-vitro, in-silico and in-vivo investigations will be invaluable in paving the way to this new world of thyroidology.
Download or read book Homeostasis and Allostasis of Thyroid Function written by and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of the negative feedback of thyroid hormones on pituitary thyroid-stimulating hormone (TSH) secretion, a classical endocrine feedback control system, has shaped diagnosis and treatment of thyroid disease for the last decades. Based on this concept, a unique diagnostic category of subclinical thyroid disorders was introduced, being defined exclusively by an abnormal TSH response in the presence of thyroid hormone concentrations within the reference range. Although this approach was able to deliver a conceptually straightforward disease definition problems surfaced in clinical practice as neither the diagnostic reference range nor the appropriate threshold for initiating substitution treatment are universally agreed upon for subclinical thyroid disorders. The situation is further aggravated by the so-called syndrome T, which comprises a substantial but heterogeneous group of L-T4 treated patients with hypothyroidism with reduced quality of life despite "normal" TSH values. A limited understanding of the physiological relationships between TSH and thyroid hormones may be a main reason for clinical difficulties in dealing with the causes of syndrome T and tailoring substitution therapy for hypothyroid patients with subclinical thyroid disorders. Feedback regulation has recently been shown to be much more complex than previously assumed. The concept of homeostatic control has also been extended to include the lesser known but equally important allostatic thyroid regulation.The latter aims at adaptive homeostasis or stability through changing setpoints and modulating structural parameters of feedback control, as may be appropriate to adapt to a vast array of conditions spanning from fetal life, aging, pregnancy, exercise, starvation, obesity, psychiatric disorders to the severe non-thyroidal illness syndrome. A better understanding of homeostatic and allostatic mechanisms, which govern the behaviour of pituitary-thyroid feedback control, is on the horizon. This promises to improve the diagnostic utility of laboratory methods, laying the foundation for personalised methods to optimise dosage and modality of substitution therapy. The emerging new world of thyroid physiology is reflected on the side of clinical medicine in a new, relational paradigm for diagnosis and treatment. Considerable progress has been made in this respect in the following key areas: • the significance of complementary information processing structures within the feedback loop, in particular ultrashort feedback of TSH on its own secretion and the action of a TSH-T3 shunt unburdening the thyroid from T4 synthesis in imminent thyroid failure, • the unravelling of spatio-temporal dynamics of hormone concentrations ranging from ultradian to circannual rhythms and including hysteresis effects, • the emergence of "non-canonical" mechanisms of thyroid hormone signalling beyond transcriptional control of gene expression, • the physiological actions of thyronine metabolites, which have been previously regarded as biologically inactive, such as thyronamines and iodothyroacetates, • the characterisation of distinct patterns in the adaptive processes to stress and strain and their conclusive explanation through reactions to type 1 and type 2 allostatic load. This collective volume contains the contributions to the Research Topic "Homeostasis and Allostasis of Thyroid Function", which was originally published by the journal Frontiers in Endocrinology. Authored by an international team of experts from three continents ,the book provides a comprehensive overview on thyroid control from recent research in basic, computational and clinical thyroidology. Many aspects addressed here can be expected to stimulate future research. A more comprehensive view and better integration of in-vitro, in-silico and in-vivo investigations will be invaluable in paving the way to this new world of thyroidology.
Download or read book Vertebrate Endocrinology written by David O. Norris and published by Academic Press. This book was released on 2013-05-04 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vertebrate Endocrinology represents more than just a treatment of the endocrine system-it integrates hormones with other chemical bioregulatory agents not classically included with the endocrine system. It provides a complete overview of the endocrine system of vertebrates by first emphasizing the mammalian system as the basis of most terminology and understanding of endocrine mechanisms and then applies that to non-mammals. The serious reader will gain both an understanding of the intricate relationships among all of the body systems and their regulation by hormones and other bioregulators, but also a sense of their development through evolutionary time as well as the roles of hormones at different stages of an animal's life cycle. Includes new full color format includes over 450 full color, completely redrawn image Features a companion web site hosting all images from the book as PPT slides and .jpeg files Presents completedly updated and revitalized content with new chapters, such as Endocrine Disrupters and Behavioral Endocrinology Offers new clinical correlation vignettes throughout
Download or read book Thyroid Hormones and Cardiac Arrhythmia written by Johannes Wolfgang Dietrich and published by Frontiers Media SA. This book was released on 2022-10-17 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Endocrine Frailty in the Elderly written by Sandro La Vignera and published by Frontiers Media SA. This book was released on 2019-12-04 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Vertebrate Endocrinology written by David O. Norris and published by Academic Press. This book was released on 2020-10-10 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vertebrate Endocrinology, Sixth Edition, provides a comprehensive, up-to-date treatment of the endocrine system for college and university students as well as researchers. This book is logically arranged, easily comprehended, and well-illustrated. It covers traditional hormone-based systems and introduces all forms of chemical communication, their implications for the health of humans, domesticated, and wild vertebrates. Written by two experts who have completed extensive research in comparative vertebrate endocrinology with an emphasis on natural and anthropogenic environmental factors influencing endocrine systems. Collectively, the authors have taught courses in endocrinology at the undergraduate and graduate level for more than 60 years. After first publishing in 1985, Vertebrate Endocrinology, Sixth Edition, continues to serve as an important resource for graduate students and advanced undergraduates in the biological sciences, animal sciences, and veterinary sciences. Endocrine researchers will also benefit from the book’s relevance in the areas of comparative, veterinary, and mammalian endocrinology. Addresses the endocrinology of all vertebrate and non-vertebrate chordates The only endocrinology textbook that deals with evolutionary aspects of endocrine systems Includes biochemical, cellular, tissue, organismic, behavioral, and environmental aspects of chemical communication
Download or read book An Introduction to Neuroendocrinology written by Richard E. Brown and published by Cambridge University Press. This book was released on 1994-01-27 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.
Download or read book Developmental Psychopathology Volume 2 written by Dante Cicchetti and published by John Wiley & Sons. This book was released on 2006-03-31 with total page 896 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developmental Psychopathology, Second Edition, contains in three volumes the most complete and current research on every aspect of developmental psychopathology. This seminal reference work features contributions from national and international expert researchers and clinicians who bring together an array of interdisciplinary work to ascertain how multiple levels of analysis may influence individual differences, the continuity or discontinuity of patterns and the pathways by which the same developmental outcomes may be achieved. This volume addresses theoretical perspectives and methodological.
Download or read book The End of Stress as We Know it written by Bruce S. McEwen and published by Dana Press. This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: While some stress is inevitable, being "stressed out" is not. McEwen teaches readers how to reduce stress, increase overall sense of health and well-being--and even turn aside the slings and arrows of life.
Download or read book Approaches to Understanding the Cumulative Effects of Stressors on Marine Mammals written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-05-04 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine mammals face a large array of stressors, including loss of habitat, chemical and noise pollution, and bycatch in fishing, which alone kills hundreds of thousands of marine mammals per year globally. To discern the factors contributing to population trends, scientists must consider the full complement of threats faced by marine mammals. Once populations or ecosystems are found to be at risk of adverse impacts, it is critical to decide which combination of stressors to reduce to bring the population or ecosystem into a more favorable state. Assessing all stressors facing a marine mammal population also provides the environmental context for evaluating whether an additional activity could threaten it. Approaches to Understanding the Cumulative Effects of Stressors on Marine Mammals builds upon previous reports to assess current methodologies used for evaluating cumulative effects and identify new approaches that could improve these assessments. This review focuses on ways to quantify exposure-related changes in the behavior, health, or body condition of individual marine mammals and makes recommendations for future research initiatives.
Download or read book Trends in Posttraumatic Stress Disorder Research written by Thomas A. Corales and published by Nova Publishers. This book was released on 2005 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Posttraumatic Stress Disorder, or PTSD, is a psychiatric disorder that can occur following the experience or witnessing of life-threatening events such as military combat, natural disasters, terrorist incidents, serious accidents, or violent personal assaults like rape. People who suffer from PTSD often relive the experience through nightmares and flashbacks, have difficulty sleeping, and feel detached or estranged, and these symptoms can be severe enough and last long enough to significantly impair the person's daily life. PTSD is marked by clear biological changes as well as psychological symptoms. PTSD is complicated by the fact that it frequently occurs in conjunction with related disorders such as depression, substance abuse, problems of memory and cognition, and other problems of physical and mental health. The disorder is also associated with impairment of the person's ability to function in social or family life, including occupational instability, marital problems and divorces. PTSD is associated with a number of distinctive neurobiological and physiological changes. PTSD is treated by a variety of forms of psychotherapy and drug therapy. This new book presents leading research from around the world.
Download or read book Hormones Brain and Behavior Online written by and published by Academic Press. This book was released on 2002-06-18 with total page 5944 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormones, Brain, and Behavior, Second Edition is a comprehensive work discussing the effect of hormones on the brain and, subsequently, behavior. This major reference work has 109 chapters covering a broad range of topics with an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. To truly understand all aspects of our behavior, we must take every influence (including the hormonal influences) into consideration. Donald Pfaff and a number of well-qualified editors examine and discuss how we are influenced by hormonal factors, offering insight, and information on the lives of a variety of species. Hormones, Brain, and Behavior offers the reader comprehensive coverage of growing field of research, with a state-of-the-art overview of hormonally-mediated behaviors. This reference provides unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics. The topics cover an unusual breadth (from molecules to ecophysiology), ranging from basic science to clinical research, making this reference of interest to a broad range of scientists in a variety of fields. Available online exclusively via ScienceDirect. A limited edition print version is also available. Comprehensive coverage of a growing field of research Unique treatment of all major vertebrate and invertebrate model systems with excellent opportunites for relating behavior to molecular genetics Covers an unusual breadth ranging from molecules to ecophysiology, and from basic science to clinical research
Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Download or read book Oxford Textbook of Endocrinology and Diabetes written by John A.H. Wass and published by Oxford University Press, USA. This book was released on 2011-07-28 with total page 2158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its second edition, the Oxford Textbook of Endocrinology and Diabetes is a fully comprehensive, evidence-based, and highly-valued reference work combining basic science with clinical guidance, and providing first rate advice on diagnosis and treatment.
Download or read book Adaptogens in Medical Herbalism written by Donald R. Yance and published by Simon and Schuster. This book was released on 2013-09-20 with total page 815 pages. Available in PDF, EPUB and Kindle. Book excerpt: A scientifically based herbal and nutritional program to master stress, improve energy, prevent degenerative disease, and age gracefully • Explains how adaptogenic herbs work at the cellular level to enhance energy production and subdue the pro-inflammatory state behind degenerative disease • Explores the author’s custom adaptogenic blends for the immune system, cardiovascular health, thyroid function, brain health, and cancer treatment support • Provides more than 60 monographs on herbs and nutritional compounds based on more than 25 years of clinical practice with thousands of patients Weaving together the ancient wisdom of herbalism and the most up-to-date scientific research on cancer, aging, and nutrition, renowned medical herbalist and clinical nutritionist Donald Yance reveals how to master stress, improve energy levels, prevent degenerative disease, and age gracefully with the elite herbs known as adaptogens. Yance’s holistic approach, called the Eclectic Triphasic Medical System (ETMS), is based on extensive scientific research, more than 25 years of clinical practice, and excellent results with thousands of patients. It centers on four interconnected groups of health tools: botanical formulations, nutritional supplements, diet, and lifestyle. Defining three categories for adaptogenic herbs, he explains how formulations should combine herbs from each category to create a synergistic effect. He provides more than 60 monographs on herbs and nutritional compounds as well as custom combinations to revitalize the immune system, build cardiovascular health, protect brain function, manage weight, and support cancer treatment. He explains the interplay of endocrine health, the hypothalamic-pituitary-adrenal (HPA) axis, thyroid function, and stress in the aging process and reveals how adaptogenic treatment begins at the cellular level with the mitochondria--the microscopic energy producers present in every living cell. Emphasizing spirituality, exercise, and diet in addition to herbal treatments and nutritional supplements, Yance’s complete lifestyle program explores how to enhance energy production in the body and subdue the proinflammatory state that lays the groundwork for nearly every degenerative disease, taking you from merely surviving to thriving.
Download or read book The Making of a Physician written by Cohen Sheldon and published by eBookIt.com. This book was released on 2012-11 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: Are you contemplating a career in the medical field; an M.D., D.O., Nurse Practitioner, Physician Assistant? If so, let a former practicing physician guide you through his own career from incubation through fruition, through the good and the bad. Let him describe for you forty years of primary care medical practice through a period of breath-taking advance and change as medical care transitions into the future. The need is greater than ever and will require more than a few good men and women. The author encourages you to join this group, but only if prepared to work hard and understand that true satisfaction resides in what you can do for others. Sheldon Cohen M.D. FACP
Download or read book Metabolism and Medicine written by Brian Fertig and published by CRC Press. This book was released on 2022-01-25 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic disease states of aging should be viewed through the prism of metabolism and biophysical processes at all levels of physiological organization present in the human body. This book describes the building blocks of understanding from a reasonable but not high-level technical language viewpoint, employing the perspective of a clinical physician. It brings together concepts from five specific branches of physics relevant to biology and medicine, namely, biophysics, classical electromagnetism, thermodynamics, systems biology and quantum mechanics. Key Features: Broad and up-to-date overview of the field of metabolism, especially connecting the spectrum of topics that range from modern physical underpinnings with cell biology to clinical practice. Provides a deeper basic science and interdisciplinary understanding of biological systems that broaden the perspectives and therapeutic problem solving. Introduces the concept of the Physiological Fitness Landscape, which is inspired by the physics of phase transitions This first volume in a two-volume set, primarily targets an audience of clinical and science students, biomedical researchers and physicians who would benefit from understanding each other’s language.
