Download or read book Molecular Pathology of Breast Cancer written by Sunil Badve and published by Springer. This book was released on 2016-11-26 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complex landscape of breast cancer requires distinct strategies for the management of various molecular subtypes of this disease. Rapid advances in the field of molecular biology have been bewildering for those involved in its study and management. “Molecular Pathology of Breast Cancer” aims to close this knowledge gap by discussing comprehensively the evolution, biological basis and clinical applications with a focus on the “what, when, and how” of the most significant molecular markers known to date. These markers are evaluated in the context of genomic, transcriptomic and proteomic profiles, which is integral to the practice of precision medicine. The application of next generation sequencing (NGS) has provided new insights in the regulation of genomic and transcriptomic structure and function. Alterations in DNA such as mutations and single nucleotide polymorphisms (SNPs) have been correlated with outcomes and provide for novel therapeutic approaches. These NGS analyses have also revealed the extensive contributions of epigenetic mechanisms such as histone modifications, non-coding RNA and alternative splicing. All of these changes together contribute to alterations in proteome. Newer assays that allow greater stability and analytical consistency are emerging. These alterations in tumor profiles can be also now detected by imaging techniques. The heterogeneity of both tumor and tumor microenvironment, an inevitable reality, is discussed in detail with particular focus on cancer stem cells and immune signaling. A chapter is dedicated to the emerging technology of “liquid biopsy”, which opens a novel approach for “continuous” monitoring of cancer that might be superior to conventional diagnostics, “Molecular Pathology of Breast Cancer” provides a quick and easy, not to mention essential, tour for clinicians, pathologists and scientists who are seeking to understand the integration of molecular biology into the diagnosis, prognosis and management of breast cancer.

Download or read book Shafer S Textbook Of Oral Pathology 6Th Edition written by R. Rajendran and published by Elsevier India. This book was released on 2009 with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Evidence Based Pathology and Laboratory Medicine written by Alberto M. Marchevsky and published by Springer Science & Business Media. This book was released on 2011-07-01 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on practical, patient related issues, this volume provides the basic concepts of Evidence Based Medicine (EBM) as they relate to Pathology and Laboratory Medicine and presents various practical applications. It includes EBM concepts for use in the identification of cost-effective panels of immunostains and other laboratory tests and for improvement of diagnostic accuracy based on the identification of selected diagnostic features for particular differential diagnosis. EBM concepts are also put forth for use in Meta-analysis to integrate the results of conflicting literature reports and use of novel analytical tools such as Bayesian belief networks, neural networks, multivariate statistics and decision tree analysis for the development of new diagnostic and prognostic models for the evaluation of patients. This volume will be of great value to pathologists who will benefit from the concepts being promoted by EBM, such as levels of evidence, use of Bayesian statistics to develop diagnostic and other rules and stronger reliance on "hard data" to support therapeutic and diagnostic modalities.

Download or read book Tumors of the Chest written by Konstantinos N. Syrigos and published by Springer Science & Business Media. This book was released on 2006-10-06 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this textbook is to meticulously depict all aspects of chest tumors in a comprehensive volume format that encompasses their biology, clinical presentation and management. It is the only book to do this. Chapters of specific interest have also been included to cover such wide-ranging topics as management of the elderly and chemoprevention, along with ethical, social and financial issues associated with such tumors. All participating authors, selected from an international panel of highly regarded scientists currently pioneering lung cancer research, are major contributors in the area of expertise they have been chosen to present.

Download or read book Who Classification of Tumours of the Lung Pleura Thymus and Heart written by International Agency for Research on Cancer and published by World Health Organization. This book was released on 2015-03-16 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart is the seventh volume in the Fourth Edition of the WHO series on histological and genetic typing of human tumors. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome.

Download or read book Diagnostic Cytopathology E Book written by Winifred Gray and published by Elsevier Health Sciences. This book was released on 2010-05-24 with total page 947 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edition stresses not just the diagnostic cytological features of the various conditions encountered, but also the diagnostic pitfalls and the grey areas between so as to enable the reader to give more evidence-based reports. In recognition of their rapid expansion, there are new chapters on recent technological developments and on the cytodiagnosis of childhood tumours. A special section on the importance of multidisciplinary team meetings that include the cytopathologist as a core member of the team has also been included at the end of each chapter. As active members of this team, cytopathologists can define their role in the management pathway and thus bring the patient and the microscope together as never before. The full text can be accessed online and images downloaded via Expert Consult.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1968 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Pathology of Asbestos Associated Diseases written by Victor L. Roggli and published by Springer Science & Business Media. This book was released on 2006-04-29 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathology of Asbestos-Associated Diseases integrates the newest research and advances in its discussion of asbestos-induced diseases. Organized in 13 chapters, the book begins with background information on the mineralogy of asbestos, occupation and environmental exposure to asbestos, and asbestosis. A detailed discussion on mesothelioma includes a historical background, addresses etiologic considerations and epidemiology, pathologic features, differential diagnosis and treatment and prognosis. Guidelines for assessing and identifying asbestos-associated carcinomas of the lung, including histopathology and differential diagnosis, are discussed. The text also addresses the explosion of research in the area of molecular biology and the abundance of information bearing on the mechanisms by which asbestos causes disease. Chapters also cover cytopathology and experimental models of asbestos-related diseases. The diseases associated with asbestos have significant medico-legal implications, and there are two chapters dedicated to addressing the issue. More than 190 illustrations complement the text. An invaluable reference for the pathologist, pulmonologist, radiologist, and occupational medical practitioner interested in asbestos-related disease as well as malpractice attorneys needing an understanding of asbestos, the diseases it induces, prognosis and clinical implications.

Download or read book Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas written by M. A. Hayat and published by Elsevier. This book was released on 2004-06-16 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: The various cell types have traditionally been recognized and classified according to their appearance in the light microscope following the process of fixing, processing, sectioning, and staining tissues that is known as histology. Classical histology has been augmented by immunohistochemistry (the use of specific antibodies to stain particular molecular species in situ). Immunohistochemistry has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system. Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, along with the benefits and limitations of each method. The topics of region-specific gene expression, its role in cancer development and the techniques that assist in the understanding of the molecular basis of disease are relevant and necessary in science today, ensuring a wide audience for this book. - The only book available that translates molecular genetics into cancer diagnosis - Provides the readers with tools necessary to perform and optimize sensitive, powerful techniques, including immunohistochemistry and fluorescence in situ hybridization, used in tumor diagnosis - Written by experts in this field, the book provides theoretical considerations as well as practical approaches to carry out effectively these techniques - Offers suggestions, tips, cautions, and guidelines to avoid artifacts and misdiagnosis - Introduces new techniques to detect genes and proteins involved in the initiation and progression of cancer - Covers the latest developments and a wide range of applications to the detection of antigens and single-copy DNA and RNA - Written in a uniform format, each chapter includes Introduction, Materials required, step-by-step detailed Methods, Results, Discussion, and comprehensive up-to-date References

Download or read book Pathology and Genetics of Tumours of the Digestive System written by Lauri A. Aaltonen and published by Oxford University Press, USA. This book was released on 2000 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative guide to the histological and genetic typing of human tumours of the digestive system. Prepared by 113 experts from 17 countries, the book covers neoplasms of the entire gastrointestinal tract, liver, biliary system, and exocrine pancreas. In view of their increasingly recognized importance, inherited tumour syndromes involving the digestive system are also described. Over 2200 references are included in this authoritative international tool. The book is organized according to ten groups of tumours. Each tumour is introduced with a concise definition and discussion of nomencl.

Download or read book Arthrogryposis written by Lynn T. Staheli and published by Cambridge University Press. This book was released on 1998-04-28 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: The term arthrogryposis describes a range of congenital contractures that lead to childhood deformities. It encompasses a number of syndromes and sporadic deformities that are rare individually but collectively are not uncommon. Yet, the existing medical literature on arthrogryposis is sparse and often confusing. The aim of this book is to provide individuals affected with arthrogryposis, their families, and health care professionals with a helpful guide to better understand the condition and its therapy. With this goal in mind, the editors have taken great care to ensure that the presentation of complex clinical information is at once scientifically accurate, patient oriented, and accessible to readers without a medical background. The book is authored primarily by members of the medical staff of the Arthrogryposis Clinic at Children's Hospital and Medical Center in Seattle, Washington, one of the leading teams in the management of the condition, and will be an invaluable resource for both health care professionals and families of affected individuals.

Download or read book Cerebrovascular Bibliography written by and published by . This book was released on 1972 with total page 1034 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology written by Andrew S. Field and published by Springer Nature. This book was released on 2020-02-22 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text describes a system of reporting breast fine needle aspiration biopsy that uses five clearly defined categories, each described by a specific term and each with a specific risk of malignancy. The five categories are insufficient/inadequate, benign, atypical, suspicious of malignancy and malignant. Each category has a risk of malignancy and is linked to management recommendations, which include several options because it is recognized that diagnostic infrastructure, such as the availability of core needle biopsy and ultrasound guidance, vary between developed and low and middle income countries. This text includes key diagnostic cytological criteria for each of the many lesions and tumors found in the breast. The cytopathology of specific lesions is illustrated with high quality photomicrographs with clear figure descriptions. Chapters also discuss current and potential future ancillary tests, liquid based cytology, nipple cytology and management. An additional chapter provides an overview of an approach to the diagnosis of direct smears of breast fine needle aspiration biopsies. The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology provides a clear logical approach to the diagnosis and categorization of breast lesions by FNAB cytology, and aims to facilitate communication with breast clinicians, further research into breast cytopathology and related molecular pathology, and improve patient care.

Download or read book Handbook of Oncobiology From Basic to Clinical Sciences written by R. C. Sobti and published by Springer Nature. This book was released on with total page 1584 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Who s who in Italy written by and published by . This book was released on 1995 with total page 1306 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Handbook of Practical Immunohistochemistry written by Fan Lin and published by Springer. This book was released on 2015-02-21 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a conceptually current, quick-reference, Question & Answer format, the second edition of Handbook of Practical Immunohistochemistry: Frequently Asked Questions continues to provide a comprehensive and yet concise state-of-the-art overview of the major issues specific to the field of immunohistochemistry. With links to the authors Immunohistochemical Laboratory website, this volume creates a current and up-to-date information system on immunohistochemistry. This includes access to tissue microarrays (TMA) of over 10,000 tumors and normal tissue to validate common diagnostic panels and provide the best reproducible data for diagnostic purposes. Fully revised and updated from the first edition, the new features of the second edition include over 200 additional questions or revised questions with an IHC panel to answer each question; over 250 new color photos and illustrations; over 20 new useful biomarkers; hundreds of new references; several new chapters to cover phosphoproteins, rabbit monoclonal antibodies, multiplex IHC stains, overview of predictive biomarkers, and integration of IHC into molecular pathology; many new coauthors who are international experts in a related field; many updated IHC panels using Geisinger IHC data collected from over 10,000 tumors and normal tissues; and updated appendices containing detailed antibody information for both manual and automated staining procedures. Comprehensive yet practical and concise, the Handbook of Practical Immunohistochemistry: Frequently Asked Questions, Second Edition will be of great value for surgical pathologists, pathology residents and fellows, cytopathologists, and cytotechnologists.

Download or read book Atlas of Breast Tomosynthesis written by Martin Sonnenschein and published by Springer. This book was released on 2017-06-08 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: This superbly illustrated atlas of breast tomosynthesis covers all aspects and applications of the technology, which reduces tissue overlap and facilitates the recognition of small cancers. After clear explanation of basic principles of the technique, individual chapters address diagnostic criteria, indications, and use of breast tomosynthesis as a screening tool. The findings obtained in the full range of benign and malignant conditions, including postoperative changes, are then presented with the aid of a wealth of high-quality illustrations from case examples. Detailed attention is paid to the BI-RADS classification, bearing in mind the ability of tomosynthesis to reduce categorizations as BI-RADS 3 and 0, thereby decreasing the recall rate. The book concludes by examining tomosynthesis-guided interventions such as vacuum-assisted breast biopsy and galactography.