Download or read book High Temperature Ultra fast Liquid Chromatography written by Jonathan D. Thompson and published by . This book was released on 2003 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fast Liquid Chromatography mass Spectrometry Methods In Food And Environmental Analysis written by Oscar Nunez and published by World Scientific. This book was released on 2015-02-03 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a growing need for high-throughput separations in food and environmental research that are able to cope with the analysis of a large number of compounds in very complex matrices. Whereas the most common approach for solving many analytical problems has often been high-performance liquid chromatography (HPLC), the recent use of fast or ultra-fast chromatographic methods for environmental and food analysis has increased the overall sample throughput and laboratory efficiency without loss (and even with an improvement) in the resolution obtained by conventional HPLC systems.This book brings together researchers at the top of their field from across the world to discuss and analyze recent advances in fast liquid chromatography-mass spectrometry (LC-MS) methods in food and environmental analysis. First, the most novel approaches to achieve fast and ultra-fast methods as well as the use of alternative and complementary stationary phases are described. Then, recent advances in fast LC-MS methods are addressed, focusing on novel treatment procedures coupled with LC-MS, new ionization sources, high-resolution mass spectrometry, and the problematic confirmation and quantification aspects in mass spectrometry. Finally, relevant LC-MS applications in food and environmental analysis such as the analysis of pesticides, mycotoxins, food packaging contaminants, perfluorinated compounds and polyphenolic compounds are described.The scope of the book is intentionally broad and is aimed at worldwide analytical laboratories working in food and environmental applications as well as researchers in universities worldwide.
Download or read book High Temperature Liquid Chromatography written by Thorsten Teutenberg and published by Royal Society of Chemistry. This book was released on 2010-06-03 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-temperature liquid chromatography has attracted much interest in recent years but has not yet recognized its full potential in the chromatographic community. There is a widespread reluctance in industry to use temperature to speed up the separation process, influence the selectivity of a separation or implement novel detection techniques. However, the technology has now matured and could revolutionize chromatography as we see it today. Better equipment, such as heating systems able to generate faster heating rates, is becoming more readily available. Also, columns based on silica gel, which can withstand higher temperatures for an extended period, are now being introduced. Nevertheless, further technological and methodical efforts are needed to establish the method in a regulated environment like the pharmaceutical industry. This is the only text to cover all the practical aspects, as well as the underlying theoretical principles, of setting up an HPLC system for high temperature operation. It is not intended solely for academics but will also benefit the researcher interested in more practical considerations. The author is a recognized expert and has conducted several studies with partners from industry to validate the method. Many real examples from these studies have been included in the book. The aim is to support practitioners in the creation of their own protocols without the need to rely solely on trial and error. The book starts with a brief definition of high temperature liquid chromatography before going on to cover: system set up; the heating system; mobile phase considerations; suitable stationary phases; method development using temperature programming; analyte stability, and special hyphenation techniques using superheated water as a mobile phase. In each chapter, experimental data is used to illustrate the main statements and the advantages over conventional HPLC are evaluated. The book concludes with a critical outlook on further developments and applications underlining the necessary advances needed to make high temperature HPLC more robust.
Download or read book Multidimensional Liquid Chromatography written by Steven A. Cohen and published by John Wiley & Sons. This book was released on 2008-05-09 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multidimensional Liquid Chromatography (MDLC) is a very powerful separation technique for analyzing exceptionally complex samples in one step. This authoritative reference presents a number of recent contributions that help define the current art and science of MDLC. Topics covered include instrumentation, theory, methods development, and applications of MDLC in the life sciences and in industrial chemistry. With the information to help you perform very difficult separations of complex samples, this reference includes chapters contributed by leading experts or teams of experts.
Download or read book High temperature Liquid Chromatography written by Thorsten Teutenberg and published by Royal Society of Chemistry. This book was released on 2010 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-temperature liquid chromatography has attracted much interest in recent years but has not yet recognized its full potential in the chromatographic community. There is a widespread reluctance in industry to use temperature to speed up the separation process, influence the selectivity of a separation or implement novel detection techniques. However, the technology has now matured and could revolutionize chromatography as we see it today. Better equipment, such as heating systems able to generate faster heating rates, is becoming more readily available. Also, columns based on silica gel, which can withstand higher temperatures for an extended period, are now being introduced. Nevertheless, further technological and methodical efforts are needed to establish the method in a regulated environment like the pharmaceutical industry. This is the only text to cover all the practical aspects, as well as the underlying theoretical principles, of setting up an HPLC system for high-temperature operation. It is not intended solely for academics but will also benefit the researcher interested in more practical considerations. The author is a recognized expert and has conducted several studies with partners from industry to validate the method. Many real examples from these studies have been included in the book. The aim is to support practitioners in the creation of their own protocols without the need to rely solely on trial and error. The book starts with a brief definition of high-temperature liquid chromatography before going on to cover: system set up; the heating system; mobile phase considerations; suitable stationary phases; method development using temperature programming; analyte stability, and special hyphenation techniques using superheated water as a mobile phase. In each chapter, experimental data is used to illustrate the main statements and the advantages over conventional HPLC are evaluated. The book concludes with a critical outlook on further developments and applications underlining the necessary advances needed to make high-temperature HPLC more robust.
Download or read book Advances in Chromatography Volume 57 written by Nelu Grinberg and published by CRC Press. This book was released on 2020-08-09 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than five decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to date information on a wide range of developments in chromatographic methods and applications. The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill. This volume considers the achievements and legacy of Lloyd R. Snider in separation science and analytical chemistry. Key Features: • Provides a historical perspective of the evolution of SMB technology together with a theoretical analysis of the most relevant underlying phenomena • Presents a brief survey of the polar columns suitable for HILIC separations and pays special attention to the role of the mobile phase in RP and HILIC modes • Describes recent strategies of method development in Kosmotropic chromatography • Surveys the many approaches to avert the effects of temperature in reversed-phase liquid chromatographic separations • Reviews separation of isotopic compounds by HPLC in relation to the advances of columns and stationary phases
Download or read book Liquid Chromatography written by Salvatore Fanali and published by Elsevier. This book was released on 2017-06-22 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liquid Chromatography: Fundamentals and Instrumentation, Second Edition, is a single source of authoritative information on all aspects of the practice of modern liquid chromatography. It gives those working in both academia and industry the opportunity to learn, refresh, and deepen their understanding of new fundamentals and instrumentation techniques in the field. In the years since the first edition was published, thousands of papers have been released on new achievements in liquid chromatography, including the development of new stationary phases, improvement of instrumentation, development of theory, and new applications in biomedicine, metabolomics, proteomics, foodomics, pharmaceuticals, and more. This second edition addresses these new developments with updated chapters from the most expert researchers in the field. Emphasizes the integration of chromatographic methods and sample preparation Explains how liquid chromatography is used in different industrial sectors Covers the most interesting and valuable applications in different fields, e.g., proteomic, metabolomics, foodomics, pollutants and contaminants, and drug analysis (forensic, toxicological, pharmaceutical, biomedical) Includes references and tables with commonly used data to facilitate research, practical work, comparison of results, and decision-making
Download or read book Optimization in HPLC written by Stavros Kromidas and published by John Wiley & Sons. This book was released on 2021-08-06 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn to maximize the performance of your HPLC or UHPLC system with this resource from leading experts in the field Optimization in HPLC: Concepts and Strategies delivers tried-and-tested strategies for optimizing the performance of HPLC and UHPLC systems for a wide variety of analytical tasks. The book explains how to optimize the different HPLC operation modes for a range of analyses, including small molecules, chiral substances, and biomolecules. It also shows readers when and how computational tools may be used to optimize performance. The practice-oriented text describes common challenges faced by users and developers of HPLC and UHPLC systems, as well as how those challenges can be overcome. Written for first-time and experienced users of HPLC technology and keeping pace with recent developments in HPLC instrumentation and operation modes, this comprehensive guide leaves few questions unanswered. Readers will also benefit from the inclusion of: A thorough introduction to optimization strategies for different modes and uses of HPLC, including working under regulatory constraints An exploration of computer aided HPLC optimization, including ChromSwordAuto and Fusion QbD A treatment of current challenges for HPLC users in industry as well as large and small analytical service providers Discussions of current challenges for HPLC equipment suppliers Tailor-made for analytical chemists, chromatographers, pharmacologists, toxicologists, and lab technicians, Optimization in HPLC: Concepts and Strategies will also earn a place on the shelves of analytical laboratories in academia and industry who seek a one-stop reference for optimizing the performance of HPLC systems.
Download or read book Multi Dimensional Liquid Chromatography written by Dwight R. Stoll and published by CRC Press. This book was released on 2022-12-30 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two-dimensional liquid chromatography (2D-LC) is finding increasingly wide application principally due to the analysis of mixtures of moderate to high complexity. Many industries are developing increasingly complex products that are challenging the separation capabilities of state-of-the-art 1D-LC and need new analytical methodologies with substantially more resolving power, and 2D-LC meets that need. This text, organized by two leaders in the field, establishes a sound fundamental basis for the principles of the technique, followed by a discussion of important practical considerations. The book begins with an introduction to multi-dimensional separations and a discussion of the history and development of the technique over the past 40 years, followed by several chapters that provide a theoretical basis for development of 2D-LC methods, including foundational concepts regarding separation complementarity, under-sampling, and dynamics of liquid chromatography separations. Instrumentation for 2D-LC is discussed extensively, including practical aspects such as interface selection and setup. Building on this foundation, two separate chapters are focused on method development for non-comprehensive and comprehensive separations, followed by a chapter dedicated to data analysis. Finally, applications of 2D-LC in several fields ranging from pharmaceutical analysis to polymer science are summarized. The book is an important resource for both students and practitioners who are already using 2D-LC or are interested in getting started in the field. Key Features: Demonstrates the conditions under which a 2D-LC method should be considered as an alternative to a 1D-LC method. Establishes a sound fundamental basis of the principles of the technique, followed by guidelines for method optimization. Provides a single source for technical knowledge advances and practical guidance described in recent literature. Assists with the initial decision to develop a 2D-LC method. Guides the reader in developing a high-quality method that meets the needs of their application.
Download or read book Advances in Chromatography written by Eli Grushka and published by CRC Press. This book was released on 2012-01-27 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than four decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. For Volume 50, the series editors have invited established, well-known chemists from across the globe to offer cutting-edge reviews on their areas of expertise. The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill.
Download or read book Advances in Chromatography Volume 53 written by Eli Grushka and published by CRC Press. This book was released on 2016-11-03 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than four decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. For Volume 53, the series editors have invited established, well-known chemists to offer cutting-edge reviews of chromatographic methods with applications in the life sciences. The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill.
Download or read book Ultra High Performance Liquid Chromatography and Its Applications written by Q. Alan Xu and published by John Wiley & Sons. This book was released on 2013-04-01 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explores both the benefits and limitations of new UHPLC technology High performance liquid chromatography (HPLC) has been widely used in analytical chemistry and biochemistry to separate, identify, and quantify compounds for decades. The science of liquid chromatography, however, was revolutionized a few years ago with the advent of ultra-high performance liquid chromatography (UHPLC), which made it possible for researchers to analyze sample compounds with greater speed, resolution, and sensitivity. Ultra-High Performance Liquid Chromatography and Its Applications enables readers to maximize the performance of UHPLC as well as develop UHPLC methods tailored to their particular research needs. Readers familiar with HPLC methods will learn how to transfer these methods to a UHPLC platform and vice versa. In addition, the book explores a variety of UHPLC applications designed to support research in such fields as pharmaceuticals, food safety, clinical medicine, and environmental science. The book begins with discussions of UHPLC method development and method transfer between HPLC and UHPLC platforms. It then examines practical aspects of UHPLC. Next, the book covers: Coupling UHPLC with mass spectrometry Potential of shell particles in fast liquid chromatography Determination of abused drugs in human biological matrices Analyses of isoflavones and flavonoids Therapeutic protein characterization Analysis of illicit drugs The final chapter of the book explores the use of UHPLC in drug metabolism and pharmacokinetics studies for traditional Chinese medicine. With its frank discussions of UHPLC's benefits and limitations, Ultra-High Performance Liquid Chromatography and Its Applications equips analytical scientists with the skills and knowledge needed to take full advantage of this new separation technology.
Download or read book Fast Comprehensive Two dimensional High Performance Liquid Chromatography written by Dwight Robert Stoll and published by . This book was released on 2007 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Resolving Spectral Mixtures written by and published by Elsevier. This book was released on 2016-08-13 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Resolving Spectral Mixtures: With Applications from Ultrafast Time-Resolved Spectroscopy to Superresolution Imaging offers a comprehensive look into the most important models and frameworks essential to resolving the spectral unmixing problem—from multivariate curve resolution and multi-way analysis to Bayesian positive source separation and nonlinear unmixing. Unravelling total spectral data into the contributions from individual unknown components with limited prior information is a complex problem that has attracted continuous interest for almost four decades. Spectral unmixing is a topic of interest in statistics, chemometrics, signal processing, and image analysis. For decades, researchers from these fields were often unaware of the work in other disciplines due to their different scientific and technical backgrounds and interest in different objects or samples. This led to the development of quite different approaches to solving the same problem. This multi-authored book will bridge the gap between disciplines with contributions from a number of well-known and strongly active chemometric and signal processing research groups. Among chemists, multivariate curve resolution methods are preferred to extract information about the nature, amount, and location in time (process) and space (imaging and microscopy) of chemical constituents in complex samples. In signal processing, assumptions are usually around statistical independence of the extracted components. However, the chapters include the complexity of the spectral data to be unmixed as well as dimensionality and size of the data sets. Advanced spectroscopy is the key thread linking the different chapters. Applications cover a large part of the electromagnetic spectrum. Time-resolution ranges from femtosecond to second in process spectroscopy and spatial resolution covers the submicronic to macroscopic scale in hyperspectral imaging. Demonstrates how and why data analysis, signal processing, and chemometrics are essential to the spectral unmixing problem Guides the reader through the fundamentals and details of the different methods Presents extensive plots, graphical representations, and illustrations to help readers understand the features of different techniques and to interpret results Bridges the gap between disciplines with contributions from a number of well-known and highly active chemometric and signal processing research groups
Download or read book High Throughput Analysis in the Pharmaceutical Industry written by Perry G. Wang and published by CRC Press. This book was released on 2008-08-20 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The introduction of combinatorial chemistry technology has increased the amount of compounds generated in a year from 50 to 2000. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery to take on the shape of a bottleneck, like traffic through a toll booth. In order to break the bottleneck, a corres
Download or read book Gas Chromatography written by Colin Poole and published by Elsevier. This book was released on 2021-04-20 with total page 936 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gas Chromatography, Second Edition, offers a single source of authoritative information on all aspects relating to the practice of gas chromatography. A focus on short, topic-focused chapters facilitates the identification of information that will be of immediate interest for familiar or emerging uses of gas chromatography. The book gives those working in both academia and industry the opportunity to learn, refresh and deepen their understanding of fundamental and instrumental aspects of gas chromatography and tools for the interpretation and management of chromatographic data. Users will find a consolidated guide to the selection of separation conditions and the use of auxiliary techniques. This new edition restores the contemporary character of the book with respect to those involved in advancing the technology, analyzing the data produced, or applying the technique to new application areas. New topics covered include hyphenated spectroscopic detectors, micromachined instrument platforms, derivatization and related microchemical techniques, petrochemical applications, volatile compounds in the atmosphere, and more. Includes chapters written by recognized authoritative and visionary experts in the field, thus providing an overview and focused treatments on a single topic Provides comprehensive coverage of modern gas chromatography, from theory, to methods and selected applications Places modern developments in research literature into a general context not always apparent to inexperienced users of the techniques
Download or read book Fundamentals and Analytical Applications of Multiway Calibration written by and published by Elsevier. This book was released on 2015-08-10 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals and Analytical Applications of Multi-Way Calibration presents researchers with a set of effective tools they can use to obtain the maximum information from instrumental data. It includes the most advanced techniques, methods, and algorithms related to multi-way calibration and the ways they can be applied to solve actual analytical problems. This book provides a comprehensive coverage of the main aspects of multi-way analysis, including fundamentals and selected applications of chemometrics that can resolve complex analytical chemistry problems through the use of multi-way calibration. Includes the most advanced techniques, methods, and algorithms related to multi-way calibration and the ways they can be applied to solve actual analytical problems Presents researchers with a set of effective tools they can use to obtain the maximum information from instrumental data Provides comprehensive coverage of the main aspects of multi-way analysis, including fundamentals and selected applications of chemometrics
