Download or read book High Resolution Positron Emission Tomography Systems written by Max Kesselberg and published by . This book was released on 1987 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mathematics and Physics of Emerging Biomedical Imaging written by Committee on the Mathematics and Physics of Emerging Dynamic Biomedical Imaging and published by National Academies Press. This book was released on 1996-03-13 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cross-disciplinary book documents the key research challenges in the mathematical sciences and physics that could enable the economical development of novel biomedical imaging devices. It is hoped that the infusion of new insights from mathematical scientists and physicists will accelerate progress in imaging. Incorporating input from dozens of biomedical researchers who described what they perceived as key open problems of imaging that are amenable to attack by mathematical scientists and physicists, this book introduces the frontiers of biomedical imaging, especially the imaging of dynamic physiological functions, to the educated nonspecialist. Ten imaging modalities are covered, from the well-established (e.g., CAT scanning, MRI) to the more speculative (e.g., electrical and magnetic source imaging). For each modality, mathematics and physics research challenges are identified and a short list of suggested reading offered. Two additional chapters offer visions of the next generation of surgical and interventional techniques and of image processing. A final chapter provides an overview of mathematical issues that cut across the various modalities.
Download or read book Towards High Sensitivity and High Spatial Resolution Positron Emission Tomography Imaging written by Zheng Gu and published by . This book was released on 2014 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: High sensitivity and high resolution have been pursued as some of the most important research goals for preclinical Positron Emission Tomography (PET) imaging. PETbox4, a new, fully tomographic bench top PET scanner dedicated for mouse imaging, was designed and developed in this work. The aim of the PETbox4 scanner is to achieve very high sensitivity and produce high quality PET tomographic images for molecular imaging based biomedical research. Performance of the prototype PETbox4 system was characterized using the National Electrical Manufacturers Association (NEMA) NU 4-2008 standards. Due to the different characteristics caused by the compact geometrical factors, PETbox4 requires data acquisition protocols that differ from those optimized for conventional large diameter ring systems. In this work the energy window for data acquisitions with PETbox4 was optimized using the Geant4 Application for Tomographic Emission (GATE) simulation. A lower level discriminator (LLD) of 350 keV was proposed as the optimized energy threshold. Pulse pileup is a common problem in multiplexed scintillator detectors readout by resistor divider networks. In this work, a new pileup rejection method named position shift rejection (PSR) is introduced. The PSR method is based on the detection of position shifts on event location as the signal is being integrated. Both simulations and physical measurements show that PSR performs more accurate rejection and avoids erroneous rejection and loss of sensitivity compared to the conventional leading edge rejection (LER) method. A new phoswich DOI Detector with crystal scatter identification capability is being designed and developed for implementation in a next generation small animal PET system at UCLA. Both simulations and measurements were performed to evaluate the characteristics and benefits of the proposed design. In conclusion, these results demonstrate that the proposed detector is feasible and can potentially lead to a high spatial resolution, high sensitivity and DOI PET system.
Download or read book Physics of PET and SPECT Imaging written by Magnus Dahlbom and published by CRC Press. This book was released on 2017-02-17 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: PET and SPECT imaging has improved to such a level that they are opening up exciting new horizons in medical diagnosis and treatment. This book provides a complete introduction to fundamentals and the latest progress in the field, including an overview of new scintillator materials and innovations in photodetector development, as well as the latest system designs and image reconstruction algorithms. It begins with basics of PET and SPECT physics, followed by technology advances and computing methods, quantitative techniques, multimodality imaging, instrumentation, pre-clinical and clinical imaging applications.
Download or read book Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy written by Yuji Kuge and published by Springer. This book was released on 2016-04-02 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is devoted to understanding the recent advances in nuclear medicine and molecular imaging technologies along with their application to integrated medical therapy and future drug development. This anthology is based on the international symposium in 2015 entitled “Perspective on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. “The symposium provided an opportunity to exchange ideas on how to promote nuclear medicine technology and how to extend the technology to medical therapy and drug development, and was also a good opportunity to discuss the future perspective of nuclear medicine and molecular imaging by worldwide leaders in the field. Molecular imaging technologies have been rapidly developed worldwide in recent years. Among those developments, nuclear medicine has come to play an important role in quantitative analysis of biological process in vivo as well as in wide clinical use. With the current progress of nuclear medicine and molecular imaging, this modality has been applied for treatment monitoring and predicting its outcome with the use of optimal imaging biomarkers and suitable quantitative analysis. Truly, a new era has arrived with clinical use of nuclear medicine and molecular imaging for personalized medicine. This volume will benefit a wide variety of researchers in life science including those working in drug development, molecular imaging, and medical therapy as well as physicians who utilize diagnostic imaging.
Download or read book A Novel High Resolution Positron Emission Tomography System for Measurement of Bone Metabolism written by and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the work reported here is to develop high-resolution PET instrumentation for imaging the long bones. To-date a single plane prototype and a single plane second-generation instrumentation have been completed. The latter is currently being evaluated. A generalized multi-planar detector element has also been designed and evaluated experimentally and a volumetric instrument has been designed through simulation studies. A radiopharmaceutical for bone growth rate imaging labeled tetracycline is currently being developed for use in a demonstration study of imaging in a monkey osteoporosis model.
Download or read book Medical Imaging Systems written by Andreas Maier and published by Springer. This book was released on 2018-08-02 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book gives a complete and comprehensive introduction to the fields of medical imaging systems, as designed for a broad range of applications. The authors of the book first explain the foundations of system theory and image processing, before highlighting several modalities in a dedicated chapter. The initial focus is on modalities that are closely related to traditional camera systems such as endoscopy and microscopy. This is followed by more complex image formation processes: magnetic resonance imaging, X-ray projection imaging, computed tomography, X-ray phase-contrast imaging, nuclear imaging, ultrasound, and optical coherence tomography.
Download or read book Functional Neuromarkers for Psychiatry written by Juri D. Kropotov and published by Academic Press. This book was released on 2016-05-03 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Neuromarkers for Psychiatry explores recent advances in neuroscience that have allowed scientists to discover functional neuromarkers of psychiatric disorders. These neuromarkers include brain activation patterns seen via fMRI, PET, qEEG, and ERPs. The book examines these neuromarkers in detail—what to look for, how to use them in clinical practice, and the promise they provide toward early detection, prevention, and personalized treatment of mental disorders. The neuromarkers identified in this book have a diagnostic sensitivity and specificity higher than 80%. They are reliable, reproducible, inexpensive to measure, noninvasive, and have been confirmed by at least two independent studies. The book focuses primarily on the analysis of EEG and ERPs. It elucidates the neuronal mechanisms that generate EEG spontaneous rhythms and explores the functional meaning of ERP components in cognitive tasks. The functional neuromarkers for ADHD, schizophrenia, and obsessive-compulsive disorder are reviewed in detail. The book highlights how to use these functional neuromarkers for diagnosis, personalized neurotherapy, and monitoring treatment results. Identifies specific brain activation patterns that are neuromarkers for psychiatric disorders Includes neuromarkers as seen via fMRI, PET, qEEG, and ERPs Addresses neuromarkers for ADHD, schizophrenia, and OCD in detail Provides information on using neuromarkers for diagnosis and/or personalized treatment
Download or read book Positron Emission Tomography written by Dale L. Bailey and published by Springer Science & Business Media. This book was released on 2006-07-06 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential for students, science and medical graduates who want to understand the basic science of Positron Emission Tomography (PET), this book describes the physics, chemistry, technology and overview of the clinical uses behind the science of PET and the imaging techniques it uses. In recent years, PET has moved from high-end research imaging tool used by the highly specialized to an essential component of clinical evaluation in the clinic, especially in cancer management. Previously being the realm of scientists, this book explains PET instrumentation, radiochemistry, PET data acquisition and image formation, integration of structural and functional images, radiation dosimetry and protection, and applications in dedicated areas such as drug development, oncology, and gene expression imaging. The technologist, the science, engineering or chemistry graduate seeking further detailed information about PET, or the medical advanced trainee wishing to gain insight into the basic science of PET will find this book invaluable. This book is primarily repackaged content from the Basic Science section of the 'big' Valk book on PET. It contains new, completely revised and unchanged chapters covering the "basic sciences" section of the main book - total 18 chapters: 2 new (chapters 1, 16) 8 completely revised (chapters 4, 5, 8, 13, 14, 15, 17, 18) 3 minor corrections (chapters 2, 6, 11) 5 unchanged (chapters 3, 7, 9, 10, 12)
Download or read book Investigation of Advanced Clinical PET System Designs written by Fan-Chung Hsu and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Positron emission tomography (PET) is a functional radionuclide imaging modality commonly used for managing diseases such as cancer. High-resolution, high-sensitivity, quantitative PET imaging could open up potential new uses in early stage cancer management such as guiding biopsy or surgical resection. Locoregional PET systems with reconfigurable field-of-views (FOV) can further increase the sensitivity and resolution for a specific organ of interest. We will start this thesis by introducing the physics and basic detector designs of PET systems. It will then discuss design and performance of whole-body and locoregional PET system designs that are being investigated in the field. Then, the thesis will describe in detail a 1 mm resolution clinical locoregional PET scanner that is being constructed at Stanford. The design choices and electronics of this system will be discussed, and then system calibrations and performance test results will be shown. Finally, we will discuss additional data correction algorithms specific to this system, such as randoms correction and limited angle tomography image artifact correction algorithms. The results presented in this thesis show that the prototype subsystem of the 1 mm resolution clinical locoregional PET system can achieve spatial resolution of 0.73 mm at the center of the FOV, energy resolution of 11.34%, and coincident timing resolution (CTR) of 13.92 ns. The unique 3D position sensitive scintillation (3D-PSS) detectors used in the system allows for intercrystal scatter positioning algorithms that can be used to improve contrast-to-noise ratio (CNR) by 8.4%, or reduce the patient dose by 12% while maintaining the same image quality. This thesis may be useful for readers that are interested in the physics, electronics, and image quality of high-resolution PET scanners with small scintillation crystal elements. Interesting topics include investigations of detector signal multiplexing across a system, limited angle tomography effects in the reconstructed image, and ICS positioning in a system with multiplexed detectors.
Download or read book Monolithic Scintillator Detectors for High resolution Positron Emission Tomography written by Marnix Christiaan Maas and published by Pro Universitate. This book was released on 2008 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NATO Advances Research Workshop (ARW) 'Secure Telematic Applications for National Scale Projects' is organized in the frame of the National Week of Information Technologies and Sixth International Congress 'Scientific and Methodological Facilitation of the Development of Informatization and the System of Scientific and Technical Information in the Republic of Belarus. Secure Telematic Applications in National and International Projects'. The participants of the event came to Minsk from all regions of Europe, as well as from Asia and Africa. Besides the general ARW topic, the participants also discussed the progress in the activity of the High Technologies Park, the creation of the corporate network of libraries of Belarus on the basis of the National Library of Belarus and the newest technologies of e-government. The presentations are also oriented on creation of the National Scientific and Research Computer Network of the Republic of Belarus on the basis of Academic Network BASNET. It is expected that the scientific and practical achievements of the forum will considerably influence both the development of the information technologies and their utilization for advantage of the national economy of Belarus and all participating countries.
Download or read book PET written by Michael E. Phelps and published by Springer Science & Business Media. This book was released on 2006-12-30 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed to give the reader a solid understanding of the physics and instrumentation aspects of PET, including how PET data are collected and formed into an image. Topics include basic physics, detector technology used in modern PET scanners, data acquisition, and 3D reconstruction. A variety of modern PET imaging systems are also discussed, including those designed for clinical services and research, as well as small-animal imaging. Methods for evaluating the performance of these systems are also outlined. The book will interest nuclear medicine students, nuclear medicine physicians, and technologists.
Download or read book Design and Development of a 1mm Resolution Clinical Positron Emission Tomography PET System written by Frances Wing Yee Lau and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Positron Emission Tomography (PET) is an in-vivo medical imaging modality that extracts information about molecular processes associated with disease. A PET system produces an image of radiopharmaceuticals that have preferentially accumulated in certain cells of tissues in the body, such as cancerous lesions. Clinical PET systems have about 5-10mm spatial resolution, and thus have difficulty resolving very small lesions. So, improving the resolution of PET is an active area of research. This thesis describes the design of a 1mm resolution PET system for breast cancer imaging and the strategies used to overcome the challenges of developing such a high resolution PET system. The detectors in this PET system consist of lutetium yttrium oxyorthosilicate (LYSO) scintillation crystal arrays coupled to position-sensitive avalanche photodiodes (PSAPDs). There will be over 2000 Dual-LYSO-PSAPD detector modules in the final system, each requiring a bias voltage of 1750 Volts. A programmable high voltage distribution method allows the bias voltage to be optimized for each detector module. Multiplexing of detector signals reduced the number of interconnects by 40% and front-end electronic channels by 33%. Charge division and charge sharing signal conditioning compensate for the mismatch between the detector signal and the front-end electronics input dynamic range, as well as for parasitic capacitance introduced by interconnect. A model of the detectors and electronics was created to help understand the system and to assist in the system design process. Two cartridges of the system, consisting of 256 Dual-LYSO-PSAPD detectors, were constructed and characterized. The system energy resolution was 11% FWHM (full-width-at-half-maximum) and the measured spatial resolution was less than 1mm. The system was able to produce reconstructed images of a phantom with 1.2mm rods filled with a solution of the positron emitter Fluorine-18.
Download or read book Fluorine and Health written by Alain Tressaud and published by Elsevier. This book was released on 2008-06-06 with total page 821 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms.Medicinally relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized. New approach of topics involving chemistry, biology and medicinal techniques Transdisciplinar papers on fluoride products Importance of fluoride products in health Updated data on specific topics
Download or read book Algorithms for High resolution Positron Emission Tomography written by Kyle Morgan Champley and published by . This book was released on 2010 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book PET in Oncology written by Stefan Dresel and published by Springer Science & Business Media. This book was released on 2009-04-20 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: At last, here is a comprehensive compilation of the accumulated knowledge on PET and PET/CT in oncology. It covers the entire spectrum from solidly documented indications, such as staging and monitoring of lung and colorectal cancer, to the application of PET/CT in head and neck surgery, gynecology, radiation therapy, urology, pediatrics and others. The chapters are supplemented by an introduction into the underlying techniques of both imaging devices and radiopharmacy.
Download or read book Quantification of Brain Function Using PET written by and published by Elsevier. This book was released on 1996-07-17 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional imaging of the brain is one of the most rapidly advancing areas of neuroscience and Positron Emission Tomography (PET) plays a major role in this progress. This book provides a comprehensive overview of the current status of PET and state-of-the-art neuroimaging. It is comprised of summaries of the presentations by experts in the field. Topics covered include radiotracer selection, advances in instrumentation, image reconstruction and data analysis, and statistical mapping of brain activity. This book focuses on the accuracy of the functional image and the strategies for addressing clinical, scientific, and diagnostic questions. Covers the PET imaging process from tracer selection to analysis and interpretation Contains 79 concise reports with abundant illustrations The definitive state-of-the-art book for functional neuroscience with PET
