Download or read book Translational Medicine written by Joy A. Cavagnaro and published by CRC Press. This book was released on 2021-11-26 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Download or read book Angola Em Movimento written by Beatrix Heintze and published by Verlag Otto Lembeck. This book was released on 2008 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book aims to provide a better understanding of the significance and dynamics of communication and transport routes in Angola and its hinterland."--Back cover.

Download or read book Innovation and Quality in the University written by and published by EDIPUCRS. This book was released on 2008 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book World Anthropologies written by Gustavo Lins Ribeiro and published by Routledge. This book was released on 2020-07-13 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its inception, anthropology's authority has been based on the assumption that it is a unified discipline emanating from the West. In an age of heightened globalization, anthropologists have failed to discuss consistently the current status of their practice and its mutations across the globe. World Anthropologies is the first book to provoke this conversation from various regions of the world in order to assess the diversity of relations between regional or national anthropologies and a contested, power-laden Western discourse. Can a planetary anthropology cope with both the 'provincial cosmopolitanism' of alternative anthropologies and the 'metropolitan provincialism' of hegemonic schools? How might the resulting 'world anthropologies' challenge the current panorama in which certain allegedly national anthropological traditions have more paradigmatic weight - and hence more power - than others? Critically examining the international dissemination of anthropology within and across national power fields, contributors address these questions and provide the outline for a veritable world anthropologies project.

Download or read book Calibre Manual written by Kovid Goyal and published by Samurai Media Limited. This book was released on 2015-10-28 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calibre is an ebook library manager. It can view, convert and catalog ebooks in most of the major ebook formats. It can also talk to many ebook reader devices. It can go out to the Internet and fetch metadata for your books. It can download newspapers and convert them into ebooks for convenient reading. It is cross platform, running on Linux, Windows and OS X.

Download or read book ICGR 2018 Proceedings of the International Conference on Gender Research written by Ana Azevedo and published by Acpil. This book was released on 2018-03-22 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: These proceedings represent the work of researchers participating in the International Conference on Gender Research (ICGR 2018) which is being hosted this year by the ISCAP in Porto, Portugal on 12-13 April 2018. ICGR is a new event on the international research conferences calendar and provides a valuable platform for individuals to present their research findings, display their work in progress and discuss conceptual and empirical advances in the areas surrounding Gender Research. It provides an important opportunity for researchers across a diverse range of fields all looking at aspects relating to Gender to come together with peers to share their varied and valuable experiences. The first day will be opened with a keynote presentation by Bruce I Newman from DePaul University in Chicago, USA who will address the topic Gender and Democracy. In the afternoon, there will be an additional keynote address on Empowering women in the IT/IS research: the importance of role models given by Isabel Ramos from, University of Minho, Portugal. The second day of the conference will be opened by Paola Paoloni from "NiccolÒ Cusano" University, Rome, Italy. Paola will be talking about A Relational Capital Dimension in Universities. In this event, participants will have the opportunity to have access to the latest research and developments concerning Gender Research and after an initial submission of 180 Abstracts, there will be 62 Research Papers, 8 PhD Research Papers, 2 Masters Papers, 1 Non-Academic and 4 Work in Progress Paper published in these Conference Proceedings. These papers represent truly global research in the field, with contributions from Australia, Belgium, Brazil, Canada, Colombia, Costa Rica, Cyprus, Czech Republic, Denmark, France, Germany, Greece, Iran, Italy, Kazakhstan, Lithuania, Malaysia, Mexico, Nepal, Nigeria, Pakistan, Philippines, Poland, Portugal, Russia, Slovakia, South Africa, Spain, Sweden, Taiwan, Thailand, The Netherlands, Turkey, UAE, UK and USA.

Download or read book New Museology written by Peter Vergo and published by Reaktion Books. This book was released on 1997-06-01 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: With essays by Charles Saumarez Smith, Ludmilla Jordanova, Paul Greenhalgh, Colin Sorensen, Nick Merriman, Stephen Bann, Philip Wright, Norman Palmer and Peter Vergo. "A lively and controversial symposium ... thought-provoking"—The Sunday Times (Paperbacks of the Year, 1989) "The essays are all distinguished by their topicality and lucidity."—MuseumNews "A welcome addition to the library of Museology"—Art Monthly "The New Museology is essential reading for all those seeking to understand the current debate in museum ideologies."—International Journal of Museum Management and Scholarship

Download or read book Disabled Widows written by Donald T. Ferron and published by . This book was released on 1972 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt: Report and compilation of statistical tables resulting from a survey of the handicapped (disabled person), undertaken in 1966 by the social security administration, on demographic aspects and health-related characteristics of handicapped widowed married women in the USA, together with information on their eligibility to receive disability benefits.

Download or read book Consumer Action Handbook 2010 Edition written by U.S. Services Administration and published by GPO FCIC. This book was released on 2010 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Use this guide to get help with consumer purchases, problems and complaints. Find consumer contacts at hundreds of companies and trade associations; local, state, and federal government agencies; national consumer organizations; and more.

Download or read book The Art of Concentration written by Harriet Griffey and published by Pan Macmillan. This book was released on 2010-11-30 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: We are all overwhelmed with technological input in our daily lives – whether it is our mobile phone ringing, our Blackberry bleeping or emails that pour in endlessly – we are all becoming hyperstimulated and unable to switch on (concentrate) or switch off (relax) because we’re all on permanent standby. As a result, we have lost the art of concentrating properly. Luckily, this cutting edge personal development book is here to help readers navigate their way through the deluge and provides the tools we need to learn how to concentrate and focus. Rooted in scientific fact and research, it includes a detailed look at how your brain works, what inhibits brain function and concentration and covers things such as lack of down-time, distraction, poor lifestyle habits and stress. Featuring techniques and exercises to help improve concentration, it is guaranteed to help us all improve the way we work and the way we live our lives.

Download or read book A Tale of the Dispossessed La Multitud Errante written by Laura Restrepo and published by Harper Collins. This book was released on 2003 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the acclaimed author of "The Dark Bride" comes a new novella published in a bilingual English/Spanish edition.

Download or read book The Human Face of War written by Jim Storr and published by A&C Black. This book was released on 2011-10-27 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Warfare is hugely important. The fates of nations, and even continents, often rests on the outcome of war and thus on how its practitioners consider war. The Human Face of War is a new exploration of military thought. It starts with the observation that much military thought is poorly developed - often incoherent and riddled with paradox. The author contends that what is missing from British and American writing on warfare is any underpinning mental approach or philosophy. Why are some tank commanders, snipers, fighter pilots or submarine commanders far more effective than others? Why are many generals sacked at the outbreak of war? The Human Face of War examines such phenomena and seeks to explain them. The author argues that military thought should be based on an approach which reflects the nature of combat. Combat - fighting - is primarily a human phenomenon dominated by human behaviour. The book explores some of those human issues and their practical consequences. The Human Face of War calls for, and suggests, a new way of considering war and warfare.

Download or read book Preclinical Safety Evaluation of Biopharmaceuticals written by Joy A. Cavagnaro and published by John Wiley & Sons. This book was released on 2013-03-07 with total page 1012 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.

Download or read book Managing University Museums written by OECD and published by OECD Publishing. This book was released on 2001-08-24 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication focuses on the role of university museums, their organisation, management, governance and finance. Most university museum collections have been assembled for the purposes of teaching and research rather than for public display ...

Download or read book Image Building written by Therese Lichtenstein and published by National Geographic Books. This book was released on 2018-03-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This generously illustrated examination of architectural photography from the 1930s to the present shows how the medium has helped shape familiar views of iconic buildings. Photography has both manipulated and bolstered our appreciation of modern architecture. With beautiful photographs of private and public buildings by Julius Shulman, Candida Höfer, Andreas Gursky, Thomas Struth, and others, this book examines the central and active role that photography plays in defining and perpetuating the iconic nature of buildings and places. This volume shows how different photographers represent the same building, offers commentaries on the "American dream," and explores changes in commercial architectural photography. Placing decades-old images alongside modern ones, Image Building depicts the idea of the comfortable middle-class home and the construction of suburbia as an ironic ideal. It presents the ways that public spaces such as libraries, museums, theaters, and office buildings are experienced differently as photographers highlight the social, cultural, psychological, and aesthetic conditions to reveal the layered meanings of place and identity. Looking at how photography shapes and frames our understanding of architecture, this volume offers thought-provoking points of view through an exploration of social and cultural issues. Published in association with the Parrish Art Museum

Download or read book Brandjam written by Marc Gobe and published by Simon and Schuster. This book was released on 2010-06-29 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brandjam, the follow-up to the groundbreaking best-seller Emotional Branding, presents a powerful new concept from renowned designer and business guru Mark Gobe. The Brandjam concept is about innovation, intuition, and risk. Gobe explains how design is the “instrument” companies can use for jazzing up a brand—how design puts the face on the brand and creates an irresistible message that connects buyers to the product in a visceral way. Using jazz as his metaphor, he shows how the instinctive nature of the creative process leads to unusual solutions that make people gravitate toward a brand and make brands resonate with people by bringing more joy into their lives. It explores how design represents the personality of a company and provides its window to the world. Brandjam is an inspiration for brands and people as it reveals the transforming impact brands have on their audience. • Follow-up to Emotional Branding—50,000 copies sold in nine languages • Insider's look at creating powerful, compelling brands and identities • Exciting new ideas for using design to drive consumers to embrace brands Allworth Press, an imprint of Skyhorse Publishing, publishes a broad range of books on the visual and performing arts, with emphasis on the business of art. Our titles cover subjects such as graphic design, theater, branding, fine art, photography, interior design, writing, acting, film, how to start careers, business and legal forms, business practices, and more. While we don't aspire to publish a New York Times bestseller or a national bestseller, we are deeply committed to quality books that help creative professionals succeed and thrive. We often publish in areas overlooked by other publishers and welcome the author whose expertise can help our audience of readers.

Download or read book The Protective Arm of the Renin Angiotensin System RAS written by Thomas Unger and published by Academic Press. This book was released on 2015-04-18 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.