Download or read book The Oriental herald and colonial review ed by J S Buckingham written by James Silk Buckingham and published by . This book was released on 1826 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Oriental Herald and Colonial Review written by and published by . This book was released on 1826 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Rules for Reasoning written by Richard E. Nisbett and published by Psychology Press. This book was released on 2013-02-01 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines two questions: Do people make use of abstract rules such as logical and statistical rules when making inferences in everyday life? Can such abstract rules be changed by training? Contrary to the spirit of reductionist theories from behaviorism to connectionism, there is ample evidence that people do make use of abstract rules of inference -- including rules of logic, statistics, causal deduction, and cost-benefit analysis. Such rules, moreover, are easily alterable by instruction as it occurs in classrooms and in brief laboratory training sessions. The fact that purely formal training can alter them and that those taught in one content domain can "escape" to a quite different domain for which they are also highly applicable shows that the rules are highly abstract. The major implication for cognitive science is that people are capable of operating with abstract rules even for concrete, mundane tasks; therefore, any realistic model of human inferential capacity must reflect this fact. The major implication for education is that people can be far more broadly influenced by training than is generally supposed. At high levels of formality and abstraction, relatively brief training can alter the nature of problem-solving for an infinite number of content domains.

Download or read book Paper written by and published by . This book was released on 1985 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Oriental Herald and Colonial Review written by James Silk Buckingham and published by . This book was released on 1826 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Computational tools in inferring cancer tissue of origin and molecular classification towards personalized cancer therapy Volume III written by Min Tang and published by Frontiers Media SA. This book was released on 2024-09-25 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our second Research Topic in this series, Computational tools in inferring cancer tissue-of-origin and molecular classification towards personalized cancer therapy, Volume II (https://fro.ntiers.in/14361) has over 8 accepted articles and further manuscripts currently under review. Due to the continued success of these Research Topics and the interest in the subject, we will launch a third volume on the same topic. Inferring cancer tissue-of-origin and molecular classification are two critical problems in personalized cancer therapy. It is known that there are about 5% cancers of unknown primary (CUP) site. These kinds of patients are under empirical chemotherapy, which leads to a very low survival rate. Thus, it is important to infer cancer tissue-of-origin. However, experimental methods usually fail to identify the exact tissue-of-origin even after the death of a patient, which provides a need for computational methods especially in the era of big biomedical data. Based on the finding that gene expressions of metastasis cancer cells are more similar to those of original tissue than metastasis tissue, there have been a few computational methods developed in this area. However, the accuracy of the methods is yet to be improved to assure a clinical usage. In addition to CUP, inferring cancer tissue-of-origin is also important in avoiding misdiagnosis even if the cancer origin is known.

Download or read book Origins of Human Neuropathology The Significance of Teneurin Latrophilin Interaction written by David A. Lovejoy and published by Frontiers Media SA. This book was released on 2020-07-22 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: We are delighted to introduce this new special issue on “The Origins of Neuropathology: The Roles of Teneurins and Latrophilins”. Although the title may seem particularly bold, and indeed, perhaps presumptuous, we the editors, think our title well warranted based on the findings and interpretation provided by a dedicated group of researchers who have developed this field over the last 25 years. In this publication, we introduce the readers to researchers whom have pioneered this field, and those whom have played an essential role in developing this research direction. Now, together, their combined work have elucidated a novel ligandreceptor network that evolved during the earliest period of animal evolution, and has fostered a new insight into the ancient evolutionary organization of the central nervous system (CNS). Specifically, this work offers a new understanding of several aspects of neuropathology including degenerative, psychiatric and mood disorders and, furthermore, illuminates a fundamental role that teneurins and latrophilins play in cell-to-cell metabolism that may be associated with various forms of cancer both within and outside of the brain. In 1994, the laboratories of Professors Ron Wides in Israel and Ruth Chiquet-Ehrismann working in Switzerland, independently reported the existence of a novel transmembrane protein and its gene in Drosophila. A complex gene/protein, its closest homologue was that of the tenascins. The gene was named either odd oz (odz) or tenascin major (ten-m) by these researchers. Subsequent studies indicated that the gene was highly expressed in the brains of vertebrates and the term ‘teneurin’ was coined to reflect both its relationship with tenascins and with the CNS. Around the same time as these studies, a novel G protein-coupled receptor was identified by Yuri Ushkaryov and his team in the United Kingdom (in fact the latrophilins then named CIRL, calcium-independent receptor for a-latrotoxin, was first identified by the group of Petrenko at NYU Medical Center in New York, USA), which was subsequently established as a cognate receptor for the teneurins. This receptor was later termed as the latrophilins and more recently ‘Adhesion receptor G-protein coupled receptor, family L or ADGRL. In Part 1 of this publication, the early history on the origin and discovery of teneurins has been described by Stefan Baumgartner and Ron Wides; Ron Wides; and Richard Tucker. Recent structural studies by Verity Jackson and her colleagues, as well as Demet Arae¸ and Jingxian Li have provided molecular models to understand how teneurins are ensconced in the plasma membrane and play a role in synaptic interaction. In addition, their work integrates the molecular mechanisms with the early evolution of both teneurins and latrophilins. In Part 2, four studies build upon the evolutionary development of teneurins by examining its role in nematodes by Ulrike Topf and Krzysztof Drabikowski, a model of teneurin action in the Drosophilia nervous system by Alison DePew and associates; and two studies on fish. Angela Cheung and her colleagues describe the neurological function and expression in zebrafish, whereas Ross Reid and his coworkers have described novel actions of the teneurins with respect to metabolism in fish. Part 3 of this publication is focused on the latrophilins and is led off by Yuri Ushkaryov and his team describing the discovery, structure and function of the latrophilins. This work is followed by a review by Ana Moreno-Salinas and colleagues in Antony Boucard´s laboratory describing the structure of the latrophilins and its interaction with associated transmembrane proteins with respect to adhesion, neuronal function and pathology. The following paper, by Torsten Schönberg and Simone Prömel links the previous papers with a comparison of teneurin and latrophilin interactions in invertebrates and vertebrates. Finally, in this section, Peter Burbach and Dimphna Meijer provide an interesting overview of the relationship of teneurins and latrophilins with respect to other proteins described in these other papers. Together, these studies provide a novel understanding of how the teneurins and latrophilins interact in a complex set of associated proteins. The next section (Part 4) of the publication focuses on the development and maintenance of the CNS in mammals. Here, Catherine Leamey and Atomu Sawatari lead off with a discussion of the role of teneurin-associated neuro-circuit formation using knockout studies in mice. A detailed review by Luciane Sita and her colleagues in the Bittencourt laboratory frames this and previous studies in a comparative neuroanatomical background, and in addition, provides a neuroanatomical rationale for new studies associated with other regions of the CNS. Building upon these studies, David Hogg and his coworkers include a review on the behavioral actions of the teneurin C-terminal associated peptide (TCAP) in mammals and its potential relationship to brain metabolism and forms of neuropathology. Finally, in this section, a study by Gesttner Tessarin in the Casatti laboratory shows for the first time, teneurins may be associated with astrocyte function, indicating a novel function for teneurins with respect to some glial-based disorders in the brain. Finally in our last section, we have provided some studies on the potential roles of the teneurins and latrophilins with respect to carcinogenesis. Although these studies are somewhat removed from our treatise on the role of teneurins and latrophilins with respect to neuronal development, maintenance and pathology, they provide interesting observations that may be relevant to some types of CNS pathology. Thus, Boris Rebolledo-Jaramillo and Annemarie Ziegler include a review on the relationship of teneurins to several types of cancers. This is followed by a research report by Mia Husić and her colleagues suggesting that the TCAP region of the teneurins could play a role in modulating the adhesion of the cancer-like cell line, HEK293 and finally, Sussy Bastias-Candia and associates have provided novel data on the role of teneurin-3 with respect to Wnt signalling and have discussed its potential role in neural development and carcinogenesis. Overall, we posit that the teneurins and latrophilins played a major role in the early evolution of the nervous system and may underlie the etiology of a number of neurological disorders that are thus-far misunderstood. Indeed, we hope that this publication will stimulate further research into the actions of teneurins and latrophilins and lead to novel approaches of understanding and ultimately treatment. Obituary: Ruth Chiquet-Ehrismann (1954-2015): A Teneurin Pioneer A major player in the discovery and characterization of teneurins was the Swiss scientist, Ruth Chiquet-Ehrismann. Dr. Chiquet-Ehrismann had a long-standing interest in cell-cell and cell-extracellular matrix interactions, particularly during development and tumorigenesis. She earned her Ph.D. at the ETH Zurich under the mentorship of David C. Turner, where she performed early work on the cell and heparin-binding sites of fibronectin. Shortly after joining the Friedrich Miescher Institute in Basel as a junior group leader in 1984, Ruth, in collaboration with Eleanor J. Mackie and Teruyo Sakakura, published a paper in Cell describing an extracellular matrix glycoprotein that she named “tenascin”. A key observation made in this widely cited paper was the presence of tenascin in the extracellular matrix of embryonic tissues and the stroma of breast cancer, but its absence from most normal adult tissues. We now know that the original “tenascin” was the founding member of a diverse gene family, and that members of this family promote cell motility, proliferation and differentiation in a variety of tissue environments, both normal and pathological. But in the early 1990s, it was unclear how tenascins functioned. Specifically, its receptors and binding partners were not understood. Subsequently, Ruth engaged in a multi-pronged approach to studying tenascin function in an attempt to identify its homologues in Drosophila. This work, led by her postdoctoral fellow Dr. Stefan Baumgartner, resulted in the discovery of a novel family of type-2 transmembrane proteins that they named ten-a and ten-m, for “tenascin-like proteins accessory and major”. When the homologues of ten-a and ten-m were found in vertebrates and they were shown to be highly expressed in the nervous system, Ruth proposed the name “teneurins”. This name combined the names of the original proteins from Drosophila with neurons, which appeared to be their most prominent site of expression. From that point onward, Ruth’s research group at the Friedrich Miescher Institute studied two topics: the roles of tenascins in cancer and the roles of teneurins in development. Using numerous model systems, her research included studies of teneurins in arthropods (Drosophila), nematodes (C. elegans) and chordates (birds and humans). Key firsts that came from Ruth’s laboratory include the cloning and sequencing of human teneurins, experimental evidence of teneurin processing by furin and the potential nuclear localization of the intracellular domain, the ability of teneurins to promote growth cone spreading, patterning defects in teneurin knockout animals, a description of the ancient origins of teneurins via horizontal gene transfer, the complementary expression patterns of different teneurins during development, the cytotoxic properties of the teneurin C-terminal domain, and the presence of homotypic adhesion domains in teneurins. Since 1994, Ruth’s group published 24 papers on the cloning, expression, origins and functions of teneurins. Contributing to these papers were 15 graduate students and postdoctoral fellows, often with the expert technical guidance of Jacqueline Ferralli, Marianne Brown-Luedi and Doris Martin. This work has provided a foundation for a new generation of researchers in the field of teneurins. Ruth Chiquet-Ehrismann passed away at her home near Basel on September 4, 2015. She is survived by her husband and collaborator Matthias Chiquet, three children, Daniel, Patrice and Fabian, and an expanding cohort of grandchildren. Richard P. Tucker Davis, California

Download or read book Source tracking molecular epidemiology and antigenic diversity of SARS CoV 2 infections causing coronavirus disease 2019 COVID 19 written by Charles A. Narh and published by Frontiers Media SA. This book was released on 2022-11-16 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Consumer Neuroscience Foundation Validation and Relevance written by Thomas Zoëga Ramsoy and published by Frontiers Media SA. This book was released on 2023-08-07 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Consumer neuroscience has become an expanding area of both research and conduct – spanning from academic interests in the brain bases of consumption choices to commercial application of neuroscience tools and metrics. However, many of these advances are still criticized for low applicability, scattered publication records, conceptual vagueness, and a lack of proper scientific and commercial validation. To make matters worse, there is now a host of proposed commercial applications of both the insights from neuroscience and the application of neuroscience and neurophysiology tools to test consumer responses. While many of these approaches may be valid, many other approaches are either not properly validated, or may be flawed, misguided, or even outright lies. As a discipline, there is a need for both the basic and applied research in consumer neuroscience to become aligned. The purpose of this Research Topic is to provide this much-needed platform for such an industrial alignment. In doing so, this Research Topic will provide perspectives on three main areas: 1. distinctions between basic, translational and applied consumer neuroscience research 2. conceptual clarification on key concepts relevant to the science and application of consumer neuroscience 3. validation of consumer neuroscience methods and how they relate to commercially relevant cases. For this Research Topic, we therefore welcome submissions that combine academic and commercial research, all in the vein of making advances in establishing a valid, applicable consumer neuroscience.

Download or read book Document Analysis Systems written by Seiichi Uchida and published by Springer Nature. This book was released on 2022-05-17 with total page 795 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 15th IAPR International Workshop on Document Analysis Systems, DAS 2022, held in La Rochelle, France, in May 2022. The full papers presented were carefully reviewed and selected from numerous submissions addressing key techniques of document analysis.

Download or read book Germania written by Brendan McNally and published by Simon and Schuster. This book was released on 2009-02-10 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: In their youth, Manni and Franzi, together with their brothers, Ziggy and Sebastian, captured Germany's collective imagination as the Flying Magical Loerber Brothers -- one of the most popular vaudeville acts of the old Weimar days. The ensuing years have, however, found the Jewish brothers estranged and ensconced in various occupations as the war is drawing near its end and a German surrender is imminent. Manni is traveling through the Ruhr Valley with Albert Speer, who is intent on subverting Hitler's apocalyptic plan to destroy the German industrial heartland before the Allies arrive; Franzi has become inextricably attached to Heinrich Himmler's entourage as astrologer and masseur; and Ziggy and Sebastian have each been employed in pursuits that threaten to compromise irrevocably their own safety and ideologies. Now, with the Russian noose tightening around Berlin and the remnants of the Nazi government fleeing north to Flensburg, the Loerber brothers are unexpectedly reunited. As Himmler and Speer vie to become the next Führer, deluded into believing they can strike a bargain with Eisenhower and escape their criminal fates, the Loerbers must employ all their talents -- and whatever magic they possess -- to rescue themselves and one another. Deftly written and darkly funny, Germania is an astounding adventure tale -- with subplots involving a hidden cache of Nazi gold, Hitler's miracle U-boats, and Speer's secret plan to live out his days hunting walrus in Greenland -- and a remarkably imaginative novel from a gifted new writing talent.

Download or read book Dictionary Catalog of the Edward E Ayer Collection of Americana and American Indians in the Newberry Library written by Newberry Library and published by . This book was released on 1961 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Frozen Elephant Trunk Surgery in Aortic Dissection written by Antonio Miceli and published by Frontiers Media SA. This book was released on 2023-04-06 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Julian Assange written by Julian Assange and published by Canongate Books. This book was released on 2011-09-22 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: In December 2010, Julian Assange signed a contract with Canongate Books to write a book – part memoir, part manifesto – for publication the following year. At the time, Julian said: ‘I hope this book will become one of the unifying documents of our generation. In this highly personal work, I explain our global struggle to force a new relationship between the people and their governments.’ In the end, the work was to prove too personal. Despite sitting for more than fifty hours of taped interviews and spending many late nights at Ellingham Hall (where he was living under house arrest) discussing his life and the work of WikiLeaks with the writer he had enlisted to help him, Julian became increasingly troubled by the thought of publishing an autobiography. After reading the first draft of the book at the end of March, Julian declared: ‘All memoir is prostitution.’ In June 2011, with thirty-eight publishing houses around the world committed to releasing the book, Julian told us he wanted to cancel his contract. We disagree with Julian’s assessment of the book. We believe it explains both the man and his work, underlining his commitment to the truth. Julian always claimed the book was well written; we agree, and this also encouraged us to make the book available to readers. And the contract? By the time Julian wanted to cancel the deal he had already used the advance money to settle his legal bills. So the contract still stands. We have decided to honour it – and to publish. This book is the unauthorised first draft. It is passionate, provocative and opinionated – like its author. It fulfils the promise of the original proposal and we are proud to publish it. Canongate Books, September 2011

Download or read book Machine Learning in Image Analysis and Pattern Recognition written by Munish Kumar and published by MDPI. This book was released on 2021-09-08 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is to chart the progress in applying machine learning, including deep learning, to a broad range of image analysis and pattern recognition problems and applications. In this book, we have assembled original research articles making unique contributions to the theory, methodology and applications of machine learning in image analysis and pattern recognition.

Download or read book Report of the Hypertension Task Force written by National Heart, Lung, and Blood Institute. Hypertension Task Force and published by . This book was released on 1979 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Title List of Documents Made Publicly Available written by U.S. Nuclear Regulatory Commission and published by . This book was released on 1980 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: