Download or read book Genetically Modified Mosquitoes for Malaria Control written by Christophe Boete and published by CRC Press. This book was released on 2006-07-15 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite a century of research and attempts to control one of the deadliest foes of mankind, the malaria situation remains a major public health problem. Obviously biological explanations (the resistance of parasites and mosquitoes against available drugs and insecticides respectively) are often given, but they remain partial and incomplete. Indeed,
Download or read book Genetic Control of Malaria and Dengue written by Zach N. Adelman and published by Academic Press. This book was released on 2015-10-15 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Control of Malaria and Dengue focuses on the knowledge, technology, regulation and ethics of using genetically modified mosquitoes to interrupt the transmission of important vector-borne diseases including Malaria. It contains coverage of the current state of knowledge of vector-borne diseases and how they are currently controlled; vaccine, drug and insecticide development; various strategies for altering the genome of mosquitoes in beneficial ways; and the regulatory, ethical and social environment concerning these strategies. For more than five decades, the prospect of using genetically-modified mosquitoes to control vector-borne disease transmission has been a purely hypothetical scenario. We simply did not have the technology or basic knowledge to be able to do it. With the explosion of field trials and potential interventions in development, Genetic Control of Malaria and Dengue provides a comprehensive overview of research in genetics, microbiology, virology, and ecology involved in the development and implementation of genetic modification programs for virus and disease control. This book is meant to provide a practical guide to researchers, regulators and the general public about how this technology actually works, how it can be improved, and what is still unknown. - Includes coverage of vectorial capacity, critical to understanding vector-borne disease transmission - Provides a summary of the concepts of both population suppression and population replacement - Contains pivotal coverage of ethical and ecological ramifications of genetics-based control strategies
Download or read book Genetically Modified and other Innovative Vector Control Technologies written by Brij Kishore Tyagi and published by Springer Nature. This book was released on 2022-01-01 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively covers the latest development in developing and deploying the genetically modified vectors, particularly Anopheles and Aedes mosquitoes responsible for transmitting malaria parasites and dengue viruses, the most deadly and/or debilitating among all the vector-borne diseases. It is considered timely and commensurate to bring about a book dealing with the various ecological, biological and social as well as regulatory aspects for the deployment of genetically modified vectors in special context with the biosafety of humans, his associates, and the environment. Written by an array of specialists and experts in various subjects of genetically modified organisms, this book centrally addresses the (i) basic principles of the genetic manipulation of vectors and they are potential impact on human and the environment, (ii) ecological, biological, ethical, legal and social implications of the use of genetically modified vectors, (iii) identification of potential hazards; assessment and management of risks for human and environment; risk/benefit analysis, (iv) principles and practices for the assessment and management of biosecurity and biosafety in laboratories (and in the field), (v) guiding principles for creation and management of institutional or national biosafety review boards and ethics review committees, and (vi) development and application of a biosafety regulatory framework and its related legal principles at national levels for securing the development and use of vector control methods based on genetic modification strategies. This publication will be useful to researchers, scientists, and professionals engaged in academic and research institutions, government or non-government, as well as students in universities and medical colleges.
Download or read book Ecological Aspects for Application of Genetically Modified Mosquitoes written by W. Takken and published by Springer Science & Business Media. This book was released on 2003-07-31 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the reflection of a workshop, held in June 2002. Experts on mosquito ecology met for the first time to discuss the current knowledge of mosquito ecology with respect to GM-insect technology. Emphasis of the workshop was on evaluating how human health and natural ecosystems, including target wild-mosquito populations, will respond to the invasion of GM vectors. This volume will stimulate discussion by clearly showing the importance of vector ecology for prevention of vector-borne diseases.
Download or read book Mosquito Gene Drives and the Malaria Eradication Agenda written by Rebeca Carballar-Lejarazú and published by CRC Press. This book was released on 2023-02-24 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is one of most serious infectious diseases today and has afflicted humankind for thousands of years. A significant number of people still die from this mosquito-borne disease, despite the use of various malaria prevention and control methods over hundreds of years and more than a century of coordinated global control efforts using modern tools, together with research into and development of new strategies for prevention, diagnosis, and disease treatment. Genetic approaches that focus on the vector mosquitoes to prevent malaria parasite transmission have been considered for many decades. Genetic control strategies received a significant boost with the successful development of gene drive systems, genetic methods for rapidly spreading beneficial genes and phenotypes through mosquito populations. This book reviews some concepts of gene drive systems and describes pioneering applications to control mosquito populations and prevent parasite transmission.
Download or read book Saving Lives Buying Time written by Institute of Medicine and published by National Academies Press. This book was released on 2004-09-09 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.
Download or read book Gene Drives on the Horizon written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-08-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.
Download or read book Biosafety Concerns Involving Genetically Modified Mosquitoes to Combat Malaria and Dengue in Developing Countries written by Graciela R. Ostera and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria and dengue are the most prevalent mosquito-borne infections worldwide. Because traditional vector control methods have proven to be insufficient to control mosquito populations in endemic areas, scientists are actively working in the design of new strategies, such as genetically modified (GM) mosquitoes, to reduce disease transmission. The replacement of natural populations with GM mosquitoes is becoming a tangible possibility, however, many fear that the release of these organisms into the environment could constitute a significant risk to biodiversity and may cause the unintended spread of GM organisms across national borders. The Cartagena Protocol on Biosafety, an international agreement originally intended to oversee the trade of GM crops, did not include specific provisions for the safe use of GM insects. Recently, the Ad Hoc Technical Expert Group (AHTEG) on Risk Assessment and Risk Management to the Conference of the Parties, provided guidelines on the use of GM arthropods for the control of human disease. However, these guidelines did not address some significant technical and safety issues associated with the use of genetically or biologically modified vectors. A new global treaty, specifically intended to address issues related to genetic or biological modifications of arthropod vectors seem to be necessary before we endorse the decision of releasing modified arthropod vectors into the natural environment.
Download or read book Evaluation of genetically modified mosquitoes for the control of vector borne diseases written by and published by World Health Organization. This book was released on 2020-09-30 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Disease Control Priorities Third Edition Volume 6 written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Download or read book Innovative Strategies for Vector Control written by Constantianus J.M. Koenraadt and published by Brill Wageningen Academic. This book was released on 2021-03-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 6th volume of the ECVD series reflects on the progress of GVCR. The introduction and concluding chapters of the book have been written in collaboration with WHO.
Download or read book Developing and Adopting Complex Health Innovations written by Valentina Cisnetto and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Towards Malaria Elimination written by Sylvie Manguin and published by BoD – Books on Demand. This book was released on 2018-07-18 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Towards Malaria Elimination - A Leap Forward was started to mark the occasion for renewed commitment to end malaria transmission for good (the WHO's call for "Malaria Free World" by 2030). This book is dedicated for the benefit of researchers, scientists, program and policy managers, students and anyone interested in malaria and other mosquito-borne diseases with the goal of sharing recent information on success stories, innovative control approaches and challenges in different regions of the world. Some main issues that emerged included multidrug-resistant malaria and pandemic risk, vaccines, cross-border malaria, asymptomatic parasite reservoir, the threat of Plasmodium vivax and Plasmodium knowlesi, insecticide resistance in Anopheles vectors and outdoor malaria transmission. This book is one little step forward to bring together in 17 chapters the experiences of malaria-expert researchers from five continents to present updated information on disease epidemiology and control at the national/regional level, highlighting the constraints, challenges, accomplishments and prospects of malaria elimination.
Download or read book Guidance framework for testing genetically modified mosquitoes written by and published by World Health Organization. This book was released on 2021-05-18 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Global Technical Strategy for Malaria 2016 2030 written by World Health Organization and published by World Health Organization. This book was released on 2015-11-04 with total page 35 pages. Available in PDF, EPUB and Kindle. Book excerpt: The World Health Organization's Global Technical Strategy for Malaria 2016- 2030 has been developed with the aim to help countries to reduce the human suffering caused by the world's deadliest mosquito-borne disease. Adopted by the World Health Assembly in May 2015 it provides comprehensive technical guidance to countries and development partners for the next 15 years emphasizing the importance of scaling up malaria responses and moving towards elimination. It also highlights the urgent need to increase investments across all interventions - including preventive measures diagnostic testing treatment and disease surveillance- as well as in harnessing innovation and expanding research. By adopting this strategy WHO Member States have endorsed the bold vision of a world free of malaria and set the ambitious new target of reducing the global malaria burden by 90% by 2030. They also agreed to strengthen health systems address emerging multi-drug and insecticide resistance and intensify national cross-border and regional efforts to scale up malaria responses to protect everyone at risk.
Download or read book Genetically Modified and Other Innovative Vector Control Technologies written by Brij Kishore Tyagi and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively covers the latest development in developing and deploying the genetically modified vectors, particularly Anopheles and Aedes mosquitoes responsible for transmitting malaria parasites and dengue viruses, the most deadly and/or debilitating among all the vector-borne diseases. It is considered timely and commensurate to bring about a book dealing with the various ecological, biological and social as well as regulatory aspects for the deployment of genetically modified vectors in special context with the biosafety of humans, his associates, and the environment. Written by an array of specialists and experts in various subjects of genetically modified organisms, this book centrally addresses the (i) basic principles of the genetic manipulation of vectors and they are potential impact on human and the environment, (ii) ecological, biological, ethical, legal and social implications of the use of genetically modified vectors, (iii) identification of potential hazards; assessment and management of risks for human and environment; risk/benefit analysis, (iv) principles and practices for the assessment and management of biosecurity and biosafety in laboratories (and in the field), (v) guiding principles for creation and management of institutional or national biosafety review boards and ethics review committees, and (vi) development and application of a biosafety regulatory framework and its related legal principles at national levels for securing the development and use of vector control methods based on genetic modification strategies. This publication will be useful to researchers, scientists, and professionals engaged in academic and research institutions, government or non-government, as well as students in universities and medical colleges.
Download or read book The Deadly Air written by Christian Jennings and published by Guardian Books. This book was released on with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hundreds of thousands of people die every year from malaria. No one’s quite sure of the exact number. It’s just too difficult to keep track of the disease as it tears through more than 200 million cases each year, many of them in countries wracked by war and blighted by other problems. What is certain is that it is people living in these situations and, more specifically, children aged under five, who suffer disproportionately. It is for these areas that universities and NGOs, drugs companies, governments and philanthropists from around the world are united in an ongoing battle against the disease. Malaria has been with us for thousands of years. The Ancient Egyptians had it; Chinese dynasties before them. One of the first treatments for the disease was quinine, brought to Europe from Peru in the mid-fifteenth century. In some arenas during the second world war, more soldiers were hospitalised by malaria than by injuries sustained during fighting. Today, malaria remains one of the most resilient and most adaptive diseases out there, constantly mutating as it finds ways around the drugs deployed to combat it. One of the key parts of the problem is the method by which malaria transmits itself from person to person: mosquito bites. Breeding, feeding and transmitting at an incredible rate, mosquitoes are unavoidable in whatever environment they live. Now, cutting edge science is being called upon to help save lives lost to malaria. By genetically modifying the mosquitoes, scientists are aiming to turn the disease’s vector against itself, severing the link that enables malaria to spread. In The Deadly Air, Christian Jennings mixes together his own experiences of suffering from malaria with a history of mankind’s struggle with the disease and an account of the scientists engaged in the modification of the mosquito’s genome. Rich in detail and scientific intrigue, The Deadly Air is the story of malaria and of the millions of lives at stake in our fight against it.
