Download or read book Vaccine Safety Forum written by Institute of Medicine and published by National Academies Press. This book was released on 1997-08-10 with total page 71 pages. Available in PDF, EPUB and Kindle. Book excerpt: On November 6, 1995, the Institute of Medicine's Vaccine Safety Forum convened a workshop on detecting and responding to adverse events following vaccination. Workshop speakers and participants discussed the difficulties in detecting adverse events, current adverse events detection and response methods and procedures, suggestions for improving the means of detecting and responding to adverse events following vaccination, and future areas of research. This document represents a summary of that workshop.
Download or read book The Molecular Pathology of Autoimmune Diseases written by Argyrios N Theofilopoulos and published by CRC Press. This book was released on 2002-12-06 with total page 1518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Remarkable advances have been made in the pathogenesis of autoimmunity, such as with bone marrow transplantation, which is becoming a powerful strategy in treating certain life-threatening diseases. The Molecular Pathology of Autoimmune Diseases is a concise and centralized resource for information on the topic, with a special focus on the molecular and genetic basis of these disorders. Dozens of international experts devote themselves to illuminating the reader in this volume, with discussions on the basic aspects of autoimmune processes to systemic and organ-specific diseases. This volume is an invaluable reference to students and professionals in immunology and related fields.
Download or read book Genes and Genetics of Autoimmunity written by A. N. Theofilopoulos and published by Karger Medical and Scientific Publishers. This book was released on 1999 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmunity is one of the most highly investigated areas of immunologic research. The principle of immune system discrimination between self and foreign molecules is fundamental to the survival of the species, and the failure to establish or maintain this discrimination can lead to a wide spectrum of diseases. As a consequence of intensive studies, much has been learned with regard to the normal functioning of the immune system and the editing processes by which self-tolerance is established. Moreover, many theories and experimental models have been developed to explore the mechanisms of autoimmune disease pathogenesis. This book is the first volume of the new series 'Current Directions in Autoimmunity', which aims to consolidate current knowledge of autoimmunity focusing on both basic and clinical aspects. Given that these diseases have a strong genetic basis, it seems appropriate that the first volume addresses this topic. It reviews the most recent findings on genes affecting autoimmunity and genome-wide studies defining the multiple loci predisposing to prominent autoimmune diseases, such as lupus, arthritis, diabetes and multiple sclerosis. For each of these entities, studies in experimental models as well as humans are covered. The authoritative and timely material will be of interest to investigators in the fields of immunology and genetics, to clinicians with interest in rheumatology, endocrinology and neurology, and to those working to devise gene-specific therapies for a variety of inflammatory conditions.
Download or read book The Molecular Biology of Autoimmune Disease written by Andrew G. Demaine and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune diseases are common and often associated with considerable morbidity or - in diseases such as IDDM, myasthenia gravis and multiple sclerosis - mortality. In this volume, experts of international stature in basic science and clinical medicine with a common interest in understanding the normal and aberrant immune response present their experiences. It was their intention to fur- ther the understanding of potential clinical application of scientific observations and to help to comprehend the huge amount of results in autoimmunity research.
Download or read book The molecular aspects of autoimmunity written by Nadir Farid and published by Elsevier. This book was released on 2012-12-02 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Molecular Aspects of Autoimmunity contains a selection of the papers presented at the first of a series of biannual meetings on molecular aspects of autoimmunity held in L'Esterel, Quebec, Canada, October 30-November 2, 1988. The book contains 20 chapters and begins with a study of the expression of the Ly-1 gene and V gene families in autoantibodies. This is followed by separate chapters on the structural characteristics of human IgM autoantibodies; human IgV gene segments for autoantibodies; and the genetic basis of anti-DNA immune responses. Subsequent chapters cover topics such as the epibodies from the immune response to the acetylcholine receptor (AChR); the specificities and idiotypes of anti-histone H1 autoantibodies; T cell tolerance; and T cell antigen receptor (TCR) gene biology and the genomic composition and expressed repertoire of these genes in several autoimmune and normal mouse strains. Also discussed are MHC Class II associations with autoimmune disorders such as type 1 diabetes, rheumatoid arthritis, and thyroid disease.
Download or read book Genetics of Autoimmunity written by Gregory R. Bock and published by John Wiley & Sons. This book was released on 2005-09-01 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title provides an extremely helpful analysis of genes that may be associated with autoimmunity, and answers questions such as how these genes can be identified, and how the functions of the gene products can be elucidated. Incorporating data on disease-associated chromosomal loci that has been accumulated from inbred mice, the title: descibes how some susceptibility loci may be common to many diseases, whereas others are relatively disease specific discusses the importance of developing criteria for establishing the significance of these different categories of disease-associated loci.
Download or read book Primary Immunodeficiency Diseases written by Hans D. Ochs, MD, Dr.med and published by Oxford University Press. This book was released on 2013-11-01 with total page 930 pages. Available in PDF, EPUB and Kindle. Book excerpt: Primary immunodeficiency diseases, first recognized 60 years ago, are inherited disorders that affect human adaptive and innate immunity. In most cases, affected individuals experience recurrent infections, but they may also suffer from autoimmune diseases and malignancies. This third edition of Primary Immunodeficiency Diseases provides readers with the historic and scientific background, clinical presentations, immunologic characteristics, and the molecular/genetic underpinnings of this rapidly enlarging class of diseases. With up-to-date diagnostic tools and therapeutic options -- from prophylactic anti-infective measures to hematopoietic stem cell transplantation and gene therapy -- this volume will remain an authoritative resource on this increasingly important area.
Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book Genetic Models of Immune and Inflammatory Diseases written by Abul K. Abbas and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the proceedings of the Serono Symposia USA interna tional symposium on Genetic Models of Immune and Inflammatory Dis eases held on October 20 to 23, 1994, in Savannah, Georgia. The advent of methods for introducing genes into the germlines of mice, and for targeted disruption of particular genes by homologous recombination, has provided scientists in many disciplines with an extraordinarily powerful set of analyti cal tools. Some of the most informative applications of transgenic and gene knockout technology have been in studies of lymphocyte development and activation. The goal of this symposium was to bring together investigators using these genetic approaches for analyzing the immune system, with a view to defining common themes and novel directions. Transgenic mice have a wide variety of important applications in immu nology. Defined proteins can be expressed in selected tissues throughout development, thus acquiring the essential characteristic of "self" antigens. Such models have been used to study how immune responses to these artificially created "self" antigens are controlled. Antigen receptors of lym phocytes have been expressed as transgenes, and because lymphocytes are endowed with the unique property of allelic exclusion, such transgenic mice become essentially monospecific. Immunomodulatory agents have been expressed in defined tissues or throughout the body, providing tools for studying the functional consequences of dysregulated expression of biologi cal response modifiers.
Download or read book Immunogenetics of Autoimmune Disease written by Jorge R. Oksenberg and published by Springer Science & Business Media. This book was released on 2007-12-22 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases are characterized by modest disease risk heritability and m- tifaceted interactions with environmental influences. Yet, several recent discoveries have dramatically changed our ability to examine genetic variation as it relates to human disease. In addition to the development of large-scale laboratory methods and tools to efficiently recognize and catalog DNA diversity, over the past few years there has been real progress in the application of new analytical and data-manage ment approaches.
Download or read book The Autoimmune Diseases II written by M. Eric Gershwin and published by Elsevier. This book was released on 2012-12-02 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with autoimmune disease in humans (as opposed to autoimmunity itself). It discusses the biological basis of disease at the molecular, genetic, cellular, and epidemiologic levels. It also describes the clinical problems of diagnosis, prognosis, and treatment. The intended audience includes physicians of all specialties in practice, physicians in training such as house staff and fellows, and medical students. It will also be valuable for basic scientists and graduate students interested in the solution of important clinical problems. The book concentrates on topics that have grown or changed dramatically since publication of The Autoimmune Diseases.
Download or read book HLA and MHC written by Michael J. Browning and published by Taylor & Francis. This book was released on 1996 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a review of the major histocompatibility complex (MHC), and the role it plays in the immune response and in disease. The emphasis throughout is on the human MHC, but relevant animal studies are inclded to give a comprehensive review of the subject.
Download or read book The Immunogenetics of Autoimmune Diseases written by Nadir R. Farid and published by CRC Press. This book was released on 1990-11-21 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many developments in immunology have occurred over the past 10 years that give us a better understanding of the immune system and its dysfunctions. Refined mapping of the major histocompatibility complex
Download or read book B Cell Receptor Signaling written by Tomohiro Kurosaki and published by Springer. This book was released on 2015-12-26 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.
Download or read book Quantal Theory Of Immunity The The Molecular Basis Of Autoimmunity And Leukemia written by Kendall A Smith and published by World Scientific. This book was released on 2010-08-18 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains how the immune system functions, namely, how individual cells of the immune system make the decision to respond or not to respond to foreign microbes and molecules, and how the critical molecules function to trigger the cellular reactions in an all-or-none (quantal) manner. To date, there has not been a complete description of the immune system and its cells and molecules, primarily because most of the information has accumulated only in the last 40 years and our understanding has been expanding rapidly only in the last 20 years. It is now clear that the cells have evolved a way to “count” the number of foreign antigenic molecular “hits”, and they only react when a critical number of events have accumulated. Subsequently, control over the reaction is transferred to a systemic lymphocytotrophic hormone system that determines the tempo, magnitude and duration of the immune reaction.This book explains in detail how the immune system, cells and molecules work for the first time. With this understanding as a basis, the pathogenesis of autoimmunity can now be understood as a mutational usurpation of the genes encoding molecules that participate in a sensitive feedback regulatory control of the immune reaction. By comparison, malignant transformation is understood as a mutational usurpation of the genes encoding the molecules that control the quantal decision to proliferate, so that normal ligand/receptor cell growth control is circumvented./a
Download or read book The Immunogenetics of Autoimmune Diseases written by Nadir R. Farid and published by CRC Press. This book was released on 1990-11-30 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many developments in immunology have occurred over the past 10 years that give us a better understanding of the immune system and its dysfunctions. Refined mapping of the major histocompatibility complex MHC; elucidation of its gene structure and polymorphism, as well as the molecular basis of MHC restriction; the arrangement, expression, and regulation of immunoglobulins; definition of the structure of the T cell receptor and organization of its genes; and the characterization of soluble factors involved in cell/cell interactions and cloning of their genes are among the major accomplishments. Volumes I and II build on these developments in basic immunology to introduce animal models of various diseases, corresponding human studies, and the genetic analysis of autoimmune traits at the patient population level. The book will be a tremendous asset to immunologists, geneticists, and physicians in various areas of clinical subspecialties.
Download or read book Immunogenetics A Molecular and Clinical Overview written by Muneeb U. Rehman and published by Academic Press. This book was released on 2021-11-30 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Molecular Approach to Immunogenetics, Immunogenetics: A Molecular and Clinical Overview, Volume One provides readers with an exclusive, updated overview on the scientific knowledge, achievements and findings in the field of immunogenetics. The book presents readily available, updated information on the molecular and clinical aspects of immunogenetics, from origin and development to clinical applications and future prospects. The breadth of information goes from basics to developments, clinical applications and future prospects. The book's most attractive attribute is its academic and clinical amalgamation that covers both the theoretical and practical aspects of immunogenetics. An additional feature of the book is a special chapter on viral genetics that covers COVID-19. Above all, the book contains chapters that discuss immunogenetics in relation to pharmaco-genomics and immune-toxicology. Contains exclusive information about research on immunogenetics from around the globe Includes minute and recent details that will be the prerequisite requirement for any researcher who wants to work on immunogenetics and its applications Comes fully-equipped with pictures, illustrations and tables that deliver information in a meticulous manner
