Download or read book Generation of Antibody Diversity in the Memory Response to Phosphocholine written by Mary P. Stenzel-Poore and published by . This book was released on 1986 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Somatic Hypermutation in V Regions written by E. J. Steele and published by CRC Press. This book was released on 1991-01-03 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides critical reviews regarding the process of somatic hypermutation in antibody V genes. Topics covered include the in vivo kinetics of antigen-driven somatic hypermutation in a number of well-studied systems in mice; the instability of lg genes in cultured cells; the key role played in vivo by germinal centers in providing the appropriate "mutational" microenvironment; the types of nucleotide sequence errors generated; the process of hypermutation in pre-arranged V regions expressed in transgenic mice; and a critical evaluation of the status of molecular models proposed to explain hypermutation. Other topics include a detailed review of data from hypervariable retroviral systems, as well as precise studies on the mutagenic potential of various DNA polymerases in vitro. The book will provide indispensable information for immunologists, geneticists, molecular biologists, biochemists, and cell biologists.
Download or read book T Cell Dependent and Independent B Cell Activation written by E. Charles Snow and published by CRC Press. This book was released on 1990-12-19 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an analysis of the current subdisciplines comprising the study of humoral immune response. The first chapter presents a detailed discussion regarding the experimental and conceptual studies conducted prior to the mid-1970s that have served as a valuable research framework for investigators interested in the process by which B cells are activated following their exposure to antigens. Other chapters focus on topics such as membrane-associated proteins with important functional roles during B cell activation and differentiation; thymus-independent and thymus-dependent activation; mechanisms operative during B-T cell interactions, including the role of B cells as antigen-presenting cells; and the importance of soluble mediators. Additional topics include the regulatory role of T cells during B cell repertoire expression, memory development, tolerance, and autoimmunity. T-Cell Dependent and Independent B-Cell Activation is an important history and reference resource for humoral immune response investigators, as well as advanced graduate and medical students.
Download or read book Somatic Diversification of Immune Responses written by Garnett Kelsoe and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discovery of the mechanism for V(D)J hypermutation remains a basic goal of immunology despite the best efforts of many labo ratories. The existence of catalyzed, site-specific mutation and its exploitation for the somatic evolution of lymphocytes are re markable adaptations, yet since the discovery of hypermutation in 1970 (see cover), much hard work has generated little. Indeed, our knowledge of what is probably absolutely required for the mutator's action can be succinctly expressed: /g gene enhancers. Table 1 of Winter et a!.'s chapter puts into a historical perspec tive how our notions of the mutator have changed over the years. Despite these modest gains, most of us feel that this is the best of times. Our work has not only shown us what the mutator is not, it has also, like an artist's preliminary sketch, defined the questions and experiments we must face without diminishing the potential for new biology. In short, it is great fun to toil against a significant and enigmatic problem.
Download or read book H 2 Antigens written by C. David and published by Springer. This book was released on 2014-11-14 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Journal of Immunology written by and published by . This book was released on 1995 with total page 1040 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Antibodies written by Maurizio Zanetti and published by CRC Press. This book was released on 1996-12-19 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibodies have always been vital to any major progress within immunology. From diagnostic tools to vehicles for modern therapy against cancer, infections and autoimmune diseases, antibodies serve many purposes, yet our knowledge of them, their properties and structural characteristics is still incomplete. The Antibodies: Volume 2 is a comprehensive review of topics of contemporary interest for specialists in B cell immunology. This volume investigates such topics as sequencing the variable regions of human antibodies directed against exogenous antigens; a review of the protective immune response; a review of the utilization of the VH4-34 (VH4-21) gene segment in normal, neoplastic and autoimmune repertoires; and a review of antigenized antibodies. Exciting, innovative technological developments used for exploring new areas of study and medical applications are also covered. Traditional aspects of the field are revisited so that relevant information and concepts are maintained as a point of reference to more modern aspects.
Download or read book Molecular Immunology written by and published by . This book was released on 1994 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Evolution and Vertebrate Immunity written by Garnett Kelsoe and published by . This book was released on 1987 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cold Spring Harbor Symposia on Quantitative Biology written by Cold Spring Harbor Laboratory of Quantitative Biology and published by . This book was released on 1933 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1991 with total page 1320 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Positive T cell Selection in the Thymus written by and published by . This book was released on 1993 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Federation Proceedings written by Federation of American Societies for Experimental Biology and published by . This book was released on 1987-03 with total page 914 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1942- include proceedings of the American Physiological Society.
Download or read book Regulation of the Immune Response Focusing on Somatic Hyper mutation written by Eva Källberg and published by . This book was released on 1995 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Journal of Experimental Medicine written by and published by . This book was released on 1988 with total page 1236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Gene Vaccines written by Josef Thalhamer and published by Springer Science & Business Media. This book was released on 2011-08-31 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the “world of naked gene vaccines”, namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.
Download or read book Immunoglobulin Idiotypes written by Charles A. Janeway and published by . This book was released on 1981 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt:
