Download or read book Gene Therapy and Prostate Cancer written by P. Ronald and published by GRIN Verlag. This book was released on 2017-06-20 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essay from the year 2011 in the subject Biology - Genetics / Gene Technology, grade: 4.5, University of Michigan, language: English, abstract: The subject of gene therapy first came up in the late 1960s and early 1970s, and is still the latest innovation in the field of medicine. Gene therapy works on the basis of manipulating the basis of human inheritance, the DNA. In a lot of medical conditions, the underlying problem is an abnormality in the gene which is the basic building block of inheritance and transfer of information from generation to generation. Gene therapy can be broadly defined as a branch of biomedical engineering which deals with the insertion, withdrawal or alteration of DNA (gene) within specific cells in order to treat a medical condition. Usually, the most common form of gene therapy involves the insertion of an artificially synthesized gene into a specific genetic locus to replace a transformed gene.
Download or read book Prostate Cancer written by Leland W. K. Chung and published by Springer Science & Business Media. This book was released on 2007-11-10 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, reviews new, valuable approaches to the treatment of prostate cancer in men. The latest edition contains new material on molecular imaging, new treatments for prostate cancer, molecular targets, cell signaling pathways, bioinformatics, and pathogenomics. The book details the latest innovations and advances in prostate cancer and may be used as a rapid reference text for readers. The volume profiles the latest advances in cancer research and treatment and includes profound studies in prostate stem cells, cancer-host interactions, hedgehog signaling in development and cancer, cholesterol and cell signaling, gene therapy for advanced prostate cancer, and noninvasive strategies such as molecular imaging to visualize gene expression. This new edition also investigates expression profiling and somatic alterations in prostate cancer progression and linkage studies of prostate cancer families to identify susceptibility genes. The issues of racial differences in prostate cancer mortality, radiotherapy for the treatment of locally advanced prostate cancer, recombinant antibody candidates for treatment, taxane-based chemotherapy, lethal phenotypes, and novel and efficient translation clinical trials are also presented in great depth. Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, provides readers with a general reference for prostate cancer from prevention to therapy and will be of value to clinicians, scientists, and administrators who strive to solve the cancer problem.
Download or read book Gene Therapy for Prostate Cancer written by Pejman Cohan and published by . This book was released on 1995 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Gene Based Therapies for Cancer written by Jack A. Roth and published by Springer Science & Business Media. This book was released on 2010-07-28 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer gene therapy is a novel therapy that targets the underlying genetic defects in the cancer cell. Progress in this field has been rapid and gene therapy promises to further extend personalized cancer treatment. In this volume leading experts have contributed their experience in developing gene therapies for a variety of cancers. Translational gene therapy approaches are emphasized. Chapters include discussions of specific gene delivery technologies as well as their application to various cancers with extensive discussions of ongoing clinical trials. This information should be useful to both students, fellows, and experienced scientists with an interest in this rapidly developing area.
Download or read book Gene Therapy in Cancer written by Grace W. Redberry and published by Nova Publishers. This book was released on 2005 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. This new book offers the latest research in a field bursting with new developments, hope and expectations.
Download or read book Oncolytic Gene Therapy for Prostate Cancer written by and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overall purpose of this award has been to study the molecular pharmacology of replication restricted adenoviral vectors for prostate cancer gene therapy. The scope of the research is to identify relevant transcription units, which are prostate and cancer selective for the creation of potent oncolytic adenoviral vectors for ultimate translation to human clinical trials. Major findings of this award have been several. First, we have developed a first generation vector, CN706, which is prostate selective for PSA based on regulation of the ElA gene by the prostate specific enhancer promotor PSE from the PSA gene. Second, our DOD award research studies show antineoplastic action by killing by apoptosis. These vectors kill hormone refractory prostate cancer clones, which can be synergized by ionizing radiation at doses, which are clinically administered. We also have found these vectors have preclinical efficacy when given intravenously. Second, we have identified a new transcription unit, and the HIF gene as potent constructs and targets for improved gene therapy killing of hypoxic prostate cancer cells in vitro and in vivo. Our studies show that HIF is expressed as a gene therapy target in prostate cancer, but not normal prostate cells in humans and transgenic models. Basic research and creation of HIF PSA chimeric Ad S vectors has disclosed HIF is an important transcription target for oncolytic vectors. These new discoveries are currently being exploited in the creation of second generation vectors. The molecular pharmacology of oncolytic vectors suggests this is a new antineoplastic modality for hormone refractory prostate cancer.
Download or read book Gene Therapy for Cancer written by Kelly K. Hunt and published by Springer Science & Business Media. This book was released on 2007-10-26 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.
Download or read book Preclinical Evaluation of Adenovirus mediated Suicide Gene Therapy for Prostate Cancer and Multimodality Imaging of Viral Biodistribution and Transgene Expression written by Mai H. Johnson and published by . This book was released on 2008 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cancer Gene Therapy written by David T. Curiel and published by Springer Science & Business Media. This book was released on 2007-11-03 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.
Download or read book Nitric Oxide Gene Therapy for Prostate Cancer written by and published by . This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditional therapies for advanced prostate cancer are unable to cure a majority of patients. An approach to therapy we have tested involves production of nitric oxide (NO) by introduction of replication defective adenovirus containing the DNA sequences for inducible nitric oxide synthase (iNOS). An adenovirus vector with an iNOS cDNA and a CMV promoter (Ad5-CMV-iNOS) was constructed and tested. The production of nitric oxide in prostate cancer cells after infection with Ad5-CMV-iNOS was measured. Maximum NO release rate occurred when cells were infected at multiplicity of infection (MOl) 15 and after 24 to 36 hours incubation. Direct cell killing of cells growing in monolayer commenced within 1 day after infection and occurred at MOl greater than 5. An in vitro cell survival investigation utilized Du-145 and PC-3 prostate tumor cells growing to high density in a collagen matrix. Both control viral vector and Ad5-CMV-iNOS produced direct cell kill but no radiation sensitization in these cell systems. Sensitization was not observed in either aerobic or hypoxic conditions. Sensitization was also not observed after Ad5-CMV-iNOS gene therapy of Du-145 and PC-3 xenograft tumors in nude mice as assayed by the in vivo/in vitro method.
Download or read book Gene Therapy of Cancer written by Edmund C. Lattime and published by Academic Press. This book was released on 2013-08-28 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laboratory investigators to clinical practitioners, will find this book to be instructive. Cancer gene therapy, like cancer therapy in general, is evolving rapidly, testing new concepts, targets and pathways, evoking new technologies, and passing new regulatory hurdles. Its essence, however, has not changed: the hope and challenges of returning altered genes to normal, using targeted gene expression to alter the function of both tumor and microenvironment, and in some cases normal cells, and delivering functionally important genes to specific cell types to increase sensitivity to killing or to protect normal cells from cancer therapies. In some instances, gene therapy for cancer forms a continuum from gene repair through the use of molecularly modified cells; the use of viral and non-viral vector based gene delivery to both tumor and tumor microenvironment; the use of viral and gene based vaccines; and development of new gene-based therapeutics. The unique mechanistically chosen vector platforms are at the heart of this technology because they allow for direct and selective cell death and transient to sustained delivery of vaccine molecules or molecules that affect the microenvironment, vasculature, or the immune response. - Explains the underlying cancer biology necessary for understanding proposed therapeutic approaches - Presents in-depth description of targeting systems and treatment strategies - Covers the breadth of gene therapy approaches including immunotherapeutic, drug resistance,oncolytic viruses, as well as regulatory perspectives from both the NCI and FDA
Download or read book Prostate Cancer Clinical And Scientific Aspects Bridging The Gap written by Paul David Abel and published by World Scientific. This book was released on 2003-12-01 with total page 1255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the advent of the genomic era, the perceived benefits of close collaboration between clinicians and scientists are not always realised and the gap between bench and bedside remains. Closer collaboration should expedite advances in treating disease. This important book, with a foreword by Fritz H Schröder, is designed to enhance the relationship between the two communities. It contains data from a multinational authorship, the thirty-eight chapters being written by experts with widely differing training and expectations. Their aim is to facilitate both understanding and in-depth knowledge of their subject. By bridging the gap between clinicians and scientists, the hope is to enhance translational research in their common goal of improving the diagnosis and treatment of prostate cancer, the single most important cancer affecting men./a
Download or read book Prostate Cancer written by Gordana Kocic and published by Springer Nature. This book was released on with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of Prostate Cancer written by Manfred Wirth and published by Walter de Gruyter. This book was released on 2013-05-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Gene Therapy and Cancer Research Focus written by Rebecca N. Campbell and published by Nova Publishers. This book was released on 2008 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. The volume presents significant new research results in this promising field.
Download or read book Cancer Gene Therapy by Viral and Non viral Vectors written by Malcolm Brenner and published by John Wiley & Sons. This book was released on 2014-02-25 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides expert, state-of-the-art insight into the current progress of viral and non-viral gene therapy Translational medicine has opened the gateway to the era of personalized or precision medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. This book provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains how these are being used for gene-based cancer therapies. Designed as a volume in the Translational Oncology book series, Cancer Gene Therapy by Viral and Non-viral Vectors deals with the practice of gene-therapy, with reference to vectors for gene expression and gene transfer, as well as viral therapy. It covers the history and current and future applications of gene transfer in cancer, and provides expert insight on the progress of viral and non-viral gene therapy with regard to delivery system, vector design, potential therapeutic genes, and principles and regulations for cancer gene therapy. Presented in three parts, Cancer Gene Therapy by Viral and Non-viral Vectors covers: Delivery Systems • Translational Cancer Research: Gene Therapy by Viral and Non-viral Vectors • Retroviruses for Cancer Therapy • DNA Plasmids for Non-viral Gene Therapy of Cancer • Cancer Therapy with RNAi delivered by Non-viral Membrane/Core Nanoparticles Targeted Expression • Cancer Gene Therapy by Tissue-specific and Cancer-targeting Promptors • MicroRNAs as Drugs and Drug Targets in Cancer Principles of Clinical Trials in Gene Therapy • Regulatory issues for Manufacturers of Viral Vectors and Vector-transduced Cells for Phase I/II Trials • US Regulations Governing Clinical Trials in Gene Therapy • Remaining Obstacles to the Success of Cancer Gene Therapy Focusing on speeding the process in clinical cancer care by bringing therapies as quickly as possible from bench to bedside, Cancer Gene Therapy by Viral and Non-viral Vectors is an absolutely vital book for physicians, clinicians, researchers, and students involved in this area of medicine.
Download or read book Prostate Cancer New Horizons in Research and Treatment written by Michael L. Cher and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years the pace of research in prostate cancer has increased dramatically. Creative ideas in combination with new and emerging technologies have led to an explosion of discovery. These types of advances in prostate cancer research presage an era of new treatment strategies based on an understanding of the cellular and molecular mechanisms of disease. In creating this book, we aimed to cover a broad "bench to bedside" research spectrum ranging from: genetic, molecular and cellular analyses to epidemiological studies, refinements in local treatment strategies and new biologically based non-hormonal treatments for systemic disease. Researchers and clinicians will find in this book a group of timely and clinically relevant chapters on prostate cancer research and treatment.
