Download or read book Gap Junctions Molecular Basis of Cell Communication in Health and Disease written by Dale J. Benos and published by Gulf Professional Publishing. This book was released on 1999-12-14 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first gap junction protein (connexin) was cloned over a decade ago, more than a dozen connexin genes have been cloned. Consequently, a wealth of information on the molecular basis of gap junctional communication has been accumulated. This book pays tribute to this exciting era in the history of cell communication research by documenting the great strides made in this field as a result of the merging of biophysics and molecular biology, two of the most powerful approaches to studying the molecular basis of membrane channel behavior. Twenty-eight comprehensive chapters, authored by internationally recognized leaders in the field, discuss the biophysical, physiological, and molecular characteristics of cell-to-cell communication via gap junctions. Key aspects of molecular structure, formation, gating, conductance, and permeability of vertebrate and invertebrate gap junction channels are highlighted. In addition, a number of chapters focus on recent discoveries that implicate connexin mutations and alterations of gap junctional communication in the pathogenesis of several diseases, including the X-linked Charcot-Marie-Tooth demyelinating disease, some forms of inherited sensorineural deafness, malignant transformation, cardiac malformations and arrhythmia, eye lens cataract, and Chagas disease.
Download or read book Gap Junction Mediated Intercellular Signalling in Health and Disease written by Gail Cardew and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gap junctions are key elements in communication between cells in multicellular organisms. It is clear that their activity is essential for normal embryonic development and normal function in adult organs, although the individual roles of the proteins that form the channels (connexins) are not yet fully understood. The last few years have seen considerable progress in this field and exciting new issues concerning gap junctional intercellular communication are being raised. Perturbed gap junction activity is beginning to be linked to certain pathologies, e.g. mutations in the major connexin of the heart have been found in human patients suffering from visceroatrial heterotaxia syndrome and mutations in the gene encoding another connexin have been found in patients with Charcot-Marie-Tooth disease. This book is the first to highlight the recent progress in understanding gap junction structure and to discuss the specific roles of individual connexins. It features contributions from an interdisciplinary group of experts who review the role of gap junctions in the heart, the retina and lens, the auditory system, the reproductive system, and in cell proliferation and cancer. The book will appeal to people interested in cell and molecular biology, embryonic development, neurobiology, cardiology, gynaecology and oncology.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Gap Junctions in Development and Disease written by Elke Winterhager and published by Springer Science & Business Media. This book was released on 2005-11-04 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Communication between cells via intercellular channels – gap junctions – appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed. Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field.
Download or read book Cell Intercommunication written by Walmore C. De Mello and published by CRC Press. This book was released on 2018-01-18 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important publication addresses intercellular communication in health and disease. It includes recent advances in morphology and chemical organization of gap junctions. It discusses the possible role of intercellular channels in excitable and non-excitable tissues. The book presents modulation of junctional permeability, as well as the possible role of cell communication in embryonic development and growth. The text concludes with a synthetic view of the role of gap junctions and potential implications to cardiology, oncology, and other areas of pathology. This volume is important to professionals in pharmacology, physiology, biochemistry, biomedical science, pathobiology, pathology, molecular genetics, toxicology and human development.
Download or read book Gap Junctions written by E.L. Hertzberg and published by Elsevier. This book was released on 2000-01-10 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective in editing this volume was twofold: to provide a reasoned overview of the field as well as to furnish one that provided this overview within the context of the intellectual boundaries of those who initially attempted to define the purview of gap junction research. The latter objective has been realized by selecting the topics for review in this volume. The former objective was achieved by securing the cooperation of leaders in their fields as chapter co-authors.
Download or read book Cell Cell Channels written by František Baluška and published by Springer Science & Business Media. This book was released on 2006-08-28 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers cell-cell channels at all levels of biological organization. The purpose of this book is to document that cells are not physically separated and fully autonomous units of biological life as stated by the currently valid Cell Theory. If not the cell then some lower level unit must fulfill this role. The book deals also with the identity of this elusive unit of biological life.
Download or read book Gap Junction Mediated Intercellular Signalling in Health and Disease written by Novartis Foundation and published by Wiley. This book was released on 1999-04-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gap junctions are key elements in communication between cells in multicellular organisms. It is clear that their activity is essential for normal embryonic development and normal function in adult organs, although the individual roles of the proteins that form the channels (connexins) are not yet fully understood. The last few years have seen considerable progress in this field and exciting new issues concerning gap junctional intercellular communication are being raised. Perturbed gap junction activity is beginning to be linked to certain pathologies, e.g. mutations in the major connexin of the heart have been found in human patients suffering from visceroatrial heterotaxia syndrome and mutations in the gene encoding another connexin have been found in patients with Charcot-Marie-Tooth disease. This book is the first to highlight the recent progress in understanding gap junction structure and to discuss the specific roles of individual connexins. It features contributions from an interdisciplinary group of experts who review the role of gap junctions in the heart, the retina and lens, the auditory system, the reproductive system, and in cell proliferation and cancer. The book will appeal to people interested in cell and molecular biology, embryonic development, neurobiology, cardiology, gynaecology and oncology.
Download or read book Heart Cell Coupling and Impulse Propagation in Health and Disease written by Walmor C. de Mello and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart Cell Coupling and Impulse Propagation in Health and Disease includes an up-to-date review on how heart cells communicate and impulse propagation under normal as well as under pathological conditions. The complexity of intercellular coupling and impulse propagation is discussed, providing the reader with a broad view of the importance of these processes and how they contribute to the generation of cardiac arrhythmias and heart failure. The different aspects and intricacies of heart cell communication is discussed by different authors, each one an expert in their own field. The present publication will be of interest to cardiologists, electrophysiologists, heart physiologists, cardiac pharmacologists, biophysicists, and cell or molecular biologists.
Download or read book Gap Junctions in the Nervous System written by David C. Spray and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the types of gap junction proteins (connexins) and their distribution within the nervous system, the physiological properties of channels formed of each connexin, and the role of gap junction channels in functions of normal and pathological brain and peripheral nerve. Although glial tissue is emphasized, additional groups of chapters deal with neurons in the central nervous system and with the retina.
Download or read book Molecular Mechanisms of Epithelial Cell Junctions written by Sandra Citi and published by . This book was released on 1994 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text examines past and current progress on the structural, biochemical and molecular characterization of specialized cell-cell junctions in various types of epithelial tissue. Special attention is devoted to the recent characterization of specific protein components of junctions, and to questions of structure/function relationships in development, disease and phylogeny in epithelial junctions.
Download or read book Molecular and Cellular Insights to Ion Channel Biology written by Robert A. Maue and published by Gulf Professional Publishing. This book was released on 2004 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation Contains fresh perspectives and up-to-date view points from international experts Illustrates the diverse array of techniques applied to ion channel research Represents a valuable resource to both the beginner and expert researcher, with over 2500 references and more than 100 figures and tables.
Download or read book Molecular Communication written by Tadashi Nakano and published by Cambridge University Press. This book was released on 2013-09-12 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive guide, by pioneers in the field, brings together, for the first time, everything a new researcher, graduate student or industry practitioner needs to get started in molecular communication. Written with accessibility in mind, it requires little background knowledge, and provides a detailed introduction to the relevant aspects of biology and information theory, as well as coverage of practical systems. The authors start by describing biological nanomachines, the basics of biological molecular communication and the microorganisms that use it. They then proceed to engineered molecular communication and the molecular communication paradigm, with mathematical models of various types of molecular communication and a description of the information and communication theory of molecular communication. Finally, the practical aspects of designing molecular communication systems are presented, including a review of the key applications. Ideal for engineers and biologists looking to get up to speed on the current practice in this growing field.
Download or read book Gap Junction Structure and Chemical Regulation written by Camillo Peracchia and published by Academic Press. This book was released on 2019-02-16 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gap Junction Structure and Chemical Regulation: Direct Calmodulin Role in Cell-to-Cell Channel Gating describes and discusses the findings of major studies conducted during the past century on the structure and chemical regulation of direct cell-to-cell communication via gap junction channels. Chapters bring together important findings on direct cell communication, from its history, to its structure and regulation. These channels are essential for normal organ function, and mutations in their protein (connexin) cause various diseases. The book is useful for established investigators who need a review on the field and young investigators who need a thorough resource for study and comprehension. - Contains comprehensive, historical coverage on direct cell-to-cell communication - Provides detailed coverage of gap junction channel structure and regulation, with extensive coverage of the direct role of calmodulin in channel gating - Delivers a thorough description of models proposed for the chemical gating of gap junction channels
Download or read book Gap Junction Channels and Hemichannels written by Taylor & Francis Group and published by CRC Press. This book was released on 2021-03-30 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gap junction channels are a group of intercellular channels expressed in tissues and organs to synchronize many physiological processes. A gap junction channel is formed by the docking of two hemichannels, and each hemichannel is a hexamer of connexins. The field of gap junction channel and hemichannel research has recently exploded and became one of the most active areas of cell biology. Numerous novel approaches and techniques have been developed, but there is no single book dedicated to the unique techniques and protocols employed for the research on these large pore channels. This book fills the gap and focuses on protocols, approaches and reviews of gap junction channels and connexin hemichannels. It will be a useful reference for graduate students, postdoctoral fellows and researchers. Anyone with an interest in gap junction channels and hemichannels will need this summary of state-of-the-art techniques and protocols.
Download or read book Astrocytes and Epilepsy written by Jacqueline A. Hubbard and published by Academic Press. This book was released on 2016-07-05 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. - Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume - Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions - Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
Download or read book Connexins written by Andrew Harris and published by Springer Science & Business Media. This book was released on 2008-11-09 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Connexins: A Guide is a practical and valuable reference and text covering a wide scope of information about the connexin family of membrane channel proteins. The editors and contributing authors intend for this cutting-edge work to be informative to scientists wishing to learn about the field, as well as to those who are active researchers in this area. Connexins: A Guide masterfully addresses specific needs of the scientific community; it is a comprehensive and comprehensible narrative of the uncommonly diverse connexin field, making previously hard-to-find information easily accessible, while also presenting intelligible insights into the extensive experimental methods and conceptual frameworks necessary to appreciate and understand the important roles that connexin channel proteins play in health and disease.
