Download or read book Functionalized Nanoparticles for the Selective Killing of Cancer Cells written by Paul Todd Thevenot and published by ProQuest. This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of nanoparticles for cancer imaging and drug delivery has produced some success in improving the efficacy and safety of cancer chemotherapy. It is generally believed that the efficiency of nanoparticle-based cancer therapy would be greatly improved if such particles could be designed to directly interact with and eradicate tumor. Many recent studies have revealed that surface functionality plays an important role in particle:cell interactions. Using titanium dioxide (TiO2) nanoparticles (21 nm diameter) as test subjects, nanoparticles with different functional groups, hydroxyl ( -OH), amine ( -NH2), and carboxyl ( -COOH) were produced and used in this investigation. An in vitro cell culture system was used to evaluate the interaction of a series of surface functionalized TiO2 nanoparticles with a number of normal animal and cancer cell lines, including B16F10 melanoma, Lewis lung carcinoma (LLC), JHU prostate cancer cells, and 3T3 fibroblasts. It was observed that cell viability following exposure to TiO2 nanoparticles was dependent on particle concentration, cell line, and TiO 2 surface chemistry. Overall, the TiO2 nanoparticles, both functionalized and uncoated, exerted the strongest toxicity effects on LLC cells and least toxicity on B16F10 cells and 3T3 fibroblasts. Cell viability was observed to depend on the specific surface chemistry of the particles. In general, particles with -NH2 or -OH functional groups exhibited significantly higher toxicity than those functionalized with -COOH groups. Microscopy analysis of cell viability as well as spectophotometric analysis of lactate dehydrogenase (LDH) content and arrays of cell proliferation indicated that the TiO 2 nanoparticles disrupt the cell membrane integrity leading to cell death. Overall, the present results suggest that functionalized TiO2 nanoparticles, and presumably other nanoparticles similarly surface modified, may be engineered specifically for targeted cancer therapy. The ability to fully understand how a precisely chemically defined surface interacts with both cell monolayers and body tissues will help scientists and engineers in the design of materials that will perform their desired function while also minimizing unfavorable interactions within the body.

Download or read book Design and Evaluation of Plasmonic Magnetic Au MFe2O4 M Fe Co Mn Core Shell Nanoparticles Functionalized with Doxorubicin for Cancer Therapeutics written by Ravichandran Manisekaran and published by Springer. This book was released on 2017-10-30 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis documents the development of a multifunctional nanoparticle system to enhance the chemotherapeutic efficiency of anti-cancer drugs, and contributes to research that helps decrease the side-effects in cancer patients while simultaneously increasing their survival rates. The work begins with an introduction to nanomedicine and cancer therapy, and contains a literature review on magnetic, gold, and core-shell nanoparticles. It also covers synthesis techniques, properties, various surface modifications, and the importance of magnetic and gold nanoparticles. The author dedicates a chapter to characterization techniques, experimental setup, and cell cultivation techniques for in-vitro studies. Further chapters describe the background, characterizations, and applications of multifunctional magnetite coated gold core-shell nanoparticles, and the doping of cobalt to magnetite and manganese to magnetite nanoparticles. The important highlight of this research was the control of the size, shape, composition, and surface chemistry of nanoparticles.

Download or read book Functionalized Nanomaterials for Cancer Research written by Hamed Barabadi and published by Elsevier. This book was released on 2024-03-22 with total page 771 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functionalized Nanomaterials for Cancer Research: Applications in Treatments, Tools and Devices presents an in-depth and step by step description of knowledge on functionalized nanomaterials for cancer research, including treatment and future developments as well as their impact on patients' overall outcomes. The book discusses the functionalized nanoplatforms for cancer detection and imaging, interactions between nanomaterials and cancer cells, and drug resistant malignancies. The chapters are organized in a manner that can be readily adopted as sources for new and further studies by highlighting the main in vitro and in vivo nano-therapeutic achievements on cancer. Additionally, current trends on functionalized nanomaterials for cancer research and commercial scale opportunities are discussed. It is a valuable resource for researchers, oncologists, students, and members of the biomedical and medical fields who want to learn more about the potential of nanotechnology in cancer research and treatment. - Provides comprehensive coverage on functionalized nanomaterials for cancer therapeutics and future developments - Explores current trends on functionalized nanomaterials for cancer research and commercial scale opportunities - Discusses real-world case studies on functionalized nanomaterials for cancer therapy and research

Download or read book Nanopharmaceuticals Principles and Applications Vol 3 written by Vinod Kumar Yata and published by Springer Nature. This book was released on 2020-08-19 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.

Download or read book Synthesis of a Drug Delivery Vehicle for Cancer Treatment Utilizing DNA functionalized Gold Nanoparticles written by Tyler Brann and published by . This book was released on 2014 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt: The treatment of cancer with chemotherapeutic agents has made great strides in the last few decades but still introduces major systemic side effects. The potent drugs needed to kill cancer cells often cause irreparable damage to otherwise healthy organs leading to further morbidity and mortality. A therapy with intrinsic selective properties and/or an inducible activation has the potential to change the way cancer can be treated. Gold nanoparticles (GNPs) are biocompatible and chemically versatile tools that can be readily functionalized to serve as molecular vehicles. The ability of these particles to strongly absorb light with wavelengths in the therapeutic window combined with the heating effect of surface plasmon resonance makes them uniquely suited for noninvasive heating in biologic applications. Specially designed DNA aptamers have shown their ability to serve as drug carriers through intercalation as well as directly acting as therapeutic agents. By combining these separate molecules a multifaceted drug delivery vehicle can be created with great potential as a selective and controllable treatment for cancer. Oligonucleotide-coated GNPs have been created using spherical GNPs but little work has been reported using gold nanoplates in this way. Using the Diasynth method gold nanoplates were produced to absorb strongly in the therapeutic near infrared (nIR) window. These particles were functionalized with two DNA oligonucleotides: one serving as an intercalation site for doxorubicin, and another, AS1411, serving directly as an anticancer targeting/therapeutic agent. These functional particles were fully synthesized and processed along with confirmation of DNA functionalization and doxorubicin intercalation. Doxorubicin is released via denaturation of the DNA structure into which doxorubicin is intercalated upon the heating of the gold nanoplate well above the DNA melting temperature. This temperature increase, due to light stimulation of surface plasmon resonance, was measured during laser application. Successful release of doxorubicin via laser application was measured with fluorescence measurements providing proof that the doxorubicin was successfully intercalated and released.

Download or read book Multi functionalization of Micro and Nanoparticles for Cancer Theranostics written by Ezhil Amirthalingam and published by . This book was released on 2018 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis has its main focus on developing multi-functional nanomaterials, that we called nano- and microtools through two different approaches, top-down to provide support and bottom up to give functionality to prepare nanomaterials for diagnosis and therapy in cancer cells (theranostics). It includes functionalization of inorganic and or metallic nano- and microparticles with natural and synthetic receptors capable of acting as sensors to monitor different cellular parameters in living cells and deliverers specifically for diagnosis and therapy in cancer cells (theranostics). For this purpose, we used micro- and nanoparticles as substrates, made up of polysilicon or polysilicon-gold and gold nanoparticles, and functionalized them with (bio)molecules. The first objective was to develop a novel microtool for cell adhesion. For this purpose specially designed polysilicon microparticles of different shapes and sizes were chemically modified, to sense carbohydrates present on tumour cell membranes. An optimized protocol for bio-functionalization of polysilicon microparticles with lectins (WGA and Con A), both on surfaces and in suspension, was developed. Influence of different shapes in bio-functionalization of the microparticles was also observed. The final yield of the number of bio-functionalized microparticles was between 12-21 % with a major loss of approximately 50 % of microparticles during the activation step. These bio-functionalized microparticles in suspension were stable for three consecutive weeks, stored in PBS at room temperature. In vitro experiments were carried out which showed, Con A bio-functionalized Batch 2 microparticles adhered to the membrane of the Dictyostelium discoideum (Dicty) whereas, WGA bio-functionalized microparticles did not adhere to the cell membrane of Dicty or HeLa cells. Therefore, a synthetic lectin called Boronic Acids (BAs) was used and an optimized protocol for functionalization of polysilicon microparticles with 4-formylphenylboronic acid (PBA), through stable secondary amine bonds was developed. Interaction of BA functionalized surfaces with carbohydrate, N-acetylglucosamine (GlcNAc) was also studied on surfaces using ARS, which indicates stronger interaction between BA and GlcNAc. Polysilicon microparticles of different sizes functionalized using BA showed adhesion to the cell membranes of Dicty and HeLa cells. In the second objective, the primary goal is to sense intracellular pH in living cells using bi-functional microparticles (polysilicon-gold), in order to differentiate between cancer cells and normal cells. The immobilization of pH dependent fluorophores, Oregon green, pHrodo, SNARF and Alexa fluor on to polysilicon surfaces was achieved successfully. An optimized protocol for the bi-functionalization of two pH dependent fluorophores, Oregon green (on polysilicon) and pHrodo (on gold) on to a hexahedral bi-functional microparticle was achieved for pH sensing. The third objective was the generation and sensing of Reactive oxygen species (ROS) using a bio-photosensitizer for photodynamic therapy. The selected bio-photosensitizer, Cytochrome c (Cyt c) showed generation of ROS in solution. BODIPY was able to sense the production of ROS from the Cyt c in solution. An optimized protocol for immobilizing Cyt c on to the polysilicon surfaces and BODIPY on gold surfaces and microparticles was achieved. Protocol for bi-functionalization of ROS generator: Cyt c and ROS sensor: BODIPY on bi-functional microparticles was also developed for ROS sensing. The fourth objective is to deliver anionic drugs using gold nanoparticles synthesized using imidazolium based macrocycles. The ability of these gold nanoparticles to extract and incorporate ibuprofenate from an aqueous phase was calculated to be ca 85 %. The release of ibuprofenate from the gold nanoparticles system follows Fickian diffusion, which could be potentially used for local drug delivery applications.

Download or read book Recent Advances in Novel Drug Carrier Systems written by Ali Demir Sezer and published by BoD – Books on Demand. This book was released on 2012-10-31 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Download or read book Nano Drug Delivery Strategies for the Treatment of Cancers written by Awesh K. Yadav and published by Academic Press. This book was released on 2020-09-03 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nano Drug Delivery Strategies for the Treatment of Cancers discusses several current and promising approaches for the diagnosis and treatment of cancer by using the most recent developments in nanomedical technologies. The book presents introductory information about the biology of different types of cancer in order to provide the reader with knowledge on their specificities. In addition, it discusses various novel drug delivery systems, detailing their functionalities, expected outcomes and future developments in the field, focusing on brain, mouth and throat, breast, lung, liver, pancreas, stomach, colon, bool, skin and prostate cancers. The book is a valuable source for cancer researchers, oncologists, pharmacologists and nanotechnologists who are interested in novel drug delivery systems and devices for treatment of various types of cancer that take advantage of recent advances in this exciting field. - Discusses a wide range of promising approaches for the diagnosis and treatment of cancer using the latest advancement in cutting-edge nanomedical technologies - Provides foundational information on different types of cancer and their biology to help the reader choose the best nano drug delivery system for patients - Presents novel drug delivery systems based on nanoparticles, microparticles, liposomes, self-assembling Micelles and block copolymer micelles

Download or read book Carbon Nanostructures for Biomedical Applications written by Tatiana Da Ros and published by Royal Society of Chemistry. This book was released on 2021-02-15 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbon nanostructures, namely fullerenes, single and multiwall carbon nanotubes, graphene as well as the most recent graphene quantum dots and carbon nanodots, have experienced a tremendous progress along the last two decades in terms of the knowledge acquired on their chemical and physical properties. These insights have enabled their increasing use in biomedical applications, from scaffolds to devices. Edited by renowned experts in the subject, this book collects and delineates the most notable advances within the growing field surrounding carbon nanostructures for biomedical purposes. Exploration ranges from fundamentals around classifications to toxicity, biocompatibility and the immune response. Modified nanocarbon-based materials and emergent classes, such as carbon dots and nanohorns are discussed, with chapters devoted from carriers for drug delivery and inhibitors of emergent viruses infection, to applications across imaging, biosensors, tissue scaffolding and biotechnology. The book will provide a valuable reference resource and will extensively benefit researchers and professionals working across the fields of chemistry, materials science, and biomedical and chemical engineering.

Download or read book Advances in Bionanomaterials written by Stefano Piotto and published by Springer. This book was released on 2017-07-24 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reports on multidisciplinary research focusing on the analysis, synthesis and design of bionanomaterials. It merges the biophysicists’, the biochemists’ and bioengineers’ perspectives, covering the study of the basic properties of materials and their interaction with biological systems, the development of new devices for medical purposes such as implantable systems, and new algorithms and methods for modeling the mechanical, physical or biological properties of biomaterials. The different chapters, which are based on selected contributions presented at the second edition of BIONAM, held on October 4-7, 2016, in Salerno, Italy, cover both basic and applied research. This includes novel synthetic strategies for nanomaterials, as well as the implementation of bio- and smart materials for pharmacological and medical purposes (e.g. drug delivery, implantable systems), environmental applications, and many others. The book provides a broad audience of academic and professionals with a comprehensive, timely snapshot of the field of biomaterials. Besides offering a set of innovative theories together with the necessary practical tools for their implementation, it also highlights current challenges in the field, thus fostering new discussions and possible future collaborations between groups with different backgrounds.

Download or read book Nanomaterials for Cancer Therapy written by Challa S. S. R. Kumar and published by Wiley-VCH. This book was released on 2006-07-24 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first comprehensive overview on nanotechnological approaches to cancer therapy brings together therapeutic oncology and nanotechnology, showing the various strategic approaches to selectively eliminating cancerous cells without damaging the surrounding healthy tissue. The strategies covered include magnetic, optical, microwave and neutron absorption techniques, nanocapsules for active agents, nanoparticles as active agents, and active and passive targeting, while also dealing with fundamental aspects of how nanoparticles cross biological barriers. A valuable single source gathering the many articles published in specialized journals often difficult to locate for members of the other disciplines involved.

Download or read book Cancer Nanotechnology written by and published by Academic Press. This book was released on 2018-06-23 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research, Volume 139, provides invaluable information on the exciting and fast-moving field of cancer research. Original reviews are presented on a variety of topics relating to the rapidly developing intersection between nanotechnology and cancer research, with unique sections in the new release focusing on Exosomes as a theranostic for lung cancer, Nanotechnology and cancer immunotherapy, Ultrasound imaging agents and delivery systems, Dendronized systems for the delivery of chemotherapeutics, Thermosensitive liposomes for image-guided drug delivery, Supramolecular Chemistry in Tumor Analysis and Drug Delivery, Gold nanoparticles for delivery of cancer therapeutics, and Single cell barcode microchip for cancer research and therapy. Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike

Download or read book TiO2 Nanoparticles written by Aiguo Wu and published by John Wiley & Sons. This book was released on 2020-06-02 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique book that summarizes the properties, toxicology, and biomedical applications of TiO2-based nanoparticles Nanotechnology is becoming increasingly important for products used in our daily lives. Nanometer-sized titanium dioxide (TiO2) are widely used in industry for different purposes, such as painting, sunscreen, printing, cosmetics, biomedicine, and so on. This book summarizes the advances of TiO2 based nanobiotechnology and nanomedicine, covering materials properties, toxicological research, and biomedical application, such as antibacter, biosensing, and cancer theranostics. It uniquely integrates the TiO2 applications from physical properties, toxicology to various biomedical applications, and includes black TiO2 based cancer theranostics. Beginning with a comprehensive introduction to the properties and applications of nanoparticles, TiO2 Nanoparticles: Applications in Nanobiotechnology, Theranostics and Nanomedicine offers chapters on: Toxicity of TiO2 Nanoparticles; Antibacterial Applications of TiO2 Nanoparticles; Surface Enhanced Raman Spectrum of TiO2 Nanoparticle for Biosensing (TiO2 Nanoparticle Served as SERS Sensing Substrate); TiO2 as Inorganic Photosensitizer for Photodynamic Therapy; Cancer Theranostics of Black TiO2 Nanoparticles; and Neurodegenerative Disease Diagnostics and Therapy of TiO2-Based Nanoparticles. This title: -Blends the physical properties, toxicology of TiO2 nanoparticles to the many biomedical applications -Includes black TiO2 based cancer theranostics in its coverage -Appeals to a broad audience of researchers in academia and industry working on nanomaterials-based biosensing, drug delivery, nanomedicine TiO2 Nanoparticles: Applications in Nanobiotechnology, Theranostics and Nanomedicine is an ideal book for medicinal chemists, analytical chemists, biochemists, materials scientists, toxicologists, and those in the pharmaceutical industry.

Download or read book Nanomedicine for Cancer Diagnosis and Therapy written by Arshi Malik and published by Springer Nature. This book was released on 2021-08-01 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the current applications and future prospects of nanomaterials in cancer diagnostics and therapy. Nanomaterials have recently emerged as a remarkable and promising tool for cancer therapy and diagnosis, due to their broad range of intrinsic molecular properties. To overcome the current limitations of nanoparticles in drug delivery systems, attempts have been made to synthesize nanoparticles from biological materials for targeted cancer therapy. This book provides concise evaluations of various potential bio-inspired platforms that mimic natural components of the body and offer effective and versatile drug delivery systems for cancer therapy. It also assesses the potential of nanoparticles to enhance the outcomes of cancer immunotherapy via immune cell activation and tumor microenvironment modulation. The book also summarizes in the applications of nanomaterials for the detection, prevention, and treatment of solid tumors and in the treatment of leukemia and lymphomas. In closing, it discusses ethical issues in nanomedicine, including risk assessment, risk management, and risk communication during clinical trials. The book offers offers a valuable source of information for students, academics, researchers, scientists, clinicians, and healthcare professionals working in nanotechnology and cancer research.

Download or read book Advances in Nucleic Acid Therapeutics written by Sudhir Agrawal and published by Royal Society of Chemistry. This book was released on 2019-02-08 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sequencing of the human genome and subsequent elucidation of the molecular pathways that are important in the pathology of disease have provided unprecedented opportunities for the development of new therapeutics. Nucleic acid-based drugs have emerged in recent years to yield extremely promising candidates for drug therapy to a wide range of diseases. Advances in Nucleic Acid Therapeutics is a comprehensive review of the latest advances in the field, covering the background of the development of nucleic acids for therapeutic purposes to the array of drug development approaches currently being pursued using antisense, RNAi, aptamer, immune modulatory and other synthetic oligonucleotides. Nucleic acid therapeutics is a field that has been continually innovating to meet the challenges of drug discovery and development; bringing contributions together from leaders at the forefront of progress, this book depicts the many approaches currently being pursued in both academia and industry. A go-to volume for medicinal chemists, Advances in Nucleic Acid Therapeutics provides a broad overview of techniques of contemporary interest in drug discovery.

Download or read book Nanotechnology written by Sunipa Roy and published by CRC Press. This book was released on 2017-09-18 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nano particles have created a high interest in recent years by virtue of their unusual mechanical, electrical, optical and magnetic properties and find wide applications in all fields of engineering. This edited volume aims to present the latest trends and updates in nanogenerators, thin film solar cells and green synthesis of metallic nanoparticles with a focus on nanostructured semiconductor devices. Exclusive chapter on electrical transport of nanostructure explains device physics for material properties for reduced dimensions. Additionally, the text describes the functionality of metallic nanoparticles and their application in molecular imaging and optical metamaterials. Piezoelectric nanogenerators has been touched upon from the energy perspective as well. Key Features: • Organized contents on Nanogenerators, VOC sensing, nanoelectronics, and NEMS. • Discusses eco-friendly green synthesis methods for metallic nanoparticles. • Touches upon low power nano devices (e.g. nanogenerators) for energy harvesting with quantum mechanical study. • Thin film/heterojunction based high efficiency solar cell addressed aimed at reducing global energy consumption.

Download or read book Nanooncology written by Gil Gonçalves and published by Springer. This book was released on 2018-06-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a systematic overview of the most relevant nanomaterials and their respective intrinsic properties that have been highly explored by the scientific community and pharmaceutical companies in several different modalities for cancer therapy and bioimaging. The chapters explore the synergistic effects provided by the different nanostructured materials and highlight the main in vitro and in vivo therapeutic achievements on cancer. This work also provides relevant discussion about the recent progresses and future challenges that nanotechnology faces on the conception of more efficient nanoformulations against primary tumors, circulating cancer cells and metastases.