Download or read book Respiratory Genetics written by Edwin Silverman and published by CRC Press. This book was released on 2005-09-30 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a recent explosion of knowledge in the field of respiratory genetics. This authoritative text brings together current knowledge in respiratory genetics in a single volume. The book includes a comprehensive introductory section to provide guidance and aid understanding of key basic concepts in respiratory genetics, including statistical methods, sample collection, bioinformatics, and functional genomics. This is followed by a series of disease-specific chapters that review epidemiology, natural history, monogenic determinants, complex disease components, disease management, and likely future developments. Respiratory Genetics is an essential reference for pulmonologists, translational researchers, and clinical geneticists, and the text will also be a useful library reference.
Download or read book Functional Genomics of Lung Disease written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functional Genomics of Lung Disease written by and published by . This book was released on 2004 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functional genomics of lung disease written by and published by . This book was released on 2004 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Supplement written by American Thoracic Society and published by . This book was released on 2004 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Supplement Functional Genomics of Lung Disease written by Pittsburgh International Lung Conference and published by . This book was released on 2004 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Download or read book Clinical Relevance of Genetic Factors in Pulmonary Diseases written by Takeshi Kaneko and published by Springer. This book was released on 2018-07-12 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the underlying genetic basis of common pulmonary diseases and discusses their pathogenesis and pathophysiology. These insights provide the basis for understanding different subtypes and phonotypes, and will promote better treatment strategies and individualized medicine. The book provides new and valuable information for the development of the areas of study, as well as practical guidelines for clinicians engaged in treating pulmonary diseases. This volume of the Respiratory Disease Series – Diagnostic Tools and Disease Managements will broaden the understanding of beginning and experienced researchers and clinicians who treat pulmonary diseases. Moreover, residents and clinicians engaged in medical oncology will find it a valuable guide to support them in their day-to-day work.
Download or read book Making Genomics Functional in Lung Disease written by and published by . This book was released on 2007 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Pathology of Lung Diseases written by Dani S. Zander and published by Springer Science & Business Media. This book was released on 2010-05-26 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: This major work, complete with 150 illustrations, many of them in color, bridges the gap between clinical pulmonary pathology and basic molecular science. Through a highly visual approach that features an abundance of tables and diagrams, the book offers a practical disease-based overview. The first two sections of the volume provide the reader with general concepts, terminology and procedures in molecular pathology. The remainder of the volume is subdivided into neoplastic and non-neoplastic lung diseases with detailed chapters covering the current molecular pathology of specific diseases. The book will be essential reading for pathologists, pulmonologists, thoracic surgeons and other health care providers interested in lung disease.
Download or read book Network Medicine written by Joseph Loscalzo and published by Harvard University Press. This book was released on 2017-02-01 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. With contributions from leading experts, Network Medicine introduces this rapidly evolving field of research, which promises to revolutionize the diagnosis and treatment of human diseases.
Download or read book The Global Impact of Respiratory Disease written by Darcy D. Marciniuk and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetics of Asthma and Chronic Obstructive Pulmonary Disease written by Dirkje S. Postma and published by CRC Press. This book was released on 2007 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Responding to the substantial growth that has taken place in the field over the past decade, this reference provides an in-depth overview of current thought on the genetics and genomics of asthma and COPD in relation to their pathogenesis and treatment. With contributions by an esteemed team of international authorities on the topic, this source spans the latest developments in the utilization of microarray techniques, linkage and association studies, mapping strategies, comparative genetics, microarray techniques, proteomics, and pharmacogenomics.
Download or read book Exploring the Role of Gene environment Interactions in Asthma written by Minal Caliskan and published by . This book was released on 2013 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human rhinovirus (HRV) is the most frequent causative pathogen of the common cold and is also involved in the inception and morbidity of several upper and lower respiratory illnesses including bronchiolitis in infancy, childhood pneumonia, and acute exacerbations of chronic respiratory diseases such as asthma, chronic obstructive lung disease, and cystic fibrosis. In this dissertation, I aimed to uncover the genetic and gene expression contributions to inter-individual variation in response to human rhinovirus infection (HRV) in relation to asthma and lung function phenotypes. In Chapter 2, I explored the suitability of lymphoblastoid cell lines (LCLs) for functional genomics studies. I found evidence suggesting that LCLs may be a faithful model for expression quantitative trait loci (eQTL) mapping studies but not for studies of perturbations that affect immune and stress response. In Chapter 3, I studied the main and interactive effects of the genotype at the 17q21 asthma susceptibility locus and HRV wheezing illnesses in early life on inception of asthma in children. I found that variation at the 17q21 locus is associated with the risk and number of HRV wheezing illnesses in the first three years of life. I also showed that 17q21 locus is associated with asthma only in children who had had HRV wheezing illness in early life, suggesting an interaction between a common genetic risk factor (17q21 genotype) and a common environmental risk factor (HRV wheezing illness) with respect to childhood-onset asthma. In Chapter 4, I integrated genome-wide gene expression and genotype data in uninfected and HRV-infected peripheral blood mononuclear cells (PBMCs). I identified local genetic variation that affects gene expression in uninfected and HRV-infected PBMCs. Additionally, I discovered genotype x HRV interactions that influence the expression levels of 32 genes, and showed that HRV-interacting regulatory variations are promising QTLs for pulmonary function phenotypes.
Download or read book Nutritional Genomics of Pulmonary Function written by Jiayi Xu and published by . This book was released on 2019 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accelerated pulmonary function decline is a key risk factor for development of chronic obstructive pulmonary disease (COPD), the 3rd leading cause of death worldwide. Chronic inflammation is central to the pathogenesis of steep pulmonary function decline and COPD and a healthy diet rich in sources of antioxidant and anti-inflammatory nutrients is hypothesized to counter inflammation and contribute to better lung function and lower risk of COPD. This dissertation investigated whether higher levels of biomarkers of nutrients with anti-inflammatory function (i.e., vitamin D, omega-3 fatty acids) and nutrient with antioxidant function (i.e., vitamin E) were associated with higher pulmonary function and whether the nutrients' positive effects were stronger in cigarette smokers, given the oxidative damage smoking causes in the lungs. In addition, given the role of genetic variation in nutrient metabolism and pulmonary function, this dissertation also investigated whether nutritional status and genetic variation jointly affect pulmonary function. First, we designed a cohort-specific analysis plan and conducted a meta-analysis in 8 cohort studies to investigate the cross-sectional association of serum vitamin D concentration with pulmonary function (measured by forced expiratory volume in the 1st second [FEV1] and forced vital capacity [FVC]). We found consistently positive associations across the cohorts and the ancestries (European ancestry [EA] and African ancestry [AA]), with a stronger effect in ever smokers. Next, we investigated another set of nutrients that contribute to anti-inflammatory pathways, specifically the omega-3 fatty acids. We conducted a meta-analysis in 7 cohorts to investigate whether the association of genetic variants with pulmonary function depends on blood levels of omega-3 fatty acids. We found that docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA) were positively associated with pulmonary function, with a stronger effect in current smokers. In the genome-wide interaction analysis, we identified a novel genetic variant, the major allele (A) of rs11683320 on the DPP10 gene that was inversely associated with FVC. The negative association of rs11683320 was attenuated by a higher DHA concentration, with a stronger effect in former smokers. This novel locus, which was missed in previous standard genome-wide association studies (GWAS) that did not account for the interaction with DHA, was replicated in one independent cohort study and passed the Bonferroni-corrected genome-wide significance level (P
Download or read book A Nationwide Framework for Surveillance of Cardiovascular and Chronic Lung Diseases written by Institute of Medicine and published by National Academies Press. This book was released on 2011-08-26 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic diseases are common and costly, yet they are also among the most preventable health problems. Comprehensive and accurate disease surveillance systems are needed to implement successful efforts which will reduce the burden of chronic diseases on the U.S. population. A number of sources of surveillance data-including population surveys, cohort studies, disease registries, administrative health data, and vital statistics-contribute critical information about chronic disease. But no central surveillance system provides the information needed to analyze how chronic disease impacts the U.S. population, to identify public health priorities, or to track the progress of preventive efforts. A Nationwide Framework for Surveillance of Cardiovascular and Chronic Lung Diseases outlines a conceptual framework for building a national chronic disease surveillance system focused primarily on cardiovascular and chronic lung diseases. This system should be capable of providing data on disparities in incidence and prevalence of the diseases by race, ethnicity, socioeconomic status, and geographic region, along with data on disease risk factors, clinical care delivery, and functional health outcomes. This coordinated surveillance system is needed to integrate and expand existing information across the multiple levels of decision making in order to generate actionable, timely knowledge for a range of stakeholders at the local, state or regional, and national levels. The recommendations presented in A Nationwide Framework for Surveillance of Cardiovascular and Chronic Lung Diseases focus on data collection, resource allocation, monitoring activities, and implementation. The report also recommends that systems evolve along with new knowledge about emerging risk factors, advancing technologies, and new understanding of the basis for disease. This report will inform decision-making among federal health agencies, especially the Department of Health and Human Services; public health and clinical practitioners; non-governmental organizations; and policy makers, among others.
Download or read book Idiopathic Pulmonary Fibrosis written by Ulrich Costabel and published by European Respiratory Society. This book was released on 2016-03-01 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Idiopathic pulmonary fibrosis (IPF) is a steadily progressive and ultimately fatal disease of unknown origin. Recent years have seen advances in our understanding of IPF and a number of guidelines have been published. But many questions remain unanswered, particularly surrounding probable versus definite IPF. This Monograph aims to discuss the latest achievements in IPF, and covers key diagnostic issues, staging of the disease, complications and comorbidities, treatment, unmet patient needs and perspectives for the future. This book will be of interest to all clinicians and researchers in this area.
